Rotating nightshift work and hematopoietic cancer risk in U.S. female nurses
Menée aux Etats-Unis à partir des données des cohortes "the Nurses’ Health Study" et "the Nurses’ Health Study II" portant au total sur 189 933 femmes, cette étude analyse l'association entre le travail de nuit en horaires rotatifs et le risque de cancer hématopoïétique (1 910 cas), par sous-types
Résumé en anglais
Nightshift work is a plausible risk factor for hematologic cancer, but epidemiological evidence remains sparse, especially for individual subtypes. We prospectively examined the association of rotating nightshift work with hematopoietic cancer risk.This cohort study included US females from the Nurses’ Health Study (NHS: n = 76,846, 1988-2012) and Nurses' Health Study II (NHSII: n = 113,087, 1989-2013). Rotating nightshift work duration was assessed at baseline (both cohorts) and cumulatively updated (NHSII). Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (95%CIs) for overall hematopoietic cancer and specific histologic subtypes. All statistical tests were two-sided.We documented 1,405 (NHS) and 505 (NHSII) incident hematopoietic cancer cases during follow-up. In NHS, compared to women who never worked rotating nightshifts, longer rotating nightshift work duration was associated with an increased risk of overall hematopoietic cancer (HR1-14yrs=0.93, 95%CI, 0.83-1.04; HR≥15yrs=1.28, 95%CI, 1.06-1.55; P for trend=.009). In NHSII, results were similar, though not statistically significant (HR1-14yrs=0.99, 95%CI, 0.82-1.21; HR≥15yrs=1.41, 95%CI, 0.88-2.26; P for trend=.47). In the subtype analyses in the NHS, the association of history of rotating nightshift work with risk of diffuse large B-cell lymphoma varied by duration (HR1-14yrs=0.71, 95%CI, 0.51-0.98; HR≥15yrs=1.69, 95%CI, 1.07-2.67; P for trend=.01), compared with those never having worked rotating nightshifts. Women reporting a longer history of rotating nightshifts also had suggestive (statistically non-significant) increased risks of overall non-Hodgkin lymphoma (HR≥15yrs=1.19, 95%CI, 0.95-1.49), Hodgkin lymphoma (HR≥15yrs=1.32, 95%CI, 0.43-4.06), and multiple myeloma (HR≥15yrs=1.42, 95%CI, 0.85-2.39).Longer duration (≥15 years) of rotating nightshift work was associated with increased risks of overall and several subtypes of hematopoietic cancer.
