A partir d'une revue systématique de la littérature (24 études, 3 607 patients), cette étude analyse l'intérêt de l'analyse d'impédance bioélectrique (BIA) pour détecter une sarcopénie chez les patients adultes atteints d'un cancer

Bioelectrical Impedance Analysis for the Assessment of Sarcopenia in Patients with Cancer: A Systematic Review

Aleixo, Gabriel F.P. ; Shachar, Shlomit S. ; Nyrop, Kirsten A. ; Muss, Hyman B. ; Battaglini, Claudio L. ; Williams, Grant R.

Background : The loss of muscle mass, known as sarcopenia, is a natural process of aging that is associated with adverse health outcomes regardless of age. Because cancer is a disease of aging, interest in sarcopenia and its potential impact in multiple cancer populations has increased significantly. Bioelectrical impedance analysis (BIA) is a guideline‐accepted method for sarcopenia detection. This systematic review assesses the literature pertaining to BIA use in the detection of sarcopenia [...]

Menée en Suède à partir de données portant sur 52 853 personnes infectées par le virus de l'hépatite C et sur 523 649 témoins, cette étude de cohorte analyse l'évolution de l'incidence du cancer du foie sur la période 1990-2015

Hepatitis C virus infection and the temporal trends in the risk of liver cancer: a national register-based cohort study in Sweden

Batyrbekova, Nurgul ; Aleman, Soo ; Lybeck, Charlotte ; Montgomery, Scott ; Duberg, Ann-Sofi

Background: In many countries, including Sweden, the birth cohorts with the highest prevalence of hepatitis C virus (HCV) infection have now reached the ages with high risk of primary liver cancer (PLC). The aims were to investigate the temporal trends in PLC incidence and the relative risks of PLC among people diagnosed with HCV-infection between 1990 and 2015. Methods: The HCV-cohort (n: 52,853) was compared with a matched non-HCV comparison-cohort (n: 523,649). Both the Cancer (CR) and Death [...]

Menée à partir des données du registre californien des cancers sur la période 1988-2014, cette étude analyse l'évolution des disparités ethniques dans l'incidence du carcinome hépatocellulaire (47 992 cas)

Disparities in Hepatocellular Carcinoma Incidence in California: An Update

Sangaramoorthy, Meera ; Yang, Juan ; DeRouen, Mindy C. ; Ho, Chanda ; Somsouk, Ma ; Tana, Michele M. ; Thompson, Caroline A ; Gibbons, Joseph ; Gomez, Scarlett Lin ; Shariff-Marco, Salma

Background: Given changes in hepatocellular carcinoma (HCC) incidence and the ethno-demographic landscape, we analyzed recent HCC incidence patterns and trends in California. Methods: Using 47,992 primary, invasive HCC cases diagnosed 1988-2014 from the California Cancer Registry, we calculated age-adjusted incidence rates (IRs), annual percent change (APC), and 95% confidence intervals (CIs), by sex, race/ethnicity, and nativity among Hispanics and Asian ethnic groups. Results: Compared to [...]

Menée aux Etats-Unis à partir de données portant sur 252 adolescents et jeunes adultes décédés d'un cancer entre 2013 et 2016 (âge : 15-39 ans), cette étude rétrospective analyse l'effet de divers indicateurs de pauvreté sur le lieu et les soins de fin de vie

End-of-life care among adolescent and young adult patients with cancer living in poverty

Roeland, Eric J. ; Lindley, Lisa C. ; Gilbertson-White, Stephanie ; Saeidzadeh, Seyedehtanaz ; Currie, Erin R. ; Friedman, Sarah ; Bakitas, Marie ; Mack, Jennifer W.

Background : To the authors' knowledge, end‐of‐life (EOL) care outcomes among adolescents and young adults (AYAs) with cancer who are living in poverty remain poorly understood. The primary aim of the current study was to examine the effect of poverty on EOL care for AYA patients with cancer. Methods : The authors conducted a multisite, retrospective study of AYA patients with cancer aged 15 to 39 years who died between January 2013 and December 2016 at 3 academic sites. Medical record‐based [...]

Menée dans les pays nordiques, cette étude analyse l'évolution sur la période 1980-2013 de la survie relative à 5 ans chez des patients atteints d'un cancer, selon la catégorie d'âge au diagnostic (enfants : 0-14 ans , adolescents et jeunes adultes : 15-24 ans, adultes : 25-34 ans)

Survival after cancer in children, adolescents and young adults in the Nordic countries from 1980 to 2013

Rostgaard, Klaus ; Hjalgrim, Henrik ; Madanat-Harjuoja, Laura ; Johannesen, Tom B. ; Collin, Sofia ; Hjalgrim, Lisa L.

Background : The present study aimed to assess whether the widespread concern of inferior cancer survival in adolescents and young adults (AYAs) compared with children and adults holds true in a Nordic setting with important differences in healthcare organisation compared with the United States (e.g. free access to healthcare) and the United Kingdom (e.g. young teenagers are treated in paediatric departments). Methods : Five-year relative survival was calculated for 17 diagnostic groups in [...]

A partir d'une revue de la littérature, cette étude analyse les facteurs associés au risque de complications neurologiques chez les patients atteints d'un mélanome et présente les stratégies de prise en charge

Neurologic complications of melanoma

Cohen, Justine V. ; Wang, Nancy ; Venur, Vyshak A. ; Hadfield, Matthew J. ; Cahill, Daniel P. ; Oh, Kevin ; Brastianos, Priscilla K.

Neurologic complications are common in patients with melanoma and are often associated with a poor prognosis. In an era with new, effective treatments, patients are living longer, and this has resulted in an increase in complications of both the disease and the therapy. A multidisciplinary approach to neurologic complications in patients with melanoma, with involvement from medical oncology, neuro‐oncology, radiation oncology, and often neurosurgery, is necessary. In this review, neurologic [...]

Menée à partir des données des registres américains et de la base Medicare portant sur 635 patients atteints d'un myélome récidivant (âge médian : 72 ans), cette étude analyse les facteurs associés au risque d'événements indésirables de nature cardiopulmonaire induits par le carfilzomib

Measuring cardiopulmonary complications of carfilzomib treatment and associated risk factors using the SEER-Medicare database

Fakhri, Bita ; Fiala, Mark A. ; Shah, Nina ; Vij, Ravi ; Wildes, Tanya M.

Background : Carfilzomib improves survival in patients with recurrent myeloma. Given the strict eligibility criteria in clinical trials, the actual frequency of cardiac adverse events (CAEs) and pulmonary adverse events (PAEs) and the risk factors associated with these AEs in the general population need to be established. Methods : The authors extracted myeloma cases in the Surveillance, Epidemiology, and End Results (SEER)–Medicare linked database from 2000 through 2013 and corresponding [...]

Menée en Suède à partir de données portant sur 4 256 patients atteints d'un cancer du poumon à petites cellules diagnostiqué entre 2002 et 2011, cette étude analyse l'association entre le niveau d'éducation (durée d'années d'études), la prise en charge thérapeutique et le risque de décès

Educational level, management and outcomes in small-cell lung cancer (SCLC): a population-based cohort study

Tendler, Salomon ; Holmqvist, Marit ; Wagenius, Gunnar ; Lewensohn, Rolf ; Lambe, Mats ; De Petris, Luigi

Objectives : To examine if educational status is associated with outcome in patients with Small Cell Lung Cancer (SCLC). The study also investigated differences in patterns of management (lead times and treatment intensity) between educational levels. Material and methods : This nationwide cohort study was based on data from Lung Cancer Data Base Sweden (LCBaSe) generated by record linkages between the Swedish National Lung Cancer Register and several other population-based registers. [...]

Menée à partir des données des registres américains des cancers et de la base Medicare portant sur 620 patients atteints d'un cancer de la prostate et sur 3 100 témoins, cette étude analyse l'association entre le fait d'avoir reçu une greffe d'organe avant ou après le diagnostic de la maladie et la mortalité globale

Prostate Cancer Outcomes Following Solid-Organ Transplantation: A SEER-Medicare Analysis

Liauw, Stanley L ; Ham, Sandra A ; Das, Lauren C ; Rudra, Sonali ; Packiam, Vignesh ; Koshy, Matthew ; Weichselbaum, Ralph R ; Becker, Yolanda T ; Bodzin, Adam ; Eggener, Scott E

Background : Immunosuppressive regimens associated with organ transplantation increase the risk of developing cancer. Transplant candidates and recipients with prostate cancer are often treated, even if low risk features would ordinarily justify active surveillance. Methods : Using SEER-Medicare, we identified 163,676 men aged ≥66, diagnosed with non-metastatic prostate cancer. History of solid organ transplant was identified using diagnosis or procedure codes. A propensity score-matched cohort [...]

Menée à partir des données d'un registre américain des cancers sur la période 2004-2014, cette étude analyse l'évolution de l'incidence du cancer agressif de la prostate, selon l'origine ethnique (89 133 cas)

Temporal and spatial trends and determinants of aggressive prostate cancer among Black and White men with prostate cancer

Wang, Ming ; Chi, Guangqing ; Bodovski, Yosef ; Holder, Sheldon L. ; Lengerich, Eugene J. ; Wasserman, Emily ; McDonald, Alicia C.

Purpose : Few studies have reported temporal and spatial trends of aggressive prostate cancer (PC) among black men who are known to have more aggressive disease. We examined these trends for highly aggressive PC at diagnosis among black and white men in Pennsylvania (PA). Methods : Men, aged ≥ 40 years, with a primary, clinical PC diagnosis were identified from the Pennsylvania Cancer Registry, 2004–2014. Joinpoint analysis was used to evaluate the temporal trend of highly aggressive PC [...]

Menée aux Pays-Bas à partir de données portant sur 6 042 patients atteints d'un cancer du testicule traité entre 1976 et 2006, cette étude analyse l'association entre des chimiothérapies à base de sels de platine et la mortalité spécifique (durée médiane de suivi : 17,6 ans ; 800 décès)

Platinum exposure and cause-specific mortality among patients with testicular cancer

Groot, Harmke J. ; van Leeuwen, Flora E. ; Lubberts, Sjoukje ; Horenblas, Simon ; de Wit, Ronald ; Witjes, J. Alfred ; Groenewegen, Gerard ; Poortmans, Philip M. ; Hulshof, Maarten C. C. M. ; Meijer, Otto W. M. ; de Jong, Igle J. ; van den Berg, Hetty A. ; Smilde, Tineke J. ; Vanneste, Ben G. L. ; Aarts, Maureen J. B. ; Jóźwiak, Katarzyna ; van den Belt-Dusebout, Alexandra W. ; Gietema, Jourik A. ; Schaapveld, Michael

Background : Although testicular cancer (TC) treatment has been associated with severe late morbidities, including second malignant neoplasms (SMNs) and ischemic heart disease (IHD), cause‐specific excess mortality has been rarely studied among patients treated in the platinum era. Methods : In a large, multicenter cohort including 6042 patients with TC treated between 1976 and 2006, cause‐specific mortality was compared with general population mortality rates. Associations with treatment were [...]

Menée aux Etats-Unis à partir de données portant sur 1 901 patients ayant survécu à un cancer de la tête et du cou diagnostiqué entre 1996 et 2012 et sur 7 796 témoins, cette étude analyse les facteurs associés au risque d'événements indésirables et de maladies respiratoires

Adverse respiratory outcomes among head and neck cancer survivors in the Utah Cancer Survivors Study

Kawakita, Daisuke ; Abdelaziz, Sarah ; Chen, Yuji ; Rowe, Kerry ; Snyder, John ; Fraser, Alison ; Smith, Ken ; Herget, Kimberly ; Deshmukh, Vikrant ; Newman, Michael ; Monroe, Marcus ; Hashibe, Mia

Background : The number of head and neck cancer (HNC) survivors has been increasing because of improving survival in the United States. The aim of this study was to evaluate the incidence of respiratory disease diagnoses in HNC survivors in comparison with cancer-free individuals. A second aim was to investigate risk factors for respiratory disease among HNC survivors. Methods : Patients with HNC diagnosed from 1996 to 2012 were identified in the Utah Cancer Registry (n = 1901). Up to 5 [...]

Menée à partir des données des registres américains des cancers sur la période 2004-2015 portant sur 57 118 patients atteints d'un cancer de la tête et du cou de stade IV (âge moyen : 61,9 ans), cette étude de cohorte analyse les disparités ethniques et de genre dans l'incidence de la maladie

Rising incidence of late-stage head and neck cancer in the United States

Thompson-Harvey, Adam ; Yetukuri, Mahi ; Hansen, Alec R. ; Simpson, Matthew C. ; Adjei Boakye, Eric ; Varvares, Mark A. ; Osazuwa-Peters, Nosayaba

Background : The current study was conducted to determine whether the incidence of late-stage head and neck cancer (HNC) is decreasing and to estimate the risk of late-stage HNC diagnosis based on race and sex. Methods : Age-adjusted incidence rates for patients aged ≥18 years with stage IV HNC were abstracted from the Surveillance, Epidemiology, and End Results database (2004-2015). Rates were stratified by race, sex, and age. Joinpoint regression estimated annual percent changes (APCs) in [...]

Menée en Allemagne auprès de 632 adultes ayant survécu à un cancer pendant l'enfance, cette étude analyse l'intérêt d'un outil pour analyser les facteurs associés à leur souhait d'avoir ou non un enfant

The desire for children among adult survivors of childhood cancer: Psychometric evaluation of a cancer-specific questionnaire and relations with sociodemographic and psychological characteristics

Ernst, Mareike ; Brähler, Elmar ; Wild, Philipp S. ; Faber, Jörg ; Merzenich, Hiltrud ; Beutel, Manfred E.

Objective : Long-term childhood cancer survivors (CCS) are less likely to become parents than their peers of the same age. Previous research has suggested that besides fertility, this outcome is shaped by psychosocial factors such as emotional motives toward having a child. Drawing from a sample of CCS with survival times >25 years, we present the validation of a questionnaire assessing cancer-specific reproductive motives and concerns. Methods : We evaluated the cancer-specific version of the [...]

Menée aux Etats-Unis par questionnaire auprès de 87 dyades constitutées du patient atteint d'un cancer de stade avancé et du conjoint aidant, cette étude analyse l'effet, sur la durée du sommeil du couple, de symptômes d'anxiété et de dépression

Dyadic effects of distress on sleep duration in advanced cancer patients and spouse caregivers

Otto, Amy K. ; Gonzalez, Brian D. ; Heyman, Richard E. ; Vadaparampil, Susan T. ; Ellington, Lee ; Reblin, Maija

Objective : Short sleep duration is a common problem for both advanced cancer patients and their spouse caregivers. Sleep and distress have been shown to be interdependent in patient-caregiver and spouse dyads, yet virtually, no work has explored the dyadic effects of psychological distress on sleep in advanced cancer patients and spouse caregivers. The goal of the present study was to examine the dyadic impact of anxiety and depression on sleep duration in a sample of advanced cancer patients [...]

Menée en Suède par enquête auprès de 133 mères et 92 pères ayant perdu leur enfant d'un cancer 1 à 5 ans auparavant, cette étude analyse les facteurs associés à des symptômes de chagrin qui perdurent

Factors During a Child’s Illness Are Associated With Levels of Prolonged Grief Symptoms in Bereaved Mothers and Fathers

Lilian Pohlkamp ; Ulrika Kreicbergs ; Josefin Sveen

PURPOSE : Previous research shows that bereaved parents are at an increased risk for intense and prolonged grief responses. To offer effective support to parents during a child’s cancer treatment and after their child’s death, more knowledge is needed about factors related to the child’s illness trajectory that may contribute to prolonged grief in bereaved parents and about possible sex differences related to such factors. Therefore, we examined possible contributing factors associated with [...]

A partir d'une revue systématique de la littérature (28 essais, 2 082 patients), cette méta-analyse évalue l'efficacité des interventions de nature psychosociale pour augmenter et renforcer l'affect positif des patients ayant survécu à un cancer

Psychosocial interventions for cancer survivors: A meta-analysis of effects on positive affect

Salsman, John M. ; Pustejovsky, James E. ; Schueller, Stephen M. ; Hernandez, Rosalba ; Berendsen, Mark ; McLouth, Laurie E. Steffen ; Moskowitz, Judith T.

Purpose : Positive affect has demonstrated unique benefits in the context of health-related stress and is emerging as an important target for psychosocial interventions. The primary objective of this meta-analysis was to determine whether psychosocial interventions increase positive affect in cancer survivors. Methods : We coded 28 randomized controlled trials of psychosocial interventions assessing 2082 cancer survivors from six electronic databases. We calculated 76 effect sizes for positive [...]

Menée au Canada à partir de données portant sur 4 773 mères et 7 897 frères et soeurs d'un enfant atteint d'un cancer diagnostiqué entre 1998 et 2014, cette étude analyse les facteurs associés à la survenue d'événements psychiatriques sévères et à la santé psychique des membres de la famille (urgences psychiatriques, hospitalisation dans des services psychiatriques, suicide, etc.)

Long-Term Mental Health Outcomes in Mothers and Siblings of Children With Cancer: A Population-Based, Matched Cohort Study

Jacqui van Warmerdam ; Rinku Sutradhar ; Paul Kurdyak ; Cindy Lau ; Jason D. Pole ; Paul C. Nathan ; Sumit Gupta

PURPOSE : Although a diagnosis of childhood cancer can have a profound effect on the entire family unit, its impact on the long-term mental health of family members is not well characterized. METHODS : A provincial childhood cancer registry in Ontario, Canada, was linked to birth records to identify separate population-based cohorts of mothers and siblings of children diagnosed with cancer between 1998 and 2014. The mother and sibling cohorts were matched to corresponding population controls [...]

Menée au Danemark à partir de données portant sur 2 002 femmes ayant des antécédents familiaux de cancer et sur 18 018 témoins, cette étude analyse l'association entre une ovariectomie bilatérale prophylactique et une utilisation d'antidépresseurs, en fonction de l'âge lors du traitement prophylactique et de l'utilisation d'un traitement hormonal substitutif

Use of antidepressants in women after prophylactic bilateral oophorectomy: A Danish national cohort study

Abildgaard, Julie ; Ahlström, Magnus Glindvad ; Nielsen, Dorte Lisbeth ; Daugaard, Gedske ; Lindegaard, Birgitte ; Obel, Niels ; Lidegaard, Øjvind

OBJECTIVE : To investigate the association between prophylactic bilateral oophorectomy and use of antidepressants in women with a family history of cancer. METHODS : Nationwide population‐based cohort study using Danish National Registries including women oophorectomized due to a family history of cancer (n = 2,002) and an age matched reference group (n = 18,018). Analyses were stratified by age at time of bilateral oophorectomy and use of hormone replacement therapy (HRT). RESULTS : Women [...]

A partir d'une revue systématique de la littérature publiée entre 2009 et 2017 (22 études), cette étude analyse l'efficacité, pour améliorer la santé psychique, la qualité de vie et le sentiment d'auto-efficacité, d'interventions de nature psychosociale destinées aux aidants de patients atteints d'un cancer du poumon

Psychosocial Interventions for Informal Caregivers of Lung Cancer Patients: A Systematic Review

Kedia, Satish K. ; Collins, Andy ; Dillon, Patrick J. ; Akkus, Cem ; Ward, Kenneth D. ; Jackson, Bianca M.

Objective : Caregivers of patients with lung cancer often face physical, emotional, and financial distress, which not only negatively affects the caregivers’ mental health and quality of life but may also impact patients’ well-being. The purpose of this systematic review is to examine the content, delivery, and efficacy of psychosocial interventions targeting caregivers of lung cancer patients. Methods : Studies included in this systematic review assessed psychosocial interventions for [...]

Menée en Australie par questionnaire auprès de 120 enfants (âge : 14-24 ans) de 74 patientes atteintes d'un cancer du sein, cette étude prospective analyse leur détresse psychologique et leurs besoins en soins de support

Psychosocial consequences in offspring of women with breast cancer

Chan, Arlene ; Lomma, Christopher ; Chih, HuiJun ; Arto, Carmelo ; McDonald, Fiona ; Patterson, Pandora ; Willsher, Peter ; Reid, Christopher

Purpose : Breast cancer (BC) accounts for 24% of female cancers, with approximately one‐quarter of women likely to have offspring aged <25 years. Recent publications demonstrate negative psychosocial well‐being in these offspring. We prospectively assessed for psychological distress and unmet needs in offspring of BC patients. Patient and Methods : Eligible offspring aged 14 to 24 years were consented and completed the Kessler10 Questionnaire and Offspring Cancer Needs Instrument. Demographic [...]

Menée à partir des données des registres américains des cancers et de la base Medicare sur la période 2007-2015, cette étude analyse les facteurs associés à l'utilisation de médicaments anticancéreux onéreux chez des patients atteints d'un cancer du poumon non à petites cellules de stade métastatique

Factors associated with utilization of high cost agents for the treatment of metastatic non-small cell lung cancer

Bradley, Cathy J ; Eguchi, Megan ; Perraillon, Marcelo C

Background : Antineoplastic agents approved in recent decades are a marked advancement in cancer treatment but come at considerable cost. These drugs may widen survival disparities between patients who receive these agents and those who do not. We examine factors associated with the utilization of high cost antineoplastic agents for the treatment of metastatic non-small cell lung cancer (mNSCLC). Methods : We conducted a retrospective observational study using 2007-2015 SEER-Medicare data [...]

Menée aux Etats-Unis par enquête en ligne auprès de 305 patientes ayant survécu à un cancer du sein, cette étude analyse les facteurs associés à leur volonté de communiquer avec leur médecin au sujet de la santé sexuelle

Talking about sexual health during survivorship: understanding what shapes breast cancer survivors’ willingness to communicate with providers

Canzona, Mollie Rose ; Fisher, Carla L. ; Wright, Kevin B. ; Ledford, Christy J. W.

Purpose : Breast cancer survivor (BCS)–provider communication about sexual health (SH) is often absent or inadequate. Patients report wanting providers to broach the topic, but providers cite barriers to initiating discussions. While the health care community works to address barriers, it is unrealistic to rely solely on provider initiation of SH conversations. This research investigates willingness to communicate about sexual health (WTCSH) to better understand what may interfere with [...]