Menée en Nouvelle Calédonie par questionnaire auprès de 324 personnes atteintes d'un carcinome papillaire ou folliculaire et de 402 témoins (88,3 % de femmes), cette étude analyse l'association entre un indicateur caractérisant une alimentation pro-inflammatoire et le risque de cancer de la thyroïde, en fonction du sexe, de l'origine ethnique, de l'indice de masse corporelle et du statut tabagique

Dietary Inflammatory Index and Differentiated Thyroid Carcinoma Risk: A Population-Based Case-Control Study in New Caledonia

Paquet, Melanie ; Shivappa, Nitin ; Hébert, James R ; Baron-Dubourdieu, Dominique ; Boutron-Ruault, Marie-Christine ; Guénel, Pascal ; Truong, Thérèse

Despite research efforts, current knowledge on the etiology of thyroid carcinoma remains limited. To explore the potential role of diet-induced inflammation, we examined the association between differentiated thyroid cancer risk and the energy-adjusted Dietary Inflammatory Index (E-DII®) in a population-based case-control study conducted in New Caledonia – a Pacific archipelago with one of the highest recorded thyroid cancer incidence rates in the world. The E-DII was computed from food [...]

Menée en Allemagne auprès de 3 418 hommes atteints d'un cancer du poumon et 3 488 témoins, cette étude analyse l'association entre une exposition professionnelle aux fumées de soudage, au chrome hexavalent et au nickel et le risque de développer la maladie

Exposure to Welding Fumes, Hexavalent Chromium, or Nickel and Lung Cancer Risk

Pesch, Beate ; Kendzia, Benjamin ; Pohlabeln, Hermann ; Ahrens, Wolfgang ; Wichmann, Heinz-Erich ; Siemiatycki, Jack ; Taeger, Dirk ; Zschiesche, Wolfgang ; Behrens, Thomas ; Jöckel, Karl-Heinz ; Brüning, Thomas

To investigate lung cancer risk of welding fumes, hexavalent chromium (Cr(VI)), and nickel (Ni), we analyzed 3,418 male lung cancer cases and 3,488 controls from two German case-control studies (1988–1996). We developed a welding-process exposure-matrix from measurements of these agents, which was linked with welding histories from a job-specific questionnaire to calculate cumulative exposure variables. Logistic regression models were fitted to estimate odds ratios with confidence intervals [...]

Menée en Chine auprès de 485 témoins et de 1 015 femmes atteintes d'un cancer du poumon et n'ayant jamais fumé (âge moyen : 54,9 ans), cette étude analyse l'association entre une exposition à 43 polluants atmosphériques domestiques et le risque de développer la maladie

Constituents of Household Air Pollution and Risk of Lung Cancer among Never-Smoking Women in Xuanwei and Fuyuan, China

Roel Vermeulen ; George S. Downward ; Jinming Zhang ; Wei Hu ; Lützen Portengen ; Bryan A. Bassig ; S. Katharine Hammond ; Jason Y.Y. Wong ; Jihua Li ; Boris Reiss ; Jun He ; Linwei Tian ; Kaiyun Yang ; Wei Jie Seow ; Jun Xu ; Kim Anderson ; Bu-Tian Ji ; Debra Silverman ; Stephen Chanock ; Yunchao Huang ; Nathaniel Rothman ; Qing Lan

Background : Lung cancer rates among never-smoking women in Xuanwei and Fuyuan in China are among the highest in the world and have been attributed to the domestic use of smoky (bituminous) coal for heating and cooking. However, the key components of coal that drive lung cancer risk have not been identified. Objectives : We aimed to investigate the relationship between lifelong exposure to the constituents of smoky coal (and other fuel types) and lung cancer. Methods : Using a population-based [...]

Cet article fait le point sur l'association entre une infection par la bactérie Porphyromonas gingivalis et les différents cancers digestifs

The potential role of P.gingivalis in gastrointestinal cancer: a mini review

Liu, Xiao-bo ; Gao, Zi-ye ; Sun, Chuan-tao ; Wen, Hui ; Gao, Bo ; Li, Sheng-bao ; Tong, Qiang

Bacterial infection may be involved in the entire process of tissue carcinogenesis by directly or indirectly affecting the occurrence and development of tumors. Porphyromonas gingivalis (P.gingivalis) is an important pathogen causing periodontitis. Periodontitis may promote the occurrence of various tumors. Gastrointestinal tumors are common malignant tumors with high morbidity, high mortality, and low early diagnosis rate. With the rapid development of molecularbiotechnology, the role of [...]

Menée aux Etats-Unis à l'aide du génotypage du récepteur de la mélanocortine MC1R chez 191 personnes, cette étude analyse le risque génétique de mélanome dans la population hispanique

MC1R Variation in a New Mexico Population

White, Kirsten A.M. ; Dailey, Yvonne T ; Guest, Dolores D ; Zielaskowski, Kate ; Robers, Erika ; Sussman, Andrew ; Hunley, Keith ; Hughes, Christopher R ; Schwartz, Matthew R ; Kaphingst, Kimberly A. ; Buller, David B ; Hay, Jennifer L ; Berwick, Marianne

Background : The Melanocortin 1 Receptor (MC1R) contributes to pigmentation, an important risk factor for developing melanoma. Evaluating single nucleotide polymorphisms (SNPs) in MC1R and association with race/ethnicity, skin type, and perceived cancer risk in a New Mexico population will elucidate the role of MC1R in a multi-cultural population. Methods : We genotyped MC1R in 191 New Mexicans attending a primary care clinic in Albuquerque. We obtained individuals' self-identified [...]

A partir de données de la cohorte "the Nurses’ Health Study II" portant sur 54 710 personnes (durée de suivi : 26 ans), cette étude analyse l'association entre les symptômes de stress post-traumatique et le risque de cancer de l'ovaire, en fonction du statut ménopausique (110 cas)

Posttraumatic stress disorder (PTSD) is associated with increased risk of ovarian cancer: a prospective and retrospective longitudinal cohort study

Roberts, Andrea L. ; Huang, Tianyi ; Koenen, Karestan C. ; Kim, Yongjoo ; Kubzansky, Laura D. ; Tworoger, Shelley S.

Ovarian cancer is the deadliest gynecologic cancer. Chronic stress accelerates tumor growth in animal models of ovarian cancer. We therefore postulated that posttraumatic stress disorder (PTSD) may be associated with increased risk of ovarian cancer. We used data from the Nurses' Health Study II, a longitudinal cohort study with 26 years of follow up, conducted from 1989-2015 with 54,710 subjects. Lifetime PTSD symptoms were measured in 2008. Self-reported ovarian cancer was validated with [...]

Menée à l'aide des données de 5 cohortes européennes portant au total sur 142 femmes atteintes de neurofibromatose 1 et d'un cancer du sein (âge médian au diagnostic : 46,9 ans ; durée de suivi : 1 235 personnes-années) et auprès de 355 femmes atteintes d'un cancer du sein héréditaire, cette étude analyse le risque de développer un cancer du sein controlatéral (12 cas) et évalue la survie à 5 et 10 ans

Breast cancer in neurofibromatosis 1: survival and risk of contralateral breast cancer in a five country cohort study

Evans, D. Gareth R. ; Kallionpaa, Roope A. ; Clementi, Maurizio ; Trevisson, Eva ; Mautner, Victor-Felix ; Howell, Sacha J. ; Lewis, Lauren ; Zehou, Ouidad ; Peltonen, Sirkku ; Brunello, Antonella ; Harkness, Elaine F. ; Wolkenstein, Pierre ; Peltonen, Juha

Purpose : Neurofibromatosis 1 (NF1) is an autosomal dominant condition caused by pathogenic variants of the NF1 gene. A markedly increased risk of breast cancer is associated with NF1. We have determined the breast cancer survival and risk of contralateral breast cancer in NF1. Methods : We included 142 women with NF1 and breast cancer from five cohorts in Europe and 335 women without NF1 screened for other familial breast cancers. Risk of contralateral breast cancer and death were assessed by [...]