Menée en Finlande à partir de données portant sur 29 133 hommes fumeurs, cette étude évalue l'association entre une consommation de café et de thé et le risque de cancer des voies urinaires (période de suivi : 472 402 personnes-années ; 1 201 cas)

Coffee and tea drinking and risk of cancer of the urinary tract in male smokers

Hashemian, Maryam ; Sinha, Rashmi ; Murphy, Gwen ; Weinstein, Stephanie ; Liao, Linda M. ; Freedman, Neal D. ; Abnet, Christian C. ; Albanes, Demetrius ; Loftfield, Erikka

Purpose : We evaluated the association of coffee and tea drinking with risk of the urinary tract cancer in Finnish men, with high coffee consumption, using data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Methods : The ATBC trial conducted from 1985 to 1993, enrolled 29,133 male smokers. We used Cox proportional hazards regression models to estimate hazard ratios (HRs) and confidence intervals (CIs), using men who drank >0 but <1 cup coffee/day and tea non-drinkers [...]

Menée aux Etats-Unis auprès de 25 460 employés dans huit installations de production d'acrylonitrile (durée de suivi : 1 023 922 personnes-années), cette étude analyse l'association entre l'exposition professionnelle à l'acrylonitrile et la mortalité par cancer ou toutes causes confondues (8 124 décès)

Extended Mortality Follow-up of a Cohort of 25,460 Workers Exposed to Acrylonitrile

Blair, Aaron ; Silverman, Debra T ; Beane Freeman, Laura E ; Koutros, Stella ; Graubard, Barry I ; Lubin, Jay H ; Stewart, Patricia A

We extended the mortality follow-up of a cohort of 25,460 workers employed at eight acrylonitrile (AN)-producing facilities in the United States by 21 years. Based on 8,124 deaths and 1,023,922 person-years of follow-up, we evaluated the relationship between occupational AN exposure and mortality. Standardized mortality ratios (SMR) based on deaths through December 31, 2011 were calculated. Work histories and monitoring data were used to develop quantitative estimates of AN exposure. Hazard [...]

A partir de données américaines et canadiennes portant sur 1 690 personnes atteintes d'un lymphome non hodgkinien et sur 5 131 témoins, cette étude évalue l'association entre l'utilisation d'insecticides organophosphatés ou carbamates et le risque de développer la maladie

Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the north American pooled project

Koutros, Stella ; Harris, Shelley A. ; Spinelli, John J. ; Blair, Aaron ; McLaughlin, John R. ; Zahm, Shelia Hoar ; Kim, Sungduk ; Albert, Paul S. ; Kachuri, Linda ; Pahwa, Manisha ; Cantor, Kenneth P. ; Weisenburger, Dennis D. ; Pahwa, Punam ; Pardo, Larissa A. ; Dosman, James A. ; Demers, Paul A. ; Beane Freeman, Laura E.

Organophosphates and carbamates have been among the most commonly used insecticides, with both agricultural and residential uses. Previous studies have suggested associations of non-Hodgkin lymphoma (NHL) with some of these chemicals; however, many studies have been limited in their ability to evaluate associations with lymphoma subtypes. We evaluated the use of eleven organophosphate and two carbamate insecticides in association with NHL in the North American Pooled Project, which includes [...]

Menée au Japon à l'aide d'une méthode de randomisation mendélienne et de données portant sur 32 949 personnes âgés de 40 à 69 ans (durée médiane de suivi : 15,9 ans), cette étude analyse l'association entre le diabète de type 2 et le risque de cancer

Diabetes and Cancer Risk: A Mendelian Randomization Study

Goto, Atsushi ; Yamaji, Taiki ; Sawada, Norie ; Momozawa, Yukihide ; Kamatani, Yoichiro ; Kubo, Michiaki ; Shimazu, Taichi ; Inoue, Manami ; Noda, Mitsuhiko ; Tsugane, Shoichiro ; Iwasaki, Motoki

Earlier cohort studies using conventional regression models have consistently shown an increased cancer risk among individuals with type 2 diabetes. However, reverse causality and residual confounding due to common risk factors could exist, and it remains unclear whether diabetes per se contributes to cancer development. Mendelian randomization analyses might clarify the true association between diabetes and cancer risk. We conducted a case-cohort study with 10,536 subcohort subjects and 3,541 [...]

Menée aux Etats-Unis auprès de 275 686 enfants conçus par fécondation in vitro (FIV) et auprès de 2 266 847 enfants conçus naturellement sur la période 2004-2013, cette étude analyse l'association entre la FIV et le risque de cancer dans la petite enfance (321 cas)

Association of In Vitro Fertilization With Childhood Cancer in the United States

Spector, Logan G. ; Brown, Morton B. ; Wantman, Ethan ; Letterie, Gerard S. ; Toner, James P. ; Doody, Kevin ; Ginsburg, Elizabeth ; Williams, Melanie ; Koch, Lori ; Schymura, Maria J. ; Luke, Barbara

In vitro fertilization (IVF) is associated with birth defects and imprinting disorders. Because these conditions are associated with an increased risk of childhood cancer, many of which originate in utero, descriptions of cancers among children conceived via IVF are imperative.To compare the incidence of childhood cancers among children conceived in vitro with those conceived naturally.A retrospective, population-based cohort study linking cycles reported to the Society for Assisted [...]

Menée auprès de 1 191 enfants atteints d'une leucémie aiguë lymphoblastique à cellules T et auprès de 12 178 témoins, cette étude d'association sur le génome entier identifie des loci de susceptibilité à la maladie

Genome-wide association study of susceptibility loci for T-cell acute lymphoblastic leukemia in children

Smith, Colton ; Yang, Wenjian ; Zhao, Xujie ; Li, Yizhen ; Gocho, Yoshihiro ; Qian, Maoxiang ; Relling, Mary V ; Evans, William E ; Yang, Jun J ; Winter, Stuart S ; Dunsmore, Kimberly P ; Raetz, Elizabeth A ; Carroll, William L ; Winick, Naomi J ; Rabin, Karen R ; Zweidler-McKay, Patrick A ; Wood, Brent ; Hunger, Stephen P ; Zhai, Xiaowen ; Loh, Mignon L ; Devidas, Meenakshi ; Gastier-Foster, Julie M ; Xu, Heng ; Zhang, Shouyue ; Jeha, Sima ; Pui, Ching-Hon ; Mullighan, Charles G ; Sanda, Takaomi

Acute lymphoblastic leukemia (ALL) is the most common cancer in children and can arise in B or T lymphoid lineages. Although risk loci have been identified for B-ALL, the inherited basis of T-ALL is mostly unknown, with a particular paucity of genome-wide investigation of susceptibility variants in large patient cohorts.We performed a genome-wide association study (GWAS) in 1,191 children with T-ALL and 12,178 control subjects, with independent replication using 117 cases and 5,518 controls. [...]

Menée aux Etats-Unis à partir d'échantillons sanguins prélevés sur 705 patients atteints d'un cancer du poumon et 909 témoins, cette étude identifie 10 protéines inflammatoires associées au cancer du poumon et spécifiques à la population afro-américaine

Circulating Inflammation Proteins Associated with Lung Cancer in African Americans

Meaney, Claire ; Mitchell, Khadijah A. ; Zingone, Adriana ; Brown, Derek ; Bowman, Elise ; Yu, Yunkai ; Wenzlaff, Angela S. ; Neslund-Dudas, Christine ; Pine, Sharon ; Cao, Liang ; Schwartz, Ann G. ; Ryan, Bríd M.

Introduction : Lung cancer incidence is higher among AAs compared with European Americans in the United States. We, and others, previously demonstrated a relationship between immune and inflammation proteins with lung cancer in European Americans. Our aim was to investigate the etiological relationship between inflammation and lung cancer in African Americans. Methods : We adopted a two stage, independent study design (discovery n=316 cases and n=528 controls) (validation n=399 cases and 400 [...]

Menée aux Etats-Unis à partir de données portant sur 24 735 femmes, cette étude de cohorte analyse l'effet de l'obésité sur l'association entre un diabète et le risque de cancer du sein après la ménopause

Diabetes, obesity, and subsequent risk of postmenopausal breast cancer among white and black women in the Southern Community Cohort Study

Sanderson, Maureen ; Lipworth, Loren ; Shrubsole, Martha J. ; Andersen, Shaneda Warren ; Shu, Xiao-Ou ; Zheng, Wei ; Hargreaves, Margaret K. ; Blot, William J.

Purpose : Meta-analyses have reported a small but positive association between diabetes and postmenopausal breast cancer risk, with summary relative risks of approximately 1.15. We analyzed data from the Southern Community Cohort Study (SCCS) following an underserved population with high diabetes prevalence to prospectively examine whether diabetes was associated with subsequent postmenopausal breast cancer risk and whether obesity modified this effect. Methods : Women with incident breast [...]