Mené aux Etats-Unis auprès de 120 patients atteints de cancer (sein, colôn-rectum, poumon), cet essai randomisé analyse l'efficacité d'une intervention conduite par les infirmières pour améliorer la prise en charge rapide des symptômes liés à la chimiothérapie

Nursing intervention to enhance outpatient chemotherapy symptom management: Patient-reported outcomes of a randomized controlled trial

Traeger, Lara ; McDonnell, Theresa M. ; McCarty, Caitlin E. ; Greer, Joseph A. ; El-Jawahri, Areej ; Temel, Jennifer S.

BACKGROUND The authors conducted a randomized controlled trial to evaluate a nurse practitioner (NP)-delivered symptom management intervention for patients initiating chemotherapy for nonmetastatic cancer. The aim was to reduce patient-reported symptom burden by facilitating patient-NP collaboration and the early management of symptoms. METHODS At the time of the first chemotherapy visit, adult participants with nonmetastatic breast, colorectal, or lung cancer (120 participants) completed [...]

Menée aux Etats-Unis par questionnaire auprès de 1 713 patients ayant survécu à un cancer, cette étude évalue l'intérêt de consultations menées par des infirmières en oncologie pour aider les patients à s'approprier les pratiques d'un parcours personnalisé de l'après-cancer

Promotion of self-management for post treatment cancer survivors: evaluation of a risk-adapted visit

Rosenberg, CarolA ; Flanagan, Carol ; Brockstein, Bruce ; Obel, JenniferC ; Dragon, LeonH ; Merkel, DouglasE ; Wade, ElaineL ; Law, TeresaM ; Khandekar, JanardanD ; Hensing, ThomasA

Purpose : The LIFE Cancer Survivorship Program at NorthShore University HealthSystem provides risk-adapted visits (RAV) facilitated by an oncology nurse during which a survivorship care plan (SCP) is provided and discussed. In this report, we describe and evaluate RAV in promoting individualized health care and self-management during survivorship transition. Methods : Patients complete a post-RAV questionnaire at their RAV and another ≥1 year after their RAV. Results : One thousand seven [...]

Menée en Suisse auprès de 18 patients atteints d'une leucémie myéloïde aiguë et dans l'attente de recevoir une greffe de cellules souches hématopoïétique allogénique, cette étude randomisée évalue l'efficacité d'une intervention de soins de support dédiée à la prise en charge par le patient de sa santé orale afin de réduire une mucite buccale

An oral care self-management support protocol (OrCaSS) to reduce oral mucositis in hospitalized patients with acute myeloid leukemia and allogeneic hematopoietic stem cell transplantation: a randomized controlled pilot study

Leppla, Lynn ; De Geest, Sabina ; Fierz, Katharina ; Deschler-Baier, Barbara ; Koller, Antje

Introduction : Oral mucositis (OM) is a common and debilitating side effect of chemoradiotherapy in patients awaiting allogeneic hematopoietic stem cell transplantation (aHSCT). Purpose : The aim of this pilot RCT was to compare an oral care self-management support protocol (OrCaSS) to usual pre-aHSCT care. Feasibility was tested, effect sizes calculated for OM (primary outcome), and patient adherence was measured (secondary outcome). Methods : Eighteen AML patients awaiting aHSCT and [...]

A partir d'une revue systématique de la littérature, cette étude analyse les effets du soutien social sur l'amélioration de la qualité de vie de patients atteints d'un cancer métastatique de la prostate

The Effects of Social Support on Health-Related Quality of Life of Patients with Metastatic Prostate Cancer

Colloca, Giuseppe ; Colloca, Pasquale

Patients with metastatic prostate cancer (PC) live longer than patients with metastatic tumours of other sites. Consequently, their social network can influence their quality of life (QoL) during a remarkable life span. The aim of this article is to present the findings of a systematic review of the studies that focused on social network supporting the quality of life of these patients. A systematic review for studies meeting specific criteria was undertaken on three databases. Some level of [...]

Menée aux Pays-Bas par questionnaires, cette étude longitudinale évalue l'association entre l'évolution des symptômes, des facteurs cliniques et socio-démographiques et la pratique d'une activité physique chez des patients ayant survécu à un cancer colorectal

Correlates of physical activity among colorectal cancer survivors: results from the longitudinal population-based profiles registry

van Putten, Margreet ; Husson, Olga ; Mols, Floortje ; Luyer, MishaD P. ; van de Poll-Franse, LonnekeV ; Ezendam, NicoleP M.

Purpose : Physical activity can improve health of cancer survivors. To increase physical activity levels among colorectal cancer (CRC) survivors, we need to understand which factors affect physical activity. Therefore, this study examined the longitudinal relationship between symptom-related, functioning-related, and psychological barriers and socio-demographic and clinical factors with physical activity among CRC survivors. Methods :CRC survivors identified from the population-based Eindhoven [...]

Menée aux Etats-Unis par questionnaire auprès de 254 patients ayant survécu à un cancer du cerveau (âge médian au diagnostic : 42 ans), cette étude analyse les effets indésirables à long terme des traitements

Late effects in survivors of central nervous system tumors: reports by patients and proxies

Sloane, Kelly ; Vachani, Carolyn ; Hampshire, MargaretK ; Metz, JamesM ; Hill-Kayser, ChristineE

Purpose : With the 5-year survival of patients with brain tumors increasing as treatment modalities are optimized, there are a large number of brain cancer survivors who experience long-term sequelae of their treatment. Patient-reported outcomes represent an important and often unrecorded aspect of survivorship. Methods : An Internet-based survivorship care plan tool which allowed patients or their proxies to answer a series of questions about the patient’s illness course was used to collect [...]

Cet article passe en revue les données épidémiologiques du cancer chez les populations homosexuelles et transgenres, les problématiques associées à la prévention ainsi que les facteurs psychosociaux impliqués dans l'après-cancer

Cancer and lesbian, gay, bisexual, transgender/transsexual, and queer/questioning (LGBTQ) populations

Quinn, Gwendolyn P. ; Sanchez, Julian A. ; Sutton, Steven K. ; Vadaparampil, Susan T. ; Nguyen, Giang T. ; Green, B. Lee ; Kanetsky, Peter A. ; Schabath, Matthew B.

This article provides an overview of the current literature on seven cancer sites that may disproportionately affect lesbian, gay, bisexual, transgender/transsexual, and queer/questioning (LGBTQ) populations. For each cancer site, the authors present and discuss the descriptive statistics, primary prevention, secondary prevention and preclinical disease, tertiary prevention and late-stage disease, and clinical implications. Finally, an overview of psychosocial factors related to cancer [...]

A partir des données d'un registre américain des cancers portant sur 350 patientes atteintes d'un carcinome séreux de l'ovaire ou du péritoine de bas grade, cette étude analyse l'impact de l'âge et de la localisation de la tumeur sur la survie sans progression et la survie globale

Impact of Age and Primary Disease Site on Outcome in Women With Low-Grade Serous Carcinoma of the Ovary or Peritoneum: Results of a Large Single-Institution Registry of a Rare Tumor

Gershenson, David M. ; Bodurka, Diane C. ; Lu, Karen H. ; Nathan, Lisa C. ; Milojevic, Ljiljana ; Wong, Kwong K. ; Malpica, Anais ; Sun, Charlotte C.

Purpose : Low-grade serous carcinoma of the ovary (LGSOC) or peritoneum (LGSPC) is a rare subtype of ovarian or peritoneal cancer characterized by young age at diagnosis and relative resistance to chemotherapy. The purpose of this study is to report our updated experience with women diagnosed with LGSOC or LGSPC to assess the validity of our original observations. Patients and Methods : Eligibility criteria for patients from our database were: stage I to IV LGSOC or LGSPC, original diagnosis [...]

A partir des données de la cohorte "Health Professionals Follow-Up Study" incluant 3 949 patients atteints d'un cancer de la prostate, cette étude évalue l'association entre l'utilisation de statines après le diagnostic et la mortalité spécifique (242 décès)

Post-diagnostic statin use and the risk of lethal prostate cancer in the Health Professionals Follow-up Study

Chan, June M. ; Kenfield, Stacey A. ; Paciorek, Alan ; Platz, Elizabeth A. ; Giovannucci, Edward L ; Stampfer, Meir

Background: Observational studies suggest potential chemopreventive benefits of statins on prostate cancer outcomes, but data on the impact of post-diagnostic use are sparse. Methods: We examined the association of post-diagnostic statin use and risk of lethal prostate cancer (metastases or prostate cancer death, N=242) among 3,949 men diagnosed with localized prostate cancer from the Health Professionals Follow-Up Study between 1992 and 2008 and followed through 2010 (33,302 person years). We [...]

Menée à partir de données portant sur 1 043 patients diabétiques utilisant des médicaments hypoglycémiants et atteints d'un cancer colorectal entre 1998 et 2011, cette étude évalue l'association entre l'utilisation de metformine, de statines ou d'aspirine après le diagnostic de cancer et la mortalité globale en tenant compte des effets associés à une utilisation concomitante de l'ensemble de ces substances

Are metformin, statin and aspirin use still associated with overall mortality among colorectal cancer patients with diabetes if adjusted for one another ?

Zanders, M. M. J. ; van Herk-Sukel, M. P. P. ; Vissers, P. A. J. ; Herings, R. M. C. ; Haak, H. R. ; van de Poll-Franse, L. V.

Background : Metformin, statin and aspirin use seem associated with decreased mortality in cancer patients, though, without adjusting for one another. Independent associations of these drugs with overall mortality after colorectal cancer (CRC) diagnosis within glucose-lowering drugs (GLDs) users were assessed. Methods : Patients starting GLDs before CRC diagnosis (1998–2011) were selected from the Eindhoven Cancer Registry linked with the PHARMO Database Network. The Cox regression model, with [...]

Menée aux Etats-Unis à partir de données issues de consultations d'oncogénétique portant sur 193 patients adolescents ou jeunes adultes atteints d'un cancer colorectal (moins de 35 ans lors du diagnostic), cette étude analyse la prévalence des syndromes héréditaires connus (syndrome de Lynch, polypose adénomateuse familiale, ...) et les antécédents familiaux de cancer dans cette population

High Prevalence of Hereditary Cancer Syndromes in Adolescents and Young Adults With Colorectal Cancer

Mork, Maureen E. ; You, Y. Nancy ; Ying, Jun ; Bannon, Sarah A. ; Lynch, Patrick M. ; Rodriguez-Bigas, Miguel A. ; Vilar, Eduardo

Purpose : Established guidelines recommend evaluation for hereditary cancer syndromes in patients younger than 50 years diagnosed with colorectal cancer (CRC). This group has been well described in the literature; however, patients diagnosed as adolescents and young adults are not well represented in CRC studies. Here, we define the clinical profile, including the extent of hereditary cancer syndromes and family history of cancer, in patients diagnosed with CRC at age 35 or younger. Patients [...]

Menée en Espagne auprès de 100 patientes atteintes d'un cancer du sein, cette étude évalue les facteurs prédictifs du risque de dysfonction diastolique après une chimiothérapie à base d'anthracyclines

Diastolic Dysfunction Following Anthracycline-Based Chemotherapy in Breast Cancer Patients: Incidence and Predictors

Serrano, José M. ; Gonzalez, Iria ; Del Castillo, Silvia ; Muñiz, Javier ; Morales, Luis J. ; Moreno, Fernando ; Jiménez, Rosa ; Cristóbal, Carmen ; Graupner, Catherine ; Talavera, Pedro ; Curcio, Alejandro ; Martínez, Paula ; Guerra, Juan A. ; Alonso, Joaquín J.

Cardiotoxicity represents a major limitation for the use of anthracyclines or trastuzumab in breast cancer patients. Data from longitudinal studies of diastolic dysfunction (DD) in this group of patients are scarce. The objective of the present study was to assess the incidence, evolution, and predictors of DD in patients with breast cancer treated with anthracyclines.This analytical, observational cohort study comprised 100 consecutive patients receiving anthracycline-based chemotherapy (CHT) [...]

Menée en Finlande à partir de données portant sur 134 435 femmes mariées et atteintes d'un cancer du sein de stade précoce (durée médiane de suivi : 17 ans), cette étude prospective évalue le risque de divorce et son association avec divers facteurs sociéconomiques, familiaux et médicaux

Early-stage breast cancer is not associated with the risk of marital dissolution in a large prospective study of women

Laitala, V. S. ; Saarto, T. ; Einio, E. K. ; Martikainen, P. ; Silventoinen, K.

Background: As breast cancer and its treatment are likely to interfere with traditional expectations of womanhood, it may affect marital stability. Methods: The risk of marital dissolution was analysed with respect to diagnosis of early-stage (T1–4N0–3M0) breast cancer in a cohort of 134 435 married Finnish women followed for a median of 17.0 married years. Age, socioeconomic status, education, number of children, duration of marriage and earlier marriages were taken into account and the [...]

A partir de données d'études menées dans 17 pays européens, cette étude analyse la prévalence d'une infection par le papillomavirus humain dans les néoplasies cervicales glandulaires (49 cas d'adénocarcinome cervical in situ, 104 cas de carcinome adénosquameux, 461 sous-types divers d'adénocarcinome)

Human papillomavirus prevalence and type-distribution in cervical glandular neoplasias: Results from a European multinational epidemiological study

Holl, Katsiaryna ; Nowakowski, Andrzej M. ; Powell, Ned ; McCluggage, W. Glenn ; Pirog, Edyta C. ; Collas De Souza, Sabrina ; Tjalma, Wiebren A. ; Rosenlund, Mats ; Fiander, Alison ; Castro Sánchez, Maria ; Damaskou, Vasileia ; Joura, Elmar A. ; Kirschner, Benny ; Koiss, Robert ; O'Leary, John ; Quint, Wim ; Reich, Olaf ; Torné, Aureli ; Wells, Michael ; Rob, Lukas ; Kolomiets, Larisa ; Molijn, Anco ; Savicheva, Alevtina ; Shipitsyna, Elena ; Rosillon, Dominique ; Jenkins, David

Cervical glandular neoplasias (CGN) present a challenge for cervical cancer prevention due to their complex histopathology and difficulties in detecting preinvasive stages with current screening practices. Reports of human papillomavirus (HPV) prevalence and type-distribution in CGN vary, providing uncertain evidence to support prophylactic vaccination and HPV screening. This study [108288/108290] assessed HPV prevalence and type-distribution in women diagnosed with cervical adenocarcinoma in [...]

Menée aux Etats-Unis auprès de 111 patients adolescents et jeunes adultes atteints de cancer (âge : 12-25 ans), cette étude analyse leurs besoins et préférences en matière de soins de support de nature psychosociale

Assessing the psychosocial needs and program preferences of adolescents and young adults with cancer

Barakat, LamiaP ; Galtieri, LianaR ; Szalda, Dava ; Schwartz, LisaA

Purpose : Adolescents and young adults (AYA) are a developmentally distinct cancer group, vulnerable to psychosocial late effects and with a range of unmet psychosocial needs. We sought to better understand psychosocial care needs and program preferences to inform development of more easily accessible and effective AYA psychosocial programs. Methods : AYA on and off treatment for cancer (n = 111, ages 12–25 years) were approached during an outpatient clinic visit and completed a survey as part [...]

Menée en Australie par questionnaire auprès de 486 patients ayant survécu à un cancer du testicule, cette étude analyse la prévalence et le niveau de leur détresse psychologique ainsi que les facteurs liés à la détérioration de leur qualité de vie après les traitements

The prevalence, severity, and correlates of psychological distress and impaired health-related quality of life following treatment for testicular cancer: a survivorship study

Smith, Allan“Ben” ; Butow, Phyllis ; Olver, Ian ; Luckett, Tim ; Grimison, Peter ; Toner, GuyC ; Stockler, MartinR ; Hovey, Elizabeth ; Stubbs, John ; Turner, Sandra ; Hruby, George ; Gurney, Howard ; Alam, Mahmood ; Cox, Keith ; King, MadeleineT

Purpose : This study aimed to establish the prevalence, severity, and correlates of psychological distress and impaired generic health-related quality of life (HRQOL) in testicular cancer (TC) survivors. Methods : Men who had completed active anti-cancer treatment for TC between 6 months and 5 years previously showing no evidence of recurrence were recruited from 14 Australian cancer centers from September 2009 to February 2011. Participants completed a self-report questionnaire measuring [...]

Mené aux Etats-Unis auprès de 74 patients atteints d'un cancer de la thyroïde, cet essai évalue l'efficacité d'un outil d'aide à la prise de décision relative à un traitement à l'iode radioactif

Thyroid cancer patient perceptions of radioactive iodine treatment choice: Follow-up from a decision-aid randomized trial

Sawka, Anna M. ; Straus, Sharon ; Rodin, Gary ; Heus, Lineke ; Brierley, James D. ; Tsang, Richard W. ; Rotstein, Lorne ; Ezzat, Shereen ; Segal, Phillip ; Gafni, Amiram ; Thorpe, Kevin E. ; Goldstein, David P.

BACKGROUND Patient decision aids (P-DAs) inform medical decision making, but longer term effects are unknown. This article describes extended follow-up from a thyroid cancer treatment P-DA trial. METHODS In this single-center, parallel-design randomized controlled trial conducted at a Canadian tertiary/quaternary care center, early-stage thyroid cancer patients from a P-DA trial were contacted 15 to 23 months after randomization/radioactive iodine (RAI) decision making to evaluate longer term [...]