Menée dans la région Nord Ouest de l'Angleterre à partir d'une enquête auprès de 16 193 adolescents âgés de 14 à 17 ans, cette étude analyse la relation entre le fait d'avoir essayé ou acheté des cigarettes électroniques et le comportement tabagique ou la consommation d'alcool

Associations between e-cigarette access and smoking and drinking behaviours in teenagers

Karen Hughes1*, ; Mark A Bellis12, ; Katherine A ; Hardcastle1, ; Philip McHale1, ; Andrew Bennett1, ; Robin Ireland3 ; Kate Pike4

Background : Public health concerns regarding e-cigarettes and debate on appropriate regulatory responses are focusing on the need to prevent child access to these devices. However, little is currently known about the characteristics of those young people that are accessing e-cigarettes. Methods : Using a cross-sectional survey of 14-17 year old school students in North West England (n = 16,193) we examined associations between e-cigarette access and demographics, conventional smoking [...]

Menée auprès d'une cohorte japonaise incluant 90 914 participants (âge : 40 à 69 ans ; durée de suivi : 18,7 ans), cette étude prospective évalue l'association entre la consommation de thé vert et la mortalité toutes causes confondues (12 874 cas) ou le risque de décès par cancer, maladie cardiaque, respiratoire ou cérébrovasculaire

Association of Green Tea Consumption with Mortality Due to All Causes and Major Causes of Death in a Japanese Population: the Japan Public Health Center-based Prospective Study (JPHC Study)

Saito, Eiko ; Inoue, Manami ; Sawada, Norie ; Shimazu, Taichi ; Yamaji, Taiki ; Iwasaki, Motoki ; Sasazuki, Shizuka ; Noda, Mitsuhiko ; Iso, Hiroyasu ; Tsugane, Shoichiro

Background and Purpose : We examined the association between green tea consumption and mortality due to all causes, cancer, heart disease, cerebrovascular disease, respiratory disease, injuries and other causes of death in a large-scale population-based cohort study in Japan. Methods : We studied 90,914 Japanese (aged between 40 and 69 years) recruited between 1990 and 1994. After 18.7 years of follow-up, 12,874 deaths were reported. The association between green tea consumption and risk of all [...]

Menée sur des lignées cellulaires de carcinome épidermoïde de l'œsophage et à l'aide de xénogreffes sur un modèle murin, cette étude met en évidence un mécanisme par lequel la 1,25- dihydroxy-vitamine D3 (un métabolite de la vitamine D3) inhibe la progression tumorale en réduisant la signalisation de l'interleukine IL-6

1alpha, 25-dihydroxyvitamin D3 inhibits esophageal squamous cell carcinoma progression by reducing IL-6 signaling

Chen, Ping-Tsung ; Hsieh, Ching-Chuan ; Wu, Chun-Te ; Yen, Tzu-Chen ; Lin, Paul-Yang ; Chen, Wen-Cheng ; Chen, Miao-Fen

The aim of this study was to highlight the role of 1α, 25-dihydroxyvitamin D3 (calcitriol) in esophageal squamous cell carcinoma (SCC). The human esophageal SCC cell lines CE81T and TE2 were selected for cellular and animal experiments to investigate the changes in tumor behavior after calcitriol supplementation and the underlying mechanisms. Moreover, we evaluated the relationship between calcitriol supplementation, myeloid-derived suppressor cell (MDSC) recruitment, IL-6 levels, and tumor [...]

Menée à partir d'une revue systématique de la littérature publiée jusqu'en 2013 (29 études, 461 140 participants), cette méta-analyse évalue l'association entre la consommation d'aliments riches en acides gras oméga-3 à longue chaîne et le risque de cancer de la prostate

Meta-Analysis of Long-Chain Omega-3 Polyunsaturated Fatty Acids (LC omega-3PUFA) and Prostate Cancer

Alexander, Dominik D. ; Bassett, Julie K. ; Weed, Douglas L. ; Barrett, Erin Cernkovich ; Watson, Heather ; Harris, William

We conducted a systematic review and meta-analysis to estimate the potential association between LC

Menée sur 274 patientes atteintes d'un cancer colorectal et sur 274 témoins, cette étude évalue l'association entre les niveaux plasmatiques de la 25-hydroxy-vitamine D (un métabolite de la vitamine D) avant diagnostic de la maladie et le risque de développer un cancer colorectal

Circulating Vitamin D Levels and Risk of Colorectal Cancer in Women

Chandler, Paulette D. ; Buring, Julie E. ; Manson, JoAnn E. ; Giovannucci, Edward L. ; Moorthy, M V ; Zhang, Shumin ; Lee, I-Min ; Lin, Jennifer H

Observational data on the association between circulating 25(OH)D and colorectal cancer risk are limited in women. To determine whether prediagnostic levels of 25(OH)D were associated with risk of incident colorectal cancer in the Women's Health Study (WHS), we conducted a nested case-control study using 274 colorectal cases and 274 controls. Each case was matched to a control by age, ethnicity, fasting status at the time of blood collection, time of day when blood was drawn, and month of blood [...]

Menée sur des lignées cellulaires de cancer du poumon non à petites cellules et à l'aide d'un modèle murin, cette étude montre que la cucurbitacine B, un triterpène tétracyclique d'origine végétale, modifie, via des mécanismes épigénétiques, l'expression de gènes impliqués dans la régulation de la prolifération ou de la croissance des cellules tumorales et inhibe la tumorigenèse induite chimiquement

Cucurbitacin B alters the expression of tumor-related genes by epigenetic modifications in NSCLC and inhibits NNK-induced lung tumorigenesis

Shukla, Samriddhi ; Khan, Sajid ; Kumar, Sudhir ; Sinha, Sonam ; Farhan, Mohd ; Bora, Himangsu K ; Maurya, Rakesh ; Meeran, Syed Musthapa

Non-small cell lung cancer (NSCLC) represents almost 85% of total diagnosed lung cancer. Studies have shown that combination of DNA methyltransferase (DNMTs) and histone deacetylase (HDACs) inhibitors is effective against various cancers including lung cancer. However, optimizing the synergistic dose regime is very difficult and involves adverse side effects. Therefore, in this study, we have shown that cucurbitacin B (CuB), a single bioactive triterpenoid compound, inhibits both DNMTs and [...]