Menée aux Etats-Unis auprès de 97 patients atteints d'un cancer du poumon non à petites cellules de stade avancé, cette étude prospective analyse la nature, la fréquence et la sévérité de leurs symptômes

What bothers lung cancer patients the most? A prospective, longitudinal electronic patient-reported outcomes study in advanced non-small cell lung cancer

LeBlanc, ThomasW ; Nickolich, Myles ; Rushing, ChristelN ; Samsa, GregoryP ; Locke, SusanC ; Abernethy, AmyP

Purpose : Patients with advanced non-small cell lung cancer (aNSCLC) face a significant symptom burden. Little is known about the frequency and severity of symptoms over time, so we longitudinally characterized patients’ symptoms using the Patient Care Monitor (PCM) version 2.0, an electronic symptom-assessment tool. Methods : Ninety-seven patients with aNSCLC completed the PCM at up to four clinic visits. We analyzed symptom data by incidence, severity, type (functional vs. nonfunctional), [...]

Menée en Australie par entretiens auprès de 36 patientes atteintes d'un cancer du sein et mères d'enfants en bas âge, cette étude identifie les obstacles de nature sociale et familiale limitant leurs pratiques d'activité physique

Breast cancer survivors' experiences of partner support and physical activity participation

Mackenzie, Catherine Ruth

Objective : To examine women's experiences of enablers and constraints to physical activity participation after being diagnosed with breast cancer while mothers of dependent children. Methods : In-depth, semi-structured interviews were conducted with 36 Australian women diagnosed with breast cancer while mothers of dependent children. Results : Social, structural and individual enablers and constraints to women's participation in physical activity included level of intimate partner support, [...]

A partir des données des registres américains des cancers, cette étude analyse la mortalité spécifique chez des patients d'origine asiatique atteints d'un cancer diagnostiqué entre 1991 et 2007 (130 852 cas de cancer du poumon, 313 977 cas de cancer du sein, 166 529 cas de cancer de la prostate, 165 140 cas de cancer colorectal)

Cancer-Specific Mortality of Asian Americans Diagnosed With Cancer: A Nationwide Population-Based Assessment

Trinh, Quoc-Dien ; Nguyen, Paul L. ; Leow, Jeffrey J. ; Dalela, Deepansh ; Chao, Grace F. ; Mahal, Brandon A. ; Nayak, Manan ; Schmid, Marianne ; Choueiri, Toni K. ; Aizer, Ayal A.

Background: Racial disparities in cancer survival outcomes have been primarily attributed to underlying biologic mechanisms and the quality of cancer care received. Because prior literature shows little difference exists in the socioeconomic status of non-Hispanic whites and Asian Americans, any difference in cancer survival is less likely to be attributable to inequalities of care. We sought to examine differences in cancer-specific survival between whites and Asian Americans. Methods: The [...]

A partir des données du registre allemand des mélanomes malins portant sur 446 patients âgés de moins de 18 ans, cette étude analyse l'association entre des caractéristiques liées au patient et à la tumeur, et la survie, sur la période 1983-2011

443 paediatric cases of malignant melanoma registered with the German Central Malignant Melanoma Registry between 1983 and 2011

Brecht, Ines B. ; Garbe, Claus ; Gefeller, Olaf ; Pfahlberg, Annette ; Bauer, Jurgen ; Eigentler, Thomas K. ; Offenmueller, Sonja ; Schneider, Dominik T. ; Leiter, Ulrike

Background : Malignant melanoma is a very rare paediatric tumour. This study was performed in order to understand clinical features and prognosis of malignant melanoma in children and adolescents. Methods : 443 patients ⩽18 years of age with malignant melanoma were prospectively registered with the German Central Malignant Melanoma Registry between 1983 and 2011. Cases were collected from 58 participating centres. 276 paediatric cases with a follow-up >3 months were evaluated for survival [...]

Menée aux Etats-Unis à partir de données portant sur 635 patients atteints d'un adénocarcinome pulmonaire présentant des mutations KRAS et sur 496 patients atteints d'un adénocarcinome pulmonaire présentant des mutations EGFR, cette étude analyse la survie globale en fonction du stade au diagnostic et du caractère primitif ou récidivant

Differences in the survival of patients with recurrent versus de novo metastatic KRAS-mutant and EGFR-mutant lung adenocarcinomas

Yu, Helena A. ; Sima, Camelia S. ; Hellmann, Matthew D. ; Naidoo, Jarushka ; Busby, Natalie ; Rodriguez, Katherine ; Riely, Gregory J. ; Kris, Mark G.

BACKGROUND Prognostic variables are independently associated with survival and are fundamental to clinical trial design. In the current study, the authors evaluated the impact of stage of disease at the time of the initial diagnosis on overall survival (OS) in 2 independent, oncogene-defined cohorts. METHODS All patients with epidermal growth factor receptor (EGFR)-mutant and KRAS-mutant metastatic lung adenocarcinomas were identified through routine molecular testing from January 2005 through [...]

A partir d'une base de données médico-administratives allemande portant sur 2 615 865 individus, cette étude de cohorte analyse l'incidence et la prévalence des sarcomes ainsi que la survie des patients sur la période 2005-2012

Burden of soft-tissue and bone sarcoma in routine care: Estimation of incidence, prevalence and survival for health services research

Trautmann, Freya ; Schuler, Markus ; Schmitt, Jochen

Background : Sarcomas constitute a rare group of malignant tumors which can originate from any organ, tissue, bone or cartilage. Due to their heterogeneity, estimates of sarcoma incidence, prevalence and survival are rare. We estimated the burden of sarcoma in Germany from a large unselected cohort of patients from routine healthcare. Methods : We utilized the AOK PLUS health services research database covering complete medical information on 2,615,865 individuals from the German federal state [...]

Menée en Californie par enquête auprès de 500 patientes atteintes d'un cancer du sein de stade 0 à III et devant subir un traitement chirurgical, cette étude analyse les disparités ethniques dans leurs critères de sélection de l'hôpital et du chirurgien

Racial/ethnic differences in patients’ selection of surgeons and hospitals for breast cancer surgery

Freedman, R. A. ; Kouri, E. M. ; West, D. W. ; Keating, N. L.

Importance : Racial differences in breast cancer treatment may result in part from differences in the surgeons and hospitals from whom patients receive their care. However, little is known about differences in patients’ selection of surgeons and hospitals. Objective : To examine racial/ethnic differences in how women selected their surgeons and hospitals for breast cancer surgery. Design, Setting, and Participants : We surveyed 500 women (222 non-Hispanic white, 142 non-Hispanic black, 89 [...]

A partir des données d'un registre italien des cancers, cette étude analyse l'évolution de la survie globale chez des patientes atteintes d'un cancer du sein métastatique de novo diagnostiqué entre 1990 et 2009

Twenty-years experience with de novo metastatic breast cancer

Cortesi, Laura ; Toss, Angela ; Cirilli, Claudia ; Marcheselli, Luigi ; Braghiroli, Barbara ; Sebastiani, Federica ; Federico, Massimo

Although new treatments have been widely studied to improve the survival of patients with metastatic breast cancer (BC), prognosis continues to be poor with an average survival time no longer than 3 years. We carried on a population-based study with the purpose of evaluating the outcome of metastatic breast cancer in the province of Modena from 1990 to 2009. We examined the Modena Cancer Registry and evaluated the 5-year overall survival (OS) of women diagnosed with a de novo metastatic breast [...]

Menée aux Etats-Unis à partir des données du registre national des cancers portant sur 122 796 patientes âgées de 70 ans ou plus et atteintes d'un cancer du sein ER+ de stade précoce diagnostiqué entre 1998 et 2011, cette étude analyse l'évolution de l'utilisation de la radiothérapie après une lumpectomie

The evolving role of adjuvant radiotherapy for elderly women with early-stage breast cancer

Rutter, Charles E. ; Lester-Coll, Nataniel H. ; Mancini, Brandon R. ; Corso, Christopher D. ; Park, Henry S. ; Yeboa, Debra N. ; Gross, Cary P. ; Evans, Suzanne B.

BACKGROUND : Elderly patients with early-stage breast cancer (ESBC) derive a local control benefit from radiotherapy (RT) after lumpectomy, without any apparent effect on overall survival. Therefore, the use of RT is controversial. In the current study, the authors characterized updated trends in RT for elderly patients with estrogen receptor (ER)-positive ESBC. METHODS : Patients aged ≥70 years with ER-positive ESBC measuring ≤2 cm after lumpectomy with negative resection margins and known RT [...]

A partir des données du registre suédois des cancers familiaux portant sur 858 patients, cette étude met en évidence une concordance entre un type histologique d'une tumeur du système nerveux central et une forte proximité génétique (entre parents au premier degré)

Histological concordance in familial central nervous system tumors: Evidence from nationwide Swedish Family-Cancer Database

Babaei, M. ; Fallah, M. ; Sundquist, K. ; Hemminki, K.

Background : Published studies have shown that familial risks in the primary central nervous system (CNS) tumors are usually histology-specific. If genetic factors indeed determine tumor histology it would be expected that histological types would agree between affected first-degree relatives (FDRs). Material and methods : This study was conducted using the nationwide Swedish Family-Cancer Database. FDR pairs were defined where both of them had the same histological subtype of CNS tumor. The [...]

A partir d'une revue de la littérature (62 articles), cette méta-analyse fait le point sur l'association entre des concepts psychologiques (sens de la vie et sens de la cohérence) et la détresse psychologique chez des patients atteints de cancer

Relations of meaning in life and sense of coherence to distress in cancer patients: a meta-analysis

Winger, Joseph G. ; Adams, Rebecca N. ; Mosher, Catherine E.

Objective : Cancer patients report high rates of distress. The related constructs of meaning in life (MiL) and sense of coherence (SOC) have long been recognized as important factors in the psychological adjustment to cancer; however, both constructs' associations with distress have not been quantitatively reviewed or compared in this population. Informed by Park's integrated meaning-making model and Antonovsky's salutogenic model, the goals of this meta-analysis were the following: (1) to [...]

A partir d'une revue de la littérature, cette étude développe un modèle conceptuel permettant de définir le phénomène de résilience chez des adultes atteints de cancer

Resilience in adults with cancer: development of a conceptual model

Deshields, Teresa L. ; Heiland, Mark F. ; Kracen, Amanda C. ; Dua, Priya

Objective : Resilience is a construct addressed in the psycho-oncology literature and is especially relevant to cancer survivorship. The purpose of this paper is to propose a model for resilience that is specific to adults diagnosed with cancer. Methods : To establish the proposed model, a brief review of the various definitions of resilience and of the resilience literature in oncology is provided. Results : The proposed model includes baseline attributes (personal and environmental) which [...]

Menée aux Pays-Bas par questionnaire auprès de 102 couples dont l'un des partenaires est atteint d'un cancer colorectal, cette étude analyse les problématiques rencontrées dans leur vie maritale et sexuelle

Sexual, marital, and general life functioning in couples coping with colorectal cancer: a dyadic study across time

Traa, Marjan J. ; Braeken, Johan ; De Vries, Jolanda ; Roukema, Jan A. ; Slooter, Gerrit D. ; Crolla, Rogier M. P. H. ; Borremans, Monique P. M. ; Den Oudsten, Brenda L.

Objectives : This study evaluated the following: (a) levels of sexual, marital, and general life functioning for both patients and partners; (b) interdependence between both members of the couple; and (c) longitudinal change in sexual, marital, and general life functioning and longitudinal stress-spillover effects in these three domains from a dyadic perspective. Methods : Couples (n = 102) completed the Maudsley Marital Questionnaire preoperatively and 3 and 6 months postoperatively. Mean [...]

Menée aux Etats-Unis auprès de 60 patiente ayant survécu à un cancer du sein (âgées entre 18 et 70 ans au moment du diagnostic) et 45 témoins, cette étude analyse la fiabilité de divers tests pour mesurer l'évolution de leurs fonctions neurocognitives

Reliable change in neuropsychological assessment of breast cancer survivors

Andreotti, Charissa ; Root, James C. ; Schagen, Sanne B. ; McDonald, Brenna C. ; Saykin, Andrew J. ; Atkinson, Thomas M. ; Li, Yuelin ; Ahles, Tim A.

Background : The purpose of this study was to enhance the current understanding and interpretation of longitudinal change on tests of neurocognitive function in individuals with cancer. Scores on standard neuropsychological instruments may be impacted by practice effects and other random forms of error. Methods : The current study assessed the test–retest reliability of several tests and overarching cognitive domains comprising a neurocognitive battery typical of those used for research and [...]

Mené aux Etats-Unis auprès de 100 participantes (51 patientes et 49 témoins), cet essai randomisé analyse l'efficacité à long terme (durée médiane : 11 ans) d'une psychothérapie comportementale et cognitive en groupe destinée à gérer le stress après un traitement chirurgical chez des patientes atteintes d'un cancer du sein de stade précoce

Long-term psychological benefits of cognitive-behavioral stress management for women with breast cancer: 11-year follow-up of a randomized controlled trial

Stagl, Jamie M. ; Bouchard, Laura C. ; Lechner, Suzanne C. ; Blomberg, Bonnie B. ; Gudenkauf, Lisa M. ; Jutagir, Devika R. ; Glück, Stefan ; Derhagopian, Robert P. ; Carver, Charles S. ; Antoni, Michael H.

BACKGROUND Breast cancer survivors experience long-term physical and psychological sequelae after their primary treatment that negatively influence their quality of life (QOL) and increase depressive symptoms. Group-based cognitive-behavioral stress management (CBSM) delivered after surgery for early-stage breast cancer was previously associated with better QOL over a 12-month follow-up and with fewer depressive symptoms up to 5 years after study enrollment. This 8- to 15-year follow-up [...]

Menée au Royaume-Uni, cette étude évalue le rapport coût-efficacité d'une chimiothérapie combinant nab-paclitaxel et gemcitabine pour le traitement d'un cancer métastatique du pancréas

Economic evaluation for the UK of nab-paclitaxel plus gemcitabine in the treatment of metastatic pancreas cancer

Gharaibeh, M. ; McBride, A. ; Bootman, J. L. ; Abraham, I.

Background: The combination of nab-paclitaxel plus gemcitabine (NAB-P+GEM) has shown superior efficacy over GEM monotherapy in metastatic pancreas cancer (MPC). Independent cost-effectiveness/utility analyses of NAB-P+GEM from the payer perspective have not been conducted for the UK. Methods: A Markov model simulating the health outcomes and total costs was developed to estimate the life years gained (LYG) and quality-adjusted life years gained (QALY) and incremental cost-effectiveness (ICER) [...]

En prenant l'exemple du cancer du poumon non à petites cellules, cette étude présente un modèle d'évaluation des coûts et bénéfices attendus des nouvelles thérapies ciblées dont l'autorisation de mise sur le marché a été basée sur la survie sans progression comme critère de jugement de substitution à la survie globale

Evaluating expected costs and benefits of granting access to new treatments on the basis of progression-free survival in non–small-cell lung cancer

Lakdawalla, D. N. ; Chou, J. W. ; Linthicum, M. T. ; MacEwan, J. P. ; Zhang, J. ; Goldman, D. P.

Importance : Surrogate end points may be used as proxy for more robust clinical end points. One prominent example is the use of progression-free survival (PFS) as a surrogate for overall survival (OS) in trials for oncologic treatments. Decisions based on surrogate end points may expedite regulatory approval but may not accurately reflect drug efficacy. Payers and clinicians must balance the potential benefits of earlier treatment access based on surrogate end points against the risks of [...]

A partir des données des registres britanniques des cancers, cette étude analyse, pour chacune des différentes étapes des soins, le nombre de patients ayant survécu à un cancer de la prostate, puis tire des conclusions sur les structures à développer à l'horizon 2040

Using routinely collected data to stratify prostate cancer patients into phases of care in the United Kingdom: implications for resource allocation and the cancer survivorship programme

Yip, K. ; McConnell, H. ; Alonzi, R. ; Maher, J.

Background: Prostate cancer is the most commonly diagnosed malignancy in British men. The increasing use of PSA screening test has resulted in many more patients being diagnosed with this condition. Advances in its treatment have improved the survival rate among these patients. By 2040, the prevalence of prostate cancer survivors is expected to reach 830 000. Many of them will require medical support for the management of their progressive disease or long-term toxicities from previous [...]

Menée à partir d'une microsimulation utilisant des données de la littérature scientifique, cette étude évalue le rapport coût-efficacité de 21 stratégies de détection du syndrome de Lynch

Comparative Effectiveness of Screening Strategies for Lynch Syndrome

Barzi, Afsaneh ; Sadeghi, Sarmad ; Kattan, Michael W. ; Meropol, Neal J.

Background : Colorectal cancer is the second leading cause of cancer death in the United States. Approximately 3% of colorectal cancers are associated with Lynch Syndrome. Controversy exists regarding the optimal screening strategy for Lynch Syndrome. Methods : Using an individual level microsimulation of a population affected by Lynch syndrome over several years, effectiveness and cost-effectiveness of 21 screening strategies were compared. Modeling assumptions were based upon published [...]