Mené en Chine auprès de 871 participants, cet essai randomisé évalue l'efficacité d'une crème à base d'urée pour prévenir les réactions cutanées liées au sorafénib au niveau des mains et des pieds, chez des patients atteints d'un carcinome hépatocellulaire de stade avancé

Randomized Controlled Trial of the Prophylactic Effect of Urea-Based Cream on Sorafenib-Associated Hand-Foot Skin Reactions in Patients With Advanced Hepatocellular Carcinoma

Ren, ZhengGang ; Zhu, KangShun ; Kang, HaiYan ; Lu, MinQiang ; Qu, ZengQiang ; Lu, Ligong ; Song, TianQiang ; Zhou, Weiping ; Wang, Hui ; Yang, WeiZhu ; Wang, Xuan ; Yang, YongPing ; Shi, Lehua ; Bai, Yuxian ; Guo, Xiaofeng ; Ye, Sheng-Long

Purpose : To assess whether urea-based cream (UBC) has prophylactic benefits on sorafenib-induced hand-foot skin reaction (HFSR) in patients with advanced hepatocellular carcinoma (HCC). Patients and Methods : In this randomized, open-label trial, 871 patients with advanced HCC throughout China were treated with 10% UBC three times per day plus best supportive care (BSC; n = 439) or BSC alone excluding all creams (n = 432), starting on day 1 of sorafenib treatment, for up to 12 weeks. HFSR was [...]

Menée par un comité d'experts de l'American Society of Clinical Oncology, cette étude présente une évaluation des recommandations de l'American Cancer Society pour le suivi des patients après les traitements d'un cancer de la prostate

Prostate Cancer Survivorship Care Guideline: American Society of Clinical Oncology Clinical Practice Guideline Endorsement

Resnick, Matthew J. ; Lacchetti, Christina ; Bergman, Jonathan ; Hauke, Ralph J. ; Hoffman, Karen E. ; Kungel, Terrence M. ; Morgans, Alicia K. ; Penson, David F.

Purpose : The guideline aims to optimize health and quality of life for the post-treatment prostate cancer survivor by comprehensively addressing components of follow-up care, including health promotion, prostate cancer surveillance, screening for new cancers, long-term and late functional effects of the disease and its treatment, psychosocial issues, and coordination of care between the survivor's primary care physician and prostate cancer specialist. Methods : The American Cancer Society [...]

Menée aux Pays-Bas par questionnaire, cette étude cas-témoins analyse l'évolution de la qualité de vie de survivants à long terme d'un gliome de faible grade

Health-Related Quality of Life in Stable, Long-Term Survivors of Low-Grade Glioma

Boele, Florien W. ; Douw, Linda ; Reijneveld, Jaap C. ; Robben, Rianne ; Taphoorn, Martin J.B. ; Aaronson, Neil K. ; Heimans, Jan J. ; Klein, Martin

Purpose : Patients with low-grade glioma (LGG) often experience long periods of stable disease, emphasizing the importance of maintaining good health-related quality of life (HRQOL). We assessed the changes in HRQOL in long-term survivors of WHO grade I or II astrocytoma, oligodendroglioma, or oligoastrocytoma with clinically and radiologically stable disease. Patients and Methods : Patients completed self-report measures of generic HRQOL (Short Form-36 [SF-36]) and disease-specific HRQOL [...]

A partir des données des registres américains des cancers, cette étude analyse l'évolution de l'incidence des cancers depuis 1975 et présente des projections sur la période 2010-2020

The past, present, and future of cancer incidence in the United States: 1975 through 2020

Weir, Hannah K. ; Thompson, Trevor D. ; Soman, Ashwini ; Møller, Bjørn ; Leadbetter, Steven

BACKGROUND The overall age-standardized cancer incidence rate continues to decline whereas the number of cases diagnosed each year increases. Predicting cancer incidence can help to anticipate future resource needs, evaluate primary prevention strategies, and inform research. METHODS Surveillance, Epidemiology, and End Results data were used to estimate the number of cancers (all sites) resulting from changes in population risk, age, and size. The authors projected to 2020 nationwide [...]

A partir des données de la base GLOBOCAN, cette étude présente les estimations de l'incidence des cancers et de la mortalité par cancer, pour l'année 2012 dans le monde

Global cancer statistics, 2012

Torre, Lindsey A. ; Bray, Freddie ; Siegel, Rebecca L. ; Ferlay, Jacques ; Lortet-Tieulent, Joannie ; Jemal, Ahmedin

Cancer constitutes an enormous burden on society in more and less economically developed countries alike. The occurrence of cancer is increasing because of the growth and aging of the population, as well as an increasing prevalence of established risk factors such as smoking, overweight, physical inactivity, and changing reproductive patterns associated with urbanization and economic development. Based on GLOBOCAN estimates, about 14.1 million new cancer cases and 8.2 million deaths occurred in [...]

A partir des données de sept cohortes européennes incluant 564 596 participants (âge moyen : 44 ans), cette étude fait le point sur l'association entre un score calculé à partir de divers facteurs (indice de masse corporelle, pression sanguine, niveau plasmatique de glucose, cholestérol total, triglycérides) et le risque de différents types de cancer

Metabolic risk score and cancer risk: pooled analysis of seven cohorts

Stocks, Tanja ; Bjørge, Tone ; Ulmer, Hanno ; Manjer, Jonas ; Häggström, Christel ; Nagel, Gabriele ; Engeland, Anders ; Johansen, Dorthe ; Hallmans, Göran ; Selmer, Randi ; Concin, Hans ; Tretli, Steinar ; Jonsson, Håkan ; Stattin, Pär

Background: There are few data on the joint influence of metabolic factors on risk of separate cancers. Methods: We analysed data on body mass index, blood pressure and plasma levels of glucose, total cholesterol and triglycerides from seven European cohorts comprising 564 596 men and women with a mean age of 44 years. We weighted those factors equally into a standardized metabolic risk score [MRS, mean = 0, standard deviation (SD) = 1], with an individual’s level indicated as SDs from the sex- [...]

A partir des données des registres américains des cancers, cette étude met en évidence, pour l'année 2010, une incidence des cancers plus importante dans la population des patients infectés par le VIH par rapport à la population générale

Excess Cancers Among HIV-Infected People in the United States

Robbins, Hilary A. ; Pfeiffer, Ruth M. ; Shiels, Meredith S. ; Li, Jianmin ; Hall, H. Irene ; Engels, Eric A.

Background: Nearly 900 000 people in the United States are living with diagnosed human immunodeficiency virus (HIV) infection and therefore increased cancer risk. The total number of cancers occurring among HIV-infected people and the excess number above expected background cases are unknown. Methods: We derived cancer incidence rates for the United States HIV-infected and general populations from Poisson models applied to linked HIV and cancer registry data and from Surveillance, Epidemiology, [...]

A partir des données du registre tchèque des cancers, cette étude analyse l'évolution de l'incidence de cancer chez les personnes âgées de plus de 70 ans, des traitements et de la survie, sur la période 2006-2010

Cancer in the elderly in the Czech Republic

Petera, J. ; Dušek, L. ; Sirák, I. ; Soumarova, R. ; Jarkovsky, J.

Population ageing presents a challenge to oncological care due to the particularities of cancer treatment in this population. We evaluate cancer epidemiology, treatment and survival, in the Czech Republic by age groups. Data published by the Czech National Cancer Registry from the years 2006 to 2010 were used for this study. The following cancer types were evaluated: colorectal, pancreatic, head and neck, lung, skin melanoma, breast, gynaecological, prostate, kidney and stomach cancers. The [...]

Menée en Suède à partir de données portant sur 186 627 personnes, cette étude évalue l'association entre une hospitalisation pour une tentative de suicide, la mesure d'un faible niveau sérique d'ocytocine à l'hospitalisation, et le risque de cancer

Suicide attempt and future risk of cancer: a nationwide cohort study in Sweden

Jokinen, Jussi ; Mattsson, Fredrik ; Lagergren, Katarina ; Lagergren, Jesper ; Ljung, Rickard

Purpose : Little is known about cancer incidence among patients with a history of suicide attempt. Suicide attempters have lower levels of oxytocin, a hormone related to lactation, stress, social functioning, and well-being, and recent research indicates influence on carcinogenesis. We hypothesized that the low oxytocin levels among suicide attempters results in an increased risk of cancer in general and in organs with oxytocin receptors in particular. Methods : A nationwide cohort study of [...]

Menée en Nouvelle-Zélande à partir de données de comptes-rendus de 10 réunions portant sur 106 cas de patients, cette étude qualitative observationelle analyse le processus de prise de décision au sein d'équipes pluridisciplinaires en cancérologie

Cancer Care Decision Making in Multidisciplinary Meetings

Dew, Kevin ; Stubbe, Maria ; Signal, Louise ; Stairmand, Jeannine ; Dennett, Elizabeth ; Koea, Jonathan ; Simpson, Andrew ; Sarfati, Diana ; Cunningham, Chris ; Batten, Lesley ; Ellison-Loschmann, Lis ; Barton, Josh ; Holdaway, Maureen

Little research has been undertaken on the actual decision-making processes in cancer care multidisciplinary meetings (MDMs). This article was based on a qualitative observational study of two regional cancer treatment centers in New Zealand. We audiorecorded 10 meetings in which 106 patient cases were discussed. Members of the meetings categorized cases in varying ways, drew on a range of sources of authority, expressed different value positions, and utilized a variety of strategies to justify [...]

Cette étude analyse l'évolution du risque de cancer tout au long de la vie, en fonction du genre de l'individu et de l'année de naissance (entre 1930 et 1960), au Royaume-Uni

Trends in the lifetime risk of developing cancer in Great Britain: comparison of risk for those born from 1930 to 1960

Ahmad, A. S. ; Ormiston-Smith, N. ; Sasieni, P. D.

Background : Typically, lifetime risk is calculated by the period method using current risks at different ages. Here, we estimate the probability of being diagnosed with cancer for individuals born in a given year, by estimating future risks as the cohort ages. Methods: We estimated the lifetime risk of cancer in Britain separately for men and women born in each year from 1930 to 1960. We projected rates of all cancers (excluding non-melanoma skin cancer) and of all cancer deaths forwards using [...]

Menée en Australie auprès de 1 305 patientes atteintes d'un cancer épithélial invasif de l'ovaire, cette étude cas-témoins évalue l'association entre l'utilisation d'aspirine, de médicaments anti-inflammatoires non stéroïdiens, de paracétamol et la survie

Aspirin, nonaspirin nonsteroidal anti-inflammatory drugs, acetaminophen and ovarian cancer survival

Nagle, Christina M. ; Ibiebele, Torukiri I. ; Defazio, Anna ; Protani, Melinda M. ; Webb, Penelope M.

Abstract : Aspirin and nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to decrease tumor progression in pre-clinical models of ovarian cancer, however the influence of these drugs on survival in women following a diagnosis of ovarian cancer is unknown. We included 1305 Australian women diagnosed with incident invasive epithelial ovarian cancer, recruited into a population-based case–control study. Use of aspirin, nonaspirin NSAIDs and acetaminophen in the 5 years [...]

A partir de données anglaises portant sur la période 2007-2011, cette étude analyse l'évolution de l'incidence du glioblastome et de la survie des patients

Glioblastoma in England: 2007–2011

Brodbelt, Andrew ; Greenberg, David ; Winters, Tim ; Williams, Matt ; Vernon, Sally ; Collins, V. Peter

Aims : Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumour in adults, with a poor prognosis. Changing treatment paradigms suggest improved outcome, but whole nation data for England is scarce. The aim of this report is to examine the incidence of patients with glioblastoma in England, and to assess the influence of gender, age, geographical region and treatment on outcome. Methods : A search strategy encompassing all patients coded with GBM and treated from [...]

A partir d'échantillons tumoraux inclus en paraffine après prélèvement sur 248 patients atteints dun carcinome épidermoïde des muqueuses de la tête et du cou, cette étude australienne analyse la prévalence d'une infection par le papillomavirus humain ainsi que la surexpression de la protéine p16 INK4A

Human papillomavirus status and p16INK4A expression in patients with mucosal squamous cell carcinoma of the head and neck in Queensland, Australia

Antonsson, Annika ; Neale, Rachel E. ; Boros, Samuel ; Lampe, Guy ; Coman, William B. ; Pryor, David I. ; Porceddu, Sandro V. ; Whiteman, David C.

Background : The last decade has seen changes in the epidemiology of mucosal squamous cell carcinomas of the head and neck (HNSCCs), with increasing numbers of cases attributable to human papillomavirus (HPV) infection. We sought to determine the prevalence of HPV and p16INK4a expression in Australian HNSCC patients and to identify predictors of HPV-positivity. Methods : We recruited 248 HNSCC patients with histologically confirmed primary SCC of the oropharynx, oral cavity, hypopharynx or [...]

Menée aux Etats-Unis auprès de 4 319 patients atteints d'un cancer du poumon ou du côlon-rectum récemment diagnostiqué, cette étude de cohorte évalue l'association entre des attitudes fatalistes et le stade au diagnostic de la maladie

The association between fatalistic beliefs and late stage at diagnosis of lung and colorectal cancer

Lyratzopoulos, Georgios ; Liu, Michael Pang-Hsiang ; Abel, Gary A ; Wardle, Jane ; Keating, Nancy L.

Background: Fatalistic beliefs may be implicated in longer help-seeking intervals, and consequently, greater risk of advanced stage at cancer diagnosis. Methods: We examined associations between fatalism and stage at diagnosis in a population-based cohort of 4,319 U.S. patients with newly-diagnosed lung or colorectal cancer participating in the Cancer Care Outcomes and Research Surveillance (CanCORS) study. Fatalistic beliefs were assessed with an established measure. A fatalism score (range [...]

Menée au Danemark à partir de données portant sur 5 452 survivants d'un cancer pédiatrique traité entre 1975 et 2009, cette étude de cohorte analyse leur utilisation de médicaments anti-dépresseurs à long terme

Increased risk of antidepressant use in childhood cancer survivors: A Danish population-based cohort study

Lund, Lasse Wegener ; Winther, J. F. ; Cederkvist, L. ; Andersen, K. K. ; Dalton, S. O. ; Appel, C. W. ; Rechnitzer, C. ; Schmiegelow, K. ; Johansen, C.

Aim : Childhood cancer survivors are at risk of both somatic and mental late effects, but large population-based studies of depression are lacking. Methods : Risk of antidepressant use was evaluated in a population-based cohort of 5452 Danish children treated for cancer in 1975–2009 by linkage to the National Prescription Drug Database, which worldwide is the oldest nationwide registry of prescription medication. Hazard ratios (HRs) for antidepressant use were estimated in a Cox proportional [...]

Menée au Portugal auprès de 150 patientes atteintes d'un cancer du sein, cette étude analyse les facteurs associés à la présence de symptômes de dépression

Depressive symptoms and mental adjustment in women with breast cancer

Tojal, Catarina ; Costa, Raquel

Objective : Depression is the most common psychological disorder observed in breast cancer patients. The purposes of this study were: to determine the prevalence of depressive symptoms among women with breast cancer; and examine the association of depressive symptoms and demographic and clinical variables as well as the association between mental adjustment to cancer and level of depressive symptoms. Methods : A total of 150 breast-cancer-diagnosed women were recruited in an Oncology Hospital. [...]

A partir de données portant sur des patients atteints d'un myélome multiple aux Etats-Unis et dans 38 pays après 1997, cette étude analyse l'impact des innovations en chimiothérapie sur l'espérance de vie des patients et analyse les coûts associés

The impact of recent chemotherapy innovation on the longevity of myeloma patients: US and international evidence

Hostenkamp, Gisela ; Lichtenberg, Frank R.

The longevity of multiple myeloma patients increased sharply since the late 1990s. This increase coincided with the introduction of several important innovations in chemotherapy for myeloma. In this study, we aim to quantify the impact of recent chemotherapy innovation on the longevity of myeloma patients using both time-series US data and longitudinal data on 38 countries. We estimate that almost two-thirds (0.99 years) of the 1997-2005 increase in the life expectancy of American myeloma [...]

Menée aux Etats-Unis par enquête auprès de 244 hommes dont l'épouse est décédée des suites d'un cancer, cette étude analyse leurs expériences en matière de discussions avec l'équipe médicale sur le pronostic de fin de vie

An exploratory study of end-of-life prognostic communication needs as reported by widowed fathers due to cancer

Park, Eliza M. ; Check, Devon K. ; Yopp, Justin M. ; Deal, Allison M. ; Edwards, Teresa P. ; Rosenstein, Donald L.

Objective : Effective physician communication about prognosis is a critical aspect of quality care for families affected by terminal illness. This is particularly important for spousal caregivers of terminally ill parents of dependent children, who may have unique needs for communication about anticipated death. The objective of this study was to explore end-of-life prognostic communication experiences reported by bereaved fathers whose wives died from cancer. Methods : From October 2012 to [...]

Menée en France à l'Institut Gustave Roussy par enquête auprès de 1 371 patients atteints de cancer, cette étude analyse leurs pratiques d'utilisation des technologies internet et leurs attitudes vis-à-vis d'usages en matière de santé

Internet-based technologies to improve cancer care coordination: Current use and attitudes among cancer patients

Girault, Anne ; Ferrua, Marie ; Lalloué, Benoît ; Sicotte, Claude ; Fourcade, Aude ; Yatim, Fatima ; Hébert, Guillaume ; Di Palma, Mario ; Minvielle, Etienne

Background : The uses of internet-based technologies (e.g. patient portals, websites and applications) by cancer patients could be strong drive for change in cancer care coordination practices. The goal of this study was to assess the current utilisation of internet-based technologies (IBT) among cancer patients, and their willingness to use them for their health, as well as analyse the influence of socio-demographics on both aspects. Methods : A questionnaire-based survey was conducted in June [...]