Menée auprès de 1 090 patients inclus dans 3 essais randomisés (un essai incluant des patientes atteintes d'un cancer du sein, deux essais incluant des patients atteints d'un cancer du poumon non à petites cellules), cette étude analyse la concordance entre les déclarations des patients et les observations des médecins sur 6 types de symptômes liés à la toxicité des traitements (anorexie, nausée, vomissements, constipation, diarrhée, perte de cheveux)

Symptomatic Toxicities Experienced During Anticancer Treatment: Agreement Between Patient and Physician Reporting in Three Randomized Trials

Di Maio, Massimo ; Gallo, Ciro ; Leighl, Natasha B. ; Piccirillo, Maria Carmela ; Daniele, Gennaro ; Nuzzo, Francesco ; Gridelli, Cesare ; Gebbia, Vittorio ; Ciardiello, Fortunato ; De Placido, Sabino ; Ceribelli, Anna ; Favaretto, Adolfo G. ; de Matteis, Andrea ; Feld, Ronald ; Butts, Charles ; Bryce, Jane ; Signoriello, Simona ; Morabito, Alessandro ; Rocco, Gaetano ; Perrone, Francesco

Purpose : Information about symptomatic toxicities of anticancer treatments is not based on direct report by patients, but rather on reports by clinicians in trials. Given the potential for under-reporting, our aim was to compare reporting by patients and physicians of six toxicities (anorexia, nausea, vomiting, constipation, diarrhea, and hair loss) within three randomized trials. Patients and Methods : In one trial, elderly patients with breast cancer received adjuvant chemotherapy; in two [...]

A partir des données des registres américains des cancers portant sur 484 survivants d'un cancer diagnostiqué entre l'âge de 15 et 39 ans, cette étude analyse leurs besoins en information sur le cancer et l'impact de la maladie sur leur qualité de vie

Cancer-related information needs and cancer's impact on control over life influence health-related quality of life among adolescents and young adults with cancer

DeRouen, Mindy C. ; Smith, Ashley Wilder ; Tao, Li ; Bellizzi, Keith M. ; Lynch, Charles F. ; Parsons, Helen M. ; Kent, Erin E. ; Keegan, Theresa H. M. ; for the, A. Y. A. Hope Study Collaborative Group

Objective : Adolescents and young adults (AYAs) diagnosed with cancer between 15 and 39 years of age often report need for greater amounts of cancer-related information and perceive that cancer has had a negative impact on control over their life. We examined whether unmet information need and perceived control over life are associated with health-related quality of life (HRQOL). Methods : We examined data from 484 AYA cancer survivors recruited from population-based cancer registries in [...]

Menée aux Etats-Unis auprès de 77 patientes atteintes d'un cancer du sein et recevant une chimiothérapie adjuvante, cette étude analyse les facteurs psychosociaux et biomédicaux associés à l'évolution de leur fatigue

Identification of distinct fatigue trajectories in patients with breast cancer undergoing adjuvant chemotherapy

Junghaenel, DoerteU ; Cohen, Jules ; Schneider, Stefan ; Neerukonda, AnuR ; Broderick, JoanE

Purpose : The goal of this study was to characterize changes in daily fatigue in women undergoing chemotherapy for breast cancer. We examined whether there are subgroups of patients with distinct fatigue trajectories and explored potential psychosocial and biomedical predictors of these subgroups. Methods : Participants were 77 women with breast cancer receiving adjuvant chemotherapy with AC-T (2-week cycle) and TC or TCH (3-week cycle) regimens. They completed 28 daily ratings online using an [...]

Menée aux Pays-Bas par questionnaire auprès de survivantes d'un cancer du sein de stade 0-III traité à l'aide d'une chirurgie conservatrice et d'une radiothérapie (durée médiane de suivi : 34 mois), cette étude analyse l'évolution de la qualité de vie en fonction de l'âge (moins de 50 ans ; entre 51 et 70 ans ; plus de 70 ans)

The impact of age on changes in quality of life among breast cancer survivors treated with breast-conserving surgery and radiotherapy

Bantema-Joppe, E. J. ; de Bock, G. H. ; Woltman-van Iersel, M. ; Busz, D. M. ; Ranchor, A. V. ; Langendijk, J. A. ; Maduro, J. H. ; van den Heuvel, E. R.

Background: The purpose of the study was to determine the impact of young age on health-related quality of life (HRQoL) by comparing HRQoL of younger and older breast cancer patients, corrected for confounding, and of young patients and a general Dutch population. Methods: The population consisted of breast cancer survivors (stage 0-III) after breast-conserving surgery and radiotherapy. Health-related quality of life was prospectively assessed using the EORTC QLQ-C30 and QLQ-BR23 [...]

Menée au Japon auprès de 283 patients atteints d'un cancer de la prostate, cette étude analyse l'association entre l'obésité abdominale, l'hypertension, l'utilisation de médicaments antihypertenseurs et le risque de récidive de cancer après une prostatectomie radicale

Abdominal obesity, hypertension, antihypertensive medication use and biochemical recurrence of prostate cancer after radical prostatectomy

Ohwaki, Kazuhiro ; Endo, Fumiyasu ; Hattori, Kazunori

Background : The aim of this study was to determine whether abdominal obesity, including visceral adipose tissue (VAT) measured by computed tomography and blood pressure (BP) were associated with biochemical recurrence of prostate cancer after prostatectomy. Methods : We investigated 283 patients who underwent radical prostatectomy for prostate cancer retrospectively. We obtained information on body mass index (BMI), waist circumference (WC), VAT, BP, antihypertensive drug use, pretreatment [...]

A partir des données des registres danois des cancers portant sur 19 209 cas (patients âgés de 40 à 80 ans) et 192 090 témoins, cette étude suggère qu'une prescription de traitement des hémorroïdes par un médecin généraliste est associée à un diagnostic ultérieur de cancer colorectal

Increased diagnostic activity in general practice during the year preceding colorectal cancer diagnosis

Hansen, Pernille Libach ; Hjertholm, Peter ; Vedsted, Peter

Accurate diagnostic activity in general practice before colorectal cancer (CRC) diagnosis is crucial for an early detection of CRC. This study aimed to investigate the rates of daytime consultations, hemoglobin (Hb) measurements and medicine prescriptions for hemorrhoids in general practice in the year preceding CRC diagnosis. Using Danish registries, we conducted a population-based matched cohort study including CRC patients aged 40–80 years (n = 19,209) and matched references (n = 192,090). [...]

Menée au Canada auprès de 60 survivants d'un cancer, cette étude analyse l'efficacité d'un outil permettant de détecter les niveaux cliniques de la peur de la récidive de la maladie et d'évaluer les comorbidités psychiatriques

Screening and comorbidity of clinical levels of fear of cancer recurrence

Simard, Sébastien ; Savard, Josée

Purpose : The prevalence of clinical levels of fear of cancer recurrence (FCR) in cancer survivors is unknown, which may be partly explained by the lack of an assessment method that would make it possible to distinguish between normal and clinical levels of FCR. Moreover, despite the apparent overlap between FCR and manifestations of some psychiatric disorders, no study has yet evaluated the comorbidity of clinical levels of FCR. The goals of this study were to assess the capacity of the Fear [...]

Menée aux Etats-Unis à partir de données portant sur 771 patients atteints d'un cancer de stade avancé, cette étude analyse les pratiques de diagnostic d'un délire avant le transfert des patients dans une unité de soins palliatifs

The frequency of missed delirium in patients referred to palliative care in a comprehensive cancer center

de la Cruz, Maxine ; Fan, Joanna ; Yennu, Sriram ; Tanco, Kimberson ; Shin, SeongHoon ; Wu, Jimin ; Liu, Diane ; Bruera, Eduardo

Background : Delirium is one of the most common neuropsychiatric complications in advanced cancer patients with a frequency of up to 85 % before death. It is associated with adverse clinical outcomes such as increased morbidity and mortality as well as significant family and patient distress. The aim of our study is to determine at the frequency of missed delirium (MD) and identify factors associated with MD. Methods : Seven hundred seventy-one consecutive palliative care inpatient consults [...]

A partir d'une revue systématique de la littérature (51 articles), cette étude fait le point sur les facteurs associés à la décision des patients atteints de cancer de participer à un essai clinique

Cancer patient decision making related to clinical trial participation: an integrative review with implications for patients’ relational autonomy

Bell, JenniferA H. ; Balneaves, LyndaG

Purpose : Oncology clinical trials are necessary for the improvement of patient care as they have the ability to confirm the efficacy and safety of novel cancer treatments and in so doing, contribute to a solid evidence base on which practitioners and patients can make informed treatment decisions. However, only 3–5 % of adult cancer patients enroll in clinical trials. Lack of participation compromises the success of clinical trials and squanders an opportunity for improving patient outcomes. [...]

Menée aux Pays-Bas à partir de données portant sur 1 317 participants, cette étude analyse les différences, en fonction de l'âge de l'individu (âgés de plus de 70 ans, âgés de 50 à 69 ans) atteint ou non de cancer, dans les relations entre la dépression, les stratégies pour faire face à la maladie et un indicateur associé à la croyance personnelle du contrôle des événements

The relation between depression, coping and health locus of control: differences between older and younger patients, with and without cancer

Aarts, Jurian W. F. ; Deckx, Laura ; van Abbema, Doris L. ; Tjan-Heijnen, Vivianne C. G. ; van den Akker, Marjan ; Buntinx, Frank

Objective : Depression is an important health issue in cancer patients. People use different coping strategies and health locus of control to manage stressful situations, which relate to different risks of depression. Coping strategies and health locus of control can be changed by cognitive behavioral interventions. Methods : In a cohort study, we investigated differences in coping strategy and health locus of control in older (≥70 years) and middle-aged (50–69 years) cancer patients, and older [...]

Menée aux Etats-Unis auprès de 292 participants, cette étude évalue l'association entre le statut marital, le soutien du partenaire de vie et la détresse psychologique des survivants d'un cancer de la prostate

The association between partner support and psychological distress among prostate cancer survivors in a nationwide study

Kamen, Charles ; Mustian, KarenM ; Heckler, Charles ; Janelsins, MichelleC ; Peppone, LukeJ ; Mohile, Supriya ; McMahon, JamesM ; Lord, Raymond ; Flynn, PatrickJ ; Weiss, Matthias ; Spiegel, David ; Morrow, GaryR

Purpose : Up to 38 % of prostate cancer survivors experience significant psychological distress; 6–16 % are diagnosed with depression or anxiety disorders. Support from a relationship partner can ameliorate psychological distress, but many studies treat relationship status as a dichotomous predictor without accounting for level of support provided by the partner. Methods : The current study is a secondary analysis of a sample of 292 prostate cancer survivors recruited by nine Community Clinical [...]

Menée au Canada, cette étude qualitative analyse les motivations de survivantes d'un cancer du sein pour participer, après leur traitement, à un programme d'activité physique en groupe

Breast cancer survivors’ barriers and motives for participating in a group-based physical activity program offered in the community

Wurz, Amanda ; St-Aubin, Anik ; Brunet, Jennifer

Purpose : The purpose of this qualitative study was to explore the barriers and motives experienced by women attending an 8-week group-based physical activity program offered in the community following treatment for breast cancer. Methods : Seven women were interviewed during the first and last week of the program. Data were analyzed using thematic analysis. Results : Factors that hindered women’s continued participation could be subdivided into situational barriers, which encompassed community [...]

Cet article analyse les difficultés rencontrées par les survivantes d'un cancer du sein et les enjeux liés à des interventions de nature psychosociale pour améliorer leur qualité de vie

Psychosocial/Survivorship Issues in Breast Cancer: Are We Doing Better?

Fallowfield, Lesley ; Jenkins, Valerie

Modern breast cancer treatment offers many women greater prospects of cure or lengthier, good quality survival than was possible in the past. Advances include improved diagnostic and staging procedures, sophisticated onco-plastic surgery, enhanced radiotherapy techniques, and targeted systemic therapies. Much more attention has also been paid to cancer care delivery and access to specialist nurses, counsellors, support groups, and services provided by breast cancer charities. However, there are [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mai 2014 (13 études, 1 138 participants), cette étude fait le point sur l'efficacité d'interventions pharmacologiques ou d'autre nature pour prendre en charge les troubles cognitifs chez des patientes atteintes d'un cancer du sein après leur chimiothérapie

Systematic review of pharmacologic and non-pharmacologic interventions to manage cognitive alterations after chemotherapy for breast cancer

Chan, Raymond J. ; McCarthy, Alexandra L. ; Devenish, Jackie ; Sullivan, Karen A. ; Chan, Alexandre

Purpose : Cognitive alterations are reported in breast cancer patients receiving chemotherapy. This has adverse effects on patients’ quality of life and function. This systematic review investigates the effectiveness of pharmacologic and non-pharmacologic interventions to manage cognitive alterations associated with breast cancer treatment. Methods : Medline via EBSCO host, CINAHL and Cochrane CENTRAL were searched for the period January 1999–May 2014 for prospective randomised controlled [...]

Menée aux Etats-Unis auprès de 41 patients atteints de métatstases cérébrales, cette étude analyse leurs capacités cognitives pour prendre part à la décision thérapeutique

Capacity of patients with brain metastases to make treatment decisions

Triebel, Kristen L. ; Gerstenecker, Adam ; Meneses, Karen ; Fiveash, John B. ; Meyers, Christina A. ; Cutter, Gary ; Marson, Daniel C. ; Martin, Roy C. ; Eakin, Amanda ; Watts, Olivia ; Nabors, Louis B.

Objective : The aim of this study was to investigate medical decision-making capacity (MDC) in patients with brain metastases. Methods : Participants were 41 adults with brain metastases with Karnofsky Performance Status scores of ≥70 who were recruited from an academic medical center and 41 demographically matched controls recruited from the community. We evaluated MDC using the Capacity to Consent to Treatment Instrument and its four clinically relevant consent standards (expressing a [...]

Menée aux Pays-Bas auprès de 205 patients atteints d'un cancer de la tête et du cou, cette étude identifie les facteurs permettant de prédire l'efficacité d'une intervention psychosociale menée par une infirmière pour réduire leurs symptômes de dépression, un an après leur traitement

Moderators of the response to a nurse-led psychosocial intervention to reduce depressive symptoms in head and neck cancer patients

van der Meulen, IngeborgC ; May, AnneM ; de Leeuw, J. Rob J. ; Koole, Ron ; Oosterom, Miriam ; Hordijk, Gert-Jan ; Ros, WynandJ G.

Purpose : Little is known about the variables that moderate the response to psychosocial interventions to decrease depressive symptoms in cancer patients. The purpose of this study was to determine whether variables associated with depressive symptoms in cancer patients in general moderate the response to a nurse-led psychosocial intervention in patients with head and neck cancer. Methods : This study is a secondary analysis of a randomized controlled trial evaluating the effect of the nurse [...]

Menée au Royaume-Uni à partir des données de patients atteints de cancer (1 494 cas de cancer du poumon, 2 111 cas de cancer colorectal, 246 cas de cancer de l'estomac, 513 cas de cancer de l'œsophage, 327 cas de cancer du pancréas et 345 cas de cancer de l'ovaire), cette étude analyse l'association entre la prescription d'examens par un médecin généraliste et le délai avant le diagnostic de cancer par un spécialiste

Impact of investigations in general practice on timeliness of referral for patients subsequently diagnosed with cancer: analysis of national primary care audit data

Rubin, G. P. ; Saunders, C. L. ; Abel, G. A. ; McPhail, S. ; Lyratzopoulos, G. ; Neal, R. D.

Background: For patients with symptoms of possible cancer who do not fulfil the criteria for urgent referral, initial investigation in primary care has been advocated in the United Kingdom and supported by additional resources. The consequence of this strategy for the timeliness of diagnosis is unknown. Methods: We analysed data from the English National Audit of Cancer Diagnosis in Primary Care on patients with lung (1494), colorectal (2111), stomach (246), oesophagus (513), pancreas (327), [...]

Menée au Royaume-Uni à partir de données de patients atteints d'un cancer de la prostate (104 cas), du côlon-rectum (145 cas) et du sein (223 cas), cette étude présente une évaluation des coûts associés aux soins et analyse la possibilité d'utiliser les données collectées en routine pour produire des estimations économiques

Costs of cancer care for use in economic evaluation: a UK analysis of patient-level routine health system data

Hall, P. S. ; Hamilton, P. ; Hulme, C. T. ; Meads, D. M. ; Jones, H. ; Newsham, A. ; Marti, J. ; Smith, A. F. ; Mason, H. ; Velikova, G. ; Ashley, L. ; Wright, P.

Background: The rising financial burden of cancer on health-care systems worldwide has led to the increased demand for evidence-based research on which to base reimbursement decisions. Economic evaluations are an integral component of this necessary research. Ascertainment of reliable health-care cost and quality-of-life estimates to inform such studies has historically been challenging, but recent advances in informatics in the United Kingdom provide new opportunities. Methods: The costs of [...]

Menée en Belgique, cette étude analyse l'efficacité d'un programme de formation et de développement des compétences en communication des membres d'une équipe pluridisciplinaire de radiothérapie

Transfer of Communication Skills to the Workplace: Impact of a 38-Hour Communication Skills Training Program Designed for Radiotherapy Teams

Merckaert, Isabelle ; Delevallez, France ; Gibon, Anne-Sophie ; Liénard, Aurore ; Libert, Yves ; Delvaux, Nicole ; Marchal, Serge ; Etienne, Anne-Marie ; Bragard, Isabelle ; Reynaert, Christine ; Slachmuylder, Jean-Louis ; Scalliet, Pierre ; Van Houtte, Paul ; Coucke, Philippe ; Razavi, Darius

Purpose : This study assessed the efficacy of a 38-hour communication skills training program designed to train a multidisciplinary radiotherapy team. Methods : Four radiotherapy teams were randomly assigned to a training program or a waiting list. Assessments were scheduled at baseline and after training for the training group and at baseline and 4 months later for the waiting list group. Assessments included an audio recording of a radiotherapy planning session to assess team members' [...]

Menée aux Pays-Bas auprès de 21 survivantes d'un cancer du sein, 14 survivants d'un cancer du poumon et 31 professionnels de santé, cette étude qualitative analyse leurs attentes en matière de site web interactif dédié aux survivants d'un cancer

An interactive portal to empower cancer survivors: a qualitative study on user expectations

Kuijpers, Wilma ; Groen, WimG ; Loos, Romy ; Oldenburg, HesterS A. ; Wouters, MichelW J. M. ; Aaronson, NeilK ; van Harten, WimH

Purpose : Portals are increasingly used to improve patient empowerment, but are still uncommon in oncology. In this study, we explored cancer survivors’ and health professionals’ expectations of possible features of an interactive portal. Methods : We conducted three focus groups with breast cancer survivors (n = 21), two with lung cancer survivors (n = 14), and four with health professionals (n = 31). Drafts of possible features of an interactive portal were presented as static screenshots: [...]

Menée aux Pays-Bas auprès de 174 patients atteints d'un cancer colorectal, cette étude analyse l'efficacité d'illustrations pour améliorer leur compréhension de l'information et leur satisfaction relative à un site internet d'information sur le cancer

Illustrations enhance older colorectal cancer patients' website satisfaction and recall of online cancer information

Bol, N. ; Smets, E. M. A. ; Eddes, E. H. ; de Haes, J. C. J. M. ; Loos, E. F. ; van Weert, J. C. M.

This study aims to investigate the effects of illustrations in online cancer information on older cancer patients' website satisfaction (i.e. satisfaction with the attractiveness, comprehensibility and emotional support from the website) and recall of information. In an online experiment, 174 younger (<65 years) and older (≥65 years) colorectal cancer patients were randomly exposed to a webpage about transanal endoscopic microsurgery consisting of either text-only information, text with two [...]

Menée au Canada auprès de 5 381 patients atteints d'un cancer du pancréas de stade avancé (survie médiane : 75 jours), cette étude de cohorte rétrospective analyse l'association entre une prise en charge par une unité de soins palliatifs et l'agressivité des soins de fin de vie

Palliative Care and the Aggressiveness of End-of-Life Care in Patients With Advanced Pancreatic Cancer

Jang, Raymond W. ; Krzyzanowska, Monika K. ; Zimmermann, Camilla ; Taback, Nathan ; Alibhai, Shabbir M. H.

Background: We examined the impact of palliative care (PC) on aggressiveness of end-of-life care for patients with advanced pancreatic cancer. Measures of aggressive care included chemotherapy within 14 days of death; and at least one intensive care unit (ICU) admission, more than one emergency department (ED) visit, and more than one hospitalization, all within 30 days of death. Methods: A retrospective population-based cohort study using administrative data was conducted in patients with [...]

Menée par questionnaire auprès de 339 professionnels de santé dans 16 pays du Moyen-Orient, cette étude analyse l'utilisation de médecines complémentaires par leurs patients atteints de cancer et la possibilité de les intégrer dans les soins de support

Integration of complementary medicine in supportive cancer care: survey of health-care providers’ perspectives from 16 countries in the Middle East

Ben-Arye, Eran ; Schiff, Elad ; Mutafoglu, Kamer ; Omran, Suha ; Hajjar, Ramzi ; Charalambous, Haris ; Dweikat, Tahani ; Ghrayeb, Ibtisam ; Sela, GilBar ; Turker, Ibrahim ; Hassan, Azza ; Hassan, Esmat ; Popper-Giveon, Ariela ; Saad, Bashar ; Nimri, Omar ; Kebudi, Rejin ; Dagash, Jamal ; Silbermann, Michael

Introduction : In this multinational Middle-Eastern study, we assessed health-care providers’ (HCPs) perspectives on their patients’ use of complementary and traditional medicine (CTM) and identified the leading barriers to CTM integration in supportive cancer care. Methods : A 17-item questionnaire was developed and administered to HCPs attending palliative medicine workshops conducted across the Middle East by the Middle East Cancer Consortium. Results : 339 HCPs from 16 countries across the [...]

A partir d'une revue systématique de la littérature (21 études), cette étude analyse la prise en compte des comorbidités d'un patient pour la prise de décision thérapeutique lors des réunions de concertation pluridisciplinaire en oncologie

Consideration of comorbidity in treatment decision-making in multidisciplinary cancer team meetings: a systematic review

Stairmand, J. ; Signal, L. ; Sarfati, D. ; Jackson, C. ; Batten, L. ; Holdaway, M. ; Cunningham, C.

Background : Comorbidity is very common among patients with cancer. Multidisciplinary team meetings (MDTs) are increasingly the context within which cancer treatment decisions are made internationally. Little is known about how comorbidity is considered, or impacts decisions, in MDTs. Methods : A systematic literature review was conducted to evaluate previous evidence on consideration, and impact, of comorbidity in cancer MDT treatment decision-making. Twenty-one original studies were included. [...]