Mené aux Etats-Unis auprès de 96 survivants d'un cancer (âge moyen : 56 ans), cet essai randomisé évalue l'efficacité combinée d'une psychothérapie comportementale et de l'armodafinil pour réduire la sévérité de l'insomnie et améliorer la qualité du sommeil après les traitements anticancéreux

Randomized Placebo-Controlled Trial of Cognitive Behavioral Therapy and Armodafinil for Insomnia After Cancer Treatment

Roscoe, Joseph A. ; Garland, Sheila N. ; Heckler, Charles E. ; Perlis, Michael L. ; Peoples, Anita R. ; Shayne, Michelle ; Savard, Josée ; Daniels, Nina P. ; Morrow, Gary R.

Purpose : Insomnia is a distressing and often persisting consequence of cancer. Although cognitive behavioral therapy for insomnia (CBT-I) is the treatment of choice in the general population, the use of CBT-I in patients with cancer is complicated, because it can result in transient but substantial increases in daytime sleepiness. In this study, we evaluated whether CBT-I, in combination with the wakefulness-promoting agent armodafinil (A), results in better insomnia treatment outcomes in [...]

Menée aux Etats-Unis par enquête auprès de 52 survivantes d'un cancer (âge : de 18 à 43 ans), cette étude évalue l'impact, sur la prise de décision relative à la préservation de la fertilité et sur les traitements associés, du délai écoulé entre le diagnostic de cancer et la consultation d'un spécialiste de la fertilité

Early referral makes the decision-making about fertility preservation easier: a pilot survey study of young female cancer survivors

Kim, Jayeon ; Mersereau, JenniferE

Purpose : The purpose of the study was to investigate the association between patients’ decision-making about fertility preservation (FP) and time between cancer diagnosis and FP consultation in young female cancer survivors. Methods : This is a pilot survey study of women aged 18–43 years seen for FP consultation between April 2009 and December 2010. Results : Among 52 women who completed the survey, 15 (29 %) had their FP consultation more than 2 weeks after their cancer diagnosis (late [...]

Menée aux Pays-Bas auprès de 668 participants (379 patients atteints de cancer, 289 patients atteints de maladies autres), cette étude analyse la qualité de vie de patients ayant subi une stomie, liée ou non au cancer

A mixed-method study on the generic and ostomy-specific quality of life of cancer and non-cancer ostomy patients

Jansen, Femke ; van Uden-Kraan, CorneliaF ; Braakman, J. Annemieke ; van Keizerswaard, PaulinaM ; Witte, BirgitI ; Verdonck-de Leeuw, IrmaM

Purpose : The aim of this study is to compare the generic and ostomy-specific quality of life (QoL) between cancer and non-cancer ostomy patients using a mixed-method design. Methods : All patients with an ostomy participating in the Stomapanel of the Dutch Ostomy Association were asked to complete a generic (RAND-36) and ostomy-specific (Stoma-QoL) QoL questionnaire. In addition, open-ended questions on symptoms, restrictions or adaptations influencing daily life were included. The generic and [...]

Menée au Japon à partir de données portant sur 134 patients atteints d'un cancer du poumon non à petites cellules de stade avancé, cette étude rétrospective évalue l'association entre une cachexie liée au cancer, une diminution de la masse musculaire pendant la chimiothérapie et la survie

Prognostic impact of cancer cachexia in patients with advanced non-small cell lung cancer

Kimura, Madoka ; Naito, Tateaki ; Kenmotsu, Hirotsugu ; Taira, Tetsuhiko ; Wakuda, Kazushige ; Oyakawa, Takuya ; Hisamatsu, Yasushi ; Tokito, Takaaki ; Imai, Hisao ; Akamatsu, Hiroaki ; Ono, Akira ; Kaira, Kyoichi ; Murakami, Haruyasu ; Endo, Masahiro ; Mori, Keita ; Takahashi, Toshiaki ; Yamamoto, Nobuyuki

Purpose : Cancer cachexia (CC) is commonly seen in advanced lung cancer patients and associated with poor prognosis. However, little is known about CC that develops during chemotherapy. We evaluated the prognostic impact of CC and skeletal muscle wasting that develops during the course of chemotherapy in advanced non-small cell lung cancer (NSCLC) patients. Methods : The clinical data of 134 newly diagnosed NSCLC patients were retrospectively reviewed. CC was defined as a body weight loss >5 or [...]

A partir d'une revue systématique de la littérature (9 études), cette méta-analyse évalue l'efficacité d'une thérapie par laser de faible puissance pour réduire la douleur et le gonflement du bras chez des patientes atteintes d'un lymphœdème associé au cancer du sein

Effect of low-level laser therapy on pain and swelling in women with breast cancer-related lymphedema: a systematic review and meta-analysis

Smoot, Betty ; Chiavola-Larson, Laura ; Lee, Jeannette ; Manibusan, Hidelisa ; Allen, DianeD

Purpose : This study aims to examine literature on effectiveness of low-level laser therapy (LLLT) in reducing limb volume and pain in adults with breast cancer-related lymphedema (BCRL). Methods : PubMed, PEDro, CINAHL, and Cochrane databases were searched using (lymphedema OR edema OR swelling) AND (breast cancer OR mastectomy) AND (laser OR low-level laser therapy OR LLLT OR cold laser). Intervention studies or meta-analyses reporting LLLT for BCRL were included in the search. Pooled effect [...]

Menée au Canada auprès de 142 patientes atteintes d'un cancer du sein non métastatique et recevant une chimiothérapie, cette étude prospective compare l'efficacité du filgrastim et du pegfilgrastim pour soulager la douleur et pour prévenir la survenue d'événements neutropéniques

A modified filgrastim regimen does not reduce pain burden compared to pegfilgrastim in women receiving chemotherapy for non-metastatic breast cancer

Leung, Mova ; Florendo, Joy ; Kano, Jessica ; Marr-Del Monte, Tiffany ; Higgins, Brian ; Myers, Robert ; Menon, Trishala ; Jones, Glenn

Purpose : The short half-life of filgrastim allows for modification in the dose or duration of prophylaxis to limit inconvenience, adverse effects, and cost. The objectives of this study were to characterize and compare pain and neutropenic events between filgrastim and pegfilgrastim. Methods : A prospective, observational study was performed. Eligible patients had non-metastatic breast cancer and were to receive adjuvant or neo-adjuvant chemotherapy with prophylaxis for febrile neutropenia. [...]

Mené aux Etats-Unis auprès de 121 survivantes d'un cancer du sein, cet essai évalue l'efficacité d'exercices physiques pour diminuer la sévérité des douleurs articulaires liées aux traitements par inhibiteurs de l'aromatase

Randomized Exercise Trial of Aromatase Inhibitor–Induced Arthralgia in Breast Cancer Survivors

Irwin, Melinda L. ; Cartmel, Brenda ; Gross, Cary ; Ercolano, Elizabeth ; Li, Fangyong ; Yao, Xiaopan ; Fiellin, Martha ; Capozza, Scott ; Rothbard, Marianna ; Zhou, Yang ; Harrigan, Maura ; Sanft, Tara ; Schmitz, Kathryn ; Neogi, Tuhina ; Hershman, Dawn ; Ligibel, Jennifer

Purpose : Arthralgia occurs in up to 50% of breast cancer survivors treated with aromatase inhibitors (AIs) and is the most common reason for poor AI adherence. We conducted, in 121 breast cancer survivors receiving an AI and reporting arthralgia, a yearlong randomized trial of the impact of exercise versus usual care on arthralgia severity. Patients and Methods : Eligibility criteria included receiving an AI for at least 6 months, reporting ≥ 3 of 10 for worst joint pain on the Brief Pain [...]

A partir des données d'un registre britannique des cancers portant sur 16 282 participants, cette étude compare, chez des survivants d'un cancer et en population générale, divers facteurs dont l'activité physique, l'obésité, le tabagisme et la consommation d'alcool

Diet, exercise, obesity, smoking and alcohol consumption in cancer survivors and the general population: a comparative study of 16 282 individuals

Wang, Z. ; McLoone, P. ; Morrison, D. S.

Background: Cancer survivors may be particularly motivated to improve their health behaviours. Methods: We compared health behaviours and obesity in cancer survivors with the general population, using household survey and cancer registry data. Results: Cancer survivors were more likely than those with no history of cancer to eat fruit and vegetables (ORadj 1.41, 95% CI 1.19–1.66), less likely to engage in physical activity (ORadj 0.79, 95% CI 0.67–0.93) and more likely to have stopped smoking [...]

A partir des données des registres américains des cancers portant sur la période 2004-2001 et incluant 1 110 236 patients, cette étude évalue l'incidence des décès dans le mois suivant une opération chirurgicale liée au cancer, puis identifie les facteurs de risque associés

Incidence and Determinants of 1-Month Mortality after Cancer-Directed Surgery

Mahal, B.A. ; Inverso, G. ; Aizer, A.A. ; Ziehr, D.R. ; Hyatt, A.S. ; Choueiri, T.K. ; Hoffman, K.E. ; Hu, J.C. ; Beard, C.J. ; D'Amico, A.V. ; Martin, N.E. ; Orio, P.F. ; Trinh, Q-D. ; Nguyen, P.L.

Background : Death within 1 month of surgery is considered treatment related and serves as an important healthcare quality metric. We sought to identify the incidence of and factors associated with 1-month mortality after cancer-directed surgery. Patients and Methods : We used the Surveillance, Epidemiology and End Results Program to study a cohort of 1,110,236 patients diagnosed from 2004-2011 with cancers that are among the 10 most common or most fatal who received cancer-directed surgery. [...]

Menée en Allemagne à partir des données de 11 registres des cancers, cette étude analyse l'évolution de la survie sur la période 2002 -2010 pour 24 principaux types de cancer et 11 types rares, puis compare ces données avec les données américaines

Recent cancer survival in Germany: An analysis of common and less common cancers

Jansen, Lina ; Castro, Felipe A. ; Gondos, Adam ; Krilaviciute, Agne ; Barnes, Benjamin ; Eberle, Andrea ; Emrich, Katharina ; Hentschel, Stefan ; Holleczek, Bernd ; Katalinic, Alexander ; Brenner, Hermann ; for the, Gekid Cancer Survival Working Group

The monitoring of cancer survival by population-based cancer registries is a prerequisite to evaluate the current quality of cancer care. Our study provides 1-, 5- and 10-year relative survival as well as 5-year relative survival conditional on 1-year survival estimates and recent survival trends for Germany using data from 11 population-based cancer registries, covering around one-third of the German population. Period analysis was used to estimate relative survival for 24 common and 11 less [...]

Mené auprès de 1 008 patients atteints d'un cancer de la prostate résistant à la castration, cette étude évalue l'association entre un traitement par bevacizumab et le risque de thrombose veineuse et artérielle

Bevacizumab and the risk of arterial and venous thromboembolism in patients with metastatic, castration-resistant prostate cancer treated on Cancer and Leukemia Group B (CALGB) 90401 (Alliance)

Patel, Jai N. ; Jiang, Chen ; Hertz, Daniel L. ; Mulkey, Flora A. ; Owzar, Kouros ; Halabi, Susan ; Ratain, Mark J. ; Friedman, Paula N. ; Small, Eric J. ; Carducci, Michael A. ; Mahoney, John F. ; Kelley, Michael J. ; Morris, Michael J. ; Kelly, William K. ; McLeod, Howard L.

BACKGROUND Bevacizumab is associated with an increased risk of arterial thromboembolism (ATE); however, its effect on venous thromboembolism (VTE) remains controversial. Scant data exist on the factors that increase the risk of ATE/VTE in patients with prostate cancer. The authors investigated the association of bevacizumab treatment and clinical factors with ATE/VTE risk in patients who were treated on Cancer and Leukemia Group B (CALGB) trial 90401. METHODS Patients with metastatic, [...]

A partir de données portant sur 8 952 patientes atteintes d'un cancer du sein en Californie, cette étude analyse l'association entre un diabète, des comorbidités et la survie en fonction de l'appartenance ethnique des patientes

Diabetes and other comorbidities in breast cancer survival by race/ethnicity: The California Breast Cancer Survivorship Consortium (CBCSC)

Wu, Anna H. ; Kurian, Allison W. ; Kwan, Marilyn L. ; John, Esther M. ; Lu, Yani ; Keegan, Theresa H.M. ; Gomez, Scarlett Lin ; Cheng, Iona ; Shariff-Marco, Salma ; Caan, Bette J. ; Lee, Valerie S. ; Sullivan-Halley, Jane ; Tseng, Chiu-Chen ; Bernstein, Leslie ; Sposto, Richard ; Vigen, Cheryl

Background: The role of comorbidities in survival of breast cancer patients has not been well studied, particularly in non-white populations. Methods: We investigated the association of specific comorbidities with mortality in a multiethnic cohort of 8,952 breast cancer cases within the California Breast Cancer Survivorship Consortium (CBCSC), which pooled questionnaire and cancer registry data from five California-based studies. In total, 2,187 deaths (1,122 from breast cancer) were observed [...]

Menée en Angleterre et au Pays de Galles, cette étude évalue l'association entre le statut socioéconomique et la survie relative chez des patientes atteintes d'un cancer du sein

Understanding the impact of socioeconomic differences in breast cancer survival in England and Wales: Avoidable deaths and potential gain in expectation of life

Rutherford, M. J. ; Andersson, T. M. L. ; Møller, H. ; Lambert, P. C.

Background : Socioeconomic differences in cancer patient survival are known to exist for women diagnosed with breast cancer. Standard metrics tend not to place great emphasis on evaluating the actual impact of these differences. Methods : We used two alternative, but related, methods of reporting the impact of socioeconomic differences for breast cancer patients in England and Wales. We calculated the average gain in life years for each patient should socioeconomic differences in relative [...]

A partir des données des registres américains des cancers, cette étude évalue l'association entre le statut sociéconomique et le risque de glioblastome

Socioeconomic status and glioblastoma risk: a population-based analysis

Porter, AlyxB ; Lachance, DanielH ; Johnson, DerekR

Purpose : Socioeconomic status (SES) is associated with risk of various cancer types because of correlation between SES and causal factors or increased case ascertainment, or both. Studies evaluating the association between glioblastoma and occupational or SES factors have yielded inconsistent results. We evaluated the association between SES and glioblastoma risk using a large, population-based cancer registry dataset. Methods : Data of the Surveillance, Epidemiology, and End Results Program [...]

A partir d'une revue systématique de la littérature (25 études cas-témoins), cette étude analyse les représentations négatives que les survivants d'un cancer ont de leur propre corps

Body image in cancer survivors: a systematic review of case-control studies

Lehmann, Vicky ; Hagedoorn, Mariët ; Tuinman, MarritA

Purpose : There is common consensus that cancer and its treatment can impair the body, but combined evidence of the previous literature in cancer survivors is missing. Therefore, we reviewed body image in cancer survivors and focused on case-control studies, in order to draw conclusions as to whether body image might be altered due to cancer. Methods : Medline, Cinahl, Embase, and PsycInfo were searched and after duplicate extraction, 1932 hits were retrieved and screened for eligibility. [...]

A partir des données de la cohorte "St. Jude Lifetime" incluant 69 survivants adultes d'un rétinoblastome (âge moyen : 33 ans, nombre d'années après le diagnostic : 31 ans en moyenne), cette étude analyse leurs capacités cognitives et leur insertion sociale

Cognitive function and social attainment in adult survivors of retinoblastoma: A report from the St. Jude Lifetime Cohort Study

Brinkman, Tara M. ; Merchant, Thomas E. ; Li, Zhenghong ; Brennan, Rachel ; Wilson, Matthew ; Hoehn, Mary Ellen ; Qaddoumi, Ibrahim ; Phipps, Sean ; Srivastava, Deokumar ; Robison, Leslie L. ; Hudson, Melissa M. ; Krull, Kevin R.

BACKGROUND Retinoblastoma has a 5-year survival rate exceeding 95%, yet little is known about long-term functional outcomes for these patients. METHODS Sixty-nine adult survivors of retinoblastoma (mean age, 33 years; mean years post-diagnosis, 31) who had enrolled in the St. Jude Lifetime Cohort Study completed clinical cognitive evaluations and questionnaires assessing adult social attainment. Scores on all cognitive measures were converted to z-scores (M = 0, SD = 1) using age-adjusted [...]

Cet article présente les objectifs stratégiques d'un réseau européen visant à promouvoir le développement de traitements spéficiques pour les enfants et adolescents atteints de cancer

Creating a unique, multi-stakeholder Paediatric Oncology Platform to improve drug development for children and adolescents with cancer

Vassal, Gilles ; Rousseau, Raphaël ; Blanc, Patricia ; Moreno, Lucas ; Bode, Gerlind ; Schwoch, Stefan ; Schrappe, Martin ; Skolnik, Jeffrey ; Bergman, Lothar ; Bradley-Garelik, Mary Brigid ; Saha, Vaskar ; Pearson, Andy ; Zwierzina, Heinz

Seven years after the launch of the European Paediatric Medicine Regulation, limited progress in paediatric oncology drug development remains a major concern amongst stakeholders ? academics, industry, regulatory authorities, parents, patients and caregivers. Restricted increases in early phase paediatric oncology trials, legal requirements and regulatory pressure to propose early Paediatric Investigation Plans (PIPs), missed opportunities to explore new drugs potentially relevant for [...]

Cet article présente le plan d'action élaboré à l'issue d'une conférence américaine en 2012) pour mettre en oeuvre des projets de recherche translationnelle concernant le suivi et la prise en charge des patients ayant survécu à un cancer

An Action Plan for Translating Cancer Survivorship Research Into Care

Alfano, Catherine M. ; Smith, Tenbroeck ; de Moor, Janet S. ; Glasgow, Russell E. ; Khoury, Muin J. ; Hawkins, Nikki A. ; Stein, Kevin D. ; Rechis, Ruth ; Parry, Carla ; Leach, Corinne R. ; Padgett, Lynne ; Rowland, Julia H.

To meet the complex needs of a growing number of cancer survivors, it is essential to accelerate the translation of survivorship research into evidence-based interventions and, as appropriate, recommendations for care that may be implemented in a wide variety of settings. Current progress in translating research into care is stymied, with results of many studies un- or underutilized. To better understand this problem and identify strategies to encourage the translation of survivorship research [...]