A partir d'une revue systématique de la littérature (11 études), cettte étude analyse l'association entre une consommation de tabac sans fumée et le risque d'adénocarcinome du pancréas

The association between smokeless tobacco use and pancreatic adenocarcinoma: A systematic review

Burkey, Matthew D. ; Feirman, Shari ; Wang, Han ; Choudhury, Samuel Ravi ; Grover, Surbhi ; Johnston, Fabian M.

Background : Smokeless tobacco is a possible risk factor for developing pancreatic adenocarcinoma. This systematic review addressed the question: Is there an association between smokeless tobacco use and pancreatic adenocarcinoma diagnosis? Methods : Five electronic databases, grey literature, and citations of relevant articles were searched to identify studies. Six researchers double-reviewed records for inclusion in the review. The information extracted from these studies was selected using [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2014 (28 études), cette méta-analyse fait le point sur l'association entre des perturbations du rythme circadien et le risque de cancer du sein

Circadian disrupting exposures and breast cancer risk: a meta-analysis

He, Chunla ; Anand, SoniaTaj ; Ebell, MarkH ; Vena, JohnE ; Robb, SaraWagner

Purpose : Shift work, short sleep duration, employment as a flight attendant, and exposure to light at night, all potential causes of circadian disruption, have been inconsistently associated with breast cancer (BrCA) risk. The aim of this meta-analysis is to quantitatively evaluate the combined and independent effects of exposure to different sources of circadian disruption on BrCA risk in women. Methods : Relevant studies published through January 2014 were identified by searching the PubMed [...]

Menée au Canada auprès de 1 590 cas et 1 618 témoins, cette étude évalue l'association entre le nombre de partenaires sexuels au cours de la vie, des antécédents d'infections sexuellement transmissibles et le risque de cancer de la prostate

Sexual partners, sexually transmitted infections, and prostate cancer risk

Spence, Andrea R. ; Rousseau, Marie-Claude ; Parent, Marie-Élise

Background: The etiology of prostate cancer (PCa) is poorly understood. Sexual activity and sexually transmitted infections (STIs) are among factors under scrutiny, with controversial findings to date. Methods: We examined the association between the number and gender of sexual partners, STIs and PCa risk in the context of PROtEuS, a population-based case–control study set amongst the mainly French-speaking population in Montreal, Canada. The study included 1590 histologically-confirmed PCa [...]

A partir de données issues d'études d'association sur le génome entier portant sur un total de 5 216 patients atteints d'un lymphome diffus à grandes cellules B et 12 223 témoins, cette méta-analyse identifie plusieurs nouveaux loci de susceptibilité à la maladie

Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

Cerhan, James R. ; Berndt, Sonja I. ; Vijai, Joseph ; Ghesquieres, Herve ; McKay, James ; Wang, Sophia S. ; Wang, Zhaoming ; Yeager, Meredith ; Conde, Lucia ; de Bakker, Paul I. W. ; Nieters, Alexandra ; Cox, David ; Burdett, Laurie ; Monnereau, Alain ; Flowers, Christopher R. ; De Roos, Anneclaire J. ; Brooks-Wilson, Angela R. ; Lan, Qing ; Severi, Gianluca ; Melbye, Mads ; Gu, Jian ; Jackson, Rebecca D. ; Kane, Eleanor ; Teras, Lauren R. ; Purdue, Mark P. ; Vajdic, Claire M. ; Spinelli, John J. ; Giles, Graham G. ; Albanes, Demetrius ; Kelly, Rachel S. ; Zucca, Mariagrazia ; Bertrand, Kimberly A. ; Zeleniuch-Jacquotte, Anne ; Lawrence, Charles ; Hutchinson, Amy ; Zhi, Degui ; Habermann, Thomas M. ; Link, Brian K. ; Novak, Anne J. ; Dogan, Ahmet ; Asmann, Yan W. ; Liebow, Mark ; Thompson, Carrie A. ; Ansell, Stephen M. ; Witzig, Thomas E. ; Weiner, George J. ; Veron, Amelie S. ; Zelenika, Diana ; Tilly, Herve ; Haioun, Corinne ; Molina, Thierry Jo ; Hjalgrim, Henrik ; Glimelius, Bengt ; Adami, Hans-Olov ; Bracci, Paige M. ; Riby, Jacques ; Smith, Martyn T. ; Holly, Elizabeth A. ; Cozen, Wendy ; Hartge, Patricia ; Morton, Lindsay M. ; Severson, Richard K. ; Tinker, Lesley F. ; North, Kari E. ; Becker, Nikolaus ; Benavente, Yolanda ; Boffetta, Paolo ; Brennan, Paul ; Foretova, Lenka ; Maynadie, Marc ; Staines, Anthony ; Lightfoot, Tracy ; Crouch, Simon ; Smith, Alex ; Roman, Eve ; Diver, W. Ryan ; Offit, Kenneth ; Zelenetz, Andrew ; Klein, Robert J. ; Villano, Danylo J. ; Zheng, Tongzhang ; Zhang, Yawei ; Holford, Theodore R. ; Kricker, Anne ; Turner, Jenny ; Southey, Melissa C. ; Clavel, Jacqueline ; Virtamo, Jarmo ; Weinstein, Stephanie ; Riboli, Elio ; Vineis, Paolo ; Kaaks, Rudolph ; Trichopoulos, Dimitrios ; Vermeulen, Roel C. H. ; Boeing, Heiner ; Tjonneland, Anne ; Angelucci, Emanuele ; Di Lollo, Simonetta ; Rais, Marco ; Birmann, Brenda M. ; Laden, Francine ; Giovannucci, Edward ; Kraft, Peter ; Huang, Jinyan ; Ma, Baoshan ; Ye, Yuanqing ; Chiu, Brian C. H. ; Sampson, Joshua ; Liang, Liming ; Park, Ju-Hyun ; Chung, Charles C. ; Weisenburger, Dennis D. ; Chatterjee, Nilanjan ; Fraumeni Jr, Joseph F. ; Slager, Susan L. ; Wu, Xifeng ; de Sanjose, Silvia ; Smedby, Karin E. ; Salles, Gilles ; Skibola, Christine F. ; Rothman, Nathaniel ; Chanock, Stephen J.

Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2014, cette méta-analyse évalue l'association entre des facteurs anthropométriques (taille, indice de masse corporelle, tour de taille, etc.) et le risque de cancer de l'ovaire

Anthropometric factors and ovarian cancer risk: A systematic review and nonlinear dose-response meta-analysis of prospective studies

Aune, Dagfinn ; Navarro Rosenblatt, Deborah A. ; Chan, Doris Sau Man ; Abar, Leila ; Vingeliene, Snieguole ; Vieira, Ana Rita ; Greenwood, Darren C. ; Norat, Teresa

In the World Cancer Research Fund/American Institute for Cancer Research report from 2007 the evidence relating body fatness to ovarian cancer risk was considered inconclusive, while the evidence supported a probably causal relationship between adult attained height and increased risk. Several additional cohort studies have since been published, and therefore we conducted an updated meta-analysis of the evidence as part of the Continuous Update Project. We searched PubMed and several other [...]

Menée aux Etats-Unis auprès de 6 729 participants, cette étude évalue l'association entre l'obésité et le risque de cancer de la prostate de haut grade

Obesity Increases the Risk for High-grade Prostate Cancer: Results from the REDUCE study

Vidal, Adriana C. ; Howard, Lauren E. ; Moreira, Daniel M. ; Castro-Santamaria, Ramiro ; Andriole, Gerald L ; Freedland, Stephen J.

Background: Studies suggest obesity is associated with lower risk of prostate cancer (PC) but more aggressive cancers. As obesity lowers PSA levels, these observations may be influenced by detection bias. We examined the association between obesity and risk of low- and high-grade PC in REDUCE, where biopsies were largely independent of PSA. Methods: The REDUCE study tested dutasteride for PC risk reduction in men with a PSA of 2.5-10.0 ng/mL and a negative biopsy. Study participants included [...]

A partir de données d'études d'association sur le génome entier portant sur 10 146 cas et 12 760 témoins et ayant identifié 23 polymorphismes à simple nucléotide, cette étude évalue les effets d'interaction entre des paires de polymorphismes sur le risque de cancer du sein

Additive Interactions Between Susceptibility Single-Nucleotide Polymorphisms Identified in Genome-Wide Association Studies and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium

Joshi, Amit D. ; Lindström, Sara ; Hüsing, Anika ; Barrdahl, Myrto ; VanderWeele, Tyler J. ; Campa, Daniele ; Canzian, Federico ; Gaudet, Mia M. ; Figueroa, Jonine D. ; Baglietto, Laura ; Berg, Christine D. ; Buring, Julie E. ; Chanock, Stephen J. ; Chirlaque, María-Dolores ; Diver, W. Ryan ; Dossus, Laure ; Giles, Graham G. ; Haiman, Christopher A. ; Hankinson, Susan E. ; Henderson, Brian E. ; Hoover, Robert N. ; Hunter, David J. ; Isaacs, Claudine ; Kaaks, Rudolf ; Kolonel, Laurence N. ; Krogh, Vittorio ; Le Marchand, Loic ; Lee, I-Min ; Lund, Eiliv ; McCarty, Catherine A. ; Overvad, Kim ; Peeters, Petra H. ; Riboli, Elio ; Schumacher, Fredrick ; Severi, Gianluca ; Stram, Daniel O. ; Sund, Malin ; Thun, Michael J. ; Travis, Ruth C. ; Trichopoulos, Dimitrios ; Willett, Walter C. ; Zhang, Shumin ; Ziegler, Regina G. ; Kraft, Peter

Additive interactions can have public health and etiological implications but are infrequently reported. We assessed departures from additivity on the absolute risk scale between 9 established breast cancer risk factors and 23 susceptibility single-nucleotide polymorphisms (SNPs) identified from genome-wide association studies among 10,146 non-Hispanic white breast cancer cases and 12,760 controls within the National Cancer Institute's Breast and Prostate Cancer Cohort Consortium. We estimated [...]

Menée au Royaume-Uni par questionnaire auprès de 92 834 participantes (âge médian : 64 ans), cette étude de cohorte prospective évalue l'association entre l'évolution du tour de taille et de l'adiposité abdominale, entre l'âge de 20 ans et l'âge de la ménopause, et le risque de cancer du sein

Association of skirt size and postmenopausal breast cancer risk in older women: a cohort study within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)

Fourkala, Evangelia-Ourania ; Burnell, Matthew ; Cox, Catherine ; Ryan, Andy ; Salter, Laura Currin ; Gentry-Maharaj, Aleksandra ; Parmar, Mahesh ; Jacobs, Ian ; Menon, Usha

Objectives : Several studies suggest that overall and central-obesity are associated with increased breast cancer (BC) risk in postmenopausal-women. However, there are no studies investigating changes of central obesity and BC. We report on the association of BC risk with self-reported skirt size (SS; waist-circumference proxy) changes between 20s and postmenopausal-age. Design : Prospective cohort-study.Setting UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) involving the nine [...]

Menée en Chine auprès de 839 cas et 863 témoins, cette étude évalue l'association entre une activité physique, des polymorphismes du gène FGFR2 et de gènes liés à la méthylation de l'ADN, et le risque de cancer du sein

Association of physical activity and polymorphisms in FGFR2 and DNA methylation related genes with breast cancer risk

Xi, Jing ; Su, Yi ; Fadiel, Alicia Beeghly ; Lin, Ying ; Su, Feng-Xi ; Jia, Wei-Hua ; Tang, Lu-Ying ; Ren, Ze-Fang

Purpose : Physical activity, a protective factor for breast cancer, increases the level of DNA methylation. Fibroblast growth factor receptor 2 (FGFR2), a confirmed breast cancer susceptibility gene, is predisposed to be methylated. Therefore, DNA methylation related genes, such as methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), and DNA methyltransferase (DNMT), together with physical activity and FGFR2, may interact with each other to effect breast cancer risk. Methods [...]

A partir des données de 22 études incluant 26 633 cas et 30 119 témoins, cette étude évalue les relations entre 47 polymorphismes à simple nucléotide associés à une susceptibilité au cancer du sein, 13 facteurs environnementaux et le risque de cancer du sein

Investigation of gene-environment interactions between 47 newly identified breast cancer susceptibility loci and environmental risk factors

Rudolph, Anja ; Milne, Roger L. ; Truong, Thérèse ; Knight, Julia A. ; Seibold, Petra ; Flesch-Janys, Dieter ; Behrens, Sabine ; Eilber, Ursula ; Bolla, Manjeet K. ; Wang, Qin ; Dennis, Joe ; Dunning, Alison M. ; Shah, Mitul ; Munday, Hannah R. ; Darabi, Hatef ; Eriksson, Mikael ; Brand, Judith S. ; Olson, Janet ; Vachon, Celine M. ; Hallberg, Emily ; Castelao, J. Esteban ; Carracedo, Angel ; Torres, Maria ; Li, Jingmei ; Humphreys, Keith ; Cordina-Duverger, Emilie ; Menegaux, Florence ; Flyger, Henrik ; Nordestgaard, Børge G. ; Nielsen, Sune F. ; Yesilyurt, Betul T. ; Floris, Giuseppe ; Leunen, Karin ; Engelhardt, Ellen G. ; Broeks, Annegien ; Rutgers, Emiel J. ; Glendon, Gord ; Mulligan, Anna Marie ; Cross, Simon ; Reed, Malcolm ; Gonzalez-Neira, Anna ; Arias Perez, José Ignacio ; Provenzano, Elena ; Apicella, Carmel ; Southey, Melissa C. ; Spurdle, Amanda ; kConFab, Investigators ; Aocs Group ; Häberle, Lothar ; Beckmann, Matthias W. ; Ekici, Arif B. ; Dieffenbach, Aida Karina ; Arndt, Volker ; Stegmaier, Christa ; McLean, Catriona ; Baglietto, Laura ; Chanock, Stephen J. ; Lissowska, Jolanta ; Sherman, Mark E. ; Brüning, Thomas ; Hamann, Ute ; Ko, Yon-Dschun ; Orr, Nick ; Schoemaker, Minouk ; Ashworth, Alan ; Kosma, Veli-Matti ; Kataja, Vesa ; Hartikainen, Jaana M. ; Mannermaa, Arto ; Swerdlow, Anthony ; Genica Network ; Giles, Graham G. ; Brenner, Hermann ; Fasching, Peter A. ; Chenevix-Trench, Georgia ; Hopper, John ; Benítez, Javier ; Cox, Angela ; Andrulis, Irene L. ; Lambrechts, Diether ; Gago-Dominguez, Manuela ; Couch, Fergus ; Czene, Kamila ; Bojesen, Stig E. ; Easton, Doug F. ; Schmidt, Marjanka K. ; Guénel, Pascal ; Hall, Per ; Pharoah, Paul D. P. ; Garcia-Closas, Montserrat ; Chang-Claude, Jenny

A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. We investigated whether the effects of these 41 SNPs, as well as six SNPs associated with estrogen receptor (ER) negative BC risk are modified by 13 environmental risk factors for BC. Data from 22 studies participating in BCAC were pooled, comprising up to 26,633 cases and 30,119 controls. [...]

Menée au Danemark auprès de 341 758 participantes atteintes d'une maladie auto-immune, cette étude de cohorte évalue l'association entre une utilisation de médicaments immunosuppresseurs et le risque de cancer du col de l'utérus

Risk of cervical cancer in women with autoimmune diseases, in relation with their use of immunosuppressants and screening: Population-based cohort study

Dugué, Pierre-Antoine ; Rebolj, Matejka ; Hallas, Jesper ; Garred, Peter ; Lynge, Elsebeth

Severely immunosuppressed individuals have a strongly increased risk of cervical cancer. In patients with autoimmune diseases (AID), who have defects in their immune system and receive immunosuppressants, the risk of cervical cancer is less clear. We conducted a cohort study, using Danish nationwide population-based registers including information on AID diagnoses, immunosuppressant intake, cervical screening participation, and cervical cancer incidence. Standardized incidence ratios (SIR) were [...]