A partir des données de l'essai SU.VI.MAX incluant 4 684 femmes atteintes d'un cancer du sein diagnostiqué entre 1994 et 2007, cette étude prospective évalue l'association entre une consommation de viande rouge et de viandes transformées, une supplémentation en anti-oxydants et le risque de cancer du sein

Prospective association between red and processed meat intakes and breast cancer risk: modulation by an antioxidant supplementation in the SU.VI.MAX randomized controlled trial

Pouchieu, Camille ; Deschasaux, Mélanie ; Hercberg, Serge ; Druesne-Pecollo, Nathalie ; Latino-Martel, Paule ; Touvier, Mathilde

Background: The level of evidence regarding the association between red and processed meat intakes and breast cancer risk is still low, due to insufficient prospective studies. Moreover, mechanistic data suggest that some antioxidants may modulate this relationship but epidemiological evidence is lacking. Our objectives were to investigate relationships between red and processed meat intakes and breast cancer risk, and to study whether an antioxidant supplementation modulates these [...]

A partir des données de la cohorte américaine "Health Professionals Follow-Up Study" portant sur 49 405 hommes âgés de 40 à 75 ans et suivis pendant 24 ans, cette étude évalue l'association entre une vasectomie et le risque de cancer agressif de la prostate

Vasectomy and Risk of Aggressive Prostate Cancer: A 24-Year Follow-Up Study

Siddiqui, Mohummad Minhaj ; Wilson, Kathryn M. ; Epstein, Mara M. ; Rider, Jennifer R. ; Martin, Neil E. ; Stampfer, Meir J. ; Giovannucci, Edward L. ; Mucci, Lorelei A.

Purpose : Conflicting reports remain regarding the association between vasectomy, a common form of male contraception in the United States, and prostate cancer risk. We examined prospectively this association with extended follow-up and an emphasis on advanced and lethal disease. Patients and Methods : Among 49,405 US men in the Health Professionals Follow-Up Study, age 40 to 75 years at baseline in 1986, 6,023 patients with prostate cancer were diagnosed during the follow-up to 2010, including [...]

Couplée aux données de la cohorte européenne EPIC et portant sur 365 cas et 1 284 témoins, cette étude évalue l'association entre 32 variants des gènes liés aux groupes sanguins ABO, des variants des gènes FUT et le risque de cancer gastrique de type diffus ou intestinal

Variation at ABO histo-blood group and FUT loci and diffuse and intestinal gastric cancer risk in a European population

Duell, Eric J. ; Bonet, Catalina ; Muñoz, Xavier ; Luján-Barroso, Leila ; Weiderpass, Elisabete ; Boutron-Ruault, Marie-Christine ; Racine, Antoine ; Severi, Gianluca ; Canzian, Federico ; Rizzato, Cosmeri ; Boeing, Heiner ; Overvad, Kim ; Tjønneland, Anne ; Argüelles, Marcial ; Sánchez-Cantalejo, Emilio ; Chamosa, Saioa ; Huerta, José María ; Barricarte, Aurelio ; Khaw, Kay-Tee ; Wareham, Nick ; Travis, Rutch C. ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Yiannakouris, Nikos ; Palli, Domenico ; Agnoli, Claudia ; Tumino, Rosario ; Naccarati, Alessio ; Panico, Salvatore ; Bueno-de-Mesquita, H. B. ; Siersema, Peter D. ; Peeters, Petra H. M. ; Ohlsson, Bodil ; Lindkvist, Björn ; Johansson, Ingegerd ; Ye, Weimin ; Johansson, Matthias ; Fenger, Claus ; Riboli, Elio ; Sala, Núria ; González, Carlos A.

ABO blood serotype A is known to be associated with risk of gastric cancer (GC), but little is known how ABO alleles and the fucosyltransferase (FUT) enzymes and genes which are involved in Lewis antigen formation [and in Helicobacter pylori (H. pylori) binding and pathogenicity] may be related to GC risk in a European population. The authors conducted an investigation of 32 variants at ABO and FUT1–7 loci and GC risk in a case–control study of 365 cases and 1,284 controls nested within the [...]

Menée en Allemagne sur une cohorte de 121 patients atteints d'un adénocarcinome du pancréas, 102 patients atteints d'une pancréatite chronique idiopathique et 130 témoins, cette étude rétrospective montre que la présence de mutations dans les gènes CFTR, SPINK1, PRSS1 ou CTRC n'est pas un facteur de risque d'adénocarcinome du pancréas

CFTR, SPINK1, PRSS1, and CTRC Mutations Are not Associated With Pancreatic Cancer in German Patients

Schubert, Stephanie ; Traub, Frank ; Brakensiek, Kai ; von Kopylow, Kathrein ; Marohn, Britta ; Maelzer, Madeleine ; Gaedcke, Jochen ; Kreipe, Hans ; Stuhrmann, Manfred

Objective: Mutations in the cationic trypsinogen (PRSS1), cystic fibrosis transmembrane conductance regulator (CFTR), serine protease inhibitor Kazal type 1 (SPINK1), and chymotrypsin C (CTRC) genes are associated with an elevated risk for chronic pancreatitis, which is a known risk factor for pancreatic cancer (PC). Therefore, we analyzed whether PRSS1, CFTR, SPINK1, and/or CTRC mutations are associated with pancreatic adenocarcinoma. Methods: The study cohort was composed of 121 PC patients, [...]

Menée en Chine, cette étude analyse l'association entre l'expression des gènes TMEFF2 et STAT3, une infection par Helicobacter pylori et le risque de cancer de l'estomac

Bidirectional regulation between TMEFF2 and STAT3 may contribute to Helicobacter pylori-associated gastric carcinogenesis

Sun, Tian-Tian ; Tang, Jia-Yin ; Du, Wan ; Zhao, Hui-Jun ; Zhao, Gang ; Yang, Sheng-Li ; Chen, Hao-Yan ; Hong, Jie ; Fang, Jing-Yuan

The transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) is a single-pass transmembrane protein, and it is downregulated in human gastric cancer and levels correlate with tumor progression and time of survival. However, the mechanism of its dysregulation in gastric cancer is little known. Here we investigate its regulatory mechanism and the bidirectional regulation between TMEFF2 and STAT3 in gastric carcinogenesis. TMEFF2 expression was decreased after [...]

Menée aux Etats-Unis auprès de 9 160 cas et 9 280 témoins, cette étude évalue l'association entre des polymorphismes génétiques récemment identifiés dans des études d'association sur le génome entier, des comportements individuels et le risque de cancer colorectal

Gene-environment interaction involving recently identified colorectal cancer susceptibility loci

Kantor, Elizabeth D. ; Hutter, Carolyn M. ; Minnier, Jessica ; Berndt, Sonja I. ; Brenner, Hermann ; Caan, Bette J. ; Campbell, Peter T. ; Carlson, Christopher S. ; Casey, Graham ; Chan, Andrew T. ; Chang-Claude, Jenny ; Chanock, Stephen J. ; Cotterchio, Michelle ; Du, Mengmeng ; Duggan, David ; Fuchs, Charles S. ; Giovannucci, Edward L. ; Gong, Jian ; Harrison, Tabitha A. ; Hayes, Richard B. ; Henderson, Brian E. ; Hoffmeister, Michael ; Hopper, John L. ; Jenkins, Mark A. ; Jiao, Shuo ; Kolonel, Laurence N. ; Le Marchand, Loic ; Lemire, Mathieu ; Ma, Jing ; Newcomb, Polly A. ; Ochs-Balcom, Heather M. ; Pflugeisen, Bethann M. ; Potter, John D. ; Rudolph, Anja ; Schoen, Robert E. ; Seminara, Daniela ; Slattery, Martha L. ; Stelling, Deanna L. ; Thomas, Fridtjof ; Thornquist, Mark ; Ulrich, Cornelia M. ; Warnick, Greg S. ; Zanke, Brent W. ; Peters, Ulrike ; Hsu, Li ; White, Emily

Background: Genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) that are associated with risk of colorectal cancer (CRC). Prior research has evaluated the presence of gene-environment interaction involving the first 10 identified susceptibility loci, but little work has been conducted on interaction involving SNPs at recently identified susceptibility loci, including: rs10911251, rs6691170, rs6687758, rs11903757, rs10936599, rs647161, rs1321311, [...]

Menée en Norvège auprès de 2 348 femmes âgées de 50 à 69 ans, cette étude analyse l'association entre des variants génétiques de susceptibilité au cancer du sein et la densité mammaire, en fonction de la consommation d'alcool ou de l'usage de traitements hormonaux substitutifs de la ménopause

Breast cancer susceptibility variants and mammographic density phenotypes in Norwegian postmenopausal women

Ellingjord-Dale, Merete ; Grotmol, Tom ; Lee, Eunjung ; Van Den Berg, David J. ; Hofvind, Solveig ; Couto, Elisabeth ; Sovio, Ulla ; dos Santos Silva, Isabel ; Ursin, Giske

Background:Mammographic density (MD) is one of the strongest known breast cancer risk factors. Twin studies have suggested that a large part of the variation in MD is genetically determined. We hypothesized that breast cancer susceptibility variants may affect MD, and that their effects may be modified by non-genetic factors. Methods:We assessed MD, using a computer assisted method, on 2348 postmenopausal Caucasian women (50-69 years) who participated in the Norwegian Breast Cancer Screening [...]