A partir des données de six études menées aux Etats-Unis, au Canada, au Royaume-Uni, en Nouvelle-Zélande portant sur 2 159 cas et 2 985 témoins, cette étude évalue l'association entre une consommation de cannabis et le risque de cancer du poumon

Cannabis smoking and lung cancer risk: Pooled analysis in the International Lung Cancer Consortium

Zhang, Li Rita ; Morgenstern, Hal ; Greenland, Sander ; Chang, Shen-Chih ; Lazarus, Philip ; Teare, M. Dawn ; Woll, Penella J. ; Orlow, Irene ; Cox, Brian ; on behalf of the, Cannabis ; Respiratory Disease Research Group of New, Zealand ; Brhane, Yonathan ; Liu, Geoffrey ; Hung, Rayjean J.

To investigate the association between cannabis smoking and lung cancer risk, data on 2,159 lung cancer cases and 2,985 controls were pooled from 6 case-control studies in the US, Canada, UK, and New Zealand within the International Lung Cancer Consortium. Study-specific associations between cannabis smoking and lung cancer were estimated using unconditional logistic regression adjusting for sociodemographic factors, tobacco smoking status and pack-years; odds-ratio estimates were pooled using [...]

A partir des données de 31 études (6 260 cas et 32 935 témoins issus des études cas-témoins ; 2 715 participants issus des études de cohorte), cette méta-analyse évalue l'association entre le tabagisme et le risque de cancer de la thyroïde

Thyroid cancer risk and smoking status: a meta-analysis

Cho, YoungAe ; Kim, Jeongseon

Purpose : Previous researchers have reported an inverse association between cigarette smoking and thyroid cancer risk. To summarize the role of smoking in relation to thyroid cancer occurrence, we conducted a meta-analysis. Methods : We performed a meta-analysis of 31 eligible studies to summarize the data describing the association between thyroid cancer occurrence and smoking. The case–control studies consisted of 6,260 thyroid cancer cases and 32,935 controls. Cohort studies contained 2,715 [...]

Menée en Italie auprès de 531 cas et 524 témoins, cette étude évalue l'association entre la durée et l'intensité du tabagisme et le risque de carcinome transitionnel de la vessie, en fonction du sous-type histologique

Duration and intensity of tobacco smoking and the risk of papillary and non-papillary transitional cell carcinoma of the bladder

Polesel, Jerry ; Bosetti, Cristina ; di Maso, Matteo ; Montella, Maurizio ; Libra, Massimo ; Garbeglio, Antonio ; Zucchetto, Antonella ; Turati, Federica ; Talamini, Renato ; La Vecchia, Carlo ; Serraino, Diego

Purpose : To evaluate the impact of tobacco smoking on specific histological subtypes of transitional cell carcinoma of the bladder (TCC). Methods : Between 2003 and 2009, we conducted a hospital-based case-control study in Italy, enrolling 531 incident TCC cases and 524 cancer-free matched patients. Odds ratios (OR) and corresponding 95% confidence intervals (CI) were estimated through multiple logistic regression models. Results : Compared to never smokers, TCC risk was threefold higher in [...]

A partir d'une revue systématique de la littérature (18 études, dont 10 études cas-témoins et 8 études de cohorte, 7 142 cas), cette méta-analyse évalue l'association entre une consommation d'alcool et le risque de leucémie

Alcohol drinking and risk of leukemia—A systematic review and meta-analysis of the dose–risk relation

Rota, Matteo ; Porta, Lorenzo ; Pelucchi, Claudio ; Negri, Eva ; Bagnardi, Vincenzo ; Bellocco, Rino ; Corrao, Giovanni ; Boffetta, Paolo ; La Vecchia, Carlo

Abstract : The association between alcohol and leukemia risk has been addressed in several studies in the past two decades, but results have been inconsistent. Therefore, we conducted a systematic review and meta-analysis to quantify the dose–risk relation. Through the literature search up to August 2013, we identified 18 studies, 10 case-control and 8 cohorts, carried out in a total of 7142 leukemia cases. We derived pooled meta-analytic estimates using random-effects models, taking into [...]

Menée en France auprès de 5 086 salariés travaillant dans une mine d'uranium, cette étude analyse l'association entre une exposition à des rayonnements ionisants lors d'examens médicaux, une exposition professionnelle au radon et le risque de cancer du poumon

Chest X-ray screening examinations among French uranium miners: exposure estimation and impact on radon-associated lung cancer risk

Laborde-Castérot, Hervé ; Laurier, Dominique ; Caër-Lorho, Sylvaine ; Etard, Cécile ; Acker, Alain ; Rage, Estelle

Background : Medical surveillance of uranium miners can include periodic chest X-ray examinations. This study aimed to assess the X-ray exposure due to occupational health monitoring in the French cohort of uranium miners, and to test whether consideration of this additional radiation exposure impacts the excess risk of lung cancer death associated with radon exposure. Method : X-ray exposure due to occupational health monitoring was estimated retrospectively based on review of a sample of [...]

Menée auprès de 306 cas et 950 témoins, cette étude britannique évalue l'association entre une exposition professionnelle des parents à des produits solvants et le risque de tumeurs cérébrales chez l'enfant

Childhood brain tumours: associations with parental occupational exposure to solvents

Peters, S. ; Glass, D. C. ; Greenop, K. R. ; Armstrong, B. K. ; Kirby, M. ; Milne, E. ; Fritschi, L.

Background: Parental occupational exposures have been associated with childhood brain tumours (CBT), but results are inconsistent. Few studies have studied CBT risk and parental solvent exposure, suggesting a possible association. We examined the association between CBT and parental occupational exposure to solvents in a case–control study. Methods: Parents of 306 cases and 950 controls completed detailed occupational histories. Odds ratios (ORs) and 95% confidence intervals (CIs) were [...]

A partir d'une revue systématique de la littérature publiée de 1971 à 2011 (47 études), cette méta-analyse évalue l'association entre des infections sexuellement transmissibles et le risque de cancer de la prostate

Sexually transmitted infections and prostate cancer risk: A systematic review and meta-analysis

Caini, Saverio ; Gandini, Sara ; Dudas, Maria ; Bremer, Viviane ; Severi, Ettore ; Gherasim, Alin

Abstract : Prostate cancer (PC) is the second most incident cancer and the sixth cause of death by cancer in men worldwide. Despite extensive research efforts, no modifiable risk factors have been consistently identified for PC risk. A number of studies have focused on possible relationships between sexually transmitted infections (STIs) and PC. We performed a meta-analysis to explore the association between infection caused by Neisseria gonorrheae, Treponema pallidum, Chlamydia trachomatis, [...]

Menée aux Etats-Unis auprès de 278 cas et 278 témoins, cette étude évalue l'association entre l'utilisation d'érythromycine, un médicament antibiotique, et le risque de myélome multiple

Medication use and multiple myeloma risk in Los Angeles County

Nuyujukian, DanielS ; Voutsinas, Jenna ; Bernstein, Leslie ; Wang, SophiaS

Background : The role of medication use in multiple myeloma (MM) risk remains unclear. Methods : The Los Angeles County Multiple Myeloma Case–Control Study, comprising 278 MM cases and individually matched neighborhood controls, provided data to assess associations between medication use and MM risk. Odds ratios (OR) and 95 % confidence intervals (CI) were estimated using conditional logistic regression. Results : Erythromycin (ever) use was associated with increased MM risk (OR 1.85, 95 % CI [...]

Menée aux Etats-Unis auprès de 132 cas et 125 témoins en population d'origine hispanique, cette étude analyse les facteurs génétiques et phénotypiques impliqués dans l'étiologie du cancer de l'estomac

Genetic and intermediate phenotypic susceptibility markers of gastric cancer in Hispanic Americans: A case-control study

Sun, Yuhui ; Gu, Jian ; Ajani, Jaffer A. ; Chang, David W. ; Wu, Xifeng ; Stroehlein, John R.

BACKGROUND : Hispanics are the largest nonwhite ethnic group in the US population, and they have higher incidence and mortality rates for gastric cancer (GC) than whites and Asians. Studies have identified several genetic susceptibility loci and intermediate phenotypic biomarkers for GC in whites and Asians. No studies have evaluated genetic susceptibility and intermediate phenotypic biomarkers in Hispanics. METHODS In a case-control study of 132 Hispanic patients with GC (cases) and a control [...]

Menée sur plusieurs cohortes de patients et de témoins, cette étude d'association sur le génome entier identifie un polymorphisme à simple nucléotide, situé dans le gène TET2 sur la région chromosomique 4q24, en association avec une susceptibilité au mélanome

Identification of a melanoma susceptibility locus and somatic mutation in TET2

Song, Fengju ; Amos, Christopher I. ; Lee, Jeffrey E. ; Lian, Christine G. ; Fang, Shenying ; Liu, Hongliang ; MacGregor, Stuart ; Iles, Mark M. ; Lindeman, Neal I. ; Montgomery, Grant W. ; Duffy, David L. ; Cust, Anne E. ; Jenkins, Mark A. ; Whiteman, David C. ; Kefford, Richard F. ; Giles, Graham G. ; Armstrong, Bruce K. ; Aitken, Joanne F. ; Hopper, John L. ; Brown, Kevin M. ; Martin, Nicholas G. ; Mann, Graham J. ; Bishop, D. Timothy ; Newton Bishop, Julia A. ; the GenoMEL consortium ; Kraft, Peter ; Qureshi, Abrar A. ; Kanetsky, Peter A ; Hayward, Nicholas K. ; Hunter, David J. ; Wei, Qingyi ; Han, Jiali

Although genetic studies have reported a number of loci associated with melanoma risk, the complex genetic architecture of the disease is not yet fully understood. We sought to identify common genetic variants associated with melanoma risk in a genome-wide association study (GWAS) of 2,298 cases and 6,654 controls. Thirteen out of fifteen known loci were replicated with nominal significance. A total of 69 SNPs were selected for in silico replication in two independent melanoma GWAS datasets (a [...]

A partir des données de la cohorte française "E3N" incluant 98 995 femmes nées entre 1925 et 1950, cette étude prospective évalue l'association entre des caractéristiques anthropométriques et le risque de mélanome

Anthropometric features and cutaneous melanoma risk: A prospective cohort study in French women

Kvaskoff, Marina ; Bijon, Anne ; Mesrine, Sylvie ; Vilier, Alice ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie-Christine

Background : Epidemiological studies on anthropometric features and cutaneous melanoma risk in women yielded inconsistent results, with few analyses involving prospective cohort data. Our objective was to explore several anthropometric characteristics in relation to the risk of melanoma in women. Methods : We prospectively analysed data from E3N, a French cohort involving 98,995 women born in 1925–1950. Participants completed self-administered questionnaires sent biennially over 1990–2008. [...]

A partir des données de la cohorte "Iowa Women's Health Study" incluant 22 601 participantes âgées de 63 à 81 ans (âge moyen : 72 ans), cette étude en population américaine évalue l'association entre des maladies allergiques et le risque de cancers hématopoïétiques

Allergic diseases and risk of hematopoietic malignancies in a cohort of postmenopausal women: A report from the Iowa Women's Health Study

Linabery, Amy M. ; Prizment, Anna E ; Anderson, Kristin E. ; Cerhan, James R. ; Poynter, Jenny N ; Ross, Julie A.

Background: Allergic diseases signify immune dysregulation attributable to underlying genetics and environmental exposures. Associations between various allergies and hematopoietic cancers have been observed, albeit inconsistently, however few prospective studies have examined the risk, and even fewer among older adults. Methods: We examined risk of incident hematopoietic cancers in those reporting allergic diseases in a population-based cohort of 22,601 older women (Iowa Women's Health Study). [...]

Menée aux Pays-Bas auprès de 120 852 participants, cette étude de cohorte évalue l'association entre la taille, l'activité physique, une restriction énérgétique alimentaire tôt dans la vie et le risque de cancer colorectal caractérisé par la méthylation des gènes IGFBP

Body size, physical activity, early life energy restriction, and associations with methylated insulin-like growth factor binding protein genes in colorectal cancer

Simons, Colinda C.J.M. ; van den Brandt, Piet A. ; Stehouwer, Coen ; van Engeland, Manon ; Weijenberg, Matty P.

Background: We investigated body size, physical activity, and early life energy restriction in relation to colorectal tumors with and without methylated insulin-like growth factor binding protein (IGFBP) genes, which are putative tumor suppressor genes. Methods: We determined IGFBP2, IGFBP3, and IGFBP7 promoter CpG island hypermethylation in tumors of 733 CRC cases from the Netherlands Cohort Study (N=120,852). Participants self-reported lifestyle and dietary factors at baseline in 1986. Using [...]

Menée au Canada à l'aide d'un outil développé en Europe, cette étude estime le nombre de travailleurs exposés à des agents cancérogènes

CAREX Canada: an enhanced model for assessing occupational carcinogen exposure

Peters, Cheryl E ; Ge, Calvin B ; Hall, Amy L ; Davies, Hugh W ; Demers, Paul A

Objectives : To estimate the numbers of workers exposed to known and suspected occupational carcinogens in Canada, building on the methods of CARcinogen EXposure (CAREX) projects in the European Union (EU). Methods : CAREX Canada consists of estimates of the prevalence and level of exposure to occupational carcinogens. CAREX Canada includes occupational agents evaluated by the International Agency for Research on Cancer as known, probable or possible human carcinogens that were present and [...]