Menée en Allemagne auprès de 26 patients atteints d'un cancer gastrointestinal et recevant une chimiothérapie palliative, cette étude pilote analyse l'efficacité de deux programmes destinés à améliorer leur niveau d'activité physique, leurs performances physiques et leur qualité de vie

Exercise training in patients with advanced gastrointestinal cancer undergoing palliative chemotherapy: a pilot study

Jensen, Wiebke ; Baumann, FreerkT ; Stein, Alexander ; Bloch, Wilhelm ; Bokemeyer, Carsten ; Wit, Maike ; Oechsle, Karin

Purpose : This pilot study aimed to investigate the feasibility of two different training programs in patients with advanced gastrointestinal cancer undergoing palliative chemotherapy. Potential effects of training programs on the patients’ quality of life, physical performance, physical activity in daily living, and biological parameters were exploratorily evaluated. Methods : Patients were randomly assigned to a resistance (RET) and aerobic exercise training group (AET). Both underwent [...]

Menée au Japon, cette étude analyse l'évolution, sur la période 2005-2011, des prescriptions d'antiémétiques pour la prévention des nausées et vomissements liés à la chimiothérapie

Prescription trends of prophylactic antiemetics for chemotherapy-induced nausea and vomiting in Japan

Okuyama, Ayako ; Nakamura, Fumiaki ; Higashi, Takahiro

Purpose : This study aimed at identifying prescription trends for the recommended antiemetic therapies before and after the publication of the first guidelines for antiemetic therapy in Japan. Methods : Claims data of 20 Japanese health insurance societies were analyzed. Claims for patients 18 years old or older who received chemotherapy with high or moderate emetic risk were extracted. The rate of patients who were prescribed the recommended antiemetic drugs was calculated. Results : From 2005 [...]

A partir d'une revue systématique des essais cliniques (total de 811 patients inclus), cette étude fait le point sur l'utilisation et l'efficacité de l'olanzapine pour prévenir et traiter les nausées et vomissements induits par la chimiothérapie

Olanzapine for chemotherapy-induced nausea and vomiting: a systematic review

Hocking, ChristopherM ; Kichenadasse, Ganessan

Purpose: Newer drugs incorporated in prophylactic regimens for chemotherapy-induced nausea and vomiting (CINV) have resulted in significantly reduced rates of this feared complication of cytotoxic chemotherapy. However, both delayed chemotherapy-induced nausea and breakthrough CINV remain difficult areas of management and require novel treatment strategies. Recent randomized trial evidence has suggested that olanzapine, an atypical antipsychotic, may have a role in both the prevention and [...]

Menée en Chine auprès de 346 patients atteints d'un cancer de l'œsophage, cette étude analyse les facteurs associés à leur intérêt pour un suivi de leur santé et de leur qualité de vie par téléphone après une œsophagectomie

Factors influencing response enthusiasm to telephone follow-up in patients with oesophageal carcinoma after oesophagectomy

Gao, Q. ; Yuan, L. ; Wang, W. P. ; Shi, H. ; Chen, L. Q.

Response enthusiasm to telephone follow-up is a precondition for obtaining exhaustive information; however, no study has yet examined this specific issue. This study aimed to investigate possible factors influencing response enthusiasm to telephone follow-up in patients with oesophageal carcinoma after oesophagectomy and to propose corresponding countermeasures. A telephone follow-up was conducted on patients who underwent oesophagectomy. The possible factors influencing response enthusiasm [...]

Menée en Espagne, cette étude longitudinale analyse l'incidence, les caractéristiques et la durée de dysfonctionnements cognitifs induits par une chimiothérapie adjuvante chez des patients atteints d'un cancer colorectal

Longitudinal study of cognitive dysfunctions induced by adjuvant chemotherapy in colon cancer patients

Cruzado, JuanAntonio ; López-Santiago, Sonia ; Martínez-Marín, Virginia ; José-Moreno, Gema ; Custodio, AnaBelén ; Feliu, Jaime

Background : Chemotherapy can induce cognitive impairment in cancer patients. The main goal of this longitudinal study was to determine the incidence, characteristics, and duration of cognitive dysfunction in patients treated with adjuvant chemotherapy for colon cancer. Patients and methods : We assessed cognitive function, quality of life, anxiety and depression, fatigue, and hemoglobin levels in colon cancer patients at three assessment points: pre-chemotherapy (n = 81), post-chemotherapy [...]

Mené aux Etats-Unis auprès de 120 patients atteints d'un cancer de la tête et du cou, cet essai randomisé en double aveugle analyse l'efficacité d'un hydrogel mucoadhésif pour diminuer les symptômes associés à une mucite buccale induite par la chimioradiothérapie

Multi-institutional, randomized, double-blind, placebo-controlled trial to assess the efficacy of a mucoadhesive hydrogel (MuGard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head and neck

Allison, Ron R. ; Ambrad, Aaron A. ; Arshoun, Youssef ; Carmel, Richard J. ; Ciuba, Doug F. ; Feldman, Elizabeth ; Finkelstein, Steven E. ; Gandhavadi, Ranjini ; Heron, Dwight E. ; Lane, Steven C. ; Longo, John M. ; Meakin, Charles ; Papadopoulos, Dimitrios ; Pruitt, David E. ; Steinbrenner, Lynn M. ; Taylor, Michael A. ; Wisbeck, William M. ; Yuh, Grace E. ; Nowotnik, David P. ; Sonis, Stephen T.

BACKGROUND The objective of this trial was to determine how a mucoadhesive hydrogel (MuGard), a marketed medical device, would fare when tested with the strictness of a conventional multi-institutional, double-blind, randomized, placebo-controlled study format. METHODS A total of 120 subjects planned to receive chemoradiation therapy (CRT) for treatment of head and neck cancers were randomized to receive either MuGard or sham control rinse (SC) during CRT. Subjects completed the validated Oral [...]

Menée aux Etats-Unis auprès de 6 259 survivantes d'un cancer du sein, 3 609 survivants d'un cancer de la prostate et 1 898 survivants d'un cancer colorectal et auprès de témoins non malades en population générale, cette étude analyse leurs comportements de santé, en fonction du type de cancer et du sexe de l'individu

Health behaviors among breast, prostate, and colorectal cancer survivors: a US population-based case-control study, with comparisons by cancer type and gender

LeMasters, TraciJ ; Madhavan, SundareswaranS ; Sambamoorthi, Usha ; Kurian, Sobha

Purpose : The aim of this study is to compare health behaviors between breast, prostate, female, and male colorectal cancer survivors to noncancer controls, stratified by short- and long-term survivors, and between cancer types and genders. Methods : A 3:1 population-based sample of breast (6,259), prostate (3,609), female colorectal (1,082), and male colorectal (816) cancer survivors from the 2009 Behavioral Risk Factor Surveillance System survey were matched to noncancer controls on age, [...]

Menée en Normandie à partir des données des registres des cancers, cette étude en population (68 967 cas de cancers diagnostiqués entre 1997 et 2009) analyse l'association entre l'environnement socioéconomique et le risque de cancer par localisation

Socioeconomic environment and cancer incidence: a French population-based study in Normandy

Bryere, Josephine ; Dejardin, Olivier ; Bouvier, Veronique ; Colonna, Marc ; Guizard, Anne-Valérie ; Troussard, Xavier ; Pornet, Carole ; Galateau-Sallé, Françoise ; Bara, Simona ; Launay, Ludivine ; Guittet, Lydia ; Launoy, Guy

BACKGROUND:The struggle against social inequalities is a priority for many international organizations. The objective of the study was to quantify the cancer burden related to social deprivation by identifying the cancer sites linked to socioeconomic status and measuring the proportion of cases associated with social deprivation. METHODS:The study population comprised 68 967 cases of cancer diagnosed between 1997 and 2009 in Normandy and collected by the local registries. The social environment [...]

Menée au Quatar à partir des données de dossiers médicaux de 2 048 patients atteints de cancer et traités entre 2008 et 2012, cette étude rétrospective analyse la prévalence et la sévérité de l'hyponatrémie en fonction du type de cancer, ainsi que son association avec la mortalité

Hyponatraemia in cancer: association with type of cancer and mortality

Abu Zeinah, G. F. ; Al-Kindi, S. G. ; Hassan, A. A. ; Allam, A.

Hyponatraemia is common in patients with cancer. The objectives of this study are to investigate the severity distribution of hyponatraemia and its association with mortality. We retrospectively reviewed medical records for patients admitted to a national centre for cancer care and research in Qatar between 2008 and 2012. A model was built through multivariate analyses to investigate the role of hyponatraemia in mortality. Patients were grouped into those who had moderate-severe hyponatraemia [...]

Menée par entretiens auprès de 179 parents mexicains d'enfants atteints d'un rétinoblastome unilatéral ou bilatéral, cette étude analyse l'association entre des facteurs socio-démographiques, le délai entre l'apparition des symptômes et le diagnostic, le stade au diagnostic et la mortalité

Diagnostic delay and socio-demographic predictors of stage at diagnosis and mortality in unilateral and bilateral retinoblastoma

Ramirez-Ortiz, Marco A. ; Ponce-Castañeda, M. Veronica ; Cabrera-Muñoz, M Lourdes ; Medina-Sanson, Aurora ; Liu, Xinhua ; Orjuela, Manuela

Background: More invasive retinoblastoma (Rb), characterized by increased morbidity and mortality, with lower rates of eye salvage and higher rates of extraocular dissemination, appears more prevalent in resource-poor countries. The relationship of diagnostic delay (lag time) and sociodemographic factors on the extent of disease at diagnosis has not been examined separately for unilateral and bilateral Rb. Methods: At diagnosis, consenting parents of 179 Mexican children with Rb were [...]

Menée aux Etats-Unis, cette étude de cohorte observationnelle analyse l'évolution du dépistage du cancer de la prostate par dosage du PSA chez des hommes âgés de plus de 65 ans entre 2005 et 2010 et ayant une espérance de vie limitée à neuf ans

National trends in prostate cancer screening among older American men with limited 9-year life expectancies: Evidence of an increased need for shared decision making

Drazer, Michael W. ; Prasad, Sandip M. ; Huo, Dezheng ; Schonberg, Mara A. ; Dale, William ; Szmulewitz, Russell Z. ; Eggener, Scott E.

BACKGROUND Prostate-specific antigen (PSA) screening for prostate cancer remains controversial. Most groups recommend informed decision making for men with 10 years of remaining life expectancy. The primary objective of this observational cohort study was to investigate the association between predicted 9-year mortality and prostate cancer screening among American men aged ≥65 years in 2005 and 2010. The second objective was to analyze the proportions of men who discussed screening with their [...]

Cette étude analyse l'évolution de l'incidence du cancer du sein dans le monde, chez la femme et chez l'homme, en fonction de la distribution géographique

Breast cancer: trends in international incidence in men and women

Kreiter, E. ; Richardson, A. ; Potter, J. ; Yasui, Y.

Background: The age-standardised incidence of breast cancer varies geographically, with rates in the highest-risk countries more than five times those in the lowest-risk countries. Methods: We investigated the correlation between male (MBC) and female breast cancer (FBC) incidence stratified by female age-group (<50 years, and 50 years) and used Poisson regression to examine male incidence rate ratios according to female incidence rates. Results: Age-adjusted breast cancer incidence rates for [...]

Menée aux Etats-Unis à partir des données de 20 560 patientes atteintes d'un cancer du sein et ayant subi une mastectomie entre 1998 et 2007, cette étude analyse l'évolution du recours à la reconstruction mammaire

Trends and Variation in Use of Breast Reconstruction in Patients With Breast Cancer Undergoing Mastectomy in the United States

Jagsi, Reshma ; Jiang, Jing ; Momoh, Adeyiza O. ; Alderman, Amy ; Giordano, Sharon H. ; Buchholz, Thomas A. ; Kronowitz, Steven J. ; Smith, Benjamin D.

Purpose : Concerns exist regarding breast cancer patients’ access to breast reconstruction, which provides important psychosocial benefits. Patients and Methods : Using the MarketScan database, a claims-based data set of US patients with employment-based insurance, we identified 20,560 women undergoing mastectomy for breast cancer from 1998 to 2007. We evaluated time trends using the Cochran-Armitage test and correlated reconstruction use with plastic-surgery workforce density and other [...]

Menée aux Etats-Unis auprès de 219 survivants à long terme d'un cancer de l'enfance (âgés de 12 à 46 ans) et ayant été traités avec ou sans radiothérapie crânienne, cette étude analyse l'incidence de tumeurs cérébrales détectées par IRM du cerveau

Incidental detection of late subsequent intracranial neoplasms with magnetic resonance imaging among adult survivors of childhood cancer

Sabin, NoahD ; Santucci, AimeeK ; Klimo, Paul, Jr. ; Hudson, MelissaM ; Srivastava, Deokumar ; Zhang, Nan ; Kun, LarryE ; Krasin, MatthewJ ; Pui, Ching-Hon ; Patay, Zoltan ; Reddick, WilburnE ; Ogg, RobertJ ; Hillenbrand, ClaudiaM ; Robison, LeslieL ; Krull, KevinR ; Armstrong, GregoryT

Purpose : Survivors of childhood cancer are at an increased risk of developing subsequent neoplasms. In long-term survivors of childhood malignancies treated with and without cranial radiation therapy (CRT), undergoing unenhanced magnetic resonance imaging (MRI) of the brain, we estimated detection of intracranial neoplasms. Methods : To investigate neurocognitive outcomes, 219 survivors of childhood cancer underwent unenhanced screening MRI of the brain. Of the survivors, 164 had been treated [...]

A partir d'une revue systématique de la littérature (25 études), cette étude analyse les freins perçus par les professionnels de santé et les patients pour accéder aux services de soins psychosociaux

Patient and health professional's perceived barriers to the delivery of psychosocial care to adults with cancer: a systematic review

Dilworth, Sophie ; Higgins, Isabel ; Parker, Vicki ; Kelly, Brian ; Turner, Jane

Objective : To explore the barriers experienced and perceived by health professionals and patients in the delivery of psychosocial care to adults with cancer. Methods : Systematic searches were undertaken using the PsychInfo, Medline and CINAHL electronic databases, up to October 2013. Research reporting health professional or patient experiences and perceptions of barriers to psychosocial care are included in the review. The systematic review includes studies that have non-experimental, [...]

Menée en Australie auprès de 191 patients atteints d'un cancer de la prostate, cette étude développe et analyse l'efficacité de trois modèles permettant de mesurer leurs symptômes de dépression et leur qualité de vie

Measuring Individual Burden of Illness for Depression among prostate cancer patients

Sharpley, Christopher F. ; Bitsika, Vicki ; Christie, David R. H.

Objective : This study aims to develop and test three potential models of Individual Burden of Illness for Depression (IBI-D) in prostate cancer patients. Methods : Responses to three sets of scales measuring depressive symptoms, functional impairment, and quality of life satisfaction were collected from 191 prostate cancer patients and analysed via principal components analysis to obtain weightings for each of the scales within the three sets of measures. These weightings were then used to [...]

Menée en Allemagne auprès de 329 patients atteints d'un cancer de la prostate, cette étude multicentrique analyse l'évolution de leur détresse psychologique, avant et après une prostatectomie radicale, ainsi que leur capacité à s'adapter aux effets indésirables de l'opération

Psychological distress and adjustment to disease in patients before and after radical prostatectomy. Results of a prospective multi-centre study

Köhler, N. ; Friedrich, M. ; Gansera, L. ; Holze, S. ; Thiel, R. ; Roth, S. ; Rebmann, U. ; Stolzenburg, J. U. ; Truss, M. C. ; Fahlenkamp, D. ; Scholz, H. J. ; Brähler, E.

The aim of this prospective multi-centre study was to evaluate the level of psychological distress (PD) and adjustment to disease in patients who underwent radical prostatectomy. Furthermore, the impact of urinary incontinence and erectile dysfunction on PD was assessed. Anxiety, depression and PD were evaluated using the Hospital Anxiety and Depression Scale in 329 prostate cancer patients before surgery as well as 3, 6 and 12 months after surgery. These results were compared with those of a [...]

Menée par enquête auprès de 6 400 participants (3 165 répondants), cette étude suédoise analyse l'association entre certains indicateurs de qualité de vie et le risque de suicide chez des patients atteints d'un cancer de la prostate

Are there specific health-related factors that can accentuate the risk of suicide among men with prostate cancer?

Lehuluante, Abraraw ; Fransson, Per

Purpose : The aim of this study was to explore if there were some specific factors pertinent to health-related quality of life (HRQoL) that could affect self-experienced suicide ideation in men with prostate cancer (PCa). Methods : Questionnaires containing 45 items were distributed to members of the Swedish Prostate Cancer Federation in May 2012. Out of 6,400 distributed questionnaires, 3,165 members (50 %) with PCa completed the questionnaires. Those members expressed their experienced HRQoL [...]

Menée aux Pays-Bas à partir des données de la base PHARMO et portant sur des patients atteints d'un cancer du sein ou d'un lymphome non-hodgkinien, cette étude cas-témoins rétrospective analyse l'utilisation des services et des soins de santé chez des patients atteints d'une neutropénie fébrile induite par la chimiothérapie

Healthcare utilisation in patients with breast cancer or non-Hodgkin lymphoma who experienced febrile neutropenia in the Netherlands: a retrospective matched control study using the PHARMO database

Issa, D. E. ; Gelderblom, H. ; Lugtenburg, P. J. ; van Herk-Sukel, M. P. ; Houweling, L. M. A. ; De La Orden, M. ; van der Werf-Langenberg, M. E. ; Nortier, J. W. R. ; de Jong, F. A.

Few data have been published on healthcare resource utilisation associated with chemotherapy-induced febrile neutropenia (FN) in Europe. Using the PHARMO record linkage system, we identified incident adult patients with a primary hospital discharge diagnosis of breast cancer (BC) or non-Hodgkin lymphoma (NHL) from 1998 to 2008. Patients who experienced FN were matched 1:2 non-FN reference patients. Of 1033 BC patients, 80 (8%) had FN and were matched with 160 reference patients; and of 486 NHL [...]

Menée en Nouvelle-Zélande par entretiens auprès de 21 participants dont 14 patients atteints de cancer et 7 aidants, cette étude analyse l'efficacité d'un programme de soutien et d'éducation destiné à développer leurs capacités à se sentir acteurs de leur parcours de soins

A pathway to empowerment: evaluating a cancer education and support programme in New Zealand

Kane, P. ; Jasperse, M. ; Boland, P. ; Herst, P.

Support programmes often benefit cancer patients and their families. This study evaluates how the Living Well Cancer Education Programme (LWCEP), from the Cancer Society of New Zealand, meets the needs of its clients. A purposeful sample of 21 participants representing the normal range of demographic characteristics (age, gender, diagnosis and geographical location) for the programme, participated in semi-structured interviews. Demographic data were subjected to a frequency analysis. Main data [...]

Menée au Royaume-Uni, cette étude analyse le besoin en informations relatives au cancer du sein et à ses traitements pour les femmes présentant un handicap mental

Breast cancer information and support needs for women with intellectual disabilities: a scoping study

Collins, Karen ; McClimens, Alex ; Mekonnen, Stella ; Wyld, Lynda

Objective : To examine the compass and nature of relevant research and identify gaps in the current evidence in order to determine the priority of future research about breast cancer and intellectual disability (ID). Methods : A scoping study that comprised of a consultation exercise with a wide range of key stakeholders (n=26) from one northern city (Sheffield) within the UK. Results : This study identified numerous gaps in the current evidence base. It highlighted a dearth of research that [...]