A partir des données de la cohorte européenne EPIC, cette étude évalue l'association entre une consommation d'acrylamide d'origine alimentaire et le risque de cancer de l'œsophage

Dietary intake of acrylamide and esophageal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Luján-Barroso, Leila ; González, CarlosAlberto ; Slimani, Nadia ; Obón-Santacana, Mireia ; Ferrari, Pietro ; Freisling, Heinz ; Overvad, Kim ; Clavel-Chapelon, Françoise ; Boutron-Ruault, Marie-Christine ; Racine, Antoine ; Katzke, Verena ; Kühn, Tilman ; Tjønneland, Anne ; Olsen, Anja ; Quirós, J. Ramón ; Sánchez-Cantalejo, Emilio ; Amiano, Pilar ; Navarro, Carmen ; Barricarte, Aurelio ; Khaw, Kay-Tee ; Wareham, Nick ; Travis, RuthC ; Trichopoulou, Antonia ; Bamia, Christina ; Benetou, Vassiliki ; Saieva, Calogero ; Grioni, Sara ; Tumino, Rosario ; Vineis, Paolo ; Mattiello, Amalia ; Bueno-de-Mesquita, H. Bas ; Siersema, PeterD ; Numans, MattijsE ; Peeters, PetraH ; Ericson, Ulrika ; Wirfalt, Elisabet ; Sund, Malin ; Johansson, Mattias ; Weiderpass, Elisabete ; Skeie, Guri ; Riboli, Elio ; Boeing, Heiner ; Duell, EricJ

Purpose : The relation between dietary acrylamide intake and esophageal cancer (EC) risk, including esophageal adenocarcinoma (EAC) and esophageal squamous cell carcinoma (ESCC), has not been consistent. We evaluated the association between dietary acrylamide intake and EAC, ESCC, and overall EC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Methods : Multivariate Cox proportional hazards models were used to estimate the HR and 95 % confidence interval (95 % [...]

Menée en Italie auprès de 1 294 cas et 1 451 témoins, cette étude évalue l'association entre divers régimes alimentaires et le risque de cancer de la prostate

Nutrient-based dietary patterns and prostate cancer risk: a case–control study from Italy

Rosato, Valentina ; Edefonti, Valeria ; Bravi, Francesca ; Bosetti, Cristina ; Bertuccio, Paola ; Talamini, Renato ; Dal Maso, Luigino ; Montella, Maurizio ; Ferraroni, Monica ; La Vecchia, Carlo ; Decarli, Adriano

Purpose : The role of various foods and nutrients, and their combinations, on prostate cancer risk remains largely undefined. We addressed therefore the issue of complex dietary patterns. Methods : We analyzed data from an Italian case–control study, including 1,294 men with prostate cancer and 1,451 hospital controls. We carried out an exploratory principal component factor analysis on 28 selected nutrients in order to identify dietary patterns. We estimated odds ratios (ORs) and corresponding [...]

A partir des données de la cohorte "NIH-AARP Diet and Health Study" portant sur 170 481 hommes, cette étude prospective évalue l'association entre un comportement sédentaire, le temps passé quotidiennement en position assise et le risque de cancer de la prostate

Sedentary behavior and prostate cancer risk in the NIH-AARP Diet and Health Study

Lynch, Brigid M ; Friedenreich, Christine M. ; Kopciuk, Karen A. ; Hollenbeck, Albert R. ; Moore, Steven C. ; Matthews, Charles E.

Sedentary behavior (sitting time) has been proposed as an independent risk factor for some cancers; however, its role in the development of prostate cancer has not been determined. We examined the prospective associations of self-reported daily sitting time and daily television/video viewing time with risk of developing or dying from prostate cancer among 170,481 men in the NIH-AARP Diet and Health Study. We estimated hazard ratios and 95% confidence intervals using Cox Proportional Hazards [...]

Menée auprès de 58 cas et de 246 témoins, cette étude évalue l'association entre une exposition professionnelle à de faibles niveaux de benzène et le risque de leucémie myéloïde chronique ou de maladie myéloproliférative chez des salariés de l'industrie pétrolière

Risk of myeloproliferative disease and chronic myeloid leukaemia following exposure to low-level benzene in a nested case–control study of petroleum workers

Glass, Deborah C ; Schnatter, A Robert ; Tang, Gong ; Irons, Richard D ; Rushton, Lesley

Background : Benzene exposure has been associated with increased risk of leukaemia and myelodysplastic syndrome. Existing studies are sparse for other lymphohaematopoietic cancer subtypes, such as myeloproliferative disease (MPD) and the related chronic myeloid leukaemia (CML). We pooled data from three petroleum worker nested case–control studies to address this gap. To our knowledge, this is the first study to systematically examine the relationship between MPD and quantitative benzene [...]

Menée à Taïwan auprès de 397 cas et de 410 témoins, cette étude analyse l'association entre une infection par le virus de l'hépatite C de type 1b et le risque de carcinome hépatocellulaire

Hepatitis C virus genotype 1b increases cumulative lifetime risk of hepatocellular carcinoma

Lee, Mei-Hsuan ; Yang, Hwai- I. ; Lu, Sheng-Nan ; Jen, Chin-Lan ; You, San-Lin ; Wang, Li-Yu ; L'Italien, Gilbert ; Chen, Chien-Jen ; Yuan, Yong

The association between subtypes of hepatitis C virus (HCV) and risk of hepatocellular carcinoma (HCC) remained inconclusive and evaluated in both case–control and cohort studies. In the case–control study, 397 HCC cases from medical centers were compared with 410 community-based non-HCC controls. All of them were anti-HCV-seropositive, HBsAg-seronegative with serum HCV RNA levels ≥1,000 IU/mL. Logistic regression models were used to estimate the odds ratio (OR) with 95% confidence interval [...]

Menée en France à partir des données de dix registres des cancers portant sur 289 967 patients atteints d'un premier cancer, cette étude analyse l'association entre des caractéristiques du patient (sexe, âge au diagnostic, première localisation de cancer...) et le risque de second cancer primitif

The effect of patient characteristics on second primary cancer risk in France

Jegu, Jeremie ; Colonna, Marc ; Daubisse-Marliac, Laetitia ; Tretarre, Brigitte ; Ganry, Olivier ; Guizard, Anne-Valérie ; Bara, Simona ; Troussard, Xavier ; Bouvier, Veronique ; Woronoff, Anne-Sophie ; Velten, Michel

BACKGROUND:Although cancer survivors are known to be at greater risk of developing second primary cancer (SPC), SPC incidence estimates in France are thus far lacking. We used a multivariate approach to compute these estimates and analyzed the effect of patient characteristics (gender, age at diagnosis, first cancer site, year of diagnosis and follow-up) on SPC risk. METHODS:Data from ten French population-based cancer registries were used to establish a cohort of all patients diagnosed with a [...]

A partir de données d'études précédemment publiées ainsi que sur 1 498 cas et 1 934 témoins, cette étude évalue l'association entre des polymorphismes à simple nucléotide déjà identifiés et le risque de myélome multiple

Genetic variants and multiple myeloma risk: IMMEnSE validation of the best reported associations

Martino, Alessandro ; Campa, Daniele ; Jurczyszyn, Artur ; Martínez-López, Joaquin ; Moreno, Maria Jose ; Varkonyi, Judit ; Dumontet, Charles ; Garcia-Sanz, Ramon ; GEMIGNANI, Federica ; Jamroziak, Krzysztof ; Stepien, Anna ; Jacobsen, Svend E.H. ; Andersen, Vibeke ; Jurado, Manuel ; Landi, Stefano ; Rossi, Anna Maria ; Lesueur, Fabienne ; Marques, Herlander ; Dudzinski, Marek ; Watek, Marzena ; Moreno, Víctor ; orciuolo, Enrico ; Petrini, Mario ; Reis, Rui M. ; Ríos, Rafael ; Sainz, Juan ; Vogel, Ulla ; Buda, Gabriele ; Vangsted, Annette Juul ; Canzian, Federico

Background: Genetic background plays a role in multiple myeloma (MM) susceptibility. Several single nucleotide polymorphisms (SNPs) associated with genetic susceptibility to MM were identified in the last years, but only few of them were validated in independent studies. Methods: With the aim to conclusively validate the strongest associations so far reported, we selected the polymorphisms rs2227667 (SERPINE1), rs17501108 (HGF), rs3136685 (CCR7), rs16944 (IL1B), rs12147254 (TRAF3), rs1805087 [...]

A partir d'une revue systématique de la littérature publiée de 1990 à 2012 (20 études cas-témoins, 15 études de cohorte, 444 255 patients), cette méta-analyse fait le point sur l'association entre une endométriose et le risque de cancer de l'ovaire ainsi que le pronostic de la maladie

Risk and prognosis of ovarian cancer in women with endometriosis: a meta-analysis

Kim, H. S. ; Kim, T. H. ; Chung, H. H. ; Song, Y. S.

Background: The risk and prognosis of ovarian cancer have not been well established in women with endometriosis. Thus, we investigated the impact of endometriosis on the risk and prognosis for ovarian cancer, and evaluated clinicopathologic characteristics of endometriosis-associated ovarian cancer (EAOC) in comparison with non-EAOC. Methods: After we searched an electronic search to identify relevant studies published online between January 1990 and December 2012, we found 20 case–control and [...]

Couplée aux données de la cohorte "Breakthrough Generations Study" et portant sur 265 cas et 343 témoins, cette étude analyse l'association entre le niveau d'hormones sexuelles, la densité mammaire et le risque de cancer du sein après la ménopause

Combined effects of endogenous sex hormone levels and mammographic density on postmenopausal breast cancer risk: results from the Breakthrough Generations Study

Schoemaker, M. J. ; Folkerd, E. J. ; Jones, M. E. ; Rae, M. ; Allen, S. ; Ashworth, A. ; Dowsett, M. ; Swerdlow, A. J.

Background: Mammographic density and sex hormone levels are strong risk factors for breast cancer, but it is unclear whether they represent the same aetiological entity or are independent risk factors. Methods: Within the Breakthrough Generations Study cohort, we conducted a case–control study of 265 postmenopausal breast cancer cases and 343 controls with prediagnostic mammograms and blood samples. Plasma was assayed for oestradiol, testosterone and sex hormone-binding globulin (SHBG) [...]