Menée aux Pays-Bas auprès de 201 participants, cette étude rétrospective analyse la fonction gonadique chez les survivants adultes d'un cancer pédiatrique

Gonadal function recovery in very long-term male survivors of childhood cancer

van Dorp, Wendy ; van der Geest, Ivana M. M. ; Laven, Joop S. E. ; Hop, Wim C. J. ; Neggers, Sebastian J. C. M. M. ; de Vries, Andrica C. H. ; Pieters, Rob ; van den Heuvel-Eibrink, Marry M.

Although gonadal toxicity has been reported, no data are available on recovery of gonadal function in very long-term survivors of childhood cancer. Inhibin B is a novel reliable serum marker which has been shown to be of value in childhood cancer survivor studies to identify risk groups for impaired gonadal function, but consecutive long-term follow-up studies using serum inhibin B as a marker are not available. To evaluate possible recovery of gonadal dysfunction over time in adult male [...]

Menée au Japon auprès de 321 patients cytopéniques ayant reçu une greffe allogénique de cellules souches hématopoïétiques, cette étude de cohorte évalue la faisabilité d'exercices physiques visant à améliorer leur qualité de vie et leur survie

Safety and feasibility of physical therapy in cytopenic patients during allogeneic haematopoietic stem cell transplantation

Morishita, S. ; Kaida, K. ; Setogawa, K. ; Kajihara, K. ; Ishii, S. ; Ikegame, K. ; Kodama, N. ; Ogawa, H. ; Domen, K.

This study aimed to investigate the safety and feasibility of physical therapy in cytopenic patients undergoing allogeneic haematopoietic stem cell transplantation (allo-HSCT), and to investigate the effect of physical therapy on physiological functions and quality of life (QOL) in allo-HSCT patients. The study cohort included 321 patients who underwent allo-HSCT. To investigate the safety and feasibility of physical therapy during cytopenia, patients were assigned to the physical therapy group [...]

Cette étude présente un rapport de l'American Society of Clinical Oncology relatif à la qualité des soins dédiés aux survivants d'un cancer, à leurs besoins et à leur prise en charge

American Society of Clinical Oncology Statement: Achieving High-Quality Cancer Survivorship Care

McCabe, Mary S. ; Bhatia, Smita ; Oeffinger, Kevin C. ; Reaman, Gregory H. ; Tyne, Courtney ; Wollins, Dana S. ; Hudson, Melissa M.

Over the past several decades, the number of cancer survivors has increased dramatically as a result of improved early detection of first malignancies and effective therapies. There are more than 13 million cancer survivors in the United States today. This number is expected to reach 18 million by 2022. These data underscore the public health magnitude of cancer survivorship and the importance of efforts to characterize and address the health concerns of cancer survivors...

A partir des données de deux études américaines et une étude australienne, cette étude transversale analyse et compare, pour les patients âgés de plus ou de moins de 60 ans, l'apparition, la sévérité, la fréquence des symptômes de patients atteints de cancer et soignés à l'extérieur de l'hôpital, en fonction du type de traitement

Differences in the symptom experience of older versus younger oncology outpatients: a cross-sectional study

Cataldo, Janine ; Paul, Steven ; Cooper, Bruce ; Skerman, Helen ; Alexander, Kimberly ; Aouizerat, Bradley ; Blackman, Virginia ; Merriman, John ; Dunn, Laura ; Ritchie, Christine ; Yates, Patsy ; Miaskowski, Christine

BACKGROUND:Mortality rates for cancer are decreasing in patients under 60 and increasing in those over 60 years of age. The reasons for these differences in mortality rates remain poorly understood. One explanation may be that older patients received substandard treatment because of concerns about adverse effects. Given the paucity of research on the multiple dimensions of the symptom experience in older oncology patients, the purpose of this study was to evaluate for differences in ratings of [...]

Menée auprès de 1 574 patients inclus dans l'étude américaine "CanCORS" et atteints d'un cancer métastatique du poumon non à petites cellules, cette étude analyse les pratiques de radiothérapie palliative

Palliative Radiation Therapy Practice in Patients With Metastatic Non–Small-Cell Lung Cancer: A Cancer Care Outcomes Research and Surveillance Consortium (CanCORS) Study

Chen, Aileen B. ; Cronin, Angel ; Weeks, Jane C. ; Chrischilles, Elizabeth A. ; Malin, Jennifer ; Hayman, James A. ; Schrag, Deborah

Purpose Randomized data suggest that single-fraction or short-course palliative radiation therapy (RT) is sufficient in the majority of patients with metastatic cancer. We investigated population-based patterns in the use of palliative RT among patients with metastatic non–small-cell lung cancer (NSCLC). Patients and Methods From patients diagnosed with lung cancer from 2003 to 2005 at a participating geographic or organizational site and who consented to the Cancer Care Outcomes Research and [...]

Mené sur 104 patients atteints d'un carcinome non métastatique de la prostate de stade localement avancé et recevant une radiothérapie combinée à un traitement anti-androgénique (moyenne d'âge : 67 ans) cet essai clinique randomisé évalue, du point de vue des variations en pourcentage de la densité minérale de l'épine lombaire après 1 et 2 ans de traitement, l'efficacité de l'acide résidronique, administrée par voie orale une fois par semaine, pour prévenir le risque d'ostéoporose

Randomized, Double-Blinded, Placebo-Controlled, Trial of Risedronate for the Prevention of Bone Mineral Density Loss in Nonmetastatic Prostate Cancer Patients Receiving Radiation Therapy Plus Androgen Deprivation Therapy

Choo, Richard ; Lukka, Himu ; Cheung, Patrick ; Corbett, Tom ; Briones-Urbina, Rosario ; Vieth, Reinhold ; Ehrlich, Lisa ; Kiss, Alex ; Danjoux, Cyril

Androgen deprivation therapy (ADT) has been used as an adjuvant treatment to radiation therapy (RT) for the management of locally advanced prostate carcinoma. Long-term ADT decreases bone mineral density (BMD) and increases the risk of osteoporosis. The objective of this clinical trial was to evaluate the efficacy of risedronate for the prevention of BMD loss in nonmetastatic prostate cancer patients undergoing RT plus 2 to 3 years of ADT. A double-blinded, placebo-controlled, randomized trial [...]

A partir des données des registres des cancers des pays européens, cette étude analyse l'évolution, sur la période 1999-2008, de l'incidence et de la mortalité par cancer en comparant les pays du sud-est de l'Europe (Bulgarie, Croatie, Chypre, Malte, Roumanie, Serbie, Slovénie, Turquie) à ceux du nord et de l'ouest de l'Europe

Cancer incidence and mortality patterns in South Eastern Europe in the last decade: Gaps persist compared with the rest of Europe

Znaor, Ariana ; van den Hurk, Corina ; Primic-Žakelj, Maja ; Agius, Dominic ; Coza, Daniela ; Demetriou, Anna ; Dimitrova, Nadia ; Eser, Sultan ; Karakylinc, Hulya ; Zivkovic, Snezana ; Bray, Freddie ; Coebergh, Jan W. Willem

Introduction Cancer registration coverage and cancer control programmes in South Eastern (SE) Europe, embracing about six new EU member states, remain thin, despite a relatively high incidence and mortality burden from avoidable cancers, particularly in males. We assembled the most recent cancer registry data to estimate the burden of the 17 most common cancers in the region, from Slovenia to Cyprus and Malta. Methods Data were made available for analysis from Bulgaria, Croatia, Cyprus, Malta, [...]

Menée au CHU de Besançon auprès de 167 patients adultes atteints d'une tumeur solide de stade avancé, cette étude rétrospective française analyse les traitements reçus dans les 3 derniers mois de leur vie

Specific anticancer treatments in the last 3 months of life: a French experience

Viel, Erika ; Chaigneau, Loïc ; Fanton, Eleonor ; Kalbacher, Elsa ; Thiery-Vuillemnin, Antoine ; Villanueva, Cristian ; Dobi, Erion ; Curtit, Elsa ; Almotlak, Hamadi ; Aubry, Régis ; Pivot, Xavier

Purpose: The treatment of patients with advanced cancer is becoming increasingly aggressive near the end of life, whereas poor literature is available. This study analyzes the management of patients with a solid cancer in their last 3 months of life in the Centre Hospitalier Universitaire de Besançon, France. Methods : This retrospective study includes all adult patients with a solid tumor who died in medical oncology or radiotherapy unit in 2005, 2006, and 2007. Group A had received at least [...]

Menée par questionnaire en ligne auprès de 5 499 patients entre 2007 et 2011, cette étude américaine analyse leur participation à des essais cliniques en fonction de leur statut socio-économique

Patient Income Level and Cancer Clinical Trial Participation

Unger, Joseph M. ; Hershman, Dawn L. ; Albain, Kathy S. ; Moinpour, Carol M. ; Petersen, Judith A. ; Burg, Kenda ; Crowley, John J.

Purpose Studies have shown an association between socioeconomic status (SES) and quality of oncology care, but less is known about the impact of patient SES on clinical trial participation. Patients and Methods We assessed clinical trial participation patterns according to important SES (income, education) and demographic factors in a large sample of patients surveyed via an Internet-based treatment decision tool. Logistic regression, conditioning on type of cancer, was used. Attitudes toward [...]

Menée en Israël auprès de 1 200 participants âgés de 75 à 94 ans, cette étude analyse l'impact du tabagisme sur la mortalité

Smoking and Mortality among Persons Aged 75-94

Cohen-Mansfield, Jiska

Objectives : Examine the effect of current level of smoking and lifetime tobacco consumption on mortality in persons 75-94 years of age. Methods Data were from a representative sample of older Jewish persons in Israel, which included 1,200 self-respondent participants aged 75-94 (Mean= 83.1, SD= 5.3) from the Cross-Sectional and Longitudinal Aging Study (CALAS). Data collection took place during 1989-1992. Mortality data on 95.1% of the sample at 20-year follow up were recorded from the Israeli [...]

Menée auprès de 1 335 participants, cette étude de cohorte en population suédoise évalue l'association entre le volume d'opérations réalisées au niveau de l'hôpital ou du chirurgien et la survie des patients opérés d'un cancer de l'œsophage

Hospital and Surgeon Volume in Relation to Survival After Esophageal Cancer Surgery in a Population-Based Study

Derogar, Maryam ; Sadr-Azodi, Omid ; Johar, Asif ; Lagergren, Pernilla ; Lagergren, Jesper

Purpose The influence of hospital and surgeon volume on survival after esophageal cancer surgery deserves clarification, particularly the prognosis after the early postoperative period. The interaction between hospital and surgeon volume, and the influence of known prognostic factors need to be taken into account.Methods A nationwide Swedish population-based cohort study of 1,335 patients with esophageal cancer who underwent esophageal resection in 1987 to 2005, with follow-up for survival [...]

Cette étude de cohorte en population danoise (5 538 patients) évalue l'association entre le satut socioéconomique des patients atteints d'un cancer du poumon non à petites cellules et le fait de recevoir un traitement chirurgical

Socioeconomic position and surgery for early-stage non-small-cell lung cancer: A population-based study in Denmark

Starr, Laila Kærgaard ; Osler, Merete ; Steding-Jessen, Marianne ; Frederiksen, Birgitte Lidegaard ; Jakobsen, Erik ; Østerlind, Kell ; Schüz, Joachim ; Johansen, Christoffer ; Dalton, Susanne Oksbjerg

Aim To examine possible associations between socioeconomic position and surgical treatment of patients with early-stage non-small-cell lung cancer (NSCLC). Methods In a register-based clinical cohort study, patients with early-stage (stages I–IIIa) NSCLC were identified in the Danish Lung Cancer Register 2001–2008 (date of diagnosis, histology, stage, and treatment), the Central Population Register (vital status), the Integrated Database for Labour Market Research (socioeconomic position), and [...]

A partir des données du registre néerlandais des cancers, cette étude analyse le risque de cancer de la prostate chez des survivants d'un premier cancer diagnostiqué entre 1989 et 2008

Risk of prostate cancer among cancer survivors in the Netherlands

Kok, D. E. G. ; van de Schans, S. A. M. ; Liu, L. ; Kampman, E. ; Coebergh, J. W. W. ; Kiemeney, L. A. L. M. ; Soerjomataram, I. ; Aben, K. K. H.

Background In parallel with increasing numbers of cancer patients and improving cancer survival, the occurrence of second primary cancers becomes a relevant issue. The aim of our study was to evaluate risk of prostate cancer as second primary cancer in a population-based setting. Methods Data from the Netherlands Cancer Registry were used to estimate standardized incidence ratios (SIRs) and 95% confidence intervals (CIs) for prostate cancer as second primary cancer. The effect of time since [...]

Menée en Angleterre sur la période 2006-2008, cette étude rétrospective analyse les caractéristiques de la personne, de la tumeur et des traitements chez les patients décédés d'un cancer colorectal dans l'année suivant le diagnostic

Early mortality from colorectal cancer in England: a retrospective observational study of the factors associated with death in the first year after diagnosis

Downing, A. ; Aravani, A. ; Macleod, U. ; Oliver, S. ; Finan, P. J. ; Thomas, J. D. ; Quirke, P. ; Wilkinson, J. R. ; Morris, E. J. A.

Background:: The United Kingdom performs poorly in international comparisons of colorectal cancer survival with much of the deficit owing to high numbers of deaths close to the time of diagnosis. This retrospective cohort study investigates the patient, tumour and treatment characteristics of those who die in the first year after diagnosis of their disease. Methods: Patients diagnosed with colon (n=65 733) or rectal (n=26 123) cancer in England between 2006 and 2008 were identified in the [...]

A partir de données obtenues dans 14 centres des Etats-Unis, d'Europe et d'Israël (841 patients identifiés dans 376 familles), cette étude analyse les caractéristiques démographiques et cliniques de patients atteints de gliome familial non associé à un syndrome héréditaire (neurofibromatose ou Li-Fraumeni)

Description of selected characteristics of familial glioma patients – Results from the Gliogene Consortium

Sadetzki, Siegal ; Bruchim, Revital ; Oberman, Bernice ; Armstrong, Georgina N. ; Lau, Ching C. ; Claus, Elizabeth B. ; Barnholtz-Sloan, Jill S. ; Il’yasova, Dora ; Schildkraut, Joellen ; Johansen, Christoffer ; Houlston, Richard S. ; Shete, Sanjay ; Amos, Christopher I. ; Bernstein, Jonine L. ; Olson, Sara H. ; Jenkins, Robert B. ; Lachance, Daniel ; Vick, Nicholas A. ; Merrell, Ryan ; Wrensch, Margaret ; Davis, Faith G. ; McCarthy, Bridget J. ; Lai, Rose ; Melin, Beatrice S. ; Bondy, Melissa L.

While certain inherited syndromes (e.g. Neurofibromatosis or Li-Fraumeni) are associated with an increased risk of glioma, most familial gliomas are non-syndromic. This study describes the demographic and clinical characteristics of the largest series of non-syndromic glioma families ascertained from 14 centres in the United States (US), Europe and Israel as part of the Gliogene Consortium. Families with 2 or more verified gliomas were recruited between January 2007 and February 2011. [...]

A partir des données de la cohorte "National Institutes of Health–AARP Diet and Health Study", cette étude américaine évalue l'association entre l'indice de masse corporelle avant le diagnostic de cancer, l'activité physique et la mortalité des patientes atteintes d'un cancer de l'endomètre

Prediagnosis Body Mass Index, Physical Activity, and Mortality in Endometrial Cancer Patients

Arem, Hannah ; Park, Yikyung ; Pelser, Colleen ; Ballard-Barbash, Rachel ; Irwin, Melinda L. ; Hollenbeck, Albert ; Gierach, Gretchen L. ; Brinton, Louise A. ; Pfeiffer, Ruth M. ; Matthews, Charles E.

Background Higher body mass index (BMI) and inactivity have been associated with a higher risk of developing endometrial cancer, but the impact on endometrial cancer survival is unclear.Methods Among incident endometrial cancer case subjects in the National Institutes of Health–AARP Diet and Health Study, we examined associations of prediagnosis BMI (n = 1400) and physical activity (n = 875) with overall and disease-specific 5- and 10-year mortality. Using Cox proportional hazards regression, [...]

A partir de données portant sur 41 358 adolescents, cette étude américaine analyse la nature et les causes des disparités constatées dans la vaccination contre le papillomavirus humain chez les adolescents

Social Inequalities in Adolescent Human Papillomavirus (HPV) Vaccination: A Test of Fundamental Cause Theory

Polonijo, Andrea N. ; Carpiano, Richard M.

A unique contribution of the fundamental cause theory of health disparities is its ability to account for the persistence of disparities in health and mortality, despite changes in the mechanisms that are relevant at any given time. Few studies, however, have investigated how such mechanisms are created or operate. Examining the introduction of the human papillomavirus (HPV) vaccine for adolescents—a treatment aimed at preventing cervical and other cancers that typically emerge in mid- to late [...]

Cette méta-analyse (10 études) fait le point sur l'adaptation psychologique des enfants atteints de cancer en comparaison à celle d'enfants en bonne santé

Psychological adjustment of children with cancer as compared with healthy children: a meta-analysis

Wechsler, A. M. ; Sánchez-Iglesias, I.

Childhood cancer is a life-threatening disease and the cause of great stress for children who suffer from its diagnosis and treatment. The aim of this study was to verify, through meta-analytical tools, whether children in active treatment for cancer differ in their psychological adjustment from healthy children. Ten studies fulfilled the inclusion criteria for the meta-analytic approach. A fixed effects model did not yield significant results, suggesting that there is no evidence for a [...]

A partir d'une revue systématique de la littérature (28 études de cohorte), cette étude analyse les facteurs associés au retour à l'emploi de survivants d'un cancer

Predictors of return to work and employment in cancer survivors: a systematic review

van Muijen, P. ; Weevers, N. L. E. C. ; Snels, I. A. K. ; Duijts, S. F. A. ; Bruinvels, D. J. ; Schellart, A. J. M. ; van der Beek, A. J.

The objective of this study was to provide an overview of the prognostic factors for return to work and employment of cancer survivors. Cohort studies were selected if the population consisted of cancer patients between 18 and 65 years of age, with return to work, employment or equivalent concepts as main outcome measure, studying at least one prognostic factor. The methodological quality of the included studies and level of evidence for each prognostic factor were assessed. Twenty-eight cohort [...]

Menée en Allemagne auprès de 175 patients atteints de mélanome, cette étude analyse l'impact du sentiment d'auto-efficacité à faire face au cancer sur la fatigue physique et sur la dépression des patients

Self-efficacy for coping with cancer in melanoma patients: its association with physical fatigue and depression

Albrecht, Karoline ; Droll, Hannah ; Giesler, Jürgen M. ; Nashan, Dorothee ; Meiss, Frank ; Reuter, Katrin

Objective The purpose of this study was to explore the impact of self-efficacy for coping with cancer (SECC) on physical fatigue and depressive symptoms in melanoma patients, in comparison with objective factors, such as treatment with interferon-alpha (IFN-α) and medical and sociodemographic variables. Current literature shows that psychological distress in melanoma patients is generally moderate, that they experience high quality of life, and that symptoms of depression and fatigue have been [...]

A partir d'une revue systématique de la littérature (12 études), cette méta-analyse évalue, auprès de patientes atteintes d'un cancer du sein et ayant subi une mastectomie, l'impact d'une chirurgie de reconstruction mammaire sur leur image corporelle

The effect of breast reconstruction surgery on body image among women after mastectomy: a meta-analysis

Fang, Su-Ying ; Shu, Bih-Ching ; Chang, Ying-Ju

The purpose of this study was to analyze the available evidence concerning the effects of breast reconstruction (BR) on body image of women with breast cancer. BR is a potential intervention to improve the body image of women with breast cancer. Conflicting research findings about the effects of breast reconstructive surgery on body image compared to breast conservative surgery (BCS) or mastectomy exist. A meta-analysis of studies found in MEDLINE, CINAHL, PsychINFO, PubMed as well as PQDT [...]

Cette étude américaine analyse le rapport coût-efficacité de divers traitements de première ligne pour le cancer localisé de la prostate, en fonction de la durée, de la qualité de vie du patient, d'événements indésirables et des coûts d'éventuels traitements de deuxième ligne

Primary treatments for clinically localised prostate cancer: a comprehensive lifetime cost-utility analysis

Cooperberg, Matthew R. ; Ramakrishna, Naren R. ; Duff, Steven B. ; Hughes, Kathleen E. ; Sadownik, Sara ; Smith, Joseph A. ; Tewari, Ashutosh K.

What's known on the subject? and What does the study add? * Multiple treatment alternatives exist for localised prostate cancer, with few high-quality studies directly comparing their comparative effectiveness and costs. * The present study is the most comprehensive cost-effectiveness analysis to date for localised prostate cancer, conducted with a lifetime horizon and accounting for survival, health-related quality-of-life, and cost impact of secondary treatments and other downstream events, [...]

Menée au Danemark, cette étude analyse et compare, en 2010, 2002 et 1992, les délais et temps d'attente avant un diagnostic et un traitement d'un cancer de la tête et du cou

Waiting times for diagnosis and treatment of head and neck cancer in Denmark in 2010 compared to 1992 and 2002

Lyhne, N. M. ; Christensen, A. ; Alanin, M. C. ; Bruun, M. T. ; Jung, T. H. ; Bruhn, M. A. ; Jespersen, J. B. B. ; Kristensen, C. A. ; Andersen, E. ; Godballe, C. ; Buchwald, C. ; Bundgaard, T. ; Johansen, J. ; Lambertsen, K. ; Primdahl, H. ; Toustrup, K. ; Sørensen, J. A. ; Overgaard, J. ; Grau, C.

Background and aim Significant tumour progression was observed during waiting time for treatment of head and neck cancer. To reduce waiting times, a Danish national policy of fast track accelerated clinical pathways was introduced in 2007. This study describes changes in waiting time and the potential influence of fast track by comparing waiting times in 2010 to 2002 and 1992. Methods Charts of all new patients diagnosed with squamous cell carcinoma of the oral cavity, pharynx and larynx at the [...]

Menée par questionnaires auprès de 324 soignants de personnes adultes ayant des troubles de l'apprentissage, cette étude britannique analyse leurs connaissances relatives au cancer

What knowledge and attitudes do paid carers of people with a learning disability have about cancer?

Wyatt, D. ; Talbot, P.

The purpose of this study was to explore the knowledge and attitudes of paid carers of people with a learning disability regarding cancer. A questionnaire was utilised to gather information from carers involved in the social care of adults with learning disabilities within the independent sector. A total of 324 questionnaires were returned. Subjects were asked to provide words that they associated with cancer to provide data on their attitude to cancer. Knowledge-based questions examined their [...]

Menée en Irlande par entretiens auprès de médecins, infirmières et diététiciens, cette étude qualitative analyse les façons d'aborder et de présenter au patient atteint de cancer et à sa famille l'issue fatale associée à une cachéxie réfractaire

Refractory cachexia and truth-telling about terminal prognosis: a qualitative study

Millar, C. ; Reid, J. ; Porter, S.

The purpose of this paper is to examine the consequences that medical practitioners' decisions about whether or not to be candid about terminal prognosis have for those suffering from refractory cachexia and their families. It presents the findings of a qualitative study that used focus groups and semi-structured interviews of a volunteer sample of doctors, nurses and dieticians in a cancer centre of a large teaching hospital in Northern Ireland. Respondents reported that some physicians tended [...]

A partir d'une enquête menée entre février et décembre 2011 auprès de 235 personnes ayant subi une tomographie numérique ou une tomographie d'émission monophotonique, cette étude évalue leurs connaissances vis-à-vis des risques associés à une exposition médicale aux rayonnements ionisants

Patient knowledge and understanding of radiation from diagnostic imaging

Busey Jm, Soine L. A. Yager J. R. Choi E. Shuman W. P.

Health risk from medical radiation exposure has generated controversy in recent lay and professional publications.1- 3 Data examining what patients know about radiation from commonly performed imaging, such as computed tomography (CT) and single photon emission computed tomography (SPECT), are limited. The purpose of this study was to survey patient knowledge and understanding of radiation from CT and SPECT scans.

Menée en Malaisie auprès de 959 participantes, cette étude analyse les connaissances des femmes relatives au cancer du sein et aux techniques de dépistage

Breast Screening and Health Issues among Rural Females in Malaysia: How Much do They Know and Practice?

Dahlui, Maznah ; Gan, Daniel Eng Hwee ; Taib, Nur Aishah ; Lim, Jennifer Nyuk Wo

Objective This study investigated rural women's knowledge of breast cancer and screening methods by ethnicity and examined the predictors of breast screening methods. Methods A cross-sectional survey was conducted in 2011 in five rural districts of Perak; 959 women were interviewed using a semi-structured questionnaire. Anova and regression analysis was used in data analysis. Results Women below 50 years old, of Malay ethnicity and who had secondary education scored better than those older, of [...]

A partir des résultats d'un essai randomisé contrôlé de phase III chez des patients pédiatriques, cet article discute des questions d'ordre éthique concernant les patients inclus dans le bras témoin de l'essai après la découverte des bénéfices sur la survie d'une thérapie expérimentale

Ethical Issues for Control-Arm Patients After Revelation of Benefits of Experimental Therapy: A Framework Modeled in Neuroblastoma

Unguru, Yoram ; Joffe, Steven ; Fernandez, Conrad V. ; Yu, Alice L.

In 2009, the Children’s Oncology Group (COG) phase III randomized controlled trial, ANBL0032, found that adding immunotherapy (Ch14.18) to standard therapy significantly improved outcomes in patients with high-risk neuroblastoma when administered within 110 days after autologous stem-cell transplantation (SCT). After careful deliberation and consultation, the COG Neuroblastoma Committee decided to offer Ch14.18 to prior trial participants who had been randomly assigned to the control arm (no [...]