A partir de l'analyse des données 2009 d'un système américian de surveillance des facteurs de risque ("Behavioral Risk Factor Surveillance System"), cette étude évalue la morbidité à long terme et la mortalité des survivants de cancer âgés de 15 à 29 ans

Health status of adolescent and young adult cancer survivors

Tai, Eric ; Buchanan, Natasha ; Townsend, Julie ; Fairley, Temeika ; Moore, Angela ; Richardson, Lisa C.

BACKGROUND: Adolescents and young adults (AYA) ages 15 to 29 years who are diagnosed with cancer are at risk for long-term morbidity and mortality associated with treatment of their cancer and the cancer itself. In this article, the authors describe the self-reported health status of AYA cancer survivors. METHODS: The authors examined 2009 data from the Behavioral Risk Factor Surveillance System, including demographic characteristics, risk behaviors, chronic conditions, health status, and [...]

Menée auprès de 866 patients atteints de cancer, cette étude coréenne analyse leurs habitudes quotidiennes concernant le soin de leur peau ainsi que la prévalence d'éruptions et autres symptômes cutanés

Daily skin care habits and the risk of skin eruptions and symptoms in cancer patients

Byun, H. J. ; Lee, H. J. ; Yang, J. I. ; Kim, K. H. ; Park, K. O. ; Park, S. M. ; Lee, K. E. ; Choi, J. ; Noh, D.-Y. ; Cho, K. H.

Background Cancer patients are at high risk for skin problems because rapidly proliferating skin cells are susceptible to anticancer therapies. However, the effects of daily skin care habits on development of skin problems in cancer patients have rarely been studied.Patients and methods We conducted a survey of daily skin care habits and the presence of skin problems in 866 cancer patients.Results Hot water bath >1 h significantly increased the risk of definite eruptions [odds ratio (OR) 4.09] [...]

Menée auprès de 46 patients (âge médian : 62 ans), cette étude analyse l'efficacité de l'oxycodone (analgésique stupéfiant dérivé de la thébaïne) pour soulager les douleurs des patients atteints d'un myélome multiple et traités par bortézomib

Controlled-release oxycodone for the treatment of bortezomib-induced neuropathic pain in patients with multiple myeloma

Cartoni, Claudio ; Brunetti, Gregorio ; Federico, Vincenzo ; Efficace, Fabio ; Grammatico, Sara ; Tendas, Andrea ; Scaramucci, Laura ; Cupelli, Luca ; D’Elia, Gianna ; Truini, Andrea ; Niscola, Pasquale ; Petrucci, Maria

Purpose Bortezomib, a proteasome inhibitor drug very effective against multiple myeloma, may induce the so-called bortezomib-induced peripheral neuropathy (BIPN), hardly manageable with common analgesic drugs. This study assessed the effectiveness of controlled-release (CR) oral oxycodone in controlling pain and its interference on daily functions of patients with hematologic malignancies affected by BIPN. Methods Forty-six patients (median age, 62 years) affected by myeloma and lymphoma, [...]

Menée auprès de 39 patients atteints d'un cancer du pancréas de stade avancé, cette étude analyse la prévalence des symptômes de perte de poids et de cachéxie associés à un faible apport énergétique

Symptoms in advanced pancreatic cancer are of importance for energy intake

Asta Bye ; Marit S. Jordhøy ; Grete Skjegstad ; Oddlaug Ledsaak ; Per Ole Iversen ; Marianne Jensen Hjermstad

Purpose Cancer cachexia and low energy intake (EI) probably contribute to weight loss in advanced pancreatic cancer (PC). However, little is known about the actual EI in this disease. Aims were to assess EI, weight loss and symptoms during the disease course and investigate associations between symptoms and EI. Methods Thirty-nine patients (21 males) with advanced PC were consecutively included and followed every 4 weeks until the end of life. A 24-h dietary recall was used to assess EI. The [...]

Mené au Royaume-Uni auprès de 70 participants, cet essai randomisé évalue l'efficacité d'une thérapie cognitive et comportementale destinée à des patients atteints d'un cancer de la prostate et ayant des bouffées de chaleur à la suite de leur traitement

A randomised controlled trial of a cognitive behavioural intervention for men who have hot flushes following prostate cancer treatment (MANCAN): trial protocol

Yousaf, Omar ; Stefanopoulou, Evgenia ; Grunfeld, Elizabeth ; Hunter, Myra

BACKGROUND:This randomised controlled trial (RCT) aims to evaluate the effectiveness of a guided self-help cognitive behavioural intervention to alleviate problematic hot flushes (HF) and night sweats (NS) in men who are undergoing prostate cancer treatment. The trial and the self-help materials have been adapted from a previous RCT, which showed that a cognitive behavioural intervention reduced the self-reported problem-rating of hot flushes in women with menopausal symptoms, and in women [...]

Menée auprès de 163 patientes atteintes d'un cancer du sein et de 224 femmes ayant des problèmes mammaires bénins, cette étude prospective analyse la prévalence des symptômes de dépression, d'anxiété, de fatigue et de troubles du sommeil après le diagnostic de la maladie ou l'opération chirurgicale

What is the relationship between trait anxiety and depressive symptoms, fatigue, and low sleep quality following breast cancer surgery?

Lockefeer, J. P. M. ; De Vries, J.

Background Depressive symptoms, fatigue, and low sleep quality are common symptoms during and after breast cancer (BC) treatment. In the present study, the relationship between trait anxiety and these symptoms in a long follow-up period was examined. Methods This was a prospective study. Participants, composed of 163 women with BC and 224 women with benign breast problems (BBPs), completed questionnaires on depressive symptoms, fatigue, and sleep quality before diagnosis and 1, 3, 6, 12, and [...]

Menée sur la période 1996-2010, cette étude rétrospective analyse, dans le cadre de plusieurs systèmes de santé américains, l'utilisation de l'imagerie de diagnostic et l'exposition des patients aux rayonnements médicaux

Use of Diagnostic Imaging Studies and Associated Radiation Exposure for Patients Enrolled in Large Integrated Health Care Systems, 1996-2010

Smith-Bindman, Rebecca ; Miglioretti, Diana L. ; Johnson, Eric ; Lee, Choonsik ; Feigelson, Heather Spencer ; Flynn, Michael ; Greenlee, Robert T. ; Kruger, Randell L. ; Hornbrook, Mark C. ; Roblin, Douglas ; Solberg, Leif I. ; Vanneman, Nicholas ; Weinmann, Sheila ; Williams, Andrew E.

Context  Use of diagnostic imaging has increased significantly within fee-for-service models of care. Little is known about patterns of imaging among members of integrated health care systems.Objective  To estimate trends in imaging utilization and associated radiation exposure among members of integrated health care systems.Design, Setting, and Participants  Retrospective analysis of electronic records of members of 6 large integrated health systems from different regions of the United States. [...]

A partir des données des registres américains du cancer, cette étude estime, sur la période 2012-2022, la prévalence des survivants d'un cancer aux Etats-Unis

Cancer treatment and survivorship statistics, 2012

Siegel, Rebecca ; DeSantis, Carol ; Virgo, Katherine ; Stein, Kevin ; Mariotto, Angela ; Smith, Tenbroeck ; Cooper, Dexter ; Gansler, Ted ; Lerro, Catherine ; Fedewa, Stacey ; Lin, Chunchieh ; Leach, Corinne ; Cannady, Rachel Spillers ; Cho, Hyunsoon ; Scoppa, Steve ; Hachey, Mark ; Kirch, Rebecca ; Jemal, Ahmedin ; Ward, Elizabeth

Although there has been considerable progress in reducing cancer incidence in the United States, the number of cancer survivors continues to increase due to the aging and growth of the population and improvements in survival rates. As a result, it is increasingly important to understand the unique medical and psychosocial needs of survivors and be aware of resources that can assist patients, caregivers, and health care providers in navigating the various phases of cancer survivorship. To [...]

Cette étude américaine passe en revue les travaux récents relatifs à l'impact de l'obésité sur la survie des patients atteints de cancer et sur le risque de récidive

The Role of Obesity in Cancer Survival and Recurrence

Demark-Wahnefried, Wendy ; Platz, Elizabeth A. ; Ligibel, Jennifer A. ; Blair, Cindy K. ; Courneya, Kerry S. ; Meyerhardt, Jeffrey ; Ganz, Patricia A. ; Rock, Cheryl L. ; Schmitz, Kathryn H. ; Wadden, Thomas ; Philip, Errol J. ; Wolfe, Bruce ; Gapstur, Susan M. ; Ballard-Barbash, Rachael ; McTiernan, Anne ; Minasian, Lori ; Nebeling, Linda C. ; Goodwin, Pamela J.

Obesity and components of energy imbalance, i.e., excessive energy intake and suboptimal levels of physical activity, are established risk factors for cancer incidence. Accumulating evidence suggests that these factors also may be important after the diagnosis of cancer and influence the course of disease, as well as overall health, well-being, and survival. Lifestyle and medical interventions that effectively modify these factors could potentially be harnessed as a means of cancer control. [...]

A partir des données des registres américains du cancer, cette étude évalue l'incidence de la leucémie aiguë promyélocytaire ainsi que la survie des patients, sur la période 1975-2008

Acute promyelocytic leukemia: A population-based study on incidence and survival in the United States, 1975-2008

Chen, Yiming ; Kantarjian, Hagop ; Wang, Haijun ; Cortes, Jorge ; Ravandi, Farhad

BACKGROUND: With the introduction of all-trans retinoic acid and arsenic trioxide, the management of acute promyelocytic leukemia (APL) has changed dramatically. We performed a population-based study of APL in the United States to determine its incidence and relative survival (RS) during a 34-year period. METHODS: We identified 1397 patients diagnosed with APL between 1975 and 2008 in the Surveillance, Epidemiology, and End Results database. Patients were categorized into 4 age groups and 3 [...]

Menée en Suède, cette étude de cohorte prospective incluant 772 participantes évalue l'impact du volume des seins sur la survie des patientes atteintes d'un cancer du sein

Given breast cancer, does breast size matter? Data from a prospective breast cancer cohort

Markkula, Andrea ; Bromée, Anna ; Henningson, Maria ; Hietala, Maria ; Ringberg, Anita ; Ingvar, Christian ; Rose, Carsten ; Jernström, Helena

Purpose Body mass index (BMI), waist-to-hip ratio (WHR), and tumor characteristics affect disease-free survival. Larger breast size may increase breast cancer risk, but its influence on disease-free survival is unclear. The purpose of this study was to elucidate whether breast size independently influenced disease-free survival in breast cancer patients. Methods Body measurements were obtained preoperatively from 772 breast cancer patients in a population-based ongoing cohort from southern [...]

A partir des données de 4 études de cohortes prospectives menées en Chine et aux Etats-Unis incluant 12 915 participantes, cette étude analyse l'impact des variations de poids sur la survie des patientes atteintes d'un cancer du sein

Weight Change and Survival after Breast Cancer in the After Breast Cancer Pooling Project

Caan, Bette J. ; Kwan, Marilyn L. ; Shu, Xiao-Ou ; Pierce, John P. ; Patterson, Ruth E. ; Nechuta, Sarah ; Poole, Elizabeth M. ; Kroenke, Candyce H. ; Weltzien, Erin K. ; Flatt, Shirley W. ; Quesenberry, Charles P. ; Holmes, Michelle D. ; Chen, Wendy Y.

Background: Weight change after a breast cancer diagnosis has been linked to lower survival. To further understand effects of post-diagnostic weight variation on survival, we examined the relationship by comorbid status and initial BMI. Methods: The current analysis included 12,915 breast cancer patients diagnosed between 1990 and 2006 with Stage I-III tumors from four prospective cohorts in the US and China. Hazard ratios (HR) and 95% confidence intervals (CI) representing the associations of [...]

Menée dans 26 états américains sur la période 1993-2007, cette étude analyse l'évolution des disparités socioéconomiques et ethniques dans la mortalité des patientes atteintes d'un cancer du col de l'utérus

Widening socioeconomic disparities in cervical cancer mortality among women in 26 states, 1993-2007

Simard, Edgar P. ; Fedewa, Stacey ; Ma, Jiemen ; Siegel, Rebecca ; Jemal, Ahmedin

BACKGROUND: Despite substantial declines in cervical cancer mortality because of widespread screening, socioeconomic status (SES) disparities persist. The authors examined trends in cervical cancer mortality rates and the risk of late-stage diagnoses by SES. METHODS: Using data from the National Vital Statistics System, trends in age-standardized mortality rates among women ages 25 to 64 years (1993-2007) by education level (≤12 years, 13-15 years, and ≥16 years) and race/ethnicity for [...]

Menée auprès de 19 participants, cette étude pilote espagnole évalue la faisabilité et l'efficacité d'une psychothérapie utilisant la réalité virtuelle pour induire des émotions positives chez des patients hospitalisés et atteints d'un cancer de stade avancé

A positive psychological intervention using virtual reality for patients with advanced cancer in a hospital setting: a pilot study to assess feasibility

Baños, Rosa ; Espinoza, Macarena ; García-Palacios, Azucena ; Cervera, José ; Esquerdo, Gaspar ; Barrajón, Enrique ; Botella, Cristina

Purpose This study presents data on the feasibility and possible benefits of a psychological intervention that uses virtual reality to induce positive emotions on adult hospitalized patients with metastatic cancer. The patient’s satisfaction and perceived utility was also examined. Method The sample was composed of 19 patients (53 % men, aged from 29 to 85 years old; x = 60.9; standard deviation = 14.54). The intervention consisted of four 30-min sessions during 1 week in which patients [...]

Menée au Canada auprès de 1 215 patients atteints de cancer, cette étude analyse l'efficacité d'un outil "Edmonton Symptom Assessment System" permettant de détecter et d'évaluer l'anxiété et la dépression

The utility of the Edmonton Symptom Assessment System in screening for anxiety and depression

Bagha, S. M. ; Macedo, A. ; Jacks, L. M. ; Lo, C. ; Zimmermann, C. ; Rodin, G. ; Li, M.

The Edmonton Symptom Assessment System (ESAS) is a common screening tool in cancer, although its validity for distress screening is unproven. Here, screening performance of the ESAS anxiety (ESAS-A) and depression (ESAS-D) items were validated against the anxiety [Generalised Anxiety Disorder-7 (GAD-7)] and depression [Patient Health Questionnaire-9 (PHQ-9)] subscales of the PHQ. A total of 1215 cancer patients completed the Distress Assessment and Response Tool (DART), a computerised distress [...]

Menée en Suède auprès de 60 patientes à risque héréditaire de cancer du sein, cette étude propspective évalue la qualité de vie, la sexualité et l'image de soi de patientes ayant subi une mastectomie prophylactique controlatérale pour prévenir le risque de récidive

Contralateral prophylactic mastectomy in breast cancer patients with a family history: A prospective 2-years follow-up study of health related quality of life, sexuality and body image

Unukovych, Dmytro ; Sandelin, Kerstin ; Liljegren, Annelie ; Arver, Brita ; Wickman, Marie ; Johansson, Hemming ; Brandberg, Yvonne

Contralateral prophylactic mastectomy (CPM) is the most effective option to prevent the occurrence of a second breast cancer in hereditary breast cancer patients. This study aimed to prospectively evaluate health-related quality of life (HRQoL), anxiety and depression, sexuality and body image in breast cancer patients with a family history undergoing CPM with immediate breast reconstruction. In total, 60 of 69 eligible patients agreed to participate in the study. Four validated questionnaires [...]

Menée au Canada auprès de 522 patients atteints d'un cancer de la tête et du cou, cette étude analyse leurs perceptions conceptuelles négatives de la maladie ainsi que le stress associé à celles-ci

Negative cancer stereotypes and disease-specific self-concept in head and neck cancer

Wong, Janice C. ; Payne, Ada Y. M. ; Mah, Kenneth ; Lebel, Sophie ; Lee, Ruth N. F. ; Irish, Jonathan ; Rodin, Gary ; Devins, Gerald M.

Background Life-threatening diseases, such as head and neck cancer (HNCa), can stimulate the emergence of a new disease-specific self-concept. We hypothesized that (i) negative cancer-stereotypes invoke distancing, which inhibits the adoption of a disease-specific self-concept and (ii) patient characteristics, disease and treatment factors, and cancer-related stressors moderate the phenomenon. Methods Head and neck cancer outpatients (N = 522) completed a semantic-differential measure of [...]

Cette étude analyse l'efficacité d'une psychothérapie par téléphone pour améliorer la qualité de vie psychosociale et la gestion du stress de 16 patients atteints d'un cancer de la tête et du cou

Feasibility of EASE: a psychosocial program to improve symptom management in head and neck cancer patients

Kilbourn, Kristin ; Anderson, Derek ; Costenaro, Allison ; Lusczakoski, Kate ; Borrayo, Evelinn ; Raben, David

Purpose Head and neck cancer (HNC) patients experience multiple physical and psychosocial symptoms associated with their cancer treatment. The Easing and Alleviating Symptoms during Treatment (EASE) study utilized a mixed methods design to examine the feasibility of a tailored telephone-based coping and stress management intervention to improve symptom management and psychosocial care among HNC patients. Methods An Embedded Correlational Mixed Methods Design was utilized to answer two research [...]

Menée aux Etats-Unis et portant sur la période 2000 à 2008, cette étude analyse la prévalence et les caractéristiques des patients atteints de cancer métastatique ne recevant aucun traitement, systémique ou localisé

Prevalence and characteristics of patients with metastatic cancer who receive no anticancer therapy

Small, Alexander C. ; Tsao, Che-kai ; Moshier, Erin L. ; Gartrell, Benjamin A. ; Wisnivesky, Juan P. ; Godbold, James H. ; Smith, Cardinale B. ; Sonpavde, Guru ; Oh, William K. ; Galsky, Matthew D.

BACKGROUND: A subset of patients who present with metastatic solid tumors never receive anticancer therapy. Reasons may include poor functional status, comorbidities, and patient preference. To the authors' knowledge, the prevalence and characteristics of this population have not previously been described. METHODS: The National Cancer Data Base was queried for patients diagnosed with metastatic (stage IV according to the American Joint Committee on Cancer) solid tumors (including those of the [...]

Cette étude américaine analyse le rapport coût-efficacité du dépistage du cancer colorectal par coloscopie en fonction de la spécialité médicale du praticien (gastro-entérologue ou autre)

Loss of efficacy and cost-effectiveness when screening colonoscopy is performed by nongastroenterologists

Hassan, Cesare ; Rex, Douglas K. ; Zullo, Angelo ; Cooper, Gregory S.

BACKGROUND: Specialty of the endoscopist has been related to the postcolonoscopy interval risk of colorectal cancer (CRC). However, the impact of such a difference on the long-term CRC prevention rate by screening colonoscopy is largely unknown. METHODS: A Markov model was constructed to simulate the efficacy and cost of colonoscopy screening according to the specialty of the endoscopist in 100,000 individuals aged 50 years until death. The postcolonoscopy interval CRC risk (0.02%) and the [...]

Menée au Danemark auprès de 67 médecins généralistes suivant 13 288 patientes, cette étude analyse l'impact de l'attitude et le discours du médecin généraliste vis-à-vis du dépistage du cancer du sein sur le comportement et la participation effective des femmes à ce dépistage

The association between general practitioners' attitudes towards breast cancer screening and women's screening participation

Jensen, Line ; Mukai, Thomas ; Andersen, Berit ; Vedsted, Peter

BACKGROUND:Breast cancer screening in Denmark is organised by the health services in the five regions. Although general practitioners (GPs) are not directly involved in the screening process, they are often the first point of contact to the health care system and thus play an important advisory role. No previous studies, in a health care setting like the Danish system, have investigated the association between GPs' attitudes towards breast cancer screening and women's participation in the [...]

En prenant l'exemple du registre nigérian des cancers, cette étude analyse, pour les pays à faible ou moyen revenu, l'intérêt de développer et d'investir dans les registres hospitaliers des cancers

The role of hospital-based cancer registries in low and middle income countries—The Nigerian Case Study

Jedy-Agba, Elima E. ; Curado, Maria-Paula ; Oga, Emmanuel ; Samaila, Modupeola O. ; Ezeome, Emmanuel R. ; Obiorah, Christopher ; Erinomo, Olagoke O. ; Ekanem, Ima-obong A. ; Uka, Cornelius ; Mayun, Ahmed ; Afolayan, Enoch A. ; Abiodun, Popoola ; Olasode, Babatunde J. ; Omonisi, Abidemi ; Otu, Theresa ; Osinubi, Patience ; Dakum, Patrick ; Blattner, William ; Adebamowo, Clement A.

Background: The incidence of cancer continues to rise all over the world and current projections show that there will be 1.27 million new cases and almost 1 million deaths by 2030. In view of the rising incidence of cancer in sub-Saharan Africa, urgent steps are needed to guide appropriate policy, health sector investment and resource allocation. We posit that hospital based cancer registries (HBCR) are fundamental sources of information on the frequent cancer sites in limited resource regions [...]