Menée à partir de données de la "U.S. Environmental Protection Agency" et auprès de 46 150 participantes de l'étude "Sister Study", cette étude analyse l'association entre les émissions atmosphériques de 28 composés industriels à proximité du domicile et l'incidence du cancer du sein (4 155 cas)

Industrial air emissions and breast cancer incidence in a United States-wide prospective cohort

Ish, Jennifer L. ; Madrigal, Jessica M. ; Pearce, John L. ; Keil, Alexander P. ; Fisher, Jared A. ; Jones, Rena R. ; Sandler, Dale P. ; White, Alexandra J.

Background: We evaluated air emissions of industrial compounds, many of which have carcinogenic or endocrine disrupting properties, in relation to breast cancer incidence. Methods: Using the United States Environmental Protection Agency’s Toxics Release Inventory, we quantified air emissions of 28 compounds near Sister Study participants’ residences during the 10 years leading up to study enrollment (2003-2006; n=46,150). We used Cox proportional hazards regression to estimate adjusted hazard [...]

Menée à partir de données 1974-2014 portant sur 7 936 personnes ayant survécu au moins 2 ans à une greffe de moelle osseuse autologue ou allogénique, cette étude analyse le risque de carcinome épidermoïde associé au papillomavirus humain

Human papillomavirus-related squamous cell carcinomas after blood or marrow transplantation—a BMTSS report

Holmqvist, Anna Sällfors ; Meng, Qingrui ; Landier, Wendy ; Hageman, Lindsey ; Francisco, Liton F ; Ross, Elizabeth Schlichting ; Balas, Nora ; Bosworth, Alysia ; Te, Hok Sreng ; Bhatia, Ravi ; Wong, F Lennie ; Weisdorf, Daniel ; Armenian, Saro H ; Bhatia, Smita

Human papillomavirus (HPV) is associated with an increased risk for a variety of squamous cell carcinomas (SCCs) in the general population. The risk for subsequent SCCs in BMT survivors that are potentially related to HPV (cervical, oropharyngeal, vulvar, vaginal, anal, and penile cancer; HPV-related SCCs) remains unknown.We determined the risk of HPV-related SCCs in 7,936 2 y-survivors of autologous or allogeneic BMT performed between 1974 and 2014 and identified the role of demographic and [...]

Menée à partir de données d'un registre allemand portant sur 304 patients atteints du syndrome de Li-Fraumeni, cette étude analyse le risque de cancer par phénotype en fonction de la classification du variant constitutionnel de TP53

Cancer risk in carriers of TP53 germline variants grouped into different functional categories

Müntnich, Lucas John ; Dutzmann, Christina M ; Großhennig, Anika ; Härter, Valentina ; Keymling, Myriam ; Mastronuzzi, Angela ; Montellier, Emilie ; Nees, Juliane ; Palmaers, Natalie E ; Penkert, Judith ; Pfister, Stefan M ; Ripperger, Tim ; Schott, Sarah ; Silchmüller, Farina ; Hainaut, Pierre ; Kratz, Christian P

Li-Fraumeni syndrome is a cancer predisposition syndrome caused by pathogenic TP53 germline variants and associated with a high lifelong cancer risk. We analysed the German LFS registry that contains data on 304 individuals. Cancer phenotypes were correlated with variants grouped according to their ability to transactivate target genes in a yeast assay using a traditional (non-functional, partially-functional) and a novel (clusters A, B, C) classification of variants into different groups. [...]

Menée à l'aide de données de la "Women's Health Initiative" portant sur 112 925 femmes ménopausées et n'ayant pas reçu de traitement relatif à une fécondation in vitro (durée de suivi : au moins 25 ans), cette étude analyse l'association entre l’infertilité et le risque de cancer de l’ovaire postménopausique

Infertility and risk of ovarian cancer in the women’s health initiative

Harris, Holly R. ; Lind, Kimberly ; Fest, Sable ; Thomson, Cynthia A. ; Saquib, Nazmus ; Shadyab, Aladdin H. ; Schnatz, Peter F. ; Robles-Morales, Rogelio ; Qi, Lihong ; Strickler, Howard D. ; Roe, Denise J. ; Farland, Leslie V.

Purpose: There is a consistent relationship with greater ovulation frequency and increased risk of ovarian cancer. However, prior research on infertility, which may be associated with ovulation frequency through multiple mechanisms, and ovarian cancer has yielded conflicting results, possibly due to prior research conflating fertility treatment with infertility and restricting follow-up to premenopausal cases. Our objective was to determine the association between infertility and risk of [...]

Menée à l'aide d'une méthode de randomisation mendélienne, de données de la "UK Biobank" portant sur 351 828 personnes et d'une analyse pangénomique portant sur 947 237 témoins et 61 047 patients atteints d'un cancer du poumon, cette étude analyse l'association entre une sensibilité au stress et à l'adversité et le risque de développer la maladie

Sensitivity to Environmental Stress and Adversity and Lung Cancer

Chen, Yingxi ; Lan, Qing ; Yu, Jing ; Godbole, Devika ; Byun, Jinyoung ; Amos, Christopher I. ; Zhang, Haoyu

Sensitivity to environmental stress and adversity may influence lung cancer risk, highlighting a critical link between psychosocial factors and cancer etiology.To evaluate whether genetically estimated sensitivity to environmental stress and adversity is associated with lung cancer risk.Data were obtained from a genome-wide association study identifying 37 independent genetic variants strongly associated with sensitivity to environmental stress and adversity and a cross-ancestry genome-wide [...]

Menée à l'aide des données de 9 cohortes asiatiques portant sur 259 649 femmes (durée moyenne de suivi : 17,2 ans), cette étude analyse l'association entre 10 facteurs reproductifs ou hormonaux féminins et le risque de cancer de la thyroïde (1 353 cas) par pays

Reproductive and Hormonal Factors and Thyroid Cancer Risk: Pooled Analysis of Prospective Cohort Studies in the Asia Cohort Consortium

Kazmi, Sayada Zartasha ; Shin, Aesun ; Abe, Sarah K. ; Islam, Md Rashedul ; Rahman, Md Shafiur ; Saito, Eiko ; Cho, Sooyoung ; Katagiri, Ryoko ; Merritt, Melissa A. ; Choi, Ji-Yeob ; Shu, Xiao-Ou ; Sawada, Norie ; Tamakoshi, Akiko ; Sakata, Ritsu ; Hozawa, Atsushi ; Kanemura, Seiki ; Kim, Jeongseon ; Sugawara, Yumi ; Park, Sue K. ; Cai, Hui ; Tsugane, Shoichiro ; Kimura, Takashi ; Ahsan, Habibul ; Boffetta, Paolo ; Chia, Kee Seng. ; Matsuo, Keitaro ; Qiao, You-Lin ; Rothman, Nathaniel ; Zheng, Wei ; Inoue, Manami ; Kang, Daehee

Given the female predominance of thyroid cancer (TC), particularly in the reproductive age range, female sex hormones have been proposed as an aetiology; however, previous epidemiological studies have shown conflicting results. We conducted a pooled analysis using individual data from 9 prospective cohorts in the Asia Cohort Consortium, to explore the association between 10 female reproductive and hormonal factors and TC risk. Using Cox proportional hazards models, cohort-specific hazard ratios [...]