A partir d'une revue systématique de la littérature publiée jusqu'en novembre 2022 (49 études, 59 429 patients), cette méta-analyse évalue l'association entre le statut tabagique et le risque de mélanome en fonction du sexe

Effect of smoking on melanoma incidence: a systematic review with meta-analysis

Friedman, Erica B ; Williams, Gabrielle J ; Lo, Serigne N ; Thompson, John F

There is a strong correlation between cigarette smoking and the development of many cancer types. It is therefore paradoxical that multiple reports have suggested a reduced incidence of melanoma in smokers. This study aimed to analyze all existing studies of melanoma incidence in smokers relative to non-smokers.Searches of MEDLINE and Embase were conducted for studies reporting data on melanoma in smokers and never-smokers. No study design limitations or language restrictions were applied. The [...]

Menée à partir de données d'enquête portant sur 50 085 personnes et menée à l'aide d'une méthode de randomisation mendélienne et de données pangénomiques portant sur plus de 700 000 échantillons sanguins, cette étude analyse l'association entre les niveaux d'hémoglobine et le risque de cancer (15 localisations)

Correlation between hemoglobin and the risk of common malignant tumors: a 1999–2020 retrospective analysis and causal association analysis

Li, Guo-Sheng ; Huang, Tao ; Li, Jing-Xiao ; Liu, Jun ; Gao, Xiang ; Yang, Nuo ; Zhou, Hua-Fu

Background: The role of hemoglobin (HGB) in common malignant tumors remains unclear. Methods: A retrospective analysis was conducted to identify the correlation between HGB levels and risk of 15 malignant tumors using 50,085 samples from the National Health and Nutrition Examination Survey. Mendelian Randomization analyses (MRAs) were performed based on genome-wide association study data to assess the causal relationship between HGB levels and these malignant tumors using more than 700,000 [...]

A partir d'une revue systématique de la littérature publiée jusqu'en mars 2023 (53 études, 222 187 patients), cette méta-analyse évalue l'association entre des variants constitutionnels des gènes codant pour le complexe de réparation MRN (MRE11, RAD50 et NBN) et le risque de cancer par localisation

Germline pathogenic variants in the MRE11, RAD50, and NBN (MRN) genes in cancer predisposition: A systematic review and meta-analysis

Stastna, Barbora ; Dolezalova, Tatana ; Matejkova, Katerina ; Nemcova, Barbora ; Zemankova, Petra ; Janatova, Marketa ; Kleiblova, Petra ; Soukupova, Jana ; Kleibl, Zdenek

The MRE11, RAD50, and NBN genes encode the MRN complex sensing DNA breaks and directing their repair. While carriers of biallelic germline pathogenic variants (gPV) develop rare chromosomal instability syndromes, the cancer risk in heterozygotes remains controversial. We performed a systematic review and meta-analysis of 53 studies in patients with different cancer diagnoses to better understand the cancer risk. We found an increased risk (odds ratio, 95% confidence interval) for gPV carriers [...]

Menée à partir de données portant sur 247 022 témoins et 14 394 patients atteints d'un adénocarcinome canalaire du pancréas, cette étude analyse l'association entre le variant rs2294008 et le risque de développer la maladie, en fonction de l'origine ethnique

Potential association between PSCA rs2976395 functional variant and pancreatic cancer risk

Corradi, Chiara ; Lencioni, Giulia ; Felici, Alessio ; Rizzato, Cosmeri ; Gentiluomo, Manuel ; Ermini, Stefano ; Archibugi, Livia ; Mickevicius, Antanas ; Lucchesi, Maurizio ; Malecka-Wojciesko, Ewa ; Basso, Daniela ; Arcidiacono, Paolo Giorgio ; Petrone, Maria Chiara ; Carrara, Silvia ; Götz, Mara ; Bunduc, Stefania ; Holleczek, Bernd ; Aoki, Mateus Nóbrega ; Uzunoglu, Faik G. ; Zanette, Dalila Lucíola ; Mambrini, Andrea ; Jamroziak, Krzysztof ; Oliverius, Martin ; Lovecek, Martin ; Cavestro, Giulia Martina ; Milanetto, Anna Caterina ; Peduzzi, Giulia ; Duchonova, Beatrice Mohelnikova ; Izbicki, Jakob R. ; Zalinkevicius, Rimantas ; Hlavac, Viktor ; van Eijck, Casper H. J. ; Brenner, Hermann ; Vanella, Giuseppe ; Vokacova, Klara ; Soucek, Pavel ; Tavano, Francesca ; Perri, Francesco ; Capurso, Gabriele ; Hussein, Tamás ; Kiudelis, Mindaugas ; Kupcinskas, Juozas ; Busch, Olivier R. ; Morelli, Luca ; Theodoropoulos, George E. ; Testoni, Sabrina Gloria Giulia ; Adamonis, Kestutis ; Neoptolemos, John P. ; Gazouli, Maria ; Pasquali, Claudio ; Kormos, Zita ; Skalicky, Pavel ; Pezzilli, Raffaele ; Sperti, Cosimo ; Kauffmann, Emanuele ; Büchler, Markus W. ; Schottker, Ben ; Hegyi, Peter ; Capretti, Giovanni ; Lawlor, Rita T. ; Canzian, Federico ; Campa, Daniele

Correlated regions of systemic interindividual variation (CoRSIV) represent a small proportion of the human genome showing DNA methylation patterns that are the same in all human tissues, are different among individuals, and are partially regulated by genetic variants in cis. In this study we aimed at investigating single-nucleotide polymorphisms (SNPs) within CoRSIVs and their involvement with pancreatic ductal adenocarcinoma (PDAC) risk. We analyzed 29,099 CoRSIV-SNPs and 133,615 CoRSIV-mQTLs [...]

Menée à l'aide d'une méthode de randomisation mendélienne et de données pangénomiques, cette étude analyse l'association entre des maladies bénignes (prostatite ou hyperplasie) et le risque de cancer de la prostate

Causal relationship between prostatic diseases and prostate cancer: a mendelian randomization study

Huang, Jiaguo ; Sun, Ji ; Wang, Kai ; Zheng, Liying ; Fan, Yi ; Qian, Biao

Background: Although it is thought that prostatitis or benign prostatic hyperplasia (BPH) is related to prostate cancer (PCa), the underlying causal effects of these diseases are unclear. Methods: We assessed the causal relationship between prostatitis or BPH and PCa using a two-sample Mendelian randomization (MR) approach. The data utilized in this study were sourced from genome-wide association study. The association of genetic variants from cohorts of prostatitis or BPH and PCa patients was [...]

Cet article fait le point sur les critères nécessaires au chirurgien pour reconnaître un cancer du poumon lié à l'amiante

Lung cancer caused by asbestos: What a reporting pathologist needs to know

Klebe, S. ; Rathi, Vivek ; Russell, P. A.

Asbestos is a carcinogen that can cause lung cancer. The suspicion that a lung cancer diagnosis may be associated with exposure to asbestos has no bearing on treatment. However, attributing an individual’s lung cancer to asbestos exposure has important medicolegal implications and may impact public health measures and policy. Simultaneous exposure(s) to other carcinogens (such as tobacco smoke, silica and many others) adds complexity while trying to answer the causation question. The Helsinki [...]