Menée en Espagne à partir de données portant sur 1 862 patients ayant survécu à un cancer à haut risque de récidive, cette étude analyse les facteurs sociodémographiques et médicaux liés à leur qualité de vie

Quality of life in cancer survivorship: Sociodemographic and disease-related moderators

Andreu, Yolanda ; Martínez, Paula ; Soto-Rubio, Ana ; Pérez-Marín, Marián ; Cervantes, Andres ; Arribas, Leoncio

Rationale : To identify high-risk survivors in order to provide appropriate care. Purpose : To analyse the quality of life (QOL) of cancer survivors using an instrument designed specifically for this population and considering different sociodemographic and disease-related characteristics as possible modulating variables. Methods : The Quality of Life in Adult Cancer Survivors (QLACS) was filled out by a large and heterogeneous sample of disease-free post-treatment Spanish cancer survivors [...]

Menée aux Etats-Unis à partir de données portant sur 8 969 patients ayant survécu à un cancer pédiatrique (âge moyen : 13,7 ans) et sur 44 845 témoins, cette étude de cohorte analyse les effets des recommandations 2016 des "Centers for Disease Control and Prevention" relatives aux prescriptions d'opioïdes sur un mauvais usage potentiel et sur la survenue de troubles liés à l'utilisation d'autres substances

Changes in Opioid Prescriptions and Potential Misuse and Substance Use Disorders Among Childhood Cancer Survivors Following the 2016 Opioid Prescribing Guideline

Hu, Xin ; Brock, Katharine E. ; Effinger, Karen E. ; Zhang, Bo ; Graetz, Ilana ; Lipscomb, Joseph ; Ji, Xu

Importance :The Centers for Disease Control and Prevention (CDC) released an opioid-prescribing guideline in March 2016. Little is known about the guideline’s potential effects on childhood cancer survivors, a population at high risk for pain. Objective : To examine changes in opioid prescriptions and potential misuse/substance use disorders (SUD) among childhood cancer survivors and peers without cancer following the guideline release. Design, Setting, and Participants : In this cohort study [...]

Mené aux Etats-Unis sur 128 patients atteints d'un cancer, cet essai randomisé évalue l'effet de hautes doses de dexaméthasone sur l'intensité d'une dyspnée liée à la maladie

Effect of dexamethasone on dyspnoea in patients with cancer (ABCD): a parallel-group, double-blind, randomised, controlled trial

Hui, David ; Puac, Veronica ; Shelal, Zeena ; Dev, Rony ; Hanneman, Sandra K. ; Jennings, Kristofer ; Ma, Hilary ; Urbauer, Diana L. ; Shete, Sanjay ; Fossella, Frank ; Liao, Zhongxing ; Blumenschein, George, Jr. ; Chang, Joe Y. ; O'Reilly, Michael ; Gandhi, Saumil J. ; Tsao, Anne ; Mahler, Donald A. ; Bruera, Eduardo

Background : Systemic corticosteroids are commonly prescribed for palliation of dyspnoea in patients with cancer, despite scarce evidence to support their use. We aimed to assess the effect of high-dose dexamethasone versus placebo on cancer-related dyspnoea. Methods :The parallel-group, double-blind, randomised, controlled ABCD (Alleviating Breathlessness in Cancer Patients with Dexamethasone) trial was done at the at the University of Texas MD Anderson Cancer Center and the general oncology [...]

Menée en Chine par questionnaire auprès de 410 patientes ayant survécu à un cancer du sein, cette étude transversale analyse la présence et la sévérité de douleurs articulaires en lien avec des traitements par inhibiteurs de l'aromatase

Prevalence and correlates of joint pain among Chinese breast cancer survivors receiving aromatase inhibitor treatment

Wang, Tao ; Huang, Yu-Yan ; Liu, Xian-Liang ; Molassiotis, Alex ; Yao, Li-Qun ; Zheng, Si-Lin ; Tan, Jing-Yu ; Huang, Hou-Qiang

Background : Aromatase inhibitor (AI)-induced joint pain is a common toxicity of AI treatment. Although many studies have been conducted to examine the occurrence and severity of AI-induced joint pain in breast cancer survivors, none of the studies focused on the Chinese population with breast cancer. Given that the differences in cultural background and the genetic structure between Asians and Caucasians may contribute to different phenotypes of joint pain, this cross-sectional study was [...]

Menée dans 7 pays européens à partir de données portant sur 42 361 patients ayant survécu au moins 5 ans à un cancer pédiatrique diagnostiqué entre 1940 et 2009 et couplée à une étude cas-témoins (1 000 témoins), cette étude analyse le risque d'insuffisance cardiaque et les facteurs associés

Risk Factors for Heart Failure Among Pan-European Childhood Cancer Survivors: A PanCareSurFup and ProCardio Cohort and Nested Case-Control Study

Esmée C. de Baat ; Elizabeth A.M. Feijen ; Raoul C. Reulen ; Rodrigue S. Allodji ; Francesca Bagnasco ; Edit Bardi ; Fabiën N. Belle ; Julianne Byrne ; Elvira C. van Dalen ; Ghazi Debiche ; Ibrahima Diallo ; Desiree Grabow ; Lars Hjorth ; Momcilo Jankovic ; Claudia E. Kuehni ; Gill Levitt ; Damien Llanas ; Jacqueline Loonen ; Lorna Z. Zaletel ; Milena M. Maule ; Lucia Miligi ; Helena J.H. van der Pal ; Cécile M. Ronckers ; Carlotta Sacerdote ; Roderick Skinner ; Zsuzsanna Jakab ; Cristina Veres ; Nadia Haddy ; David L. Winter ; Florent de Vathaire ; Michael M. Hawkins ; Leontien C.M. Kremer

PURPOSE : Heart failure (HF) is a potentially life-threatening complication of treatment for childhood cancer. We evaluated the risk and risk factors for HF in a large European study of long-term survivors. Little is known of the effects of low doses of treatment, which is needed to improve current treatment protocols and surveillance guidelines. METHODS : This study includes the PanCareSurFup and ProCardio cohort of ≥ 5-year childhood cancer survivors diagnosed between 1940 and 2009 in seven [...]

Menée à partir de données portant sur un total de 1 748 patients atteints d'une tumeur solide, présentant des métastases osseuses et inclus dans deux études de cohortes prospectives, cette étude rétrospective analyse l'adhésion au traitement par dénosumab

Medication adherence with denosumab in patients with bone metastases from solid tumors treated in routine clinical settings: a retrospective study

Diel, Ingo J. ; Greil, Richard ; Janssen, Jan ; Kluike, Christian W. ; Behera, Bagmeet ; Abbasi, Ali ; Seesaghur, Anouchka ; Kellner, Michael ; Jaeger, Christine ; Bjorklof, Katja ; Tomova, Antoaneta ; Haslbauer, Ferdinand

Purpose : To describe (non)adherence with denosumab among patients with solid tumors and bone metastases. Methods : This retrospective, observational study pooled data from two completed prospective, multicenter cohort studies (X-TREME; Study 240) in adult patients with bone metastases from primary breast, prostate, lung, kidney, or other solid cancer types and administered denosumab 120 mg in routine clinical practice in Germany and Central and Eastern Europe. The studies were conducted [...]

Menée à partir des données GLOBOCAN portant sur 185 pays, cette étude présente une estimation, pour les années 2020 et 2040, de l'incidence du cancer colorectal et de la mortalité spécifique

Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN

Morgan, Eileen ; Arnold, Melina ; Gini, A ; Lorenzoni, V ; Cabasag, C J ; Laversanne, Mathieu ; Vignat, Jérôme ; Ferlay, Jacques ; Murphy, Neil ; Bray, Freddie

Objective : Colorectal cancer (CRC) is the third most common cancer worldwide. The geographical and temporal burden of this cancer provides insights into risk factor prevalence and progress in cancer control strategies. We examine the current and future burden of CRC in 185 countries in 2020 and 2040. Methods : Data on CRC cases and deaths were extracted from the GLOBOCAN database for the year 2020. Age-standardised incidence and mortality rates were calculated by sex, country, world region and [...]

A partir d'une revue systématique de la littérature publiée entre 1980 et 2021 (31 études), cette étude analyse l'association entre l'accès à un logement stable et abordable, l'accès aux soins et la survie, chez des patients atteints d'un cancer

Housing and Cancer Care and Outcomes: A Systematic Review

Fan, Qinjin ; Nogueira, Leticia ; Yabroff, K Robin ; Hussaini, S M Qasim ; Pollack, Craig E

Background : Access to stable and affordable housing is an important social determinant of health in the United States. However, research addressing housing and cancer care, diagnosis, and outcomes has not been synthesized. Methods : We conducted a systematic review of studies examining associations of housing and cancer care and outcomes using PubMed, Embase, Scopus, and CINAHL. Included studies were conducted in the United States and published in English between 1980 and 2021. Study [...]

Menée aux Etats-Unis auprès de 167 patiens âgés atteints d'un cancer et recevant des soins palliatifs à l'extérieur de l'hôpital (âge moyen : 65,9 ans), cette étude analyse les facteurs psychosociaux et physiques associés à leur anxiété et à leur détresse liées à la mort

Death Anxiety and Correlates in Cancer Patients Receiving Palliative Care

Linda L. Emanuel, ; Sheldon Solomon, ; Harvey Max Chochinov, ; Marvin Omar Delgado Guay, ; George Handzo, ; Joshua Hauser, ; Sheri Kittelson, ; Sean O'Mahony, ; Tammie E. Quest, ; Michael W. Rabow, ; Tasha M. Schoppee, ; Diana J. Wilkie, ; Yingwei Yao, ; and George Fitchett

Background: Death anxiety is powerful, potentially contributes to suffering, and yet has to date not been extensively studied in the context of palliative care. Availability of a validated Death Anxiety and Distress Scale (DADDS) opens the opportunity to better assess and redress death anxiety in serious illness. Objective: We explored death anxiety/distress for associations with physical and psychosocial factors. Design: Ancillary to a randomized clinical trial (RCT) of Dignity Therapy (DT), [...]

Menée en Chine auprès de 285 parents d'enfants atteints d'un cancer et recevant un traitement anticancéreux, cette étude transversale analyse les facteurs associés à leur peur de la récidive de la maladie

Fear of progression and its associated factors in parents of children undergoing cancer treatment: a cross-sectional study

Yang, Yiling ; Zhang, Yuwei ; Liang, Lichan ; Liao, Xiaomei ; Meng, Jiangnan ; Cai, Ruiqing ; Ye, Hongyu ; Hu, Jiamin ; He, Xiaofeng ; Shi, Lei

Objective : Fear of progression (FoP) is a common psychosocial problem among adult cancer patients, but data on parents of children undergoing cancer treatment are scarce. This study aimed to determine the prevalence of FoP in parents of children undergoing cancer treatment and explore the associated factors. Methods : Overall, 285 parents of children undergoing cancer treatment were recruited from three general hospitals in China. FoP in the parents was assessed using the Chinese version of [...]

Menée dans un contexte espagnol, cette étude analyse le rapport coût-efficacité de NEPA, un traitement combinant des doses fixes de nétupitant et de palonosétron, pour prévenir les nausées et vomissements induits par une chimiothérapie hautement émétisante chez des patients atteints d'un cancer

Cost-effectiveness analysis of NEPA, a fixed-dose combination of netupitant and palonosetron, for the prevention of highly emetogenic chemotherapy-induced nausea and vomiting: an international perspective

Nilsson, Jonas ; Piovesana, Vittoria ; Turini, Marco ; Lezzi, Claudio ; Eriksson, Jennifer ; Aapro, Matti

Purpose : The aim of this study was to assess the cost-effectiveness of NEPA, a fixed-dose combination of oral netupitant (300 mg) and palonosetron (0.5 mg), compared to available treatments in Spain after aprepitant generic introduction in the market, and to discuss results in previously performed analyses in different wordwide settings. Methods : A Markov model including three health states, complete protection, complete response at best and incomplete response, was used to evaluate the [...]

Menée dans un contexte américain, cette étude analyse le rapport coût-efficacité de différentes stratégies thérapeutiques chez des patients atteints d'un cancer de la prostate à haut risque de récidive

Cost effectiveness of treatment strategies for high risk prostate cancer

Kowalchuk, Roman O. ; Kim, Hayeon ; Harmsen, William S. ; Jeans, Elizabeth B. ; Morris, Lindsay K. ; Mullikin, Trey C. ; Miller, Robert C. ; Wong, William W. ; Vargas, Carlos E. ; Trifiletti, Daniel M. ; Phillips, Ryan M. ; Choo, C. R. ; Davis, Brian J. ; Beriwal, Sushil ; Tendulkar, Rahul D. ; Stish, Bradley J. ; Breen, William G. ; Waddle, Mark R.

Background : Patients with high-risk prostate cancer (HRPC) have multiple accepted treatment options. Because there is no overall survival benefit of one option over another, appropriate treatment must consider patient life expectancy, quality of life, and cost. Methods : The authors compared quality-adjusted life years (QALYs) and cost effectiveness among treatment options for HRPC using a Markov model with three treatment arms: (1) external-beam radiotherapy (EBRT) delivered with 20 [...]

Menée aux Etats-Unis par enquête auprès de 150 parents d'enfants atteints d'un cancer, cette étude analyse l'évolution de leurs relations avec les professionnels de santé (médecins oncologues, infirmières cliniciennes) durant la première année suivant le diagnostic

Change in the Parent-Clinician Relationship Throughout the First Year of Treatment in Pediatric Oncology

Mack, Jennifer W. ; Jaung, Tim ; Uno, Hajime ; Brackett, Julienne

Importance : Challenges in the therapeutic relationship between clinicians and parents of children with cancer have been shown to emerge immediately after diagnosis, but little is known about whether such relationships improve over time. Objective : To better understand the potential evolution of parent-clinician relationships over the first year after diagnosis of pediatric cancer. Design, Setting, and Participants :This survey study was conducted from November 2015 to September 2020 at [...]

Menée aux Pays-Bas à partir de données portant sur un total de 850 patients décédés d'un cancer de stade avancé entre 2014 et 2016, cette étude analyse l'effet, sur l'utilisation des outils de diagnostic, sur les traitements et sur les interventions médicales, de soins palliatifs standardisés durant les 3 derniers mois de vie

The effect of a palliative care pathway on medical interventions at the end of life: a pre-post-implementation study

van der Padt-Pruijsten, Annemieke ; Leys, Maria B. L. ; Hoop, Esther Oomen-de ; van der Heide, Agnes ; van der Rijt, Carin C. D.

Purpose : Adequate integration of palliative care in oncological care can improve the quality of life in patients with advanced cancer. Whether such integration affects the use of diagnostic procedures and medical interventions has not been studied extensively. We investigated the effect of the implementation of a standardized palliative care pathway in a hospital on the use of diagnostic procedures, anticancer treatment, and other medical interventions in patients with incurable cancer at the [...]