Nota Bene Cancer
Nota Bene Cancer est un bulletin hebdomadaire de veille bibliographique. En libre accès, Nota Bene Cancer permet à ses abonnés de gagner du temps pour se tenir informé de l’actualité scientifique et médicale dans les divers domaines de la recherche sur les cancers.
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Pour retrouver les publications signalées par Nota Bene Cancer (archives indexées à partir du n°127 du 1" mars 2012) :
Sommaire du n° 509 du 17 décembre 2021
Lutte contre les cancers
Qualité de vie, soins de support (3)
Mené sur 230 patientes ayant survécu à un cancer du sein ou à un cancer gynécologique, cet essai de phase II évalue l'efficacité du bupropion (un agent dopaminergique) pour améliorer le désir sexuel
Randomized Controlled Phase II Evaluation of Two Dose Levels of Bupropion Versus Placebo for Sexual Desire in Female Cancer Survivors: NRG-CC004
Mené sur 230 patientes ayant survécu à un cancer du sein ou à un cancer gynécologique, cet essai de phase II évalue l'efficacité du bupropion (un agent dopaminergique) pour améliorer le désir sexuel
Randomized Controlled Phase II Evaluation of Two Dose Levels of Bupropion Versus Placebo for Sexual Desire in Female Cancer Survivors: NRG-CC004
Debra L. Barton ; Stephanie L. Pugh ; Patricia A. Ganz ; Steven C. Plaxe ; Bridget F. Koontz ; Jeanne Carter ; Natalya Greyz-Yusupov ; Seth J. Page ; Kendrith M. Rowland Jr ; Ernie P. Balcueva ; Sobia Nabeel ; Jack B. Basil ; Matthew L. Hill ; Carolyn Y. Muller ; Maria C. Bell ; Snehal Deshmukh ; Lisa A. Kachnic
PURPOSE : Because of the negative impact of cancer treatment on female sexual function, effective treatments are warranted. The purpose of this multisite study was to evaluate the ability of two dose levels of extended-release bupropion, a dopaminergic agent, to improve sexual desire more than placebo at 9 weeks, measured by the desire subscale of the Female Sexual Function Index (FSFI), and to evaluate associated toxicities. METHODS : Postmenopausal women diagnosed with breast or gynecologic [...]
A Pill for Sexual Desire in Female Cancer Survivors: Too Good to Be True?
Mené sur 230 patientes ayant survécu à un cancer du sein ou à un cancer gynécologique, cet essai de phase II évalue l'efficacité du bupropion (un agent dopaminergique) pour améliorer le désir sexuel
A Pill for Sexual Desire in Female Cancer Survivors: Too Good to Be True?
Maryam B. Lustberg ; Charles L. Loprinzi ; Lauren Streicher
Cancer survivors often experience sexual dysfunction across multiple cancer types and stages of disease. Disruption of sexual function is often persistent during and after cancer therapies, affecting quality of life. Multiple studies have highlighted the diversity of ways that cancer treatment modalities can lead to sexual dysfunction. Despite a range of literature highlighting this pervasive treatment toxicity, interventions that effectively address this subject are limited and rarely used.
Mené sur 328 patients atteints d'un gliome de haut grade, cet essai de phase III évalue l'efficacité de l'armodafinil pour réduire une fatigue modérée à sévère liée à la maladie
Efficacy of Treatment With Armodafinil for Cancer-Related Fatigue in Patients With High-grade Glioma: A Phase 3 Randomized Clinical Trial
Mené sur 328 patients atteints d'un gliome de haut grade, cet essai de phase III évalue l'efficacité de l'armodafinil pour réduire une fatigue modérée à sévère liée à la maladie
Efficacy of Treatment With Armodafinil for Cancer-Related Fatigue in Patients With High-grade Glioma: A Phase 3 Randomized Clinical Trial
Porter, Alyx B. ; Liu, Heshan ; Kohli, Sadhna ; Cerhan, Jane L. ; Sloan, Jeff ; McMurray, Ryan P. ; Le-Rademacher, Jennifer ; Loprinzi, Charles L. ; Villano, John L. ; Kizilbash, Sani H. ; Mehta, Minesh P. ; Jaeckle, Kurt A. ; Brown, Paul D.
Importance : Nearly 96% of patients with high-grade glioma (HGG) report moderate-to-severe fatigue. Armodafinil is a psychostimulant that might help cancer-related fatigue in patients with HGG. Objective : To determine whether armodafinil reduces fatigue in patients with HGG and moderate-to-severe fatigue. Design, Setting, and Participants : In this randomized multicenter, phase 3, double-blinded, placebo-controlled clinical trial, adults with HGG and moderate-to-severe fatigue who were [...]
Mené sur 160 patients atteints d'un carcinome du rhinopharynx, cet essai randomisé évalue l'efficacité du thalidomide pour prévenir une mucite buccale pendant une chimioradiothérapie
Efficacy and safety of thalidomide in preventing oral mucositis in patients with nasopharyngeal carcinoma undergoing concurrent chemoradiotherapy:...
Mené sur 160 patients atteints d'un carcinome du rhinopharynx, cet essai randomisé évalue l'efficacité du thalidomide pour prévenir une mucite buccale pendant une chimioradiothérapie
Efficacy and safety of thalidomide in preventing oral mucositis in patients with nasopharyngeal carcinoma undergoing concurrent chemoradiotherapy: A multicenter, open-label, randomized controlled trial
Liang, Leifeng ; Liu, Zhibing ; Zhu, Haisheng ; Wang, Hongqian ; Wei, Yan ; Ning, Xuejian ; Shi, Zhiling ; Jiang, Liujun ; Lin, Zhan ; Yan, Haolin ; Wang, Rensheng ; Hu, Kai
Background : This multicenter clinical trial was designed to evaluate the efficacy and safety of thalidomide (THD) in preventing oral mucositis (OM) in patients with nasopharyngeal carcinoma (NPC) undergoing concurrent chemoradiotherapy (CCRT). Methods : Patients with locally advanced NPC were randomly assigned to either a THD group or a control group. All 160 patients received radical intensity-modulated radiotherapy plus cisplatin-based concurrent chemotherapy and basic oral hygiene guidance. [...]
Observation (5)
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Increased risk of COVID-19-related admissions in patients with active solid organ cancer in the West Midlands region of the UK: a retrospective coh...
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Increased risk of COVID-19-related admissions in patients with active solid organ cancer in the West Midlands region of the UK: a retrospective cohort study
Akingboye, Akinfemi ; Mahmood, Fahad ; Amiruddin, Nabeel ; Reay, Michael ; Nightingale, Peter ; Ogunwobi, Olorunseun O
Objective: Susceptibility of patients with cancer to COVID-19 pneumonitis has been variable. We aim to quantify the risk of hospitalisation in patients with active cancer and use a machine learning algorithm (MLA) and traditional statistics to predict clinical outcomes and mortality. Design: Retrospective cohort study. Setting: A single UK district general hospital. Participants: Data on total hospital admissions between March 2018 and June 2020, all active cancer diagnoses between March 2019 [...]
Third dose of anti-SARS-CoV-2 vaccine for patients with cancer: Should humoral responses be monitored? A position paper
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Third dose of anti-SARS-CoV-2 vaccine for patients with cancer: Should humoral responses be monitored? A position paper
Barrière, J. ; Carles, M. ; Audigier-Valette, C. ; Ré, D. ; Zoubir, A. ; Seitz-Polski, B. ; Gounant, V. ; Descamps, D. ; Zalcman, G.
Taking into account higher risk of severe coronavirus disease 2019 (COVID-19) or death among patients with cancer, as well as impaired immunogenicity following anti-SARS-CoV-2 vaccines, in addition to waning immunity, booster dosing appears mandatory in this patient population. This review sought to provide reasonable evidence so as to assist oncologists in their daily practice, helping them decide when an anti-SARS-Cov2 antibodies (Abs) dosage should be scheduled following a full two-dose [...]
Six-months immunogenicity of COVID-19 mRNA-BNT162b2 vaccine in actively treated cancer patients: Updated results of the Vax-On study
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Six-months immunogenicity of COVID-19 mRNA-BNT162b2 vaccine in actively treated cancer patients: Updated results of the Vax-On study
Nelli, F. ; Fabbri, A. ; Onorato, A. ; Giannarelli, D. ; Silvestri, M. A. ; Pessina, G. ; Berrios, J. R. Giron ; Virtuoso, A. ; Marrucci, E. ; Schirripa, M. ; Mazzotta, M. ; Panichi, V. ; Cercola, P. ; Signorelli, C. ; Chilelli, M. G. ; Primi, F. ; Ruggeri, E. M.
The prospective Vax-On study was conducted at our institution as part of introducing SARS-CoV-2 mRNA-BNT162b2 (tozinameran) vaccination in actively treated cancer patients. Our preliminary findings confirmed a favorable safety profile and suggested that proximity to treatment hampers immune response to the first vaccine dose (timepoint-2). The second dose induced an exponential rise in anti-Spike protein IgG titer and seroconversion rates up to >90%, abrogating the disparity between the cohorts [...]
Impact of the COVID-19 Pandemic on Treatment Patterns for Patients with Metastatic Solid Cancer in the United States
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Impact of the COVID-19 Pandemic on Treatment Patterns for Patients with Metastatic Solid Cancer in the United States
Parikh, Ravi B ; Takvorian, Samuel U ; Vader, Daniel ; Wileyto, E Paul ; Clark, Amy S ; Lee, Daniel J ; Goyal, Gaurav ; Rocque, Gabrielle B ; Dotan, Efrat ; Geynisman, Daniel M ; Phull, Pooja ; Spiess, Philippe E ; Kim, Roger Y ; Davidoff, Amy J ; Gross, Cary P ; Neparidze, Natalia ; Miksad, Rebecca A ; Calip, Gregory S ; Hearn, Caleb M ; Ferrell, Will ; Shulman, Lawrence N ; Mamtani, Ronac ; Hubbard, Rebecca A ; for the PRACTICE Investigators
Background : The COVID-19 pandemic has led to delays in patients seeking care for life-threatening conditions; however, its impact on treatment patterns for patients with metastatic cancer is unknown. We assessed the COVID-19 pandemic’s impact on time to treatment initiation and treatment selection for patients newly diagnosed with metastatic solid cancer. Methods : We used an electronic health record-derived longitudinal database curated via technology-enabled abstraction to identify 14,136 US [...]
Study of the Veterans Affairs Health Care System highlights the impact of COVID-19 on cancer diagnoses in the USA
Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19
Study of the Veterans Affairs Health Care System highlights the impact of COVID-19 on cancer diagnoses in the USA
Parker, Stephanie
As health-care professionals and researchers worldwide continue to warn of the complications of COVID-19 on cancer, a new US-based study has now further highlighted the link between the pandemic and worsening cancer care. The time-frame study published on Dec 6, 2021, included the pre-pandemic phase and the primary surge of COVID-19 infections. The USA was hit hard by the pandemic: thousands of hospitals, medical institutions, and health-care services came to a halt in March, 2020, and [...]
Menée aux Etats-Unis, cette étude analyse l'évolution, sur la période 1970-2019, de la diversité ethnique et de la mixité dans les universités de médecine (étudiants, stagiaires, professeurs et directeurs), en oncologie médicale et en radio-oncologie
Diversity Trends by Sex and Underrepresented in Medicine Status Among US Radiation and Medical Oncology Faculty Over 5 Decades
Menée aux Etats-Unis, cette étude analyse l'évolution, sur la période 1970-2019, de la diversité ethnique et de la mixité dans les universités de médecine (étudiants, stagiaires, professeurs et directeurs), en oncologie médicale et en radio-oncologie
Diversity Trends by Sex and Underrepresented in Medicine Status Among US Radiation and Medical Oncology Faculty Over 5 Decades
Kamran, Sophia C. ; Niemierko, Andrzej ; Deville, Curtiland, Jr ; Vapiwala, Neha
Importance : It remains unclear how the historical exclusion of women and racial and ethnic minority groups from medical training, and therefore the oncologic subspecialties, has contributed to rates of faculty diversity among oncology departments over time. Oncologic faculty diversity is an important initiative to help improve care and address health disparities for an increasingly diverse US population with cancer. Objectives :To report trends in academic faculty representation by sex and by [...]
Solving the Equation of Structural Inequities in the Oncology Workforce
Menée aux Etats-Unis, cette étude analyse l'évolution, sur la période 1970-2019, de la diversité ethnique et de la mixité dans les universités de médecine (étudiants, stagiaires, professeurs et directeurs), en oncologie médicale et en radio-oncologie
Solving the Equation of Structural Inequities in the Oncology Workforce
Lansigan, Frederick ; Thomas, Charles R., Jr
In a comprehensive analysis of the radiation oncology (RO) and medical oncology (MO) workforce with an emphasis on women and races and ethnicities underrepresented in medicine (URM; defined as Black, Hispanic, and Indigenous individuals), Kamran and colleagues have carefully dissected important trends over the last 50 years. They have analyzed the pipeline starting from medical school applications and matriculation, to RO and internal medicine residency and MO fellowship, to arrive at the [...]
Menée à partir des données des registres américains des cancers portant sur 138 969 patients ayant survécu à un cancer du poumon, cette étude analyse l'impact d'un second cancer primitif du poumon sur la survie globale, en fonction du stade au diagnostic et du statut tabagique
The Survival Impact of Second Primary Lung Cancer in Patients with Lung Cancer
Menée à partir des données des registres américains des cancers portant sur 138 969 patients ayant survécu à un cancer du poumon, cette étude analyse l'impact d'un second cancer primitif du poumon sur la survie globale, en fonction du stade au diagnostic et du statut tabagique
The Survival Impact of Second Primary Lung Cancer in Patients with Lung Cancer
Choi, Eunji ; Luo, Sophia J ; Aredo, Jacqueline V ; Backhus, Leah M ; Wilkens, Lynne R ; Su, Chloe C ; Neal, Joel W ; Le Marchand, Loic ; Cheng, Iona ; Wakelee, Heather A ; Han, Summer S
Background : Lung cancer survivors have a high risk of developing second primary lung cancer (SPLC), but little is known about the survival impact of SPLC diagnosis. Methods : We analyzed data from 138,969 patients in the Surveillance, Epidemiology, and End Results (SEER), who were surgically treated for initial primary lung cancer (IPLC) in 1988–2013. Each patient was followed from the date of IPLC diagnosis to SPLC diagnosis (for those with SPLC) and last vital status through 2016. We [...]
Menée à partir de données portant sur 4 610 patientes présentant un risque familial élevé de cancer (antécédents familiaux de cancer, présence de mutations au niveau des gènes BRCA) et atteintes d'un premier cancer invasif du sein diagnostiqué entre 1993 et 2011, cette étude analyse l'association entre la pratique d'une activité physique de loisir et la mortalité toutes causes confondues ainsi que le risque de nouveau cancer ou de récidive (1 212 décès ; 473 seconds cancers ou récidive)
Recreational Physical Activity and Outcomes after Breast Cancer in Women at High Familial Risk
Menée à partir de données portant sur 4 610 patientes présentant un risque familial élevé de cancer (antécédents familiaux de cancer, présence de mutations au niveau des gènes BRCA) et atteintes d'un premier cancer invasif du sein diagnostiqué entre 1993 et 2011, cette étude analyse l'association entre la pratique d'une activité physique de loisir et la mortalité toutes causes confondues ainsi que le risque de nouveau cancer ou de récidive (1 212 décès ; 473 seconds cancers ou récidive)
Recreational Physical Activity and Outcomes after Breast Cancer in Women at High Familial Risk
Kehm, Rebecca D ; MacInnis, Robert J ; John, Esther M ; Liao, Yuyan ; Kurian, Allison W ; Genkinger, Jeanine M ; Knight, Julia A ; Colonna, Sarah V ; Chung, Wendy K ; Milne, Roger ; Zeinomar, Nur ; Dite, Gillian S ; Southey, Melissa C ; Giles, Graham G ; McLachlan, Sue-Anne ; Whitaker, Kristen D ; Friedlander, Michael L ; Weideman, Prue C ; Glendon, Gord ; Nesci, Stephanie ; kConFab Investigators ; Phillips, Kelly-Anne ; Andrulis, Irene L ; Buys, Saundra S ; Daly, Mary B ; Hopper, John L ; Terry, Mary Beth
Background : Recreational physical activity (RPA) is associated with improved survival after breast cancer (BC) in average-risk women, but evidence is limited for women who are at increased familial risk because of a BC family history or BRCA1 and BRCA2 pathogenic variants (BRCA1/2 PVs). Methods : We estimated associations of RPA (self-reported average hours-per-week within 3 years of BC diagnosis) with all-cause mortality and second BC events (recurrence or new primary) after first invasive BC [...]
Menée en France à partir des données des registres du réseau FRANCIM, cette étude compare l'évolution, sur la période 1990-2018, de l'incidence du cancer de la langue et des autres cancers de la tête et du cou chez les jeunes adultes
Diverging incidence trends of oral tongue cancer compared with other head and neck cancers in young adults in France
Menée en France à partir des données des registres du réseau FRANCIM, cette étude compare l'évolution, sur la période 1990-2018, de l'incidence du cancer de la langue et des autres cancers de la tête et du cou chez les jeunes adultes
Diverging incidence trends of oral tongue cancer compared with other head and neck cancers in young adults in France
Deneuve, Sophie ; Pérol, Olivia ; Dantony, Emmanuelle ; Guizard, Anne-Valérie ; Bossard, Nadine ; Virard, François ; Fervers, Beatrice ; the FRANCIM Network
Abstract While head and neck cancer (HNC) incidence decreased worldwide due to reduced tobacco and alcohol consumption, oral tongue cancer (OTC) incidence has been reported to be increasing in several countries. This study examines the incidence trends of OTC in France from 1990 to 2018, globally and by age; and compares the incidence trends with the evolution of the incidence of other HPV-unrelated HNSCC, i.e. cancers of the remaining subsites of the oral cavity (RSOCC) and laryngeal cancers [...]
Approches psycho-sociales (1)
Menée en Allemagne à partir de données portant sur 879 patients atteints d'un cancer et hospitalisés, cette étude transversale analyse les facteurs sociodémographiques, cliniques et psychosociaux associés à la présence d'une détresse
Distress in hospitalized cancer patients: Associations with personality traits, clinical and psychosocial characteristics
Menée en Allemagne à partir de données portant sur 879 patients atteints d'un cancer et hospitalisés, cette étude transversale analyse les facteurs sociodémographiques, cliniques et psychosociaux associés à la présence d'une détresse
Distress in hospitalized cancer patients: Associations with personality traits, clinical and psychosocial characteristics
Pichler, Theresia ; Marten-Mittag, Birgitt ; Hermelink, Kerstin ; Telzerow, Eva ; Frank, Tamara ; Ackermann, Ulrike ; Belka, Claus ; Combs, Stephanie E. ; Gratzke, Christian ; Gschwend, Jurgen ; Harbeck, Nadia ; Heinemann, Volker ; Herkommer, Kathleen ; Kiechle, Marion ; Mahner, Sven ; Pigorsch, Steffi ; Rauch, Josefine ; Stief, Christian ; Mumm, Friederike ; Heußner, Pia ; Herschbach, Peter ; Dinkel, Andreas
Objective : To improve allocation of psychosocial care and to provide patient-oriented support offers, identification of determinants of elevated distress is needed. So far, there is a lack of evidence investigating the interplay between individual disposition and current clinical and psychosocial determinants of distress in the inpatient setting. Methods : In this cross-sectional study, we investigated 879 inpatients with different cancer sites treated in a German Comprehensive Cancer Center. [...]
