Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Cancer Screening Tests and Cancer Diagnoses During the COVID-19 Pandemic

Bakouny, Ziad ; Paciotti, Marco ; Schmidt, Andrew L. ; Lipsitz, Stuart R. ; Choueiri, Toni K. ; Trinh, Quoc-Dien

Oncology patient care may be disrupted secondary to coronavirus disease 2019 (COVID-19) through delays in diagnostic investigations and surgical procedures, as well as delayed cancer diagnoses because of reduced cancer screening. This study assesses the number of patients undergoing cancer screening tests and of ensuing cancer diagnoses during the COVID-19 pandemic in the largest health care system in the northeastern United States, Massachusetts General Brigham. Methods : This study comprised [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

High mortality rate in COVID-19 patients with myeloproliferative neoplasms after abrupt withdrawal of ruxolitinib

Barbui, Tiziano ; Vannucchi, Alessandro Maria ; Alvarez-Larran, Alberto ; Iurlo, Alessandra ; Masciulli, Arianna ; Carobbio, Alessandra ; Ghirardi, Arianna ; Ferrari, Alberto ; Rossi, Giuseppe ; Elli, Elena ; Andrade-Campos, Marcio Miguel ; Kabat, Mercedes Gasior ; Kiladjian, Jean-Jaques ; Palandri, Francesca ; Benevolo, Giulia ; Garcia-Gutierrez, Valentin ; Fox, Maria Laura ; Foncillas, Maria Angeles ; Morcillo, Carmen Montoya ; Rumi, Elisa ; Osorio, Santiago ; Papadopoulos, Petros ; Bonifacio, Massimiliano ; Cervantes, Keina Susana Quiroz ; Serrano, Miguel Sagues ; Carreno-Tarragona, Gonzalo ; Sobas, Marta Anna ; Lunghi, Francesca ; Patriarca, Andrea ; Elorza, Begona Navas ; Angona, Anna ; Mazo, Elena Magro ; Koschmieder, Steffen ; Ruggeri, Marco ; Cuevas, Beatriz ; Hernandez-Boluda, Juan Carlos ; Abadia, Emma Lopez ; Cirici, Blanca Xicoy ; Guglielmelli, Paola ; Garrote, Marta ; Cattaneo, Daniele ; Daffini, Rosa ; Cavalca, Fabrizio ; Bellosillo, Beatriz ; Benajiba, Lina ; Curto-Garcia, Natalia ; Bellini, Marta ; Betti, Silvia ; De Stefano, Valerio ; Harrison, Claire ; Rambaldi, Alessandro

We report the clinical presentation and risk factors for survival in 175 patients with myeloproliferative neoplasms (MPN) and COVID-19, diagnosed between February and June 2020. After a median follow-up of 50 days, mortality was higher than in the general population and reached 48% in myelofibrosis (MF). Univariate analysis, showed a significant relationship between death and age, male gender, decreased lymphocyte counts, need for respiratory support, comorbidities and diagnosis of MF, while no [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Implementation and Outcomes of Virtual Care Across a Tertiary Cancer Center During COVID-19

Berlin, Alejandro ; Lovas, Mike ; Truong, Tran ; Melwani, Sheena ; Liu, Justin ; Liu, Zhihui Amy ; Badzynski, Adam ; Carpenter, Mary Beth ; Virtanen, Carl ; Morley, Lyndon ; Bhattacharyya, Onil ; Escaf, Marnie ; Moody, Lesley ; Goldfarb, Avi ; Brzozowski, Luke ; Cafazzo, Joseph ; Chua, Melvin L. K. ; Stewart, A. Keith ; Krzyzanowska, Monika K.

Importance : The coronavirus disease 2019 (COVID-19) pandemic has burdened health care resources and disrupted care of patients with cancer. Virtual care (VC) represents a potential solution. However, few quantitative data support its rapid implementation and positive associations with service capacity and quality. Objective : To examine the outcomes of a cancer center–wide virtual care program in response to the COVID-19 pandemic. Design, Setting, and Participants : This cohort study applied a [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Sex bias of females in survival from cancer and infections. Is X the answer?

Emran, Abdullah Al ; Gallagher, Stuart J. ; Tiffen, Jessamy C. ; Hersey, Peter

Major differences in survival of men and women from infectious diseases and cancers have been highlighted by death rates from COVID-19 infections. In cancer, attention has been focussed on differences in gene expression from X chromosomes in men and women with a preponderance of genes involved in immune responses being expressed in women. Important findings have been that some of the genes are important epigenetic regulators that play fundamental roles in immune responses. One of the striking [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Nurse navigators’ telemonitoring for cancer patients with COVID-19: a French case study

Ferrua, Marie ; Mathivon, Delphine ; Duflot-Boukobza, Adeline ; Abbas, May ; Charles, Cécile ; Barrais, Amandine ; Legendre, Jennifer ; Mendes, Christine ; Pons, Magali ; Merad, Mansouria ; Minvielle, Etienne ; Mir, Olivier ; Scotté, Florian

Purpose : The Gustave Roussy Cancer Institute implemented a patient-reported outcome platform (CAPRI-COVID) for cancer patients with coronavirus disease 2019 (COVID-19) to quarantine patients at home while ensuring monitoring of COVID-related symptoms and securing the care pathway. In this study, we described the CAPRI-COVID intervention, evaluated its use, and presented results of the tracking indicators with a focus on the nurse navigators’ (NNs) activities and the experience of patients. [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

A rationale to prioritise vaccination of HSCT patients against COVID-19

Leclerc, Mathieu ; Maury, Sebastien

Patients who are frail or have significant comorbidities are especially susceptible to severe acute respiratory syndrome coronavirus 2 infection, and are more likely to develop severe disease, with a higher risk of death than in the general population. This increased risk is notably true for patients with cancer, including those with haematological malignancies. When such patients receive a haematopoietic stem-cell transplantation (HSCT), either allogeneic or autologous, it is possible that [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Impact of the COVID-19 pandemic on the detection and management of colorectal cancer in England: a population-based study

Morris, Eva J. A. ; Goldacre, Raphael ; Spata, Enti ; Mafham, Marion ; Finan, Paul J. ; Shelton, Jon ; Richards, Mike ; Spencer, Katie ; Emberson, Jonathan ; Hollings, Sam ; Curnow, Paula ; Gair, Dominic ; Sebag-Montefiore, David ; Cunningham, Chris ; Rutter, Matthew D. ; Nicholson, Brian D. ; Rashbass, Jem ; Landray, Martin ; Collins, Rory ; Casadei, Barbara ; Baigent, Colin

Background : There are concerns that the COVID-19 pandemic has had a negative effect on cancer care but there is little direct evidence to quantify any effect. This study aims to investigate the impact of the COVID-19 pandemic on the detection and management of colorectal cancer in England. Methods : Data were extracted from four population-based datasets spanning NHS England (the National Cancer Cancer Waiting Time Monitoring, Monthly Diagnostic, Secondary Uses Service Admitted Patient Care [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Rapid implementation of telemedicine during the COVID-19 pandemic: Cancer patients' perspectives and preferences

Peleg Hasson, Shira ; Waissengrin, Barliz ; Shachar, Eliya ; Hodruj, Marah ; Fayngor, Rochelle ; Brezis, Mirika ; Nikolaevski-Berlin, Alla ; Pelles, Sharon ; Safra, Tamar ; Geva, Ravit ; Wolf, Ido

INTRODUCTION : The use of telemedicine in oncology practice is rapidly expanding and is considered safe and cost effective. However, the implications of telemedicine on patient‐physician interaction, patients' satisfaction and absence of personal touch have not been studied to date. Following the spread of COVID‐19, telemedicine services were rapidly incorporated at the oncology division of Tel Aviv Medical Center (TLVMC). We aimed to evaluate patients' perspectives and preferences regarding [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study

Sharma, Akshay ; Bhatt, Neel S. ; St Martin, Andrew ; Abid, Muhammad Bilal ; Bloomquist, Jenni ; Chemaly, Roy F. ; Dandoy, Christopher ; Gauthier, Jordan ; Gowda, Lohith ; Perales, Miguel-Angel ; Seropian, Stuart ; Shaw, Bronwen E. ; Tuschl, Eileen E. ; Zeidan, Amer M. ; Riches, Marcie L. ; Shah, Gunjan L.

Background : Haematopoietic stem-cell transplantation (HSCT) recipients are considered at high risk of poor outcomes after COVID-19 on the basis of their immunosuppressed status, but data from large studies in HSCT recipients are lacking. This study describes the characteristics and outcomes of HSCT recipients after developing COVID-19. Methods : In response to the pandemic, the Center for International Blood and Marrow Transplant Research (CIBMTR) implemented a special form for [...]

Ce dossier présente un ensemble d'articles concernant la prise en charge des cancers durant la crise sanitaire liée au COVID-19

Effect of COVID-19 on colorectal cancer care in England

Turnbull, Clare

During the rise of the COVID-19 pandemic in spring, 2020, unprecedented pressure on hospital beds and intensive care units (ICUs), redeployment of staff, caution regarding nosocomial transmission, reduced primary care access, and population lockdown combined in a perfect storm, dramatically disrupting UK cancer care pathways.1 It was predicted that colorectal cancer care might fare particularly badly, in particular due to suspension of non-emergency diagnostic endoscopy following safety [...]

Menée à partir de données d'incidence de 49 pays et de mortalité de 27 pays, cette étude analyse les facteurs associés à l'évolution, sur la période 1998-2012, de l'incidence du cancer de la thyroïde chez les enfants et adolescents (âge : inférieur ou égal à 19 ans) ainsi que la mortalité spécifique

Global patterns and trends in incidence and mortality of thyroid cancer in children and adolescents: a population-based study

Vaccarella, Salvatore ; Lortet-Tieulent, Joannie ; Colombet, Murielle ; Davies, Louise ; Stiller, Charles A. ; Schüz, Joachim ; Togawa, Kayo ; Bray, Freddie ; Franceschi, Silvia ; Dal Maso, Luigino ; Steliarova-Foucher, Eva

Background : There has been a considerable increase in thyroid cancer incidence among adults inseveral countries in the past three decades, attributed primarily to overdiagnosis. We aimed to assess global patterns and trends in incidence and mortality of thyroid cancer in children and adolescents, in view of the increased incidence among adults. Methods : We did a population-based study of the observed incidence (in 49 countries and territories)and mortality (in 27 countries) of thyroid cancer [...]

Menée à partir de données d'incidence de 49 pays et de mortalité de 27 pays, cette étude analyse les facteurs associés à l'évolution, sur la période 1998-2012, de l'incidence du cancer de la thyroïde chez les enfants et adolescents (âge : inférieur ou égal à 19 ans) ainsi que la mortalité spécifique

Thyroid cancer incidence in children and adolescents

Lamartina, Livia ; Leboulleux, Sophie ; Schlumberger, Martin

Clinically detected thyroid cancer is rare in children, with one to three cases per1 million children per year. The disease—a papillary carcinoma in most cases—is frequentlymore extensive at diagnosis in children than in adults, particularly in children agedyounger than 10 years who often have large thyroid tumours with lymph node and lungmetastases. The overall prognosis is favourable even in cases of metastatic disease, but thetreatment burden can be substantial, and thyroid cancer related [...]

Menée aux Etats-Unis sur la période 1999-2018, cette étude analyse les facteurs associés à l'évolution du taux de suicide chez les patients atteints d'un cancer

Trends of Cancer-Related Suicide in the United States: 1999-2018

Han, Xuesong ; Hu, Xin ; Zhao, Jingxuan ; Ma, Jiemin ; Jemal, Ahmedin ; Yabroff, K Robin

The suicide rate has steadily increased in the United States during the past 2 decades. Cancer patients have elevated suicide risk because of prevalent psychological distress, treatment side effects, and potentially uncontrolled pain. Efforts to promote psychosocial and palliative care may reduce this risk. Using the 1999-2018 Multiple Cause of Death database, we found a decreasing trend of cancer-related suicide during the past 2 decades with an average annual percentage change (AAPC) of [...]

Menée aux Etats-Unis sur la période 1999-2018, cette étude analyse les facteurs associés à l'évolution du taux de suicide chez les patients atteints d'un cancer

Optimizing Patient-Centered Psychosocial Care to Reduce Suicide Risk and Enhance Survivorship Outcomes Among Cancer Patients

Gage-Bouchard, Elizabeth A ; Pailler, Megan ; Devine, Katie A ; Flores, Tessa

In recent decades, substantial advances in cancer treatment and early detection have resulted in enhanced survival among cancer patients. Such advances have elevated the importance of understanding and addressing patient-centered needs related to physical, psychological, and social well-being In this issue of the Journal, Han et al. analyzed data from the Multiple Causes of Death database to examine trends in cancer-related suicide from 1999 to 2018. They found that in contrast to rising rates [...]

Mené dans un contexte américain, cette étude analyse le rapport coût-efficacité du pembrolizumab en traitement de deuxième ligne chez des patients atteints d'un carcinome hépatocellulaire

Cost-effectiveness of Pembrolizumab as a Second-Line Therapy for Hepatocellular Carcinoma

Chiang, Chi-leung ; Chan, Sik-Kwan ; Lee, Shing-fung ; Wong, Irene Oi-ling ; Choi, Horace Cheuk-wai

Importance : Immune checkpoint inhibitors have been approved for use as a second-line therapy for hepatocellular carcinoma (HCC) in patients who previously received sorafenib. Pembrolizumab has shown substantial antitumor activity and a favorable toxicity profile as a second-line treatment of HCC. However, considering the high cost of pembrolizumab, there is a need to assess its value by considering both the clinical efficacy and cost. Objective : To evaluate the cost-effectiveness of [...]

Mené dans un contexte américain, cette étude analyse le rapport coût-efficacité du pembrolizumab en traitement de deuxième ligne chez des patients atteints d'un carcinome hépatocellulaire

Challenges in Assessing the Cost-effectiveness of Cancer Immunotherapy

Green, Angela K.

Chiang et al examine the cost-effectiveness of pembrolizumab for the second-line treatment of patients with advanced hepatocellular carcinoma previously treated with sorafenib, on the basis of the results of the pivotal phase 3 trial KEYNOTE-240. The study finds that pembrolizumab for this indication is not cost-effective at the reference willingness-to-pay threshold in the US of $150 000 per quality-adjusted life-year. This result was consistent even in the optimistic setting, which assumed [...]