A partir d'une revue systématique de la littérature publiée jusqu'en novembre 2018 (16 études), cette méta-analyse évalue l'association entre un lieu de résidence à proximité d'une industrie pétrochimique et le risque de cancer hématologique

A systematic review and meta-analysis of haematological malignancies in residents living near petrochemical facilities

Jephcote, Calvin ; Brown, David ; Verbeek, Thomas ; Mah, Alice

Background: The petrochemical industry is a major source of hazardous and toxic air pollutants that are recognised to have mutagenic and carcinogenic properties. A wealth of occupational epidemiology literature exists around the petrochemical industry, with adverse haematological effects identified in employees exposed to ‘low’ concentrations of aromatic hydrocarbons (benzene, toluene, ethylbenzene, and xylene). Releases from the petrochemical industry are also thought to increase the risk of [...]

A partir d'une revue systématique de la littérature publiée jusqu'en avril 2020 (27 articles), cette étude analyse l'association entre une exposition aux pesticides organophosphorés et le risque de cancer du sein

Organophosphate Pesticide Exposure and Breast Cancer Risk: A Rapid Review of Human, Animal, and Cell-Based Studies

Yang, Kailynn June ; Lee, Jennifer ; Park, Hannah Lui

Background: Organophosphate pesticides (OPs) are one of the most commonly used classes of insecticides in the U.S., and metabolites of OPs have been detected in the urine of >75% of the U.S. population. While studies have shown that OP exposure is associated with risk of neurological diseases and some cancers, the relationship between OP exposure and breast cancer risk is not well understood. Methods: The aim of this rapid review was to systematically evaluate published literature on the [...]

Menée au Danemark à partir de données de registres portant sur 21 057 patients atteints d'une tumeur intracrânienne (cerveau, méninges, nerfs crâniens) diagnostiquée entre 1989 et 2014 (âge : au moins 20 ans), cette étude analyse l'association entre une exposition à certains polluants atmosphériques et le risque de développer la maladie

Intracranial tumors of the central nervous system and air pollution – a nationwide case-control study from Denmark

Poulsen, Aslak Harbo ; Hvidtfeldt, Ulla Arthur ; Sørensen, Mette ; Puett, Robin ; Ketzel, Matthias ; Brandt, Jørgen ; Geels, Camilla ; Christensen, Jesper H. ; Raaschou-Nielsen, Ole

Background: Inconclusive evidence has suggested a possible link between air pollution and central nervous system (CNS) tumors. We investigated a range of air pollutants in relation to types of CNS tumors. Methods: We identified all (n = 21,057) intracranial tumors in brain, meninges and cranial nerves diagnosed in Denmark between 1989 and 2014 and matched controls on age, sex and year of birth. We established personal 10-year mean residential outdoor exposure to particulate matter < 2.5   [...]

A partir d'une revue systématique de la littérature publiée entre 1980 et 2020, cette étude analyse l'association entre une infection par le papillomavirus humain et le risque de cancer de la prostate

Evidence for a causal role by human papillomaviruses in prostate cancer – a systematic review

Lawson, James S. ; Glenn, Wendy K.

It is hypothesised that high risk for cancer human papillomaviruses (HPVs) have a causal role in prostate cancer. In 26 case control studies, high risk HPVs have been identified in benign and prostate cancers. High risk HPVs were identified in 325 (22.6%) of 1284 prostate cancers and in 113 (8.6%) of 1313 normal or benign prostate controls (p = 0.001). High risk HPVs of the same type have been identified in both normal and benign prostate tissues prior to the development of HPV positive [...]

Menée au Japon à l'aide de données 1988-2009 portant sur 19 041 femmes exerçant une activité professionnelle (âge : 40-79 ans ; durée médiane de suivi : 13,3 ans), cette étude analyse l'association entre le type d'emploi (manuel ou de bureau), l'activité physique liée à cet emploi (en mouvement, principalement debout ou principalement assis) et le risque de cancer du sein (138 cas)

Association of job category and occupational activity with breast cancer incidence in Japanese female workers: the JACC study

Sari, Gita Nirmala ; Eshak, Ehab Salah ; Shirai, Kokoro ; Fujino, Yoshihisa ; Tamakoshi, Akiko ; Iso, Hiroyasu

Background: Breast cancer represented the leading cause of cancer deaths among women in Japan. Although physical activity has been reported protective against breast cancer, scientific evidence is limited on the risk of breast cancer according to job category or occupational activity in Japanese. Our objective was to examine the association of job category and occupational activity with breast cancer incidence in Japanese female workers using the data from the Japan Collaborative Cohort (JACC) [...]

Menée en Chine entre 2013 et 2015 auprès de 434 patientes atteintes d'un cancer du sein et de 700 témoins (âge médian : 52 ans), cette étude analyse l'association entre 3 polymorphismes à simple nucléotide du gène MEG3 (rs3087918, rs7158663, rs11160608) et le risque de développer la maladie

LncRNA MEG3 rs3087918 was associated with a decreased breast cancer risk in a Chinese population: a case-control study

Zheng, Yi ; Wang, Meng ; Wang, Shuqian ; Xu, Peng ; Deng, Yujiao ; Lin, Shuai ; Li, Na ; Liu, Kang ; Zhu, Yuyao ; Zhai, Zhen ; Wu, Ying ; Dai, Zhijun ; Zhu, Gaixia

Background: LncRNA MEG3 expressed abnormally in various cancers including breast cancer, but no studies reported the correlation between MEG3 SNPs and breast cancer susceptibility among Chinese women. Methods: This study is aimed to explore the association between three SNPs of MEG3 (rs3087918, rs7158663, rs11160608) and breast cancer. The study is a population-based case-control study including 434 breast cancer patients and 700 healthy controls. Genotyping was performed using Sequenom [...]

Cette étude présente une mise à jour du modèle conceptuel (Paradigm) illustrant les facteurs étiologiques connus du cancer du sein (biologiques, comportementaux, environnementaux et sociaux) et les axes de recherche

A Complex Systems Model of Breast Cancer Etiology: The Paradigm II Conceptual Model

Hiatt, Robert A. ; Engmann, Natalie J. ; Balke, Kaya ; Rehkopf, David H.

Background: The etiology of breast cancer is a complex system of interacting factors from multiple domains. New knowledge about breast cancer etiology continues to be produced by the research community, and the communication of this knowledge to other researchers, practitioners, decision makers, and the public is a challenge. Methods: We updated the previously published Paradigm model (PMID: 25017248) to create a framework that describes breast cancer etiology in four overlapping domains of [...]