Menée en Italie par enquête en ligne auprès d'oncologues et de médecins travaillant notamment dans des unités de soins palliatifs (112 répondants), cette étude analyse leurs pratiques de prescription d'antiémétiques pour prévenir les nausées et vomissements induits par les opioïdes

Prophylactic use of antiemetics for prevention of opioid-induced nausea and vomiting: a survey about Italian physicians’ practice

Giusti, Raffaele ; Mazzotta, Marco ; Filetti, Marco ; Daniele, Gennaro ; Tsukuura, Hiroaki ; Ficorella, Corrado ; Porzio, Giampiero ; Marchetti, Paolo ; Verna, Lucilla

Purpose : Antiemetics are being used both for the treatment and prophylaxis of opioid-induced nausea and vomiting (OINV) in clinical practice, despite the lack of evidence for the prophylactic benefit. Studies among Japanese physicians demonstrated over 80% prescribe antiemetics, with neuroleptic antipsychotics as the most commonly prescribed drugs. Our objective was to elucidate the current scenario of the prophylactic use of antiemetics for OINV among Italian physicians. Methods : We [...]

A partir d'une revue de la littérature, cette étude analyse l'intérêt d'interventions nutritionnelles pour traiter une fatigue liée à la maladie chez les patients atteints de cancer

Nutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review

Lin, Po-Ju ; Kerns, Sarah L. ; Kleckner, Ian R. ; Kleckner, Amber S. ; Castillo, Daniel A. ; Mustian, Karen M. ; Peppone, Luke J.

Cancer-related fatigue (CRF) is a debilitating syndrome that persists for many cancer survivors for years after treatment. Symptoms include early and persistent fatigue, functional decline, depression, and cognitive difficulties. Inflammation, assessed using pro-inflammatory biomarkers, is increased in cancer survivors with fatigue and treatments for fatigue are often aimed at reducing inflammation. Additionally, cancer and its treatment lead to nutritional complications, changes in body [...]

Menée en Allemagne auprès de 948 patients ayant survécu à un cancer, cette étude longitudinale identifie les facteurs associés au risque de fatigue, 6 mois après la sortie d'un centre de soins de réadaptation

Predictors of fatigue in cancer patients: a longitudinal study

Susanne, Kuhnt ; Michael, Friedrich ; Thomas, Schulte ; Peter, Esser ; Andreas, Hinz

Introduction : Having a better understanding of predictors of cancer-related fatigue makes it easier to early identify patients at risk of suffering from long-term fatigue. The aim of this longitudinal study was to identify factors that predict long-term fatigue 6 months after discharge from a rehabilitation clinic using a multidimensional conceptualization. Method : A mixed sample of cancer survivors (N = 948) were recruited while in-patient at a rehabilitation clinic. The follow-up survey was [...]

Menée à Taïwan auprès de 30 patients atteints d'un cancer de stade avancé, cette étude analyse l'efficacité d'une intervention d'acupression pour soulager la constipation

Effect of acupressure on constipation in patients with advanced cancer

Wang, Pei-Ming ; Hsu, Ching-Wen ; Liu, Chun-Ting ; Lai, Ting-Yu ; Tzeng, Fe-Ling ; Huang, Chih-Fang

Purpose : Constipation is a common and distressing symptom for patients with advanced cancer. Few reports have focused on the symptoms of constipation in patients with advanced cancer. The aim of this study was to investigate the effect of a short-term acupressure intervention on patients with advanced cancer. Methods : This study used a non-randomized, pre-post study design to assess the effect of acupressure intervention. A total of 30 patients with advanced cancer were recruited from the [...]

A partir d'une revue systématique de la littérature (31 articles), cette étude analyse la détresse psychosociale, la qualité de vie et les besoins en soins des patients atteints d'un sarcome

Health-related quality of life, psychosocial functioning, and unmet health needs in patients with sarcoma: a systematic review

McDonough, Joshua ; Eliott, Jaklin ; Neuhaus, Susan ; Reid, Jessica ; Butow, Phyllis

Objective : Health-related quality of life (HRQoL), psychosocial distress, and unmet health needs are important patient-reported outcomes (PROs) for patients with sarcoma treated with curative intent. Syntheses of data on these PROs in patients with sarcoma is limited. Methods : A systematic review of peer-reviewed literature published between 2007 and 2017 was conducted using five databases, guided by the PRISMA and Cochrane reporting guidelines. Results : Of 7,240 articles identified, 31 were [...]

Menée en Malaisie auprès de 42 patients atteints d'un cancer de la tête et du cou, cette étude analyse l'efficacité d'un traitement à base d'herbes utilisées en médecine tradionnelle chinoise pour soulager une xérostomie induite par la radiothérapie et améliorer la qualité de vie

Effects of herbal medicine for xerostomia in head and neck cancer patients: an observational study in a tertiary cancer hospital

Lim, Ren Jye ; Nik Nabil, Wan Najbah ; Chan, Si Yan ; Wong, Yoke Fui ; Han, Li Xian ; Gong, Jia Ying ; Ho, Kun Ling ; Shew, Yee Siang ; Xu, Li

Purpose : More than 80% head and neck cancer patients endured radiotherapy-induced xerostomia which impacts their quality of life (QoL). This observational study evaluated the effect of herbal treatment on head and neck cancer patients’ xerostomia and QoL. Methods : Head and neck cancer patients were recruited from July 2016 till March 2017 at National Cancer Institute, Ministry of Health, Malaysia. All study participants continued their standard oncology surveillance. Treatment group [...]

A partir d'une revue systématique de la littérature (12 études), cette méta-analyse évalue l'association entre le statut pondéral (poids normal ou non) avant une opération chirurgicale, des complications post-opératoires et la survie, chez des patients atteints d'un cancer de l'estomac

The Impact of Preoperative Underweight Status on Postoperative Complication and Survival Outcome of Gastric Cancer Patients: A Systematic Review and Meta-analysis

Zhang, Jingting ; Zhang, Jiale ; Zou, Shihui ; Luo, Rui ; Xu, Huimian ; Huang, Baojun

Objective: In this study, we performed a systematic review and meta-analysis to evaluate the impact of preoperative underweight status on postoperative complications and survival outcome of gastric cancer (GC) patients. Methods: The related studies were identified by searching PubMed and Embase databases. According to the body mass index (BMI), all patients were classified into underweight group (<18.5?kg/m2) and normal weight group (≥18.5?kg/m2, <25?kg/m2). The relevant data were extracted and [...]

Menée en Australie à partir de données portant sur 37 962 femmes pompiers volontaires et sur 1 682 femmes pompiers professionnelles, cette étude analyse le risque de cancer et la mortalité

Mortality and cancer incidence among female Australian firefighters

Glass, Deborah Catherine ; Del Monaco, Anthony ; Pircher, Sabine ; Vander Hoorn, Stephen ; Sim, Malcolm Ross

Objectives: To investigate the mortality and cancer incidence of female firefighters, a group where there are limited published findings. Methods : Participating fire agencies supplied records of individual firefighters including the number and type of incidents attended. The cohort was linked to the Australian National Death Index and Australian Cancer Database. Standardised mortality ratios and standardised cancer incidence ratios were calculated separately for paid and volunteer [...]

Menée aux Etats-Unis auprès de 1 751 patients ayant survécu à un cancer, cette étude identifie les facteurs associés à leur pratique d'une activité physique de faible intensité

Correlates of light physical activity among cancer survivors

Johnson, Rakiyah S. ; Fallon, Elizabeth A. ; Berg, Carla J.

Objective : Emerging evidence demonstrates the positive health benefits of light physical activity (LPA) for cancer survivors. Yet, little research has explored modifiable factors that facilitate or hinder LPA behavior in this population. Correlates of LPA among cancer survivors were examined, stratified by moderate-to-vigorous (MVPA) status. Methods : A cross-sectional analysis using the American Cancer Society's Studies of Cancer Survivors-I (N=1,751) was conducted. Correlates of interest [...]

Menée en Finlande auprès de 761 278 adolescents âgés de 14 à 16 ans entre 2000 et 2015, cette étude analyse l'association entre des facteurs socioéconomiques (niveau d'éducation des parents, chômage des parents, etc.) et l'évolution de la prévalence tabagique

Socioeconomic Trends in Adolescent Smoking in Finland From 2000 to 2015

Knaappila, Noora ; Marttunen, Mauri ; Fröjd, Sari ; Lindberg, Nina ; Kaltiala-Heino, Riittakerttu

Purpose : Smoking is a significant cause of morbidity and mortality worldwide. In the past decades, the prevalence of adolescent smoking has decreased in industrial countries. However, whether the decreasing trend can be seen across all socioeconomic groups is unknown. The aim of this study was to examine time trends in adolescent smoking according to the socioeconomic status among Finnish adolescents between 2000 and 2015. Methods : A population-based school survey was conducted biennially [...]

Menée auprès de 11 996 jeunes américains âgés de 12 à 17 ans entre 2013 et 2015, cette étude longitudinale analyse leur utilisation de la cigarette électronique et l'effet de cette pratique sur l'usage de la cigarette classique

Longitudinal e-cigarette and cigarette use among US youth in the PATH Study (2013-2015)

Stanton, Cassandra A ; Bansal-Travers, Maansi ; Johnson, Amanda L ; Sharma, Eva ; Katz, Lauren ; Ambrose, Bridget K ; Silveira, Marushka L ; Day, Hannah ; Sargent, James ; Borek, Nicolette ; Compton, Wilson M ; Johnson, Sarah ; Kimmel, Heather ; Kaufman, Annette R ; Limpert, Jeannie ; Abrams, David ; Cummings, K Michael ; Goniewicz, Maciej L ; Tanski, Susanne ; Travers, Mark J ; Hyland, Andrew J ; Pearson, Jennifer L

Background : Evidence is accumulating that youth who try ENDS (e-cigarettes) may go on to try cigarettes. This analysis examines the bidirectional patterns of ENDS and cigarette use among US youth over one year and uses propensity score matching (PSM) to examine frequency of ENDS use on changes in cigarette smoking. Methods : Our analysis included 11,996 partcipants who had two waves of available data (W1 2013-2014; W2 2014-2015) drawn from the longitudinal Population Assessment of Tobacco and [...]

Menée aux Etats-Unis à partir de données portant sur 106 966 femmes âgées entre 50 et 79 ans, cette étude de cohorte prospective évalue l'association entre la consommation d'aliments frits et la mortalité par cancer, par maladies cardio-vasculaires et toutes causes confondues (période de suivi : 1 914 691 personnes-années ; 31 558 décès)

Association of fried food consumption with all cause, cardiovascular, and cancer mortality: prospective cohort study

Sun, Yangbo ; Liu, Buyun ; Snetselaar, Linda G ; Robinson, Jennifer G ; Wallace, Robert B ; Peterson, Lindsay L ; Bao, Wei

Objective : To examine the prospective association of total and individual fried food consumption with all cause and cause specific mortality in women in the United States. Design : Prospective cohort study. Setting : Women’s Health Initiative conducted in 40 clinical centers in the US. Participants : 106 966 postmenopausal women aged 50-79 at study entry who were enrolled between September 1993 and 1998 in the Women’s Health Initiative and followed until February 2017. Main outcome measures : [...]

Menée aux Pays-Bas à partir de données portant sur 120 852 participants âgés entre 55 et 69 ans (période de suivi : 1986-1996), cette étude évalue l'association entre la consommation de viande rouge, de viandes transformées et d'autres aliments sources de protéines, et la mortalité par cancer et par maladies cardiovasculaires ou respiratoires (8 823 décès)

Red meat, processed meat, and other dietary protein sources and risk of overall and cause-specific mortality in The Netherlands Cohort Study

van den Brandt, Piet A.

Processed meat and red meat have been associated with increased mortality, but studies are inconsistent and few have investigated substitution by other protein sources. The relationship of overall and causes-specific mortality with red meat, processed meat, and other dietary protein sources was investigated in The Netherlands Cohort Study. In 1986, 120,852 men and women aged 55–69 years provided information on dietary and lifestyle habits. Mortality follow-up until 1996 consisted of linkage to [...]

Menée aux Etats-Unis à partir d'une cohorte multi-ethnique portant sur 183 656 participants âgés entre 45 et 75 ans, cette étude prospective analyse, en fonction de l'origine ethnique, l'incidence du cancer du poumon sur la période 1993-2012 (4 993 cas)

Racial/Ethnic Differences in Lung Cancer Incidence in the Multiethnic Cohort Study: An Update

Stram, Daniel O ; Park, S Lani ; Haiman, Christopher A ; Murphy, Sharon E ; Patel, Yesha ; Hecht, Stephen S ; Le Marchand, Loic

Background : We previously found that African Americans and Native Hawaiians were at highest lung cancer risk compared with Japanese Americans and Latinos; whites were midway in risk. These differences were more evident at relatively low levels of smoking intensity, fewer than 20 cigarettes per day (CPD), than at higher intensity. Methods : We apportioned lung cancer risk into three parts: age-specific background risk (among never smokers), an excess relative risk term for cumulative smoking, [...]

Menée aux Etats-Unis par questionnaire auprès de 411 puis 263 patients atteints d'un cancer localisé de la prostate et sous surveillance active, cette étude prospective analyse l'association entre la qualité de l'alimentation et la progression de la maladie mesurée par l'évolution du score de Gleason (durée médiane de suivi : 36 mois)

Diet quality and Gleason grade progression among localised prostate cancer patients on active surveillance

Gregg, Justin R. ; Zheng, Jiali ; Lopez, David S. ; Reichard, Chad ; Browman, Gladys ; Chapin, Brian ; Kim, Jeri ; Davis, John ; Daniel, Carrie R.

Background : High diet quality may support a metabolic and anti-inflammatory state less conducive to tumour progression. We prospectively investigated diet quality in relation to Gleason grade progression among localised prostate cancer patients on active surveillance, a clinical management strategy of disease monitoring and delayed intervention. Methods : Men with newly diagnosed Gleason score 6 or 7 prostate cancer enroled on a biennial monitoring regimen. Patients completed a food frequency [...]

Mené aux Etats-Unis sur 145 patients atteints d'un cancer incurable, cet essai randomisé évalue l'efficacité d'une psychothérapie comportementale personnalisée, accessible par une application mobile, pour traiter les symptômes d'anxiété et de dépression, et améliorer la qualité de vie

Randomized Trial of a Tailored Cognitive-Behavioral Therapy Mobile Application for Anxiety in Patients with Incurable Cancer

Greer, Joseph A. ; Jacobs, Jamie ; Pensak, Nicole ; MacDonald, James J. ; Fuh, Charn‐Xin ; Perez, Giselle K. ; Ward, Alina ; Tallen, Colleen ; Muzikansky, Alona ; Traeger, Lara ; Penedo, Frank J. ; El‐Jawahri, Areej ; Safren, Steven A. ; Pirl, William F. ; Temel, Jennifer S.

Background : The aim of this study was to test the efficacy of a tailored cognitive‐behavioral therapy (CBT) mobile application (app) to treat anxiety in patients with incurable cancer. Materials and Methods : Patients with incurable cancers (n = 145) who reported elevated anxiety symptoms at two cancer centers were randomized to receive either the CBT mobile app for anxiety or a mobile health education program (control) delivered via tablet computers, which patients self‐administered over 12 [...]

Menée en France auprès de 129 patients atteints de cancer (âge médian : 70 ans), cette étude prospective analyse l'effet des déficiences cognitives et des symptômes d'anxiété et de dépression sur l'adhésion aux thérapies anticancéreuses dispensées par voie orale

Impact of anxio-depressive symptoms and cognitive function on oral anticancer therapies adherence

Santos, Mélanie Dos ; Lange, M. ; Gervais, R. ; Clarisse, B. ; Capel, A. ; Barillet, M. ; Grellard, J. M. ; Heutte, N. ; Licaj, I. ; Joly, F.

Purpose : Oral anticancer therapies have an important place in the therapeutic arsenal, but factors influencing adherence to oral treatment are poorly documented in oncology. The objective of this study was to assess the impact of anxio-depressive symptoms and cognitive functioning on oral medication adherence. Methods : This prospective study included cancer patients initiating a first oral therapy. Before initiation of treatment, an assessment of depression, anxiety, and cognition was [...]

Menée en Allemagne par questionnaire auprès de 42 patients atteints d'une tumeur du cerveau et suivis en ambulatoire, cette étude analyse les facteurs associés à leur peur de la progression de la maladie et à leurs besoins en soins de support

Fear of disease progression in adult ambulatory patients with brain cancer: prevalence and clinical correlates

Goebel, Simone ; Mehdorn, Hubertus Maximilian

Background : Fear of progression (FoP) is frequent in patients with cancer and of high clinical relevance. Despite the often devastating prognosis of brain cancer, FoP has not yet been assessed in neurooncological patients. Objective : The aim of this study was thus the assessment of FoP and its clinical correlates. Methods : In an ambulatory setting, 42 patients with a primary brain tumour completed the Fear of Progression questionnaire FoP-Q-12. Clinical correlates of FoP were assessed via a [...]

Menée en Allemagne par questionnaire auprès de 2 107 femmes en 2004 puis auprès de 866 femmes en 2016, cette étude analyse l'évolution des connaissances relatives aux facteurs de risque de cancer du sein

Awareness of breast cancer incidence and risk factors among healthy women in Germany: an update after 10 years

Poehls, Uwe G. ; Hack, Carolin C. ; Wunderle, Marius ; Renner, Stefan P. ; Lux, Michael P. ; Beckmann, Matthias W. ; Fasching, Peter A. ; Nabieva, Naiba

Early breast cancer detection programs depend for effectiveness on the participation rate, which is affected by risk factor awareness. This study investigated changes in women’s risk factor awareness between 2004 and 2016. Results from a 2004 survey of 2107 healthy women were compared with new data obtained using the same questionnaire in 2016, with 866 participants indicating their knowledge and perceptions regarding breast cancer incidence, risk factors, risk perceptions, and levels of [...]

Menée au Japon auprès de 20 patients atteints d'un cancer en phase terminale (âge moyen : 72,3 ans), cette étude prospective analyse l'efficacité d'une intervention de soins palliatifs utilisant la réalité virtuelle pour soulager leurs symptômes (douleur, fatigue, somnolence, souffle court, dépression, anxiété, etc.)

A Novel Palliative Care Approach Using Virtual Reality for Improving Various Symptoms of Terminal Cancer Patients: A Preliminary Prospective, Multicenter Study

Niki Kazuyuki ; Okamoto Yoshiaki ; Maeda Isseki ; Mori Ichiro ; Ishii Ryouhei ; Matsuda Yoshinobu ; Takagi Tatsuya ; Uejima Etsuko

Background: Some terminal cancer patients wish to “go to a memorable place” or “return home.” However, owing to various symptom burdens and physical dysfunction, these wishes are difficult for them to realize. Objective: The aim of the study is to verify whether simulated travel using virtual reality (VR travel) is efficacious in improving symptoms in terminal cancer patients. Design: This is a prospective, multicenter, single-arm study. Setting/Subjects: Twenty participants with terminal [...]