A partir des données de 34 essais randomisés incluant 4 519 patients atteints d'un cancer, cette méta-analyse évalue les facteurs individuels devant être pris en compte pour proposer des interventions ciblées à base d'exercices physiques et permettre le meilleur rapport coût-efficacité de ces interventions, pendant et après les traitements anticancéreux

Targeting Exercise Interventions to Patients With Cancer in Need: An Individual Patient Data Meta-Analysis

Buffart, Laurien M. ; Sweegers, Maike G. ; May, Anne M. ; Chinapaw, Mai J. ; van Vulpen, Jonna K. ; Newton, Rob U. ; Galvão, Daniel A. ; Aaronson, Neil K. ; Stuiver, Martijn M. ; Jacobsen, Paul B. ; Verdonck-de Leeuw, Irma M. ; Steindorf, Karen ; Irwin, Melinda L. ; Hayes, Sandi ; Griffith, Kathleen A. ; Lucia, Alejandro ; Herrero-Roman, Fernando ; Mesters, Ilse ; van Weert, Ellen ; Knoop, Hans ; Goedendorp, Martine M. ; Mutrie, Nanette ; Daley, Amanda J. ; McConnachie, Alex ; Bohus, Martin ; Thorsen, Lene ; Schulz, Karl-Heinz ; Short, Camille E. ; James, Erica L. ; Plotnikoff, Ronald C. ; Arbane, Gill ; Schmidt, Martina E. ; Potthoff, Karin ; van Beurden, Marc ; Oldenburg, Hester S. ; Sonke, Gabe S. ; van Harten, Wim H. ; Garrod, Rachel ; Schmitz, Kathryn H. ; Winters-Stone, Kerri M. ; Velthuis, Miranda J. ; Taaffe, Dennis R. ; van Mechelen, Willem ; José Kersten, Marie ; Nollet, Frans ; Wenzel, Jennifer ; Wiskemann, Joachim ; Brug, Johannes ; Courneya, Kerry S.

Background : Exercise effects in cancer patients often appear modest, possibly because interventions rarely target patients most in need. This study investigated the moderator effects of baseline values on the exercise outcomes of fatigue, aerobic fitness, muscle strength, quality of life (QoL), and self-reported physical function (PF) in cancer patients during and post-treatment. Methods : Individual patient data from 34 randomized exercise trials (n = 4519) were pooled. Linear mixed-effect [...]

Cette étude passe en revue les stratégies destinées à améliorer la composition corporelle chez les patients atteints de cancer et prendre en charge une cachéxie et une myopathie liées à la maladie

Cancer cachexia and myopenia - Update on management strategies and the direction of future research for optimizing body composition in cancer - A narrative review

Pring, Edward T. ; Malietzis, George ; Kennedy, Robin H. ; Athanasiou, Thanos ; Jenkins, John T.

Purpose : Body composition degenerates with cancer. Optimizing body composition is rarely, if ever, undertaken. This narrative review highlights and evaluates emerging treatments that have the potential to improve outcomes for our cancer patients Observations : Body composition in cancer patients has been shown to be modifiable; enhanced body composition is associated with improved short term, long-term outcomes and survival in addition to improvements in function and quality of life. [...]

Cette étude compare les recommandations de 3 grands organismes américains et européen concernant la prévention et le traitement des nausées et vomissements induits par la chimiothérapie chez les patients atteints de cancer

ASCO, NCCN, MASCC/ESMO: a comparison of antiemetic guidelines for the treatment of chemotherapy-induced nausea and vomiting in adult patients

Razvi, Yasmeen ; Chan, Stephanie ; McFarlane, Thomas ; McKenzie, Erin ; Zaki, Pearl ; DeAngelis, Carlo ; Pidduck, William ; Bushehri, Ahmad ; Chow, Edward ; Jerzak, Katarzyna Joanna

Chemotherapy-induced nausea and vomiting (CINV) is a common toxicity that may impair the quality of life of patients with a variety of early- and end-stage malignancies. In light of recent changes in the optimal management of CINV, we undertook this narrative review to compare the latest guidelines published by ASCO (2017), NCCN (2018), and MASCC/ESMO (2016). The processes undertaken by each organization to evaluate existing literature were also described. Although ASCO, NCCN, and MASCC/ESMO [...]

Menée aux Etats-Unis par questionnaire auprès de 1 021 patients adultes ayant survécu à un cancer pendant l'enfance, cette étude analyse la présence de troubles de la fonction érectile et leur impact sur la qualité de vie

Erectile dysfunction in male survivors of childhood cancer

van Iersel, L. ; Li, Z. ; Chemaitilly, W. ; et al.,

Male sexual dysfunction and its association with psychological and physical well-being have been underreported in childhood cancer survivors (CCSs). To our knowledge, this study provides the first data on a large population of systematically and clinically assessed CCSs, enumerating the prevalence and consequences of erectile dysfunction (ED) and identifying potential targets for intervention. This cross-sectional, single-institution study included male CCSs, 18 years or older, 10 years or more [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2018 (28 essais randomisés), cette étude analyse l'efficacité des interventions à base d'exercices physiques pour réduire les symptômes de fatigue, améliorer les performances physiques et la qualité de vie pendant le traitement initial chez des patientes atteintes d'un cancer du sein

The effect of training interventions on physical performance, quality of life, and fatigue in patients receiving breast cancer treatment: a systematic review

Gebruers, Nick ; Camberlin, Melissa ; Theunissen, Fleur ; Tjalma, Wiebren ; Verbelen, Hanne ; Van Soom, Timia ; van Breda, Eric

Objectives : The primary purpose of this systematic review is to structure the available evidence concerning physical exercise programs and their effects on (1) physical performance outcomes, (2) experienced fatigue, and (3) quality of life (QoL) in patients during the initial treatment for breast cancer. Data sources : A systematic literature search, based upon the PRISMA guideline, up to January 1, 2018, was performed using four databases (Web of Science, Cochrane Library for Clinical Trials, [...]

A partir d'une revue systématique de la littérature (10 essais randomisés, 640 patients), cette étude analyse l'efficacité, du point de vue de l'amélioration de la qualité de vie des patients atteints d'une tumeur cérébrale, des interventions en soins de support, de nature psychosociale, pharmacologique ou proposant des médecines complémentaires et alternatives

Patient-reported health-related quality of life outcomes in supportive-care interventions for adults with brain tumors: A systematic review

Pan, Tonya M. ; Kryza-Lacombe, Maria ; Burkeen, Jeffrey ; Hattangadi-Gluth, Jona ; Malcarne, Vanessa L. ; McDonald, Carrie R.

Objectives: The objectives of this systematic review were to: (1) identify supportive‐care (psychosocial/behavioral, pharmacological, complementary or alternative) interventions that have been evaluated via randomized controlled trials (RCTs) to improve patient‐reported health‐related quality of life (HRQoL) among adults with brain tumors; (2) evaluate the quality of the intervention studies; and (3) evaluate if developed interventions have been efficacious at improving HRQoL, as compared to [...]

A partir d'une revue systématique de la littérature (13 études), cette méta-synthèse évalue l'impact des traitements anticancéreux (radiothérapie et/ou chimiothérapie) sur la vie quotidienne et la qualité de vie de patients atteints d'un cancer de la tête et du cou

Listening to the voice of patients with head and neck cancer: A systematic review and meta-synthesis

Qualizza, Marta ; Bressan, Valentina ; Rizzuto, Antonio ; Stevanin, Simone ; Bulfone, Giampiera ; Cadorin, Lucia ; Ghirotto, Luca

The aim was to conduct a systematic review and a meta-synthesis of primary qualitative studies exploring experiences of head and neck cancer patients (HNC) undergoing radio and/or chemotherapy, in order to provide a better understanding of this phenomenon and supply new directions for care and clinical practice. Six databases were systematically searched, and 13 studies were included. The meta-synthesis methodology was adopted to conceptualise the way in which patients lived their cancer [...]

Menée aux Etats-Unis à partir de données portant sur 659 patients âgés ayant survécu à un cancer (âge moyen : 71 ans), cette étude analyse les divers facteurs associés à la pratique d'une activité physique quotidienne

Contrasting characteristics of daily physical activity in older adults by cancer history

Wanigatunga, Amal A. ; Gresham, Gillian K. ; Kuo, Pei-Lun ; Martinez-Amezcua, Pablo ; Zipunnikov, Vadim ; Dy, Sydney M. ; Simonsick, Eleanor M. ; Ferrucci, Luigi ; Schrack, Jennifer A.

Background: Using objectively collected physical activity (PA) data from the Baltimore Longitudinal Study of Aging, the authors tested whether patterns of daily activity and sedentary time differed by cancer survivorship in older adults. Methods: In total, 659 participants (mean age ± standard deviation, 71 ± 10 years; 51% women) who had self-reported information on cancer history were instructed to wear an accelerometer for 7 consecutive days. Accelerometer data were summarized into: 1) PA [...]

Menée à partir du séquençage de l'ADN tumoral prélevé sur 36 patients atteints d'un adénocarcinome canalaire du pancréas traité par une chimiothérapie de type FOLFORINOX (âge médian : 65,5 ans), cette étude analyse l'association entre des mutations constitutionnelles et somatiques des gènes de réparation des dommages de l'ADN et la survie globale

Germline and Somatic DNA Damage Repair Gene Mutations and Overall Survival in Metastatic Pancreatic Adenocarcinoma Patients Treated with FOLFIRINOX

Sehdev, Amikar ; Gbolahan, Olumide ; Hancock, Brad A. ; Stanley, Melissa ; Shahda, Safi ; Wan, Jun ; Wu, Howard H. ; Radovich, Milan ; O'Neil, Bert H.

Purpose: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with lack of predictive biomarkers. We conducted a study to assess DNA damage repair (DDR) gene mutations as a predictive biomarker in PDAC patients treated with FOLFIRINOX. Experimental Design: Indiana University Simon Cancer Center pancreatic cancer database was used to identify patients with metastatic PDAC, treated with FOLFIRINOX and had tissue available for DNA sequencing. Baseline demographic, clinical, and pathologic [...]

A partir des données des registres américains des cancers portant sur 10 680 patients ayant survécu à un cancer du poumon non à petites cellules de stade précoce (stade I et II) traité par résection, cette étude analyse les facteurs associés à leur adhésion à long terme à la surveillance régulière par imagerie

Receipt of Recommended Surveillance with Imaging in Elderly Survivors of Early Stage Non-small Cell Lung Cancer

Malhotra, Jyoti ; Rotter, David ; Jabbour, Salma K. ; Aisner, Joseph ; Lin, Yong ; Manne, Sharon ; Demissie, Kitaw

Purpose : Early-stage lung cancer survivors remain at high risk for recurrence or second cancers. We measured the rates and determinants of regular surveillance imaging in early-stage non-small cell lung cancer (NSCLC) survivors. Methods : Patients (diagnosed 2001-2011) with resected stage I and II NSCLC were identified from the Surveillance Epidemiology and End Results (SEER)-Medicare linked database. Patients were censored at recurrence/second cancer diagnosis, loss to follow-up or death. [...]

Menée au Japon à partir de données portant sur 123 patients atteints d'un cancer du poumon non à petites cellules, cette étude rétrospective évalue l'association entre une fibrose pulmonaire et le risque de pneumopathie induite par l'utilisation d'anti-PD-1

Pre-existing pulmonary fibrosis is a risk factor for anti-PD-1-related pneumonitis in patients with non-small cell lung cancer: a retrospective analysis

Yamaguchi, Teppei ; Shimizu, Junichi ; Hasegawa, Takaaki ; Horio, Yoshitsugu ; Inaba, Yoshitaka ; Yatabe, Yasushi ; Hida, Toyoaki

Objectives : Pneumonitis related to the use of anti-programmed death 1 (PD-1) antibodies is a common immune-related adverse event that can be life-threatening. However, the relationship between pulmonary fibrosis/emphysema and the incidence of anti-PD-1-related pneumonitis is unclear. Materials and methods : We retrospectively reviewed data from 123 patients who were diagnosed with non-small-cell lung cancer and treated with anti-PD-1 antibodies (nivolumab or pembrolizumab) at the Aichi Cancer [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juin 2018 (26 études), cette étude évalue le risque de maladie cardiovasculaire (thromboembolie veineuse, infarctus du myocarde, accident vasculaire cérébral, angine de poitrine, insuffisance cardiaque, arythmie et maladie vasculaire périphérique) chez les patientes ayant survécu à un cancer du sein non métastatique, en lien avec l'utilisation d'une hormonothérapie adjuvante, qu'il s'agisse du tamoxifène ou d'un inhibiteur de l'aromatase

Long term adjuvant endocrine therapy and risk of cardiovascular disease in female breast cancer survivors: systematic review

Matthews, Anthony ; Stanway, Susannah ; Farmer, Ruth E ; Strongman, Helen ; Thomas, Sara ; Lyon, Alexander R ; Smeeth, Liam ; Bhaskaran, Krishnan

Objective : To investigate the effect of endocrine therapies on a wide range of specific clinical cardiovascular disease outcomes in women with a history of non-metastatic breast cancer. Design : Systematic review and meta-analysis of randomised controlled trials and observational studies. Data sources : Medline and Embase up until June 2018. Eligibility criteria for selecting studies : Studies were included if they investigated the risk of a specific cardiovascular disease outcome associated [...]

Menée aux Pays-Bas à partir de données portant sur 2 998 patients ayant survécu un an à un cancer du testicule traité avant l'âge de 50 ans par orchidectomie avec ou sans radiothérapie avec irradiation des ganglions para-aortiques entre 1976 et 2007, cette étude analyse le risque de diabète en lien avec la dose de rayonnements reçus (durée médiane de suivi : 13,4 ans ; 161 cas de diabète)

Risk of diabetes after para-aortic radiation for testicular cancer

Groot, Harmke J. ; Gietema, Jourik A. ; Aleman, Berthe M. P. ; Incrocci, Luca ; de Wit, Ronald ; Witjes, J. Alfred ; Groenewegen, Gerard ; de Brouwer, Peter ; Meijer, Otto W. M. ; Hulshof, Maarten C. C. M. ; van den Berg, Hetty A. ; Smilde, Tineke J. ; Vanneste, Ben G. L. ; Aarts, Maureen J. ; van den Bergh, Alphonsus C. M. ; Kerst, J. Martijn ; van den Belt-Dusebout, Alexandra W. ; Lubberts, Sjoukje ; Jóźwiak, Katarzina ; Horenblas, Simon ; van Leeuwen, Flora E. ; Schaapveld, Michael

Background : While the risk of diabetes is increased following radiation exposure to the pancreas among childhood cancer survivors, its association among testicular cancer (TC) survivors has not been investigated. Methods : Diabetes risk was studied in 2998 1-year TC survivors treated before 50 years of age with orchidectomy with/without radiotherapy between 1976 and 2007. Diabetes incidence was compared with general population rates. Treatment-specific risk of diabetes was assessed using a [...]

Menée en Suède à partir de données portant sur 4 254 patientes atteintes d'un cancer invasif du col de l'utérus diagnostiqué entre 2002 et 2011, cette étude évalue l'association entre l'observation d'une infection de la tumeur par un papillomavirus humain à haut risque et la mortalité (durée moyenne de suivi : 6,2 ans)

High-risk human papillomavirus status and prognosis in invasive cervical cancer: A nationwide cohort study

Lei, Jiayao ; Ploner, Alexander ; Lagheden, Camilla ; Eklund, Carina ; Nordqvist Kleppe, Sara ; Andrae, Bengt ; Elfström, K. Miriam ; Dillner, Joakim ; Sparén, Pär ; Sundström, Karin

Background : High-risk human papillomavirus (hrHPV) infection is established as the major cause of invasive cervical cancer (ICC). However, whether hrHPV status in the tumor is associated with subsequent prognosis of ICC is controversial. We aim to evaluate the association between tumor hrHPV status and ICC prognosis using national registers and comprehensive human papillomavirus (HPV) genotyping. Methods and findings : In this nationwide population-based cohort study, we identified all ICC [...]

Menée en Chine à partir de données portant sur des patients atteints d'un cancer de la tête et du cou, cette étude évalue l'association entre une consommation d'alcool avant le diagnostic, l'existence de polymorphismes des gènes ADH1B et ALDH2 et la survie

The influence of pre-diagnosis alcohol consumption and the polymorphisms of ethanol metabolizing genes on the survival of head and neck cancer patients

Lee, Wei-Ting ; Hsiao, Jenn-Ren ; Ou, Chun-Yen ; Huang, Cheng-Chih ; Chang, Chan-Chi ; Tsai, Sen-Tien ; Chen, Ken-Chung ; Huang, Jehn-Shyun ; Wong, Tung-Yiu ; Lai, Yu-Hsuan ; Wu, Yuan-Hua ; Hsueh, Wei-Ting ; Wu, Shang-Yin ; Yen, Chia-Jui ; Chang, Jang-Yang ; Lin, Chen-Lin ; Weng, Ya-Ling ; Yang, Han-Chien ; Chen, Yu-Shan ; Chang, Jeffrey S.

Background: Although alcohol drinking is an established risk factor of head and neck cancer (HNC), less is known about its role in the prognosis of HNC. The current study investigated the association between pre-treatment alcohol consumption and the overall survival (OS) of HNC patients. Methods: Cox proportional hazards models were performed to evaluate the association between pre-diagnosis alcohol drinking and the OS of HNC patients. In addition, the influence of the polymorphisms of two [...]

Menée aux Etats-Unis par enquête auprès de 355 parents d'un enfant atteint de cancer, cette étude analyse l'association entre la détresse des parents et leurs besoins d'informations sur les effets à long terme des traitements pédiatriques anticancéreux

Parental distress and desire for information regarding long-term implications of pediatric cancer treatment

Greenzang, Katie A. ; Cronin, Angel M. ; Kang, Tammy I. ; Mack, Jennifer W.

Background : Parents of children with cancer have unmet information needs regarding future limitations resulting from cancer or its treatment. Prior research has demonstrated that, in early care discussions, clinicians focus on the acute effects of therapy rather than long-term limitations, partly due to worries of causing distress. The validity of concerns regarding distress is unknown. In the current study, the authors evaluated parental distress associated with information regarding future [...]

Menée aux Etats-Unis à partir de données portant sur 1 213 patients atteints de cancer, cette étude évalue l'association entre une détresse psychologique et l'utilisation de services et de soins de nature psychosociale pendant les 12 mois suivant le diagnostic de détresse

Distress Predicts of Utilization of Psychosocial Health Services in Oncology Patients

Hamilton, Jessica ; Kroska, Emily B.

Objective : The prevalence of increased distress among cancer patients has been well-established and is known to be associated with negative consequences. Limited research has examined the association between distress and utilization of services, however, which is critical to understanding whether measurements of distress are being used to optimize patient care in the context of cancer. Method : 1213 adult cancer patients completed the Distress Thermometer and Patient Needs Assessment early in [...]

Mené aux Etats-Unis sur 59 patients âgés de plus de 70 ans, cet essai randomisé évalue l'efficacité d'une intervention de psychothérapie par téléphone pour soulager les symptômes d'anxiété et de dépression et réduire les sentiments de démoralisation et de solitude

Cancer and Aging: Reflections for Elders (CARE): A Pilot Randomized Controlled Trial of a Psychotherapy Intervention for Older Adults with Cancer

Nelson, Christian J. ; Saracino, Rebecca M. ; Roth, Andrew J. ; Harvey, Elizabeth ; Martin, Anne ; Moore, Mark ; Marcone, Dana ; Poppito, Shannon R. ; Holland, Jimmie

Objective : Cancer and Aging: Reflections for Elders (CARE), is a novel, telephone‐delivered intervention designed to alleviate distress in older cancer patients. This pilot randomized controlled trial tested the feasibility and initial efficacy of CARE, drawing from age‐appropriate developmental themes and well‐established coping theory. Method : Eligible patients were ≥70 years old, ≥six months post-diagnosis of lung, prostate, breast, lymphoma, or gynecological cancer, on active cancer [...]

A partir d'une revue systématique de la littérature publiée entre 2000 et 2017 (16 études, 1 024 donneurs), cette étude analyse les besoins en informations et en soins de nature psychosociale chez les donneurs de cellules souches hématopoïétiques ayant des liens de parenté avec des patients atteints d'une tumeur hématologique

Adult-related haematopoietic stem cell donor experiences and the provision of information and psychosocial support: A systematic literature review

Zomerdijk, Nienke ; Turner, Jane M. ; Hill, Geoffrey R.

For blood cancer patients, haematopoietic stem cells (HSC) donated by a relative can be lifesaving. However, related donors can face significant physical and psychosocial challenges. As the demand for adult-related HSC donors is increasing, it is important to review our understanding of adult-related HSC donors’ need for and availability of information and psychosocial support with a view to identifying gaps in the literature. A systematic review of relevant studies (2000–2017) was conducted [...]

Menée aux Etats-Unis à partir de données portant sur 344 patientes ayant survécu à un cancer du sein et sur 347 témoins d'âge compris entre 60 et 98 ans, cette étude évalue leurs fonctions cognitives en lien avec les traitements reçus

Cancer-Related Cognitive Outcomes Among Older Breast Cancer Survivors in the Thinking and Living With Cancer Study

Jeanne S. Mandelblatt ; Brent J. Small ; Gheorghe Luta ; Arti Hurria ; Heather Jim ; Brenna C. McDonald ; Deena Graham ; Xingtao Zhou ; Jonathan Clapp ; Wanting Zhai ; Elizabeth Breen ; Judith E. Carroll ; Neelima Denduluri ; Asma Dilawari ; Martine Extermann ; Claudine Isaacs ; Paul B. Jacobsen ; Lindsay C. Kobayashi ; Kelly Holohan Nudelman ; James Root ; Robert A. Stern ; Danielle Tometich ; Raymond Turner ; John W. VanMeter ; Andrew J. Saykin ; Tim Ahles

Purpose : To determine treatment and aging-related effects on longitudinal cognitive function in older breast cancer survivors. Methods : Newly diagnosed nonmetastatic breast cancer survivors (n = 344) and matched controls without cancer (n = 347) 60 years of age and older without dementia or neurologic disease were recruited between August 2010 and December 2015. Data collection occurred during presystemic treatment/control enrollment and at 12 and 24 months through biospecimens; surveys; [...]

Menée dans un contexte américain, cette étude compare le rapport coût-efficacité d'un traitement de première ligne combinant brentuximab védotin et chimiothérapie à base de doxorubicine, vinblastine et dacarbazine, et d'une chimiothérapie standard à base de bléomycine, chez des patients atteints d'un lymphome hodgkinien de stade III ou IV

Cost-Effectiveness Analysis of Brentuximab Vedotin With Chemotherapy in Newly Diagnosed Stage III and IV Hodgkin Lymphoma

Scott F. Huntington ; Gottfried von Keudell ; Amy J. Davidoff ; Cary P. Gross ; Sapna A. Prasad

Purpose : In a recent randomized, open-label trial (ECHELON-1), brentuximab vedotin (BV) combined with doxorubicin, vinblastine, and dacarbazine (AVD+BV) decreased the risk of progression in adults diagnosed with stage III or IV Hodgkin lymphoma (HL) compared with standard bleomycin-containing chemotherapy (doxorubicin, bleomycin, vinblastine, and dacarbazine [ABVD]). However, the cost effectiveness of incorporating BV (US$6,970 per 50-mg vial) into the first-line setting is unknown. Patients [...]

Menée aux Etats-Unis par enquête auprès de 290 patients ayant survécu à un cancer, cette étude analyse la fréquence des discussions entre le patient et les professionnels de santé à propos d'éventuelles difficultés liées à l'emploi

Patient and provider communication about employment following a cancer diagnosis

de Moor, Janet S. ; Coa, Kisha ; Kent, Erin E. ; Moten, Carmen ; Kobrin, Sarah ; Altice, Cheryl ; Yabroff, K. Robin

Purpose : Cancer treatment can precipitate functional limitations that restrict survivors’ ability to work. Yet, it is unclear whether healthcare providers discuss the potential for employment limitations with their patients. We assessed the frequency of patient-provider communication about employment, from the perspectives of survivors, and examined whether receiving a treatment summary was associated with employment communication. Methods : Cancer survivors who were working at diagnosis were [...]

Menée en Ecosse auprès de 60 patientes atteintes d'un cancer du sein, cette étude analyse leurs discussions et l'expression de leur émotions avec le médecin radiologue lors de rendez-vous médicaux après une radiothérapie, puis évalue l'association entre la qualité de ces échanges et la peur de la récidive

Emotional talk of patients with breast cancer during review appointments with therapeutic radiographers: effects on fears of cancer recurrence

Humphris, G. ; Yang, Y. ; Barracliffe, L. ; Cameron, J. ; Bedi, C.

Abstract : Fears of cancer recurrence (FCR) in patients with breast cancer may develop during radiotherapy. Radiographer communication with their patients may influence early survivorship FCR level. Aim : To investigate the management of emotional talk in patients with breast cancer attending their initial review appointments during radiotherapy and predict FCR at 6–8 weeks follow-up. Methods : A mixed-methods observational study was conducted. Patients (consecutive sample, n = 60) with breast [...]

Menée en Belgique à partir de données médico-économiques portant sur 12 839 patients atteints d'un cancer du poumon diagnostiqué entre 2010 et 2011, cette étude évalue la performance d'un algorithme pour identifier la présence de diverses comorbidités en comparant ses résultats avec un échantillon de dossiers médicaux des patients

Use of health insurance data to identify and quantify the prevalence of main comorbidities in lung cancer patients

Jegou, David ; Dubois, Cécile ; Schillemans, Viki ; Stordeur, Sabine ; De Gendt, Cindy ; Camberlin, Cécile ; Verleye, Leen ; Vrijens, France

Background : Identifying comorbidities in lung cancer patients is a complex process in population-based studies and no gold standard exists. The current study aims to identify and measure the main comorbidities using administrative health insurance data, which were available on a population-based level. Method : A literature search was conducted to identify comorbidities in lung cancer patients and to select Anatomical Therapeutic Chemical codes to measure them. For each patient, the volume of [...]