Menée en France auprès de 327 partenaires de vie et aidants de patients atteints d'un cancer puis auprès de 121 participants, cette étude analyse la pertinence d'un outil permettant d'évaluer leurs besoins en soins de support

Psychometric validation of the French version of the Supportive Care Needs Survey for Partners and Caregivers of cancer patients

Baudry, Anne-Sophie ; Anota, Amelie ; Bonnetain, Franck ; Mariette, Christophe ; Christophe, Véronique

The objective of this study was to assess the psychometric properties of the French version of the Supportive Care Needs Survey for Partners and Caregivers (SCNS-P&C-F). The SCNS-P&C-F, the Hospital Anxiety and Depression Scale (HADS) and the CareGiver Oncology Quality of Life questionnaire (CarGOQoL) were completed by 327 caregivers at the baseline. The SCNS-P&C-F was completed a second time by 121 participants within 30 days. Four factors were retained with a good explanation of variance [...]

Menée aux Etats-Unis par enquête, cette étude analyse les pratiques des médecins relatives aux prescriptions d'opioïdes pour soulager la douleur chez les patients atteints d'un cancer

Opioid Screening Practices in the Cancer Pain Patient

Liebling Dustin ; Mehta Neel ; Gulati Amitabh

Background: Despite the growing use of opioids to treat cancer pain and the probability of opioid aberrancy in the cancer setting, clinical practice guidelines (CPGs) or recommendations for active screening and monitoring of opioid compliance are lacking. Objectives: To evaluate the current practices and attitudes clinicians have toward monitoring and prescribing opioids in patients with cancer; to describe the current practice of screening and monitoring opioid compliance in the cancer [...]

A partir d'une revue systématique de la littérature, cette étude analyse les facteurs associés aux difficultés psychosociales des aidants de patients âgés de plus de 65 ans et ayant survécu à un cancer

Prevalence and predictors of psychosocial problems in informal caregivers of older cancer survivors – A systematic review: Still major gaps in current research

Jansen, Leontien ; Dauphin, Stephanie ; Akker, Marjan ; De Burghgraeve, Tine ; Schoenmakers, Birgitte ; Buntinx, Frank

Despite the abundance of studies concerning caring for patients with cancer, less is known about caring for an older cancer survivor (≥65 years). We aimed to systematically gather literature about the psychosocial well-being of caregivers of older cancer survivors and to identify possible risk factors for developing psychosocial problems. Fourteen articles met the following inclusion criteria: articles about (a) cancer, (b) informal caregivers, (c) older survivors and a (d) curative setting. [...]

A partir d'une revue systématique de la littérature publiée jusqu'en août 2018, cette méta-analyse d'essais randomisés évalue l'efficacité d'interventions à base d'exercices physiques dispensées après le diagnostic, pour améliorer les capacités physiques et la survie, limiter le risque de récidive et la survenue d'effets indésirables des traitements, chez des enfants et adolescents atteints d'un cancer (8 essais randomisés incluant 283 patients ; 5 études incluant 173 patients)

Exercise training in childhood cancer: A systematic review and meta-analysis of randomized controlled trials

Morales, Javier S. ; Valenzuela, Pedro L. ; Rincón-Castanedo, Cecilia ; Takken, Tim ; Fiuza-Luces, Carmen ; Santos-Lozano, Alejandro ; Lucia, Alejandro

Introduction : Physical capacity and quality of life (QoL) are typically impaired in children/adolescents with cancer. Our primary objective was to examine the effects of exercise training performed after diagnosis of any type of pediatric cancer on physical capacity-related endpoints, survival, disease relapse and adverse effects. Methods : a) Search and selection criteria: Systematic review in Pubmed and Web of Science (until August 2018) of randomized controlled trials (RCTs) of exercise [...]

A partir d'une revue systématique de la littérature publiée entre 2011 et 2016, cette étude met à jour les recommandations pour la pratique clinique de l''American Society of Clinical Oncology" et de l''Infectious Diseases Society of America" relatives aux stratégies de prophylaxie antibactérienne et antifongique chez des patients atteints d'une immunosuppression liée au cancer et aux traitement anticancéreux

Antimicrobial Prophylaxis for Adult Patients With Cancer-Related Immunosuppression: ASCO and IDSA Clinical Practice Guideline Update

Randy A. Taplitz ; Erin B. Kennedy ; Eric J. Bow ; Jennie Crews ; Charise Gleason ; Douglas K. Hawley ; Amelia A. Langston ; Loretta J. Nastoupil ; Michelle Rajotte ; Kenneth V. Rolston ; Lynne Strasfeld ; Christopher R. Flowers

Purpose : To provide an updated joint ASCO/Infectious Diseases Society of America (IDSA) guideline on antimicrobial prophylaxis for adult patients with immunosuppression associated with cancer and its treatment. Methods : ASCO and IDSA convened an update Expert Panel and conducted a systematic review of relevant studies from May 2011 to November 2016. The guideline recommendations were based on the review of evidence by the Expert Panel. Results : Six new or updated meta-analyses and six new [...]

Mené sur 382 patients atteints d'une thrombocytémie essentielle et âgés entre 40 et 59 ans, cet essai randomisé (période de suivi : 2 373 personnes-années ; durée médiane de suivi : 73 mois) évalue l'efficacité de l'ajout de l'hydroxycarbamide à l'aspirine pour réduire le risque de thrombose artérielle ou veineuse, d'hémorragie grave et de décès par maladie ou accident vasculaires

Hydroxycarbamide Plus Aspirin Versus Aspirin Alone in Patients With Essential Thrombocythemia Age 40 to 59 Years Without High-Risk Features

Anna L. Godfrey ; Peter J. Campbell ; Cathy MacLean ; Georgina Buck ; Julia Cook ; Julie Temple ; Bridget S. Wilkins ; Keith Wheatley ; Jyoti Nangalia ; Jacob Grinfeld ; Mary Frances McMullin ; Cecily Forsyth ; Jean-Jacques Kiladjian ; Anthony R. Green ; Claire N. Harrison ; on behalf of the United Kingdom Medical Research Council Primary Thrombocythemia-1 Study ; the United Kingdom National Cancer Research Institute Myeloproliferative Neoplasms Subgroup ; the French Intergroup of Myeloproliferative Neoplasms ; and the Australasian Leukaemia ; Lymphoma Group.

Purpose : Cytoreductive therapy is beneficial in patients with essential thrombocythemia (ET) at high risk of thrombosis. However, its value in those lacking high-risk features remains unknown. This open-label, randomized trial compared hydroxycarbamide plus aspirin with aspirin alone in patients with ET age 40 to 59 years and without high-risk factors or extreme thrombocytosis. Patients and Methods : Patients were age 40 to 59 years and lacked a history of ischemia, thrombosis, embolism, [...]

Menée auprès de 334 patientes atteintes d'un cancer du sein traité par chirurgie conservatrice et radiothérapie adjuvante (durée de suivi 1 an), cette étude analyse la concordance entre trois méthodes d'évaluation des résultats esthétiques et leur intérêt pour prédire la qualité de vie

Aesthetic outcome following breast-conserving surgery assessed by three evaluation modalities in relation to health-related quality of life

Dahlbäck, C. ; Ringberg, A. ; Manjer, J.

Background : The aim of this study was to compare the agreement between three different methods for evaluation of aesthetic outcome following breast-conserving surgery and adjuvant radiotherapy: a patient questionnaire, panel evaluation of photographs and the software BCCT.core. A further aim was to examine how these modalities predict health-related quality of life as measured by the validated Breast-Q™ questionnaire. Methods : At 1-year follow-up after breast-conserving surgery, patients [...]

A partir des données des registres américains des cancers portant sur 32 443 patients atteints d'un cancer hépatobiliaire et âgés de plus de 66 ans et sur 200 000 témoins, cette étude évalue l'association entre des maladies auto-immunes et le risque de développer la maladie, sur la période 1992-2013

Associations between autoimmune conditions and hepatobiliary cancer risk among elderly US adults

McGee, Emma E. ; Castro, Felipe A. ; Engels, Eric A. ; Freedman, Neal D. ; Pfeiffer, Ruth M. ; Nogueira, Leticia ; Stolzenberg-Solomon, Rachael ; McGlynn, Katherine A. ; Hemminki, Kari ; Koshiol, Jill

Growing evidence suggests that people with autoimmune conditions may be at increased risk of hepatobiliary tumors. In the present study, we evaluated associations between autoimmune conditions and hepatobiliary cancers among adults aged ≥66 in the United States. We used Surveillance, Epidemiology, and End Results (SEER)-Medicare data (1992-2013) to conduct a population-based, case-control study. Cases (n=32,443) had primary hepatobiliary cancer. Controls (n=200,000) were randomly selected, [...]

Menée aux Etats-Unis à partir de données portant sur 3 152 patients ayant survécu plus de 5 ans à un cancer diagnostiqué avant l'âge de 20 ans, cette étude analyse les facteurs associés au risque d'hospitalisation et de décès, sur la période 1982-2014 (durée médiane de suivi : 9 ans)

Hospitalization and mortality among pediatric cancer survivors: a population-based study

Mueller, Beth A. ; Doody, David R. ; Weiss, Noel S. ; Chow, Eric J.

Purpose : We examined serious long-term outcomes among childhood cancer survivors using population-based data. Methods : We used 1982–2014 Washington State data to compare hospitalization and/or death (including cause-specific) during up to 27 years follow-up among all 5+ year childhood cancer survivors < 20 years at diagnosis (n = 3,152) and a sample of comparison children within birth cohorts, with assessment by cancer type and child/family characteristics. Results : During follow-up (9 years [...]

A partir des données des registres finlandais, cette étude analyse l'évolution du risque de cancer chez les patients atteints d'un diabète de type 2, sur la période 1989-2014 (428 326 personnes atteintes d'un diabète ; 74 063 cas de cancer)

Cancer incidence among Finnish people with type 2 diabetes during 1989–2014

Saarela, Katri ; Tuomilehto, Jaakko ; Sund, Reijo ; Keskimäki, Ilmo ; Hartikainen, Sirpa ; Pukkala, Eero

Diabetes and cancer are common diseases both with enormous impact on health burden globally. The increased risk of several types of cancer among people with type 2 diabetes mellitus has been indicated repeatedly. This study aimed at exploring and describing the association between type 2 diabetes and cancer incidence. A cohort of 428,326 people with type 2 diabetes was identified from the Finnish National Diabetes Register and followed up through a register linkage with the Finnish Cancer [...]

Menée en Suède à partir de données portant sur 1 816 patients atteints d'un adénocarcinome de l'œsophage ou d'un carcinome épidermoïde de l'œsophage traité par œsophagectomie entre 1987 et 2010, cette étude évalue les disparités de mortalité entre les hommes et les femmes après un traitement chirurgical

Sex differences in the prognosis after surgery for esophageal squamous cell carcinoma and adenocarcinoma

Kauppila, Joonas H ; Wahlin, Karl ; Lagergren, Pernilla ; Lagergren, Jesper

Some investigations suggest a better prognosis in women compared to men with esophageal cancer but these differences are uncertain. The aim of this study was to clarify whether sex influences the prognosis after esophagectomy for esophageal squamous cell carcinoma and esophageal adenocarcinoma. A population-based and nationwide cohort study included almost all patients who underwent esophagectomy for esophageal cancer in Sweden in 1987-2010, with follow-up until 2016. Patients' sex was analyzed [...]

Menée aux Etats-Unis à partir de données portant sur 1 220 patients atteints d'un cancer du poumon non à petites cellules et sur 1 634 témoins, cette étude évalue les disparités ethniques dans l'association entre une utilisation d'aspirine, le risque de développer la maladie, et la survie

Racial and Ethnic Differences in the Relationship Between Aspirin Use and Non-Small Cell Lung Cancer Risk and Survival

Erickson, Patricia ; Gardner, Lisa D. ; Loffredo, Christopher A. ; St. George, Diane Marie ; Bowman, Elise D. ; Deepak, Janaki ; Mitchell, Khadijah A ; Meaney, Claire L. ; Langenberg, Patricia ; Bernat, Debra H. ; Amr, Sania ; Ryan, Bríd M.

Background:African Americans (AA) experience higher incidence and mortality of lung cancer as compared with European Americans (EA). Inflammation is associated with lung cancer, many aspects of which differ between AA and EA. We investigated whether use, frequency, and duration of the anti-inflammatory drug aspirin was associated with lung cancer risk and survival, separately among AA and EA populations. Methods:Using data from the Maryland Non-Small Cell Lung Cancer (NSCLC) Case-Control Study [...]

Mené au Canada par questionnaire auprès de 106 patientes atteintes d'un cancer gynécologique ou d'un cancer du sein de stade I à III, cet essai randomisé analyse la pertinence et l'efficacité d'un outil permettant de détecter et de prévenir la peur de la récidive de la maladie

Towards the validation of a new, blended theoretical model of fear of cancer recurrence

Lebel, Sophie ; Maheu, Christine ; Tomei, Christina ; Bernstein, Lori J. ; Courbasson, Christine ; Ferguson, Sarah ; Harris, Cheryl ; Jolicoeur, Lynne ; Lefebvre, Monique ; Muraca, Linda ; Ramanakumar, Agnihotram V. ; Singh, Mina ; Parrott, Julia ; Figueiredo, Danielle

Objective : Fear of cancer recurrence (FCR) is defined as “fear, worry, or concern about cancer returning or progressing”. To date, there is only one partially validated model of FCR (Lee‐Jones et al., 1997), so additional model testing is critical to inform intervention efforts. The purpose of this study is to examine the validity of a blended model of FCR that integrates Leventhal's Common Sense Model, Mishel's Uncertainty in Illness Theory, and cognitive theories of worry. Methods : [...]

Menée en Allemagne par enquête auprès de 51 médecins et 67 infirmières en oncologie s'occupant de 100 patients atteints d'un cancer de stade avancé en fin de vie, cette étude analyse la présence et l'intensité de leur détresse morale lors de la prise de décisions visant à limiter la durée des traitements

High prevalence of moral distress reported by oncologists and oncology nurses in end-of-life decision making

Mehlis, K. ; Bierwirth, E. ; Laryionava, K. ; Mumm, F.H.A. ; Hiddemann, W. ; Heußner, P. ; Winkler, E.C.

Objective : Decisions to limit life-prolonging treatment (DLT) are often accompanied by psychological and ethical difficulties. The aim of the study is to investigate prevalence and intensity of moral distress (MD) as well as potential causes experienced by oncology physicians and nurses in DLT situations. Methods : This prospective study at a German university hospital included n=100 advanced cancer inpatients with DLT. We surveyed their respective physicians and nurses to assess moral [...]

Menée aux Pays-Bas par questionnaire auprès de 124, puis 96 et 76 patients atteints d'un cancer de stade avancé, cette étude analyse leur qualité de vie auto-déclarée, leur sentiment d'espoir et les facteurs associés à leur participation à un essai de phase I

Self-reported quality of life and hope in phase-I trial participants: An observational prospective cohort study

van der Biessen, Diane A. ; Oldenmenger, Wendy H. ; van der Helm, Peer G. ; Klein, Dennis ; Oomen-de Hoop, Esther ; Mathijssen, Ron H. ; Lolkema, Martijn P. ; de Jonge, Maja J.

For advanced cancer patients deliberating early clinical trial participation, adequate information about expected effect on quality of life (HRQoL) and hope, may support decision making. The aim was to assess the potential relation of HRQoL to eligibility for phase-I trial participation, and to observe the variations in patient-reported outcomes. Patients completed questionnaires at preconsent (n = 124), baseline (n = 96), and after first evaluation of a phase-I trial (n = 76). The Mann–Whitney [...]

Menée en Australie par entretiens auprès de médecins généralistes, cette étude analyse leur rôle dans le suivi et les soins des patients pédiatriques ayant survécu à un cancer

The Role Of Primary Care Physicians in Childhood Cancer Survivorship Care: Multiperspective Interviews

Signorelli, Christina ; Wakefield, Claire E. ; Fardell, Joanna E. ; Foreman, Tali ; Johnston, Karen A. ; Emery, Jon ; Thornton‐Benko, Elysia ; Girgis, Afaf ; Lie, Hanne C. ; Cohn, Richard J. ; on behalf of the Anzchog Survivorship Study Group

Background : Primary care physicians (PCPs) are well placed to provide holistic care to survivors of childhood cancer and may relieve growing pressures on specialist‐led follow‐up. We evaluated PCPs' role and confidence in providing follow‐up care to survivors of childhood cancer. Subjects, Materials, and Methods : In Stage 1, survivors and parents (of young survivors) from 11 Australian and New Zealand hospitals completed interviews about their PCPs' role in their follow‐up. Participants [...]

Menée à partir des données de Globocan et QuintilesIMS, cette étude analyse l'association entre les dépenses liées aux médicaments anticancéreux et la mortalité par cancer, dans les pays d'Europe centrale et d'Europe de l'Est

Expenditures on Oncology Drugs and Cancer Mortality-to-Incidence Ratio in Central and Eastern Europe

Vrdoljak, Eduard ; Bodoky, György ; Jassem, Jacek ; Popescu, Razvan ; Pirker, Robert ; Cufer, Tanja ; Beslija, Semir ; Eniu, Alexandru ; Todorović, Vladimir ; Kopeckova, Katerina ; Kurteva, Galia ; Tomašević, Zorica ; Sallaku, Agim ; Smichkoska, Snezhana ; Bajić, Žarko ; Sikic, Branimir

Background : There is a steady decline in cancer mortality in Western Europe (WE), but this trend is not so obvious in Central and Eastern Europe (CEE). One of the largest discrepancies between WE and CEE is the level of investment in cancer care. The objective of our analysis was to examine the correlation between mortality‐to‐incidence (M/I) ratio and expenditures on oncology drugs in CEE and WE. Materials and Methods : This cross‐sectional analysis was done on publicly available data. Data [...]

Menée dans un contexte canadien, cette étude évalue le rapport coût-efficacité de l'osimertinib en traitement de première ligne des patients atteints d'un cancer du poumon non à petites cellules de stade avancé et présentant une mutation EGFR

Economic analysis of osimertinib in previously untreated EGFR-mutant advanced non-small cell lung cancer in Canada

Ezeife, Doreen A. ; Kirk, Veronica ; Chew, Derek S. ; Nixon, Nancy A. ; Lee, Roy ; Le, Lisa W. ; Chan, Kelvin K. W. ; Leighl, Natasha B.

Introduction : Osimertinib improves progression-free survival in previously untreated EGFR-positive advanced non-small cell lung cancer (NSCLC) patients, with marked intracranial response rates. However, its cost-effectiveness in a publically funded health care system has not been established. We assessed the cost-effectiveness of first-line osimertinib from the public payer perspective in the Canadian health care system. Methods : A Markov model was developed to project the outcomes and direct [...]

Menée au Canada par enquête auprès de 192 hommes atteints d'un cancer (âge médian : 33, 6 ans), cette étude analyse leurs besoins en information et leurs pratiques relatives à la préservation de la fertilité

A Fertility Needs Assessment Survey of Male Cancer Patients

Perez, Samara ; Lambert, Sylvie ; Lee, Virginia ; Loiselle, Carmen G. ; Chan, Peter ; Gupta, Abha ; Lo, Kirk ; Rosberger, Zeev ; Zelkowitz, Phyllis

Objective : To describe fertility-related informational needs and practices, and to examine if demographic characteristics are related to these needs and practices. Methods : A needs assessment survey was conducted at three Canadian cancer centres. Results : 192 male cancer patients (Mage=33.6) completed the survey. Most patients (70%) recalled having had a discussion with a health care provider (HCP) regarding their fertility and 44% banked their sperm. Patients reported not getting all the [...]

Mené aux Etats-Unis sur 1 196 femmes âgées de 51 à 74 ans, cet essai randomisé compare l'efficacité de trois interventions personnalisées de conseils (sur internet, par téléphone, ou combinant web et téléphone) et des méthodes standards, pour améliorer leur adhésion au dépistage du cancer colorectal

A Randomized Trial to Compare a Tailored Web-Based Intervention and Tailored Phone Counseling to Usual Care for Increasing Colorectal Cancer Screening

Champion, Victoria L. ; Christy, Shannon M. ; Rakowski, William ; Gathirua-Mwangi, Wambui G ; Tarver, Will L. ; Carter-Harris, Lisa ; Cohee, Andrea A. ; Marley, Andrew R. ; Jessup, Nenette M. ; Biederman, Erika ; Kettler, Carla D. ; Stump, Timothy E ; Monahan, Patrick ; Lairson, David R ; Rawl, Susan M

Background: Colorectal cancer mortality could be decreased with risk-appropriate cancer screening. We examined the efficacy of three tailored interventions compared to Usual Care for increasing screening adherence. Methods: Women (n=1196) ages 51 to 74, from primary care networks and non-adherent to colorectal cancer guidelines were randomized to: 1) Usual Care, 2) tailored Web intervention, 3) tailored Phone intervention, or 4) tailored Web + Phone intervention. Average-risk women could select [...]

Menée aux Etats-Unis à partir de données portant sur 2 135 patients décédés d'un cancer entre 2000 et 2013, cette étude analyse les facteurs associés à l'intensité des soins de fin de vie, chez des patients recevant une greffe allogénique de cellules souches hématopoïétiques

End-of-Life Care Intensity in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation: A Population-Level Analysis

Emily E. Johnston ; Lori Muffly ; Elysia Alvarez ; Olga Saynina ; Lee M. Sanders ; Smita Bhatia ; Lisa J. Chamberlain

Purpose : Intensity of end-of-life care receives much attention in oncology because of concerns that high-intensity care is inconsistent with patient goals, leads to worse caregiver outcomes, and is expensive. Little is known about such care in those undergoing allogeneic hematopoietic cell transplantation (HCT), a population at high risk for morbidity and mortality. Patients and Methods : We conducted a population-based analysis of patients who died between 2000 and 2013, within 1 year of [...]

Menée en France auprès de 376 médecins généralistes, cette étude transversale analyse leurs caractéristiques et leurs pratiques associées à la prescription d'opioïdes pour prendre en charge la douleur chez des patients atteints de cancer en fin de vie

Opioid Analgesics Prescription to End-of-Life Cancer Patients: Characteristics, Attitudes, and Practices of French General Practitioners

Janah, Asmaa ; Rey, Dominique ; Bouhnik, Anne-Deborah ; Mancini, Julien ; Sarradon-Eck, Aline ; Verger, Pierre ; Peretti-Watel, Patrick ; Bendiane, Marc-Karim

Background: Pain management, especially at the end of life, varies depending on the prescriber's characteristics and attitudes. Little is known about the practices of general practitioners (GPs) regarding end-of-life management for patients with cancer. Objectives: To provide an overview of the characteristics associated with GPs' attitudes and practices regarding opioids prescribing and to explore GPs' perceived role and difficulties in managing end-of-life care for patients with cancer. [...]

Cet article évalue la présence et l'importance des conflits d'intérêt et des relations financières existant entre les laboratoires pharmaceutiques et les oncologues ayant mené des essais cliniques sur des médicaments autorisés par la Food and Drug Administration

Financial conflicts of interest among oncologist authors of reports of clinical drug trials

Wayant, C. ; Turner, E. ; Meyer, C. ; Sinnett, P. ; Vassar, M.

In medical research, a financial conflict of interest (FCOI) may affect the conduct and reporting of clinical trials.1 The presence of FCOIs in clinical trials of oncology drugs that receive US Food and Drug Administration (FDA) approval is of particular concern, because these trials may change the trajectory of cancer care. These trials also generate high–impact factor publications, prestige for authors, revenue for the pharmaceutical companies, and newsworthy headlines. The primary objective [...]