A partir d'une revue systématique de la littérature (24 essais randomisés), cette méta-analyse compare l'efficacité du palonosétron et d'autres antagonistes des récepteurs 5-HT3 pour prévenir et traiter les nausées et vomissements induits par la chimiothérapie

Should palonosetron be a preferred 5-HT3 receptor antagonist for chemotherapy-induced nausea and vomiting? An updated systematic review and meta-analysis

Chow, Ronald ; Warr, David G. ; Navari, Rudolph M. ; Tsao, May ; Popovic, Marko ; Chiu, Leonard ; Milakovic, Milica ; Lam, Henry ; DeAngelis, Carlo

Purpose : Chemotherapy-induced nausea and vomiting (CINV) continues to be a common side effect of systemic anticancer therapy, decreasing quality of life and increasing resource utilization. The aim of this meta-analysis was to investigate the comparative efficacy and safety of palonosetron relative to other 5-HT3RAs. Methods : A literature search was carried out in Ovid MEDLINE, Embase, and Cochrane Central Register of Controlled Trials. Full-text references were then screened and included in [...]

A partir d'une revue systématique de la littérature (13 études), cette étude analyse les effets de programmes personnalisés de soins dédiés à l'après-cancer sur l'état de santé physique et psychologique des patients, ainsi que sur l'accès à ces soins

Systematic Review of the Impact of Cancer Survivorship Care Plans on Health Outcomes and Health Care Delivery

Paul B. Jacobsen ; Antonio P. DeRosa ; Tara O. Henderson ; Deborah K. Mayer ; Chaya S. Moskowitz ; Electra D. Paskett ; Julia H. Rowland

Purpose : Numerous organizations recommend that patients with cancer receive a survivorship care plan (SCP) comprising a treatment summary and follow-up care plans. Among current barriers to implementation are providers’ concerns about the strength of evidence that SCPs improve outcomes. This systematic review evaluates whether delivery of SCPs has a positive impact on health outcomes and health care delivery for cancer survivors. Methods : Randomized and nonrandomized studies evaluating [...]

Menée sur 876 patients atteints d'un cancer de stade avancé et admis dans des unités de soins palliatifs, cette étude analyse leurs expériences et impressions vis-à-vis de la prise en charge de leurs symptômes et de leur participation au processus de prise de décision thérapeutique

Personalized Symptom Goals and Patient Global Impression on Clinical Changes in Advanced Cancer Patients

Mercadante, Sebastiano ; Adile, Claudio ; Lanzetta, Gaetano ; Mystakidou, Kyriaki ; Maltoni, Marco ; Soares, Luiz Guilherme ; De Santis, Stefano ; Ferrera, Patrizia ; Valenti, Marco ; Rosati, Marta ; Rossi, Romina ; Cortegiani, Andrea ; Masedu, Francesco ; Marinangeli, Franco ; Aielli, Federica

Background : The aim of this study was to assess the patients’ global impression (PGI) after symptom management, as well as the achievement of personalized symptom goals (PSG). The secondary outcome was to assess related factors. Subjects, Materials, and Methods : Advanced cancer patients admitted to palliative care units rated symptom intensity by using the Edmonton Symptom Assessment Score (ESAS) at admission and then after 1 week. For each symptom, patient‐reported PGI and PSG, as well as [...]

A partir d'une revue systématique de la littérature publiée jusqu'en juin 2016 (25 études, 1 897 participants), cette étude analyse les effets des différents traitements anticancéreux (chimiothérapie, chimioradiothérapie, chirurgie) sur les fonctions physiques des patients atteints d'un cancer de l'œsophage ou d'un cancer de l'estomac, et évalue l'intérêt des programmes de réadaptation physique

Physical decline and its implications in the management of oesophageal and gastric cancer: a systematic review

O’Neill, Linda ; Moran, Jonathan ; Guinan, Emer M. ; Reynolds, John V. ; Hussey, Juliette

Purpose : The management of oesophageal and gastric cancer can cause significant physical decline, impacting on completion rates and outcomes. This systematic review aimed to (i) determine the impact of chemotherapy, chemoradiotherapy and surgery on physical function; (ii) identify associations between physical function and post-operative outcomes; and (iii) examine the effects of rehabilitation on physical function. Methods : We included randomised controlled trials (RCT), non-RCTs of [...]

A partir d'une revue systématique de la littérature (33 études, 1 304 patients), cette méta-analyse évalue les effets à long terme (5 et 10 ans) d'une résection de métastases hépatiques sur la survie globale

Long-term survival after liver metastasectomy in gastric cancer: Systematic review and meta-analysis of prognostic factors

Montagnani, Francesco ; Crivelli, Francesca ; Aprile, Giuseppe ; Vivaldi, Caterina ; Pecora, Irene ; De Vivo, Rocco ; Alberto Clerico, Mario ; Fornaro, Lorenzo

Background : Despite the amelioration of systemic therapy, overall survival (OS) of metastatic gastric cancer (GC) patients remains poor. Liver is a common metastatic site and retrospective series suggest a potential OS benefit from hepatectomy, with interesting 5-year (5y) and 10-year (10y) OS rates in selected patients. We aim to evaluate the impact of liver resection and related prognostic factors on long-term outcome in this setting. Methods : We searched Pubmed, EMBASE, and [...]

A partir des données de divers organismes américains (National Cancer Institute, American Cancer Society...), cette étude met à jour les données d'incidence des cancers, de survie et de mortalité spécifique aux Etats-Unis

Annual Report to the Nation on the Status of Cancer, part I: National cancer statistics

Cronin Kathleen A. ; Lake Andrew J. ; Scott Susan ; Sherman Recinda L. ; Noone Anne‐Michelle ; Howlader Nadia ; Henley S. Jane ; Anderson Robert N. ; Firth Albert U. ; Ma Jiemin ; Kohler Betsy A. ; Jemal Ahmedin

BACKGROUND The American Cancer Society (ACS), the Centers for Disease Control and Prevention (CDC), the National Cancer Institute (NCI), and the North American Association of Central Cancer Registries (NAACCR) collaborate to provide annual updates on cancer occurrence and trends in the United States. METHODS Incidence data were obtained from the CDC‐funded and NCI‐funded population‐based cancer registry programs and compiled by NAACCR. Data on cancer deaths were obtained from the National [...]

A partir des données de 68 études, cette étude présente les recommandations pour la pratique clinique de l'"American Society of Clinical Oncology" relatives à la prise en charge spécifique des patients âgés de plus de 65 ans et atteints de cancer

Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology

Supriya G. Mohile ; William Dale ; Mark R. Somerfield ; Mara A. Schonberg ; Cynthia M. Boyd ; Peggy S. Burhenn ; Beverly Canin ; Harvey Jay Cohen ; Holly M. Holmes ; Judith O. Hopkins ; Michelle C. Janelsins ; Alok A. Khorana ; Heidi D. Klepin ; Stuart M. Lichtman ; Karen M. Mustian ; William P. Tew ; Arti Hurria

Purpose : To provide guidance regarding the practical assessment and management of vulnerabilities in older patients undergoing chemotherapy. Methods : An Expert Panel was convened to develop clinical practice guideline recommendations based on a systematic review of the medical literature. Results : A total of 68 studies met eligibility criteria and form the evidentiary basis for the recommendations. Recommendations : In patients ≥ 65 years receiving chemotherapy, geriatric assessment (GA) [...]

Menée aux Etats-Unis à partir de données portant sur 17 564 patientes ayant survécu à un cancer diagnostiqué entre 15 et 39 ans, cette étude analyse les facteurs associés à la survenue de la naissance d'un enfant, avant et après la publication des recommandations de l' "American Society of Clinical Oncology" relatives à la préservation de la fertilité (durée de suivi : 98 397 personnes-années)

Childbirth after adolescent and young adult cancer: a population-based study

Nichols, Hazel B. ; Anderson, Chelsea ; Ruddy, Kathryn J. ; Black, Kristin Z. ; Luke, Barbara ; Engel, Stephanie M. ; Mersereau, Jennifer E.

Purpose : Annually, > 45,000 US women are diagnosed with cancer during adolescence and young adulthood (AYA). Since 2006, national guidelines have recommended fertility counseling for cancer patients. We examined childbirth after AYA cancer by calendar period, cancer diagnosis, and maternal characteristics. Methods : We identified a cohort of women with an incident invasive AYA cancer diagnosis at ages 15–39 during 2000–2013 in North Carolina. Cancer records were linked with statewide birth [...]

A partir d'une revue des essais de phase I/II conduits en Europe, aux Etats-Unis ou en Asie, cette étude analyse les disparités, selon l'origine caucasienne ou asiatique des populations, dans l'efficacité et la dose maximale tolérée et recommandée de diverses thérapies ciblées

Impact of race on dose selection of molecular-targeted agents in early-phase oncology trials

Yokota, Tomoya ; Bendell, Johanna ; LoRusso, Patricia ; Tsushima, Takahiro ; Desai, Ved ; Kenmotsu, Hirotsugu ; Watanabe, Junichiro ; Ono, Akira ; Murugesan, Bhavani ; Silva, Joseph ; Naito, Tateaki ; Greenberg, Jonathan ; Kumar, Prasanna ; Wang, Yibin ; Jikoh, Takahiro ; Shiga, Ryota ; Hyman, David M. ; Ho, Alan Loh ; Spriggs, David R. ; Schwartz, Gary K. ; Gounder, Mrinal M.

Background : We examined the impact of race on the maximum tolerated doses (MTD) and final approved doses (FAD) of single-agent molecular-targeted agents (MTA) in North America/Europe (NA/EU) and Asia. Methods : We searched PubMed and regulatory databases to identify targeted drugs approved globally and compared their FAD and MTD in corresponding phase I/II studies conducted separately in NA/EU and Asia. To evaluate this further, we conducted parallel, prospective, first-in-human studies of [...]

Menée aux Etats-Unis à partir de données portant sur 165 patients ayant survécu à une leucémie lymphoblastique aiguë pédiatrique (âge moyen : 14,4 ans), cette étude analyse les effets à long terme de la chimiothérapie sur l'activité cérébrale et les fonctions neurocognitives (durée moyenne depuis le diagnostic : 7,7 ans)

Brain Activity Associated With Attention Deficits Following Chemotherapy for Childhood Acute Lymphoblastic Leukemia

Fellah, Slim ; Cheung, Yin T. ; Scoggins, Matthew A. ; Zou, Ping ; Sabin, Noah D. ; Pui, Ching-Hon ; Robison, Leslie L. ; Hudson, Melissa M. ; Ogg, Robert J. ; Krull, Kevin R.

Background : The impact of contemporary chemotherapy treatment for childhood acute lymphoblastic leukemia on central nervous system activity is not fully appreciated. Methods : Neurocognitive testing and functional magnetic resonance imaging (fMRI) were obtained in 165 survivors five or more years postdiagnosis (average age = 14.4 years, 7.7 years from diagnosis, 51.5% males). Chemotherapy exposure was measured as serum concentration of methotrexate following high-dose intravenous injection. [...]

Menée aux Etats-Unis à partir de données portant sur la période 1995-2014, cette étude analyse l'évolution des disparités, selon l'origine ethnique, l'âge et le sexe du patient, de l'incidence du cancer du poumon

Higher Lung Cancer Incidence in Young Women Than Young Men in the United States

Jemal, Ahmedin ; Miller, Kimberly D. ; Ma, Jiemin ; Siegel, Rebecca L. ; Fedewa, Stacey A. ; Islami, Farhad ; Devesa, Susan S. ; Thun, Michael J.

Background : Previous studies showed a higher incidence of lung cancer among young women than among young men in the United States. Whether this pattern has continued in contemporary birth cohorts and, if so, whether it can be fully explained by sex differences in smoking behaviors are unknown. Methods : We examined the nationwide population-based incidence of lung cancer according to sex, race or ethnic group, age group (30 to 34, 35 to 39, 40 to 44, 45 to 49, and 50 to 54 years), year of [...]

A partir des données de divers organismes américains (National Cancer Institute, American Cancer Society...), cette étude met à jour les données d'incidence du cancer de la prostate, de survie et de mortalité spécifique en lien avec l'utilisation du test PSA, pour la période 2000-2014

Annual Report to the Nation on the Status of Cancer, part II: Recent changes in prostate cancer trends and disease characteristics

Negoita Serban ; Feuer Eric J. ; Mariotto Angela ; Cronin Kathleen A. ; Petkov Valentina I. ; Hussey Sarah K. ; Benard Vicki ; Henley S. Jane ; Anderson Robert N. ; Fedewa Stacey ; Sherman Recinda L. ; Kohler Betsy A. ; Dearmon Barbara J. ; Lake Andrew J. ; Ma Jiemin ; Richardson Lisa C. ; Jemal Ahmedin ; Penberthy Lynne

BACKGROUND Temporal trends in prostate cancer incidence and death rates have been attributed to changing patterns of screening and improved treatment (mortality only), among other factors. This study evaluated contemporary national‐level trends and their relations with prostate‐specific antigen (PSA) testing prevalence and explored trends in incidence according to disease characteristics with stage‐specific, delay‐adjusted rates. METHODS Joinpoint regression was used to examine changes in [...]

A partir des données de patients atteints d'un cancer colorectal de stade II ou III inclus dans un essai de phase III évaluant l'efficacité d'un traitement adjuvant à base de fluorouracile, de leucovorine ou d'une chimiothérapie de type FOLIFIRI, cette étude rétrospective analyse l'association entre le sexe du patient et la survenue d'événements indésirables induits par les chimiothérapies

Association of patient sex with chemotherapy-related toxic effects: A retrospective analysis of the PETACC-3 trial conducted by the EORTC gastrointestinal group

Cristina, V. ; Mahachie, J. ; Mauer, M. ; et al.,

Sex is one of several known factors responsible for the wide interpatient variability in the dose-effect relationship of drugs. It affects both pharmacokinetics and pharmacodynamics. Data on the clinical impact of sex on chemotherapy-related toxic effects are lacking for colorectal cancer (CRC). The aim of this study is to evaluate the association of sex with incidence and severity of chemotherapy-related toxic effects in patients with stage II and III CRC treated with adjuvant fluorouracil and [...]

Menée aux Etats-Unis à partir de données portant sur 3 262 patients atteints d'un cancer colorectal de stade I à III diagnostiqué entre 2006 et 2011, cette étude observationnelle évalue l'association entre le niveau de radiodensité musculaire mesuré à l'aide de la tomographie numérique, la mortalité spécifique et la mortalité toutes causes confondues

Muscle radiodensity and mortality in patients with colorectal cancer

Kroenke Candyce H. ; Prado Carla M. ; Meyerhardt Jeffrey A. ; Weltzien Erin K. ; Xiao Jingjie ; Cespedes Feliciano Elizabeth M. ; Caan Bette J.

BACKGROUND Low skeletal muscle radiodensity (SMD) is related to higher mortality in several cancers, but the association with colorectal cancer (CRC) prognosis is unclear. METHODS This observational study included 3262 men and women from the Kaiser Permanente Northern California population diagnosed between 2006 and 2011 with AJCC stages I to III CRC. The authors evaluated hazard ratios (HRs) of low SMD for all‐cause and CRC‐specific mortality, assessed by computed tomography using optimal [...]

Menée aux Etats-Unis à partir des données de la cohorte "Women’s Health Initiative" incluant 48 835 participantes après la ménopause, cet essai randomisé évalue l'association entre un régime alimentaire pauvre en graisses et la survie globale chez les patientes atteintes d'un cancer du sein (1 764 cas ; durée médiane de l'intervention nutritionnelle : 8,5 ans)

Association of low-fat dietary pattern with breast cancer overall survival: A secondary analysis of the Women’s Health Initiative randomized clinical trial

Chlebowski, R. T. ; Aragaki, A. K. ; Anderson, G. L. ; et al.,

Importance : In a randomized clinical trial, a low-fat eating pattern was associated with lower risk of death after breast cancer. However, the extent to which results were driven by dietary influence on survival after breast cancer diagnosis was unknown. Objective :To determine the association of a low-fat dietary pattern with breast cancer overall survival (breast cancer followed by death from any cause measured from cancer diagnosis). Design, Setting, and Participants : This is a secondary [...]

A partir de données portant sur 456 patientes atteintes d'un cancer du sein traité par radiothérapie entre 1958 et 2001, cette étude analyse l'effet des rayonnements ionisants sur les différentes structures cardiaques

Cardiac Structure Injury After Radiotherapy for Breast Cancer: Cross-Sectional Study With Individual Patient Data

Taylor, Carolyn ; McGale, Paul ; Brønnum, Dorthe ; Correa, Candace ; Cutter, David ; Duane, Frances K. ; Gigante, Bruna ; Jensen, Maj-Britt ; Lorenzen, Ebbe ; Rahimi, Kazem ; Wang, Zhe ; Darby, Sarah C. ; Hall, Per ; Ewertz, Marianne

Purpose : Incidental cardiac irradiation can cause cardiac injury, but little is known about the effect of radiation on specific cardiac segments. Methods : For 456 women who received breast cancer radiotherapy between 1958 and 2001 and then later experienced a major coronary event, information was obtained on the radiotherapy regimen they received and on the location of their cardiac injury. For 414 women, all with documented location of left ventricular (LV) injury, doses to five LV segments [...]

Menée aux Etats-Unis à partir de données portant sur 10 173 hommes atteints d'un cancer du sein HR+ (âge moyen : 66 ans), cette étude de cohorte rétrospective analyse l'évolution de l'utilisation d'une hormonothérapie adjuvante et évalue son efficacité, du point de vue de la survie globale, sur la période 2004-2014

Use and effectiveness of adjuvant endocrine therapy for hormone receptor–positive breast cancer in men

Venigalla, S. ; Carmona, R. ; Guttmann, D. M. ; et al.,

Importance : Although adjuvant endocrine therapy confers a survival benefit among females with hormone receptor (HR)–positive breast cancer, the effectiveness of this treatment among males with HR-positive breast cancer has not been rigorously investigated. Objective : To investigate trends, patterns of use, and effectiveness of adjuvant endocrine therapy among men with HR-positive breast cancer. Design, Setting, and Participants : This retrospective cohort study identified patients in the [...]

Menée à partir des données 2002-2010 de deux régions anglaises portant sur 18 730 patientes atteintes d'un cancer du sein ER+ et âgées de plus de 70 ans, cette étude met en évidence une association entre l'absence de traitement chirurgical et une réduction de la survie spécifique

Omission of surgery in older women with early breast cancer has an adverse impact on breast cancer-specific survival

Ward, S. E. ; Richards, P. D. ; Morgan, J. L. ; Holmes, G. R. ; Broggio, J. W. ; Collins, K. ; Reed, M. W. R. ; Wyld, L.

Background : Primary endocrine therapy is used as an alternative to surgery in up to 40 per cent of women with early breast cancer aged over 70 years in the UK. This study investigated the impact of surgery versus primary endocrine therapy on breast cancer-specific survival (BCSS) in older women. Methods : Cancer registration data for 2002–2010 were obtained from two English regions. A retrospective analysis was performed for women with oestrogen receptor (ER)-positive disease, using [...]

Menée aux Etats-Unis à partir de données portant sur 6 079 patients ayant survécu à un cancer et âgés de plus de 18 ans, cette étude analyse les facteurs associés à un diagnostic auto-déclaré de dépression

Factors associated with self-reported history of depression diagnosis among cancer survivors aged 18 years and over in the United States

Gerbi Gemechu B. ; Ivory Stranjae’ ; Booker Elaine Archie ; Claridy Mechelle D. ; Miles‐Richardson Stephanie

Objective : According to the American Cancer Society, 25 percent of cancer survivors in the United States develop depression. The objective of this study is to assess factors associated with self‐reported history of depression diagnosis among cancer survivors aged ≥18 years in the United States. Methods : Data were analyzed from the 2014 Behavioral Risk Factor Surveillance System (BRFSS) (N=6,079). The BRFSS collects data about US residents regarding their health‐related risk behaviors and [...]

A partir d'une revue de la littérature, cette étude fait le point sur les facteurs associés au risque d'épuisement professionnel chez les médecins oncologues

Burnout in Oncologists is a serious issue: What can we do about it?

Murali, Krithika ; Banerjee, Susana

The cancer burden is rising globally with an increasing need for oncologists. The significant demands associated with caring for cancer patients within a rapidly evolving scientific field, poses manifold challenges, including the risk of work-related burnout. Surveys have already shown that the prevalence of burnout in oncologists worldwide is significant. There is growing concern that burnout has a detrimental impact on the wellbeing of oncologists and their patients. In this review article, [...]

Mené à Hong Kong sur 173 dyades constituées du patient atteint d'un cancer du poumon et de son aidant, cet essai randomisé analyse leur anxiété vis-à-vis de la mort, leurs comportements et leur qualité de vie respective

Facing death alone or together? Investigating the interdependence of death anxiety, dysfunctional attitudes and quality of life in patient-caregiver dyads confronting lung cancer

Lau Bobo Hi‐Po ; Wong Daniel F.K. ; Fung Y.L. ; Zhou Jillian ; Chan Cecilia L.W. ; Chow Amy Y.M.

Background : Based on the cognitive theory, anxiety arising from the awareness of death and dying may activate dysfunctional attitudes, which may then reduce quality of life. This study examined the interdependence and the mediating role of dysfunctional attitudes on the relationship between death anxiety and quality of life among patients with lung cancer and their caregivers. Methods : From March 2016 to April 2017, 173 pairs of patients and their caregivers enrolled in a randomized [...]