Menée en Chine à partir des données de deux études de cohortes prospectives portant sur 72 451 femmes et 60 037 hommes vivant en milieu urbain, cette étude évalue l'association entre une activité physique et le risque de cancer du pancréas, selon le sexe de l'individu (durée médiane de suivi : 16,1 ans : 225 cas chez les femmes ; durée médiane de suivi : 10,3 ans ; 159 cas chez les hommes)

Physical Activity and Pancreatic Cancer Risk among Urban Chinese: Results from Two Prospective Cohort Studies

Wu, Lang ; Zheng, Wei ; Xiang, Yong-Bing ; Gao, Yu-Tang ; Li, Hong-Lan ; Cai, Hui ; Shu, Xiao-Ou

Background: Associations between physical activity and pancreatic cancer risk are unclear. Methods: In two prospective cohort studies, the Shanghai Women's Health Study and Shanghai Men's Health Study, physical activity and other information were collected at the baseline interview of 72,451 women and 60,037 men. Participants were followed up through annual linkage with a cancer registry in combination with in-person interviews taking place every 2 to 4 years. Results: We identified 225 female [...]

Menée en Italie à partir de données de deux études incluant respectivement 1 115 patients atteints d'un carcinome à cellules rénales et 2 582 témoins, et 1 417 patients atteints d'un cancer de la vessie et 1 732 témoins, cette étude évalue l'association entre une consommation de viandes transformées et le risque de développer la maladie

Processed Meat and Risk of Renal Cell and Bladder Cancers

Rosato, Valentina ; Negri, Eva ; Serraino, Diego ; Montella, Maurizio ; Libra, Massimo ; Lagiou, Pagona ; Facchini, Gaetano ; Ferraroni, Monica ; Decarli, Adriano ; Vecchia, Carlo La

We assessed the association of processed meat intake with the risk of renal cell carcinoma (RCC) and bladder cancer. We used data from two Italian hospital-based case-control studies, including 1,115 RCC cases and 2,582 controls, and 1,417 bladder cancer cases and 1,732 controls. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) with unconditional logistic regression models, adjusted for major confounders. The median consumption of processed meat in cases and controls was [...]

Menée aux Etats-Unis à partir de données portant sur 1 189 patients atteints d'un lymphome non hodgkinien et sur 982 témoins, cette étude évalue l'association entre une exposition professionnelle à 5 types de solvants chlorés et le risque de développer la maladie

Case-control investigation of occupational exposure to chlorinated solvents and non-Hodgkin’s lymphoma

Callahan, Catherine L ; Stewart, Patricia A ; Friesen, Melissa C ; Locke, Sarah ; De Roos, Anneclaire J ; Cerhan, James R ; Severson, Richard K ; Rothman, Nathaniel ; Purdue, Mark P

Objectives : Although many studies have investigated the association between trichloroethylene (TCE) exposure and non-Hodgkin’s lymphoma (NHL), less is known about other chlorinated solvents. We extended our previous analysis of occupational TCE exposure in a multicentre population-based case-control study of NHL to investigate associations with five additional chlorinated solvents: 1,1,1,-trichloroethane, carbon tetrachloride, chloroform, methylene chloride and perchloroethylene. Methods : [...]

Menée en Suède à partir de données portant sur 242 573 hommes, cette étude évalue l'association entre une appendicite avant l'âge de 20 ans et le risque de cancer de la prostate (durée médiane de suivi : 36,7 ans ; 1 684 cas)

Appendicitis before age 20 years is associated with an increased risk of later prostate cancer

Ugge, Henrik ; Udumyan, Ruzan ; Carlsson, Jessica ; Davidsson, Sabina ; Andrén, Ove ; Montgomery, Scott ; Fall, Katja

Background: Appendicitis before age 20 years has been observed to influence the risk of several inflammatory conditions, possibly through underlying immunological mechanisms. Inflammation has further been suggested to be involved in prostate cancer development. We therefore hypothesized that immunological characteristics signaled by appendicitis before late adolescence might influence the risk of later prostate cancer, and aimed to evaluate this association in a population-based study. Methods: [...]

Menée en Corée à partir de données portant sur des patients infectés par le virus de l'hépatite B chronique, cette étude de cohorte évalue l'association entre l'indice de masse corporelle et le risque de carcinome hépatocellulaire

Association of high body mass index and hepatocellular carcinoma in patients with chronic hepatitis B virus infection: A korean population-based cohort study

Kim, K. ; Choi, S. ; Park, S.

It is well established that obesity is associated with higher risk of hepatocellular carcinoma (HCC) in the general population.However, it is unclear whether body mass index (BMI [calculated as weight in kilograms divided by height in meters squared]) is associated with the risk of HCC in patients with chronic hepatitis B virus (HBV) infection because previous studies have reported inconsistent results. In this study, using data from a large nationwide, population-based cohort database, we [...]

A partir d'une revue systématique de la littérature, cette méta-analyse évalue l'association entre le niveau sérique d'acide urique, un marqueur d'une inflammation chronique, le risque de cancer et la mortalité par cancer

Serum uric acid and cancer mortality and incidence: a systematic review and meta-analysis

Dovell, Frances ; Boffetta, Paolo

Elevated serum uric acid (SUA) is a marker of chronic inflammation and has been suggested to be associated with increased risk of cancer, but its antioxidant capacity would justify an anticancer effect. Previous meta-analyses did not include all available results. We conducted a systematic review of prospective studies on SUA level and risk of all cancers and specific cancers, a conducted a meta-analysis based on random-effects models for high versus low SUA level as well as for an increase in [...]

Menée par une méthode de randomisation mendélienne à partir de données britanniques portant sur 310 000 participants, cette étude évalue l'association entre la taille de l'individu, le risque de cancer et la mortalité spécifique

Height and overall cancer risk and mortality: evidence from a Mendelian randomisation study on 310,000 UK Biobank participants

Ong, Jue-Sheng ; An, Jiyuan ; Law, Matthew H. ; Whiteman, David C. ; Neale, Rachel E. ; Gharahkhani, Puya ; MacGregor, Stuart

Background : Observational studies have shown that being taller is associated with greater cancer risk. However, the interpretation of such studies can be hampered by important issues such as confounding and reporting bias. Methods : We used the UK Biobank resource to develop genetic predictors of height and applied these in a Mendelian randomisation framework to estimate the causal relationship between height and cancer. Up to 438,870 UK Biobank participants were considered in our analysis. We [...]

A partir de données portant sur 879 patients atteints d'un myélome multiple et sur 2 389 témoins, cette étude met en évidence le rôle de mutations constitutionnelles du gène KDM1A dans l'étiologie de la maladie

Germline mutations in lysine specific demethylase 1 (LSD1/KDM1A) confer susceptibility to multiple myeloma

Wei, Xiaomu ; Calvo-Vidal, M. Nieves ; Chen, Siwei ; Wu, Gang ; Revuelta, Maria V. ; Sun, Jian ; Zhang, Jinghui ; Walsh, Michael F. ; Nichols, Kim E. ; Joseph, Vijai ; Snyder, Carrie ; Vachon, Celine M. ; McKay, James D. ; Wang, Shu-Ping ; Jayabalan, David S. ; Jacobs, Lauren M ; Becirovic, Dina ; Waller, Rosalie G ; Artomov, Mykyta ; Viale, Agnes ; Patel, Jayeshkumar ; Phillip, Jude M. ; Chen-Kiang, Selina ; Curtin, Karen ; Salama, Mohamed ; Atanackovic, Djordje ; Niesvizky, Ruben ; Landgren, Ola ; Slager, Susan L. ; Godley, Lucy A ; Churpek, Jane ; Garber, Judy E. ; Anderson, Kenneth C. ; Daly, Mark J. ; Roeder, Robert G ; Dumontet, Charles ; Lynch, Henry T. ; Mullighan, Charles G. ; Camp, Nicola J. ; Offit, Kenneth ; Klein, Robert J. ; Yu, Haiyuan ; Cerchietti, Leandro ; Lipkin, Steven M.

Given the frequent and largely incurable occurrence of multiple myeloma (MM), identification of germline genetic mutations that predispose cells to MM may provide insight into disease etiology and the developmental mechanisms of its cell of origin, the plasma cell. Here we identified familial and early-onset MM kindreds with truncating mutations in lysine-specific demethylase 1 (LSD1/KDM1A), an epigenetic transcriptional repressor that primarily demethylates histone H3 on lysine 4 and regulates [...]

Menée par une méthode de randomisation mendélienne à partir de données de 39 études portant sur 16 395 patientes atteintes d'un cancer de l'ovaire et sur 23 003 témoins, cette étude évalue l'association entre 609 polymorphismes à simple nucléotide de gènes liés à la taille de l'individu et le risque de développer la maladie

Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study

Dixon-Suen, Suzanne C. ; Nagle, Christina M. ; Thrift, Aaron P. ; Pharoah, Paul D. P. ; Ewing, Ailith ; Pearce, Celeste Leigh ; Zheng, Wei ; Chenevix-Trench, Georgia ; Fasching, Peter A. ; Beckmann, Matthias W. ; Lambrechts, Diether ; Vergote, Ignace ; Lambrechts, Sandrina ; Van Nieuwenhuysen, Els ; Rossing, Mary Anne ; Doherty, Jennifer A. ; Wicklund, Kristine G. ; Chang-Claude, Jenny ; Jung, Audrey Y. ; Moysich, Kirsten B. ; Odunsi, Kunle ; Goodman, Marc T. ; Wilkens, Lynne R. ; Thompson, Pamela J. ; Shvetsov, Yurii B. ; Dörk, Thilo ; Park-Simon, Tjoung-Won ; Hillemanns, Peter ; Bogdanova, Natalia ; Butzow, Ralf ; Nevanlinna, Heli ; Pelttari, Liisa M. ; Leminen, Arto ; Modugno, Francesmary ; Ness, Roberta B. ; Edwards, Robert P. ; Kelley, Joseph L. ; Heitz, Florian ; du Bois, Andreas ; Harter, Philipp ; Schwaab, Ira ; Karlan, Beth Y. ; Lester, Jenny ; Orsulic, Sandra ; Rimel, Bobbie J. ; Kjær, Susanne K. ; Høgdall, Estrid ; Jensen, Allan ; Goode, Ellen L. ; Fridley, Brooke L. ; Cunningham, Julie M. ; Winham, Stacey J. ; Giles, Graham G. ; Bruinsma, Fiona ; Milne, Roger L. ; Southey, Melissa C. ; Hildebrandt, Michelle A. T. ; Wu, Xifeng ; Lu, Karen H. ; Liang, Dong ; Levine, Douglas A. ; Bisogna, Maria ; Schildkraut, Joellen M. ; Berchuck, Andrew ; Cramer, Daniel W. ; Terry, Kathryn L. ; Bandera, Elisa V. ; Olson, Sara H. ; Salvesen, Helga B. ; Thomsen, Liv Cecilie Vestrheim ; Kopperud, Reidun K. ; Bjorge, Line ; Kiemeney, Lambertus A. ; Massuger, Leon F. A. G. ; Pejovic, Tanja ; Bruegl, Amanda ; Cook, Linda S. ; Le, Nhu D. ; Swenerton, Kenneth D. ; Brooks-Wilson, Angela ; Kelemen, Linda E. ; Lubinski, Jan ; Huzarski, Tomasz ; Gronwald, Jacek ; Menkiszak, Janusz ; Wentzensen, Nicolas ; Brinton, Louise ; Yang, Hannah ; Lissowska, Jolanta ; Høgdall, Claus K. ; Lundvall, Lene ; Song, Honglin ; Tyrer, Jonathan P. ; Campbell, Ian ; Eccles, Diana ; Paul, James ; Glasspool, Rosalind ; Siddiqui, Nadeem ; Whittemore, Alice S. ; Sieh, Weiva ; McGuire, Valerie ; Rothstein, Joseph H. ; Narod, Steven A. ; Phelan, Catherine ; Risch, Harvey A. ; McLaughlin, John R. ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Menon, Usha ; Gayther, Simon A. ; Ramus, Susan J. ; Gentry-Maharaj, Aleksandra ; Wu, Anna H. ; Pike, Malcolm C. ; Tseng, Chiu-Chen ; Kupryjanczyk, Jolanta ; Dansonka-Mieszkowska, Agnieszka ; Budzilowska, Agnieszka ; Rzepecka, Iwona K. ; Webb, Penelope M.

Background : Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias. Methods : We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide [...]

Cette étude analyse les interactions entre des loci de susceptibilité au cancer du poumon et des altérations somatiques de gènes impliqués dans la tumorigenèse

Interaction analysis between germline susceptibility loci and somatic alterations in lung cancer

Yuzhuo Wang ; Cheng Wang ; Jiahui Zhang ; Meng Zhu ; Xu Zhang ; Zhihua Li ; Juncheng Dai ; Hongxia Ma ; Zhibin Hu ; Guangfu Jin ; Hongbing Shen

Emerging evidence indicates that germline variations may interact with somatic events in carcinogenesis. However, the germline–somatic interaction in lung cancer remains largely unknown. We investigated whether lung cancer driver genes (CDGs) were more likely to locate within cancer susceptibility regions. Pathway analysis was performed to identify common pathways underlying CDGs and cancer susceptibility genes (CSGs). Next, we analyzed the associations between lung cancer risk SNPs and somatic [...]

A partir de données portant sur 1 086 patients atteints d'un cancer de la prostate et sur 1 244 témoins, cette étude prospective évalue l'association entre les niveaux sériques d'interleukine 16 mesurée avant le diagnostic, et le risque de développer la maladie, en fonction de l'appartenance ethnique

Prospective evaluation of serum IL-16 and risk of prostate cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Moore, Amy ; Huang, Wen-Yi ; Danforth, Kim ; Falk, Roni ; Meade, Allison ; Bagni, Rachel ; Berndt, Sonja I.

Background : Sexually transmitted infections and chronic inflammation have been associated with an increased risk of prostate cancer. Inflammatory mediators, such as cytokines and free radicals, have been hypothesized to play a role. Methods : To explore the role of inflammation in prostate cancer risk further, we examined the association between pre-diagnostic serum levels of interleukin-16 (IL-16), an important pleiotropic cytokine, and prostate cancer risk among 932 Caucasian cases and 942 [...]

Menée en Finlande à partir de données portant sur 1 663 patients atteints d'un cancer de la prostate, cette étude de cohorte évalue l'association entre le niveau de glycémie à jeun et le risque de développer la maladie, en fonction de son grade (score de Gleason) et de son stade (durée médiane de suivi : 14,7 ans)

Fasting blood glucose, glycaemic control and prostate cancer risk in the Finnish Randomized Study of Screening for Prostate Cancer

Murtola, Teemu J. ; Vihervuori, Ville J. Y. ; Lahtela, Jorma ; Talala, Kirsi ; Taari, Kimmo ; Tammela, Teuvo L. J. ; Auvinen, Anssi

Background : Diabetic men have lowered overall risk of prostate cancer (PCa), but the role of hyperglycaemia is unclear. In this cohort study, we estimated PCa risk among men with diabetic fasting blood glucose level. Methods : Participants of the Finnish Randomized Study of Screening for Prostate Cancer (FinRSPC) were linked to laboratory database for information on glucose measurements since 1978. The data were available for 17,860 men. Based on the average yearly level, the men were [...]

Menée en Chine à partir de données portant sur 10 055 patientes atteintes d'un cancer du sein et sur 14 107 témoins, cette étude d'association sur l'exome entier identifie 3 nouveaux loci de susceptibilité à la maladie

A large-scale, exome-wide association study of Han Chinese women identifies three novel loci predisposing to breast cancer

Zhang, Bo ; Chen, Men-Yun ; Sheng, Yu-Jun ; Zhuo, Xian-Bo ; Gao, Ping ; Zhou, Fu-Sheng ; Liang, Bo ; Zu, Jun ; Zhang, Qin ; Suleman, Sufyan ; Xu, Yi-Hui ; Xu, Min-Gui ; Xu, Jin-Kai ; Liu, Chen-Cheng ; Giannareas, Nikolaos ; Xia, Ji-Han ; Zhao, Yuan ; Huang, Zhong-Lian ; Yang, Zhen ; Cheng, Huaidong ; Li, Na ; Hong, Yan-Yan ; Li, Wei ; Zhang, Min-Jun ; Yu, Ke-Da ; Li, Guoliang ; Sun, Meng-Hong ; Chen, Zhen-Dong ; Wei, Gong-Hong ; Shao, Zhi-Ming

Genome-wide association studies have identified more than 90 susceptibility loci for breast cancer. However, the missing heritability is evident, and the contributions of coding variants to breast cancer susceptibility have not yet been systematically evaluated. Here we present a large-scale whole-exome association study for breast cancer consisting of 24,162 individuals (10,055 cases and 14,107 controls). In addition to replicating known susceptibility loci (e.g. ESR1, FGFR2 and TOX3), we [...]

Menée aux Etats-Unis à partir de données portant sur 91 enfants (âge : 0-4 ans) et 276 adolescents (âge : 15-19 ans) atteints d'une tumeur germinale du testicule et sur 344 témoins, cette étude évalue l'association entre le niveau d'hormones sexuelles stéroïdiennes mesuré pendant la période néonatale et le risque de développer la maladie

Neonatal Hormone Concentrations and Risk of Testicular Germ Cell Tumors (TGCT)

Morimoto, Libby M. ; Zava, David ; McGlynn, Katherine A. ; Stanczyk, Frank Z. ; Kang, Alice Y. ; Ma, Xiaomei ; Wiemels, Joseph L. ; Metayer, Catherine

Background: Testicular germ cell tumor (TGCT) incidence has increased over the last 40 years in the United States. In contrast to TGCT among infants, it is hypothesized that TGCT in adolescents and young men is the result of sex steroid hormone imbalance during early fetal development. However, little is known about the neonatal period when abrupt hormonal changes occur, and direct supporting evidence is scarce due to the difficulties in obtaining prediagnostic specimens. Methods: We conducted [...]

Couplée aux données de la cohorte européenne EPIC et portant sur 147 patients atteints d'un carcinome hépatocellulaire et sur 147 témoins, cette étude évalue le rôle de 132 métabolites sériques dans l'association entre 7 facteurs liés au mode de vie et le risque de développer la maladie

Are metabolic signatures mediating the relationship between lifestyle factors and hepatocellular carcinoma risk? Results from a nested case-control study in EPIC

Assi, Nada ; Thomas, Duncan C. ; Leitzman, Michael ; Stepien, Magdalena ; Chajès, Veronique ; Philip, Thierry ; Vineis, Paolo ; Bamia, Christina ; Boutron-Ruault, Marie-Christine ; Sandanger, Torkjel M ; Molinuevo, Amaia ; Boshuizen, Hendriek C. ; Sundkvist, Anneli ; Kühn, Tilman ; Travis, Ruth C. ; Overvad, Kim ; Riboli, Elio ; Gunter, Marc J. ; Scalbert, Augustin ; Jenab, Mazda ; Ferrari, Pietro ; Viallon, Vivian

Background: The "meeting-in-the-middle" (MITM) is a principle to identify exposure biomarkers that are also predictors of disease. The MITM statistical framework was applied in a nested case-control study of hepatocellular carcinoma (HCC) within EPIC where healthy lifestyle index (HLI) variables were related to targeted serum metabolites. Methods: Lifestyle and targeted metabolomic data were available from 147 incident HCC cases and 147 matched controls. Partial Least Squares analysis related 7 [...]