A partir d'une revue de la littérature (17 études), cette étude analyse l'efficacité des diverses stratégies de prévention et de traitement d'un syndrome pieds-mains induit par une chimiothérapie à base de capécitabine

Clinical evidence of prevention strategies for capecitabine-induced hand-foot syndrome

Huang, Xuan-zhang ; Chen, You ; Chen, Wen-Jun ; Zhang, Xi ; Wu, Cong-Cong ; Wang, Zhen-ning ; Wu, Jian

Hand-foot syndrome (HFS) is the most common adverse effect of capecitabine-containing chemotherapy. The purpose of this study was to assess the efficacies of various prevention and treatment strategies for capecitabine-induced HFS. Searches of the PubMed and Embase databases were performed to identify relevant studies. The risk ratio (RR) with the corresponding 95% confidence interval (CI) was used as an effect measure to evaluate the efficacies of these prevention and treatment strategies. [...]

Menée en Australie auprès de 96 patients atteints d'un cancer de la tête et du cou ayant reçu une radiothérapie, seule ou en combinaison avec une chimiothérapie, cette étude analyse, jusqu'à 3 ans après la fin des traitements, la prévalence des toxicités et les facteurs entravant l'alimentation par voie buccale

Treatment toxicities and their impact on oral intake following non-surgical management for head and neck cancer: a 3-year longitudinal study

Barnhart, Molly K. ; Robinson, Rachelle A. ; Simms, Virginia A. ; Ward, Elizabeth C. ; Cartmill, Bena ; Chandler, Sophie J. ; Smee, Robert I.

Purpose : Patients who receive (chemo)radiotherapy [(C)RT] for head and neck cancer (HNC) experience multiple treatment effects. However, the presence and recovery of treatment toxicities and how these impact on oral intake over time post-treatment are not fully understood. The primary aim of this study was to examine patient perceptions of the toxicities present and which are barriers to oral intake, up to 3 years post (C)RT. The secondary aim was to identify mealtime strategies used to [...]

A partir de données portant sur 1 386 patients atteints d'un tumeur solide de stade IV diagnostiquée entre 2005 et 2013, cette étude évalue l'association entre une utilisation d'opioïdes pour soulager la douleur liée à la maladie, la survenue d'événements indésirables, l'utilisation de ressources de santé (visites aux services d'urgence, hospitalisations) et la survie globale

Impact of opioid use on health care utilization and survival in patients with newly diagnosed stage IV malignancies

Zylla, Dylan ; Steele, Grant ; Shapiro, Alice ; Richter, Sara ; Gupta, Pankaj

Purpose : Patients with advanced cancers frequently experience pain. Opioids are commonly prescribed to treat cancer-related pain, but their use might be associated with undesirable consequences including adverse effects and tumor progression, resulting in increased heath care utilization and shorter survival. We examined these possibilities in a large cohort of patients diagnosed with ten common advanced malignancies. Methods : We identified 1386 newly diagnosed patients with stage IV [...]

A partir des données de 18 registres européens des cancers sur la période 1995-2012, cette étude analyse l'évolution de l'incidence du mélanome in situ ou invasif, en fonction de l'épaisseur des lésions cutanées

Trends in incidence of thick, thin and in situ melanoma in Europe

Sacchetto, L. ; Zanetti, R. ; Comber, H. ; Bouchardy, C. ; Brewster, D. H. ; Broganelli, P. ; Chirlaque, M. D. ; Coza, D. ; Galceran, J. ; Gavin, A. ; Hackl, M. ; Katalinic, A. ; Larønningen, S. ; Louwman, M. W. J. ; Morgan, E. ; Robsahm, T. E. ; Sanchez, M. J. ; Tryggvadottir, L. ; Tumino, R. ; Van Eycken, E. ; Vernon, S. ; Zadnik, V. ; Rosso, S.

Background : We analysed trends in incidence for in situ and invasive melanoma in some European countries during the period 1995–2012, stratifying for lesion thickness. Material and methods : Individual anonymised data from population-based European cancer registries (CRs) were collected and combined in a common database, including information on age, sex, year of diagnosis, histological type, tumour location, behaviour (invasive, in situ) and lesion thickness. Mortality data were retrieved [...]

Menée en Suède à partir de données portant sur 74 643 hommes, cette étude évalue l'association entre le statut socio-économique, le contexte du diagnostic, l'accès aux traitements et la mortalité spécifique (durée de suivi : 6 ans)

Socioeconomic status and diagnosis, treatment, and mortality in men with prostate cancer. Nationwide population-based study

Tomic, Katarina ; Ventimiglia, Eugenio ; Robinson, David ; Häggström, Christel ; Lambe, Mats ; Stattin, Pär

Patients with high socioeconomic status (SES) have better cancer outcomes than patients with low SES. This has also been shown in Sweden, a country with tax-financed health care aiming to provide care on equal terms to all residents. The association between income and educational level and diagnostics and treatment as outlined in national guidelines and prostate cancer (Pca) and all-cause mortality was assessed in 74,643 men by use of data in the National Prostate Cancer Register of Sweden and [...]

Menée aux Etats-Unis sur la période 2005-2015, cette étude rétrospective analyse l'évolution des disparités ethniques dans la survenue de cardiotoxicités induites par une thérapie ciblée anti-HER2 adjuvante ou néo-adjuvante (trastuzumab avec ou sans pertuzumab) et dans l'abandon des traitements chez des patientes atteintes d'un cancer du sein de stade précoce HER2+ (durée médiane de suivi : 5,2 ans)

Racial disparities in the rate of cardiotoxicity of HER2-targeted therapies among women with early breast cancer

Litvak, Anya ; Batukbhai, Bhavina ; Russell, Stuart D. ; Tsai, Hua-Ling ; Rosner, Gary L. ; Jeter, Stacie C. ; Armstrong, Deborah ; Emens, Leisha A. ; Fetting, John ; Wolff, Antonio C. ; Silhy, Raquel ; Stearns, Vered ; Connolly, Roisin M.

BACKGROUND: Human epidermal growth factor receptor 2 (HER2)-targeted therapies are highly effective at preventing breast cancer recurrence but are associated with cardiotoxicity in some patients, and minimal data are available regarding racial disparities in the incidence of this toxicity. The authors conducted a retrospective study to analyze the association of black or white race with treatment-induced cardiotoxicity and incomplete therapy among patients with HER2-positive early breast [...]

Menée en Suède par questionnaire auprès de 122 femmes ayant reçu un résultat de frottis anormal, cette étude transversale évalue l'association entre leurs connaissances sur le papillomavirus humain et leur compréhension du résultat du test, leur anxiété, leur dépression et leur qualité de vie

Swedish women’s awareness of human papillomavirus, and health-related quality of life, anxiety, and depression after a notification of an abnormal Pap smear result: a cross-sectional study

Rask, Marie ; Swahnberg, Katarina ; Oscarsson, Marie

This study aims to assess (a) women’s awareness of the human papillomavirus (HPV), (b) women’s health-related quality of life (HRQoL) and levels of anxiety and depression symptoms, and (c) to compare the outcomes between women who are aware of the sexually transmitted nature of the HPV infection and women who are not. Swedish women who have been notified of an abnormal Pap smear result completed a questionnaire. This questionnaire consisted of sociodemographic characteristics, items on [...]

A partir d'une revue systématique de la littérature (5 études), cette étude analyse l'efficacité des interventions destinées à améliorer, chez des patientes ayant survécu à un cancer du sein de stade précoce HR+, l'adhésion à une hormonothérapie adjuvante

Interventions to improve endocrine therapy adherence in breast cancer survivors: what is the evidence?

Ekinci, Ekim ; Nathoo, Salima ; Korattyil, Thushara ; Vadhariya, Aisha ; Zaghloul, Hanna A. ; Niravath, Polly A. ; Abughosh, Susan M. ; Trivedi, Meghana V.

Purpose : Endocrine therapy reduces the risk of breast cancer recurrences and mortality in hormone receptor-positive (HR+) breast cancer survivors. However, non-adherence to treatment remains a significant problem. The aim of this study was to review current literature and ongoing trials to identify interventions employed to improve adherence to adjuvant endocrine therapy (AET) in breast cancer survivors. Methods : We searched PubMed and the National Library of Medicine registry of clinical [...]