Menée aux Etats-Unis à partir de données portant sur 304 patients atteints d'un cancer et âgés de plus de 65 ans, cette étude analyse les facteurs associés au risque de fracture osseuse (durée de suivi : 2 ans)

Fractures frequently occur in older cancer patients: the MD Anderson Cancer Center experience

Edwards, Beatrice J. ; Sun, Ming ; Zhang, Xiaotao ; Holmes, Holly M. ; Song, Juhee ; Khalil, Peter ; Karuturi, Meghan ; Shah, Jay B. ; Dinney, Colin P. ; Gagel, Robert F. ; Valero, Vicente ; Champlin, Richard E. ; Tripathy, Debasish ; Murphy, William A.

Purpose and Introduction : A growing number of cancer patients are older adults aged 65 years and older. Patients with cancer are at increased risk for developing osteoporosis, falls, and fractures. We sought to identify the incidence of fractures in older adults who underwent cancer care between January 2013 and December 2015. Methods : A comprehensive geriatric assessment was performed, and bone densitometry was measured at baseline, with a 2-year follow-up. Results : In this study, among 304 [...]

A partir d'une revue systématique de la littérature (37 études), cette étude analyse les facteurs associés aux besoins en soins de support chez des patientes atteintes d'un cancer gynécologique et chez leurs aidants

A systematic literature review of the prevalence of and risk factors for supportive care needs among women with gynaecological cancer and their caregivers

Beesley, Vanessa L. ; Alemayehu, Chalachew ; Webb, Penelope M.

Purpose : This review aimed to determine the prevalence of met and unmet needs, and the risk factors for unmet needs among people affected by gynaecological cancer. Methods : The review was undertaken using the PRISMA guidelines. Eligible studies were identified though a range of electronic databases in October and November 2016. Study quality was independently appraised by two people. Results : Thirty-seven studies were included (1 review, 24 quantitative and 12 qualitative). The evidence was [...]

A partir d'une revue systématique de la littérature (6 études), cette étude analyse les caractéristiques et l'efficacité de programmes d'éducation thérapeutique et de "self-management" dédiés aux patients ayant survécu à un cancer, afin d'améliorer leur état de santé et leur qualité de vie

Self-management interventions for cancer survivors: a systematic review

Boland, Lauren ; Bennett, Kathleen ; Connolly, Deirdre

Purpose : Many cancer survivors experience problems with persisting symptoms such as pain, fatigue, anxiety and depression post-treatment. Self-management interventions are recommended for cancer patients as they can help individuals identify and manage these continuing symptoms. This systematic review examines the type, content and impact of self-management interventions for cancer survivors on health outcomes such as activity participation, self-efficacy, quality of life and symptom [...]

Menée en Irlande auprès de 12 patients atteints d'un cancer de stade avancé (âge médian : 69,5 ans), cette étude de cohorte prospective analyse l'efficacité d'une thérapie décongestive combinant soins de la peau, compression (à l'aide de bandes ou de vêtements), drainage lymphatique manuel et exercices correctifs, pour traiter un lymphœdème

Pilot Study: The Effectiveness of Complex Decongestive Therapy for Lymphedema in Palliative Care Patients with Advanced Cancer

Cobbe, Sinead ; Nugent, Kathy ; Real, Shirley

Background: Complex decongestive therapy (CDT) is a regimen of physical treatment for lymphedema. Its effectiveness is unknown in advanced cancer patients. This study evaluates effectiveness of CDT in this population. Method: This is a prospective observational cohort study for 18 months of advanced cancer patients with lymphedema, who received three or more CDT interventions. Measurements were taken before the first (T1), third (T3), and sixth (T6) treatments as follows: limb volume using [...]

Mené sur 119 patients atteints d'un cancer de la prostate et recevant une thérapie anti-androgénique, cet essai de phase II évalue la faisabilité et l'efficacité de deux stratégies d'éducation thérapeutique destinées à améliorer leur santé osseuse

Improving bone health in men with prostate cancer receiving androgen deprivation therapy: Results of a randomized phase 2 trial

Alibhai, Shabbir M. H. ; Breunis, Henriette ; Timilshina, Narhari ; Hamidi, Maryam S. ; Cheung, Angela M. ; Tomlinson, George A. ; Manokumar, Tharsika ; Samadi, Osai ; Sandoval, Joanna ; Durbano, Sara ; Warde, Padraig ; Jones, Jennifer M.

BACKGROUND: Strategies to improve bone health care in men receiving androgen deprivation therapy (ADT) are not consistently implemented. The authors conducted a phase 2 randomized controlled trial of 2 education-based models-of-care interventions to determine their feasibility and ability to improve bone health care. METHODS: A single-center parallel-group randomized controlled trial of men with prostate cancer who were receiving ADT was performed. Participants were randomized 1:1:1 to 1) a [...]

Menée au Canada à partir de données portant sur 270 089 patients ayant subi un infarctus aigu du myocarde sur la période 1995-2003, cette étude compare, chez les patients ayant survécu à un cancer (22 907 patients) et chez les patients sans antécédent de cancer (247 182 patients), l'évolution des traitements reçus et de la mortalité

Temporal changes in treatments and outcomes after acute myocardial infarction among cancer survivors and patients without cancer, 1995 to 2013

Gong, Inna Y. ; Yan, Andrew T. ; Ko, Dennis T. ; Earle, Craig C. ; Cheung, Winson Y. ; Peacock, Stuart ; Hall, Marlous ; Gale, Chris P. ; Chan, Kelvin K. W.

BACKGROUND: There is a paucity of information about treatment and mortality trends after acute myocardial infarction (AMI) for cancer survivors (CS). METHODS: In this population-based study, the authors compared temporal trends of treatments and outcomes (mortality, nonfatal cardiovascular outcomes), among CS and patients without cancer (the noncancer patient [NCP] group) with AMI in Ontario (Canada) using inverse probability treatment weight (IPTW)-adjusted modeling. RESULTS: Of 270,089 [...]

Menée au Danemark à partir de données portant sur 14 611 enfants de 8 945 patients ayant survécu à un cancer diagnostiqué avant l'âge de 35 ans et sur 40 859 enfants de 19 536 témoins, cette étude analyse le risque d'anomalies chromosomiques chez les enfants

Chromosomal Abnormalities in Offspring of Young Cancer Survivors: A Population-Based Cohort Study in Denmark

Nielsen, Betina Frydenlund ; Schmidt, Anne Aarslev ; Mulvihill, John J. ; Frederiksen, Kirsten ; Tawn, E. Janet ; Stovall, Marilyn ; Johansen, Christoffer ; Boice, Jr John D. ; Winther, Jeanette Falck

To examine whether cancer survivors diagnosed before age 35 years are more likely to have offspring with chromosomal abnormalities than their siblings, chromosomal abnormalities were determined in a population-based cohort of 14 611 offspring (14 580 live-born children and 31 fetuses) of 8945 Danish cancer survivors and 40 859 offspring (40 794 live-born children and 65 fetuses) of 19 536 siblings. Chromosomal abnormalities include numeric and structural abnormalities. Odds ratios were [...]

A partir d'une revue systématique de la littérature publiée jusqu'en septembre 2016 et des données des registres français des cancers, cette méta-analyse présente une évaluation, pour l'année 2015, des nouveaux cas de cancers liés à une infection par différents virus (14 336 cas de cancer liés à une infection)

New cancer cases in France in 2015 attributable to infectious agents: a systematic review and meta-analysis

Shield, Kevin David ; Marant Micallef, Claire ; de Martel, Catherine ; Heard, Isabelle ; Mégraud, Francis ; Plummer, Martyn ; Vignat, Jérôme ; Bray, Freddie ; Soerjomataram, Isabelle

To provide an assessment of the burden of cancer in France in 2015 attributable to infectious agents. A systematic literature review in French representative cancer cases series was undertaken of the prevalence of infectious agents with the major associated cancer types. PubMed was searched for original studies published up to September 2016; random-effects meta-analyses were performed. Cancer incidence data were obtained from the French Cancer Registries Network, thereby allowing the [...]

Menée aux Etats-Unis auprès de 331 patients adultes ayant survécu à une leucémie lymphoïde aiguë pendant l'enfance et sur 330 témoins, cette étude analyse l'association entre des comportements sédentaires (regarder la télévision, utiliser un ordinateur...), la durée consacrée à une activité physique, la composition corporelle (masse maigre, masse adipeuse) et le risque de maladie cardiovasculaire

Clinical impact of sedentary behaviors in adult survivors of acute lymphoblastic leukemia: A report from the St. Jude Lifetime Cohort study

Howell, Carrie R. ; Wilson, Carmen L. ; Ehrhardt, Matthew J. ; Partin, Robyn E. ; Kaste, Sue C. ; Lanctot, Jennifer Q. ; Pui, Ching-Hon ; Robison, Leslie L. ; Hudson, Melissa M. ; Ness, Kirsten K.

BACKGROUND: Sedentary behaviors are associated with poor health outcomes in the general population, but their clinical impact on adult survivors of childhood acute lymphoblastic leukemia (ALL) has not been characterized to date. In the current study, we described the prevalence of sedentary behaviors in survivors of ALL and examined associations between time spent sedentary and body composition and onset of cardiovascular disease (CVD) risk factors. METHODS: Participants' self-reported screen [...]

A partir des données de la cohorte "Nurses’ Health Study" incluant 77 288 infirmières entre 1986 et 2012, cette étude analyse l'association entre des antécédents de cancer de la peau hors mélanome, le risque ultérieur de développer un mélanome et la mortalité spécifique (930 cas de mélanome sans antécédent de cancer de la peau, 615 cas de mélanome avec antécédent de cancer de la peau)

Personal history of non-melanoma skin cancer diagnosis and death from melanoma in women

Chen, Steven T. ; Li, Xin ; Han, Jiali

Melanoma incidence is increasing. We evaluated risk of melanoma death after diagnosis of non-melanoma skin cancer (NMSC). We followed 77,288 female American nurses from the Nurses’ Health Study from 1986 to 2012. We used Cox proportional hazards models to determine the hazard ratio (HR) of lethal and non-lethal melanoma diagnosis and melanoma death, according to personal NMSC history. Among melanoma cases, we examined the HR of melanoma death and the odds ratio (OR) of melanoma with a Breslow [...]

Menée au Danemark à partir de données portant sur 1 523 patientes atteintes d'un cancer du col de l'utérus de stade précoce sur la période 2005-2013, cette étude analyse les facteurs associés au risque de récidive de la maladie et évalue le risque de décès lié à une récidive

Risk of recurrence, prognosis, and follow-up for Danish women with cervical cancer in 2005-2013: A national cohort study

Taarnhøj, Gry Assam ; Christensen, Ib Jarle ; Lajer, Henrik ; Fuglsang, Katrine ; Jeppesen, Mette Moustgaard ; Kahr, Henriette Strøm ; Høgdall, Claus

BACKGROUND: In developed countries, women attend follow-up after treatment for cervical cancer to detect recurrence. The aim of this study was to describe the Danish population of women with early-stage cervical cancer at risk for recurrence and death due to recurrence. METHODS: Data were extracted from 3 nationwide databases to find women diagnosed with stage 1A1 to 1B1 cervical cancer in 2005-2013. Recurrences were determined from data on oncological or surgical treatment more than 3 months [...]

Menée au Japon auprès de 122 patients atteints d'un cancer du poumon récemment diagnostiqué, cette étude analyse les facteurs cliniques (déficiences cognitives, symptômes dépressifs, fragilité, etc) associés à leur capacité à prendre des décisions concernant le choix des traitements

Decision-Making Capacity for Chemotherapy and Associated Factors in Newly Diagnosed Patients with Lung Cancer

Ogawa, Asao ; Kondo, Kyoko ; Takei, Hiroyuki ; Fujisawa, Daisuke ; Ohe, Yuichiro ; Akechi, Tatsuo

Background : The objective of this study was to assess decision‐making capacity in patients newly diagnosed with lung cancer, clinical factors associated with impaired capacity, and physicians’ perceptions of patients’ decision‐making capacity. Materials and Methods : We recruited 122 patients newly diagnosed with lung cancer. One hundred fourteen completed the assessment. All patients were receiving a combination of treatments (e.g., chemotherapy, chemo‐radiotherapy, or targeted therapy). [...]

Menée dans un contexte canadien à partir de données portant sur 100 patients atteints d'un cancer, cette étude analyse les effets, sur l'augmentation des coûts et dépenses globales de santé, de l'utilisation du test génomique "Oncotype Dx" basé sur l'expression de 21 gènes dans des échantillons biopsiques pour prédire la réponse thérapeutique à une chimiothérapie

Population-Based Study to Determine the Health System Costs of Using the 21-Gene Assay

Nicole Mittmann ; Craig C. Earle ; Stephanie Y. Cheng ; Jim A. Julian ; Farah Rahman ; Soo Jin Seung ; Mark N. Levine

Purpose : The 21-gene assay Oncotype Dx (Genomic Health, Redwood City, CA) test is used to aid the decision about chemotherapy in patients with hormone receptor–positive breast cancer who received endocrine therapy. Economic studies to support test adoption used decision-analytic models with assumptions and data derived from disparate sources. The objective was to evaluate whether the 21-gene assay test resulted in an overall cost expense or saving to the health system. Patients and Methods : [...]

A partir des données d'un essai mené au Royaume-Uni évaluant l'efficacité d'un dépistage multimodal du cancer de l'ovaire utilisant le dosage de l'antigène tumoral CA 125 dans le sang, cette étude analyse, dans le contexte américain, le rapport coût-efficacité d'un tel dépistage chez les femmes à partir de 50 ans

Estimating cost-effectiveness of a multimodal ovarian cancer screening program in the United States: Secondary analysis of the UK collaborative trial of ovarian cancer screening (UKCTOCS)

Moss, H. A. ; Berchuck, A. ; Neely, M. L. ; Myers, E. R. ; Havrilesky, L. J.

Importance The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) is the largest randomized clinical trial to evaluate screening’s impact on ovarian cancer mortality, assigning women to multimodal screening (MMS) with serum cancer antigen 125 (CA-125) interpreted using a risk algorithm. If the MMS screening method is eventually shown to reduce mortality and be cost-effective, then it may be accepted by the medical community as a feasible screening tool. Objective To [...]

Menée aux Etats-Unis par enquête auprès de 165 patients atteints d'un cancer du poumon non à petites cellules de stade I, cette étude prospective évalue l'association entre la qualité des échanges entre le patient et son médecin et le processus de prise de décision thérapeutique avant un traitement chirurgical ou une radiothérapie corporelle stéréotaxique

Patient-clinician communication among patients with stage I lung cancer

Nugent, Shannon M. ; Golden, Sara E. ; Thomas, Charles R. ; Deffebach, Mark E. ; Sukumar, Mithran S. ; Schipper, Paul H. ; Tieu, Brandon H. ; Moghanaki, Drew ; Wisnivesky, Juan ; Slatore, Christopher

Purpose : Limited data exist about patient-centered communication (PCC) and patient-centered outcomes among patients who undergo surgery or stereotactic body radiation therapy (SBRT) for stage I non-small cell lung cancer (NSCLC). We aimed to examine the relationship between PCC and decision-making processes among NSCLC patients, using baseline data from a prospective, multicenter study. Methods : Patients with stage 1 NSCLC completed a survey prior to treatment initiation. The survey assessed [...]

Menée aux Etats-Unis à partir des données d'une enquête nationale menée entre 1999 et 2014 auprès de 43 644 participants, cette étude analyse l'évolution des facteurs associés à une utilisation de compléments alimentaires à base de plantes chez des patients adultes atteints de cancer

Trends in botanical dietary supplement use among US adults by cancer status: The National Health and Nutrition Examination Survey, 1999 to 2014

Li, Chao ; Hansen, Richard A. ; Chou, Chiahung ; Calderón, Angela I. ; Qian, Jingjing

BACKGROUND: Patients with cancer may use botanical dietary supplements (BDS) in an attempt to manage the side effects of chemotherapy, yet evidence about BDS use among patients with cancer is limited. The authors examined trends in BDS use among US adults according to cancer status and patient characteristics. METHODS: A serial, cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey from 1999 through 2014 (n = 43,644). Self-reported cancer [...]