Mené aux Etats-Unis auprès de 144 patientes ayant survécu à un cancer de l'ovaire, cet essai randomisé évalue l'efficacité d'une intervention, dispensée par téléphone pendant 6 mois incitant à la pratique d'exercices physiques et à une marche active, pour améliorer leur qualité de vie et réduire leurs symptômes de fatigue liée à la maladie

Randomized Trial of Exercise on Quality of Life in Women With Ovarian Cancer: Women’s Activity and Lifestyle Study in Connecticut (WALC)

Zhou, Yang ; Cartmel, Brenda ; Gottlieb, Linda ; Ercolano, Elizabeth A. ; Li, Fangyong ; Harrigan, Maura ; McCorkle, Ruth ; Ligibel, Jennifer A. ; Von Gruenigen, Vivian E. ; Gogoi, Radhika ; Schwartz, Peter E. ; Risch, Harvey A. ; Irwin, Melinda L.

Background: Ovarian cancer survivors experience a wide range of treatment side effects that can negatively affect health-related quality of life (HRQOL). Physical activity has been shown to improve HRQOL and cancer-related fatigue (CRF) for other cancer survivors; however, no large randomized controlled trial (RCT) has been conducted for ovarian cancer. Methods: This study examined the impact of a six-month RCT of exercise vs attention control on change in HRQOL (Short Form Health Survey-36) [...]

Menée auprès de 47 patientes atteintes d'un cancer du sein, cette étude randomisée évalue l'efficacité de la minocycline pour prévenir une neuropathie périphérique et un syndrome de douleur aiguë induits par une chimiothérapie à base de paclitaxel

A pilot study of minocycline for the prevention of paclitaxel-associated neuropathy: ACCRU study RU221408I

Pachman, Deirdre R. ; Dockter, Travis ; Zekan, Patricia J. ; Fruth, Briant ; Ruddy, Kathryn J. ; Ta, Lauren E. ; Lafky, Jacqueline M. ; Dentchev, Todor ; Le-Lindqwister, Nguyet Anh ; Sikov, William M. ; Staff, Nathan ; Beutler, Andreas S. ; Loprinzi, Charles L.

Purpose : Paclitaxel is associated with both an acute pain syndrome (P-APS) and chronic chemotherapy-induced peripheral neuropathy (CIPN). Given that extensive animal data suggest that minocycline may prevent chemotherapy-induced neurotoxicity, the purpose of this pilot study was to investigate the efficacy of minocycline for the prevention of CIPN and the P-APS. Methods : Patients with breast cancer were enrolled prior to initiating neoadjuvant or adjuvant weekly paclitaxel for 12 weeks and [...]

A partir de données portant sur 329 patientes atteintes d'un cancer du sein, incluses dans un essai de phase III évaluant l'efficacité de diverses durées d'un traitement adjuvant par anastrozole et présentant une altération de la fonction ovarienne induite par le tamoxifène (âge médian : 50 ans), cette étude analyse l'efficacité, du point de vue du taux de récupération de la fonction ovarienne, d'un traitement adjuvant par inhibiteurs de l'aromatase

Ovarian Function Recovery During Anastrozole in Breast Cancer Patients With Chemotherapy-Induced Ovarian Function Failure

van Hellemond, Irene E. G. ; Vriens, Ingeborg J. H. ; Peer, Petronella G. M. ; Swinkels, Astrid C. P. ; Smorenburg, Carolien H. ; Seynaeve, Caroline M. ; van der Sangen, Maurice J. C. ; Kroep, Judith R. ; de Graaf, Hiltje ; Honkoop, Aafke H. ; Erdkamp, Frans L. G. ; van den Berkmortel, Franchette W. P. J. ; Kitzen, Jos J. E. M. ; de Boer, Maaike ; de Roos, Wïlfred K. ; Linn, Sabine C. ; Imholz, Alexander L. T. ; Tjan-Heijnen, Vivianne C. G.

Background: Aromatase inhibitors (AIs) are given as adjuvant therapy for hormone receptor–positive breast cancer in postmenopausal women, also to those with chemotherapy-induced ovarian function failure. The current analysis reports on endocrine data of patients with chemotherapy-induced ovarian function failure who were included in the phase III DATA study assessing different durations of adjuvant anastrozole after tamoxifen. Methods: We identified all patients with chemotherapy-induced [...]

Menée aux Pays-Bas à partir de données portant sur 89 018 femmes présentant une néoplasie cervicale intraépithéliale de grade 3 (CIN3) et sur 89 018 témoins, cette étude évalue à long terme le risque de carcinomes et de lésions pré-cancéreuses liés au papillomavirus humain après diagnostic de lésions CIN3

Long-Lasting Increased Risk of Human Papillomavirus–Related Carcinomas and Premalignancies After Cervical Intraepithelial Neoplasia Grade 3 : A Population-Based Cohort Study

Ebisch, Renée M. F. ; Rutten, Dominiek W. E. ; IntHout, Joanna ; Melchers, Willem J. G. ; Massuger, Leon F. A. G. ; Bulten, Johan ; Bekkers, Ruud L. M. ; Siebers, Albert G.

Purpose : The aim of this study was to determine the risk of human papillomavirus (HPV)–related carcinomas and premalignancies in women diagnosed with cervical intraepithelial neoplasia grade 3 (CIN3). Knowledge of this risk is important to preventing the development and progression of other HPV-related premalignancies and carcinomas, by considering prophylactic HPV vaccination and/or by paying increased attention to other HPV-related carcinomas and premalignancies when CIN3 is identified. [...]

Menée aux Etats-Unis à partir de données portant sur des patients atteints d'une leucémie myéloïde aiguë pendant l'enfance et inclus dans des essais cliniques successifs, cette étude analyse les facteurs associés à l'amélioration de la survie globale à 5 ans (davantage de soins de supports, intensité plus faible des traitements)

Decreased relapsed rate and treatment-related mortality contribute to improved outcomes for pediatric acute myeloid leukemia in successive clinical trials

Alexander, Thomas B. ; Wang, Lei ; Inaba, Hiroto ; Triplett, Brandon M. ; Pounds, Stanley ; Ribeiro, Raul C. ; Pui, Ching-Hon ; Rubnitz, Jeffrey E.

BACKGROUND: Outcomes for children with acute myeloid leukemia (AML) have improved over the past 20 years even though the medications used for induction therapy have not changed. METHODS: This study analyzed data from patients with AML who were enrolled in successive protocols (AML97 and AML02) to determine the contributors to the improved outcomes of the latter clinical trial. RESULTS: There were significant improvements in 5-year overall survival (48.9% vs 71.2%; P < .0001) and event-free [...]

A partir d'une revue systématique de la littérature (72 études), cette étude analyse les facteurs cliniques et psychologiques associés au processus de croissance post-traumatique chez des patients atteints de cancer

Psychological and clinical correlates of posttraumatic growth in cancer: A systematic and critical review

Casellas-Grau, Anna ; Ochoa, Cristian ; Ruini, Chiara

Objective: The objective of this study is to describe major findings on posttraumatic growth (PTG) in cancer, by analyzing its various definitions, assessment tools, and examining its main psychological and clinical correlates. Methods: A search in relevant databases (PsycINFO, Pubmed, ProQuest, Scopus, and Web of Science) was performed using descriptors related to the positive reactions in cancer. Articles were screened by title, abstract, and full text. Results: Seventy-two met the inclusion [...]

A partir d'une revue de la littérature (15 études), cette étude analyse les effets, sur la santé psychique à long terme des patientes atteintes d'un cancer du sein unilatéral, d'une mastectomie visant à réduire le risque de cancer du sein controlatéral

The psychosocial impact of contralateral risk reducing mastectomy (CRRM) on women: A rapid review

Collins, Karen ; Gee, Melanie ; Clack, Anna ; Wyld, Lynda

Objectives : For women who have been diagnosed with unilateral breast cancer, there is an increasing trend for them to request removal of the contralateral healthy breast, the so-called contralateral risk reducing mastectomy (CRRM). The current literature is only just beginning to identify patient-reported reasons for undergoing CRRM and associated patient-reported outcomes. It is also unclear whether women at moderate/high risk of developing a subsequent primary contralateral breast cancer [...]

A partir de données danoises portant sur la période 1998-2011, cette étude analyse l'utilisation de médicaments antidépresseurs chez les 26 256 hommes ayant une partenaire de vie atteinte d'un cancer du sein diagnostiqué pendant cette période

First use of antidepressant medication in male partners of women with breast cancer in Denmark from 1998 to 2011

Cromhout, Pernille F. ; Latocha, Kristine M. ; Olsen, Maja H. ; Suppli, Nis P. ; Christensen, Jane ; Johansen, Christoffer ; Dalton, Susanne O.

Objective: A diagnosis of breast cancer disrupts the life of the patient, but also the partner may experience adverse psychological effects. We examined partners' risk for first use of antidepressant medication, as a proxy for pharmacologically treated depression. Methods: By linkage of national registers, we identified 1 420 592 depression-free men living with a cancer-free female partner in 1998 to 2011. During follow-up, breast cancer was diagnosed in female partners of 26 256 men. In [...]

Menée aux Etats-Unis à partir de données portant sur 95 patientes atteintes de schizophrénie et d'un cancer du sein traité entre 1993 et 2015, cette étude évalue les facteurs psychiatriques associés à l'arrêt des traitements anticancéreux

Predictors of Disruptions in Breast Cancer Care for Individuals with Schizophrenia

Irwin, Kelly E. ; Park, Elyse R. ; Shin, Jennifer A. ; Fields, Lauren E. ; Jacobs, Jamie M. ; Greer, Joseph A. ; Taylor, John B. ; Taghian, Alphonse G. ; Freudenreich, Oliver ; Ryan, David P. ; Pirl, William F.

Patients with schizophrenia experience markedly increased breast cancer mortality, yet reasons for this disparity are poorly understood. We sought to characterize disruptions in breast cancer care for patients with schizophrenia and identify modifiable predictors of those disruptions.We performed a medical record review of 95 patients with schizophrenia and breast cancer treated at an academic cancer center between 1993 and 2015. We defined cancer care disruptions as processes that interfere [...]

Menée en Suède à partir de données portant sur 272 patients atteints d'un cancer colorectal et de métastases hépatiques, cette étude de cohorte rétrospective évalue, du point de vue du taux de résection, la qualité de la prise en charge du patient par une équipe pluridisciplinaire de spécialistes en hépatologie

The Impact of a Hepatobiliary Multidisciplinary Team Assessment in Patients with Colorectal Cancer Liver Metastases: A Population-Based Study

Engstrand, Jennie ; Kartalis, Nikolaos ; Strömberg, Cecilia ; Broberg, Mats ; Stillström, Anna ; Lekberg, Tobias ; Jonas, Eduard ; Freedman, Jacob ; Nilsson, Henrik

Background : Assessing patients with colorectal cancer liver metastases (CRCLM) by a liver multidisciplinary team (MDT) results in higher resection rates and improved survival. The aim of this study was to evaluate the potentially improved resection rate in a defined cohort if all patients with CRCLM were evaluated by a liver MDT. Patients and Methods : A retrospective analysis of patients diagnosed with colorectal cancer during 2008 in the greater Stockholm region was conducted. All patients [...]

A partir des données des registres américains des cancers et de la base Medicare incluant 3 038 bénéficiaires atteints d'un myélome diagnostiqué entre 2007 et 2011, cette étude analyse l'association entre une aide financière pour les personnes à faibles revenus, les coûts restant à la charge du patient et l'utilisation de médicaments anticancéreux immunomodulateurs dispensés par voie orale

Subsidies for Oral Chemotherapy and Use of Immunomodulatory Drugs Among Medicare Beneficiaries With Myeloma

Adam J. Olszewski ; Stacie B. Dusetzina ; Charles B. Eaton ; Amy J. Davidoff ; Amal N. Trivedi

Purpose : The low-income subsidy (LIS) substantially lowers out-of-pocket costs for qualifying Medicare Part D beneficiaries who receive orally administered chemotherapy. We examined the association of LIS with the use of novel oral immunomodulatory drugs (IMiDs; lenalidomide and thalidomide) among beneficiaries with myeloma, who can receive either orally administered or parenteral (bortezomib-based) therapy. Methods : Using SEER-Medicare data, we identified Part D beneficiaries diagnosed with [...]

Menée en Suisse auprès de 263 étudiants en 4ème année d'études médicales, cette étude analyse l'efficacité de deux stratégies d'apprentissage pour développer des compétences en matière d'annonce de mauvaises nouvelles en oncologie

Individual training at the undergraduate level to promote competence in breaking bad news in oncology

Berney, Alexandre ; Carrard, Valérie ; Schmid Mast, Marianne ; Bonvin, Raphael ; Stiefel, Friedrich ; Bourquin, Céline

Objective: Training medical students in breaking bad news (BBN) in oncology may be key to improve patient care in an area where many physicians tend to be uncomfortable. Given the lack of evidence in the literature, this study aimed to assess empirically the impact of 2 teaching strategies to prepare students for the task of BBN in oncology: one-to-one simulated patient (SP) training with individual feedback (intervention group) vs small-group SP training with collective feedback (comparison [...]

Menée au Japon auprès de 805 membres de la famille de patients décédés d'un cancer à leur domicile, cette étude analyse l'association entre des soins palliatifs, une rumination mentale de l'expérience de la maladie et un processus de croissance post-traumatique

Quality of death, rumination, and posttraumatic growth among bereaved family members of cancer patients in home palliative care

Hirooka, Kayo ; Fukahori, Hiroki ; Taku, Kanako ; Togari, Taisuke ; Ogawa, Asao

Objective: The current study was designed to test the hypothesis that quality of death (QOD) and intrusive and deliberate rumination are associated with posttraumatic growth (PTG) among bereaved family members of cancer patients in home palliative care. Methods: Data were collected from 805 bereaved family members of cancer patients who died at home in Japan. We used a cross-sectional design and participants completed Good Death Inventory, Event-Related Rumination Inventory, and PTG Inventory. [...]

Menée aux Etats-Unis par enquête auprès de 875 patients atteints d'un cancer, cette étude analyse leurs opinions relatives à l'usage secondaire de leurs données médicales pour alimenter un système permettant aux oncologues d'exploiter rapidement un grand volume de données recueillies en dehors d'essais cliniques

Perspectives of Patients With Cancer on the Ethics of Rapid-Learning Health Systems

Reshma Jagsi ; Kent A. Griffith ; Aaron Sabolch ; Rochelle Jones ; Rebecca Spence ; Raymond De Vries ; David Grande ; Angela R. Bradbury

Purpose : To inform the evolving implementation of CancerLinQ and other rapid-learning systems for oncology care, we sought to evaluate perspectives of patients with cancer regarding ethical issues. Methods : Using the GfK Group online research panel, representative of the US population, we surveyed 875 patients with cancer; 621 (71%) responded. We evaluated perceptions of appropriateness (scored from 1 to 10; 10, very appropriate) using scenarios and compared responses by age, race, and [...]