A partir des données de la cohorte européenne EPIC portant sur 452 patients atteints d'un cancer colorectal et sur 452 témoins, cette étude évalue l'association entre divers marqueurs biologiques d'une dysfonction métabolique (récepteur soluble de la leptine, taux d'hémoglobine glyquée), une prise de poids à l'âge adulte et le risque de développer la maladie

Metabolic Mediators of the Association Between Adult Weight Gain and Colorectal Cancer: Data From the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort

Krasimira Aleksandrova; ; Sabrina Schlesinger; ; Veronika Fedirko; ; Mazda Jenab; ; Bas Bueno-de-Mesquita; ; Heinz Freisling; ; Isabelle Romieu; ; Tobias Pischon; ; Rudolf Kaaks; ; Marc J. Gunter;

Evidence indicates that gaining weight in adult life is associated with an elevated risk of colorectal cancer; however, biological mechanisms that may explain this association remain unclear. We evaluated the mediation effect of 20 different biomarkers on the relationship between adult weight gain and colorectal cancer, using data from a prospective nested case-control study of 452 incident cases diagnosed between 1992 and 2003 and matched within risk sets to 452 controls within the European [...]

Menée aux Pays-Bas par questionnaire auprès de 120 852 participants âgés entre 55 et 69 ans, cette étude de cohorte évalue l'association entre une consommation de viandes, de poissons et le risque de développer un cancer de la tête et du cou, par sous-type (durée moyenne de suivi : 20,3 ans ; 430 cas)

Intake of meat and fish and risk of head–neck cancer subtypes in the Netherlands Cohort Study

Perloy, Andy ; Maasland, Denise H. E. ; van den Brandt, Piet A. ; Kremer, Bernd ; Schouten, Leo J.

Purpose :To date, the role of meat and fish intake in head–neck cancer (HNC) etiology is not well understood and prospective evidence is limited. This prompted us to study the association between meat, fish, and HNC subtypes, i.e., oral cavity cancer (OCC), oro- and hypopharyngeal cancer (OHPC), and laryngeal cancer (LC), within the Netherlands Cohort Study (NLCS). Methods : In 1986, 120,852 participants (aged 55–69 years) completed a baseline 150-item food frequency questionnaire (FFQ), from [...]

Menée en France à partir des données de la cohorte E3N incluant 86 960 participantes, cette étude prospective évalue l'association entre la pigmentation de la peau auto-rapportée, la présence de nævus, une exposition aux ultraviolets sur le lieu de résidence et le risque de cancer de la thyroïde (période de suivi : 1990-2008)

Nevi, ambient ultraviolet radiation, and thyroid cancer risk: a French prospective study

Mesrine, Sylvie; ; Kvaskoff, Marina; ; Bah, Thierno; ; Wald, Lucien; ; Clavel-Chapelon, Françoise; ; Boutron-Ruault, Marie-Christine

Background: Incidence rates have increased considerably worldwide for both differentiated thyroid cancer and cutaneous melanoma, and two-way associations between these neoplasms have been described. Whether melanoma risk factors are associated with thyroid cancer risk remains unknown. Methods: Using Cox regression modeling, we prospectively analyzed the relationship between self-reported pigmentary traits, baseline residential ultraviolet (UV) exposure, and thyroid cancer risk in 86,960 women [...]

A partir d'échantillons tumoraux prélevés sur six patients atteints d'un carcinome épidermoïde du scrotum, cette étude identifie, pour 3 d'entre eux, la présence d'ADN du papillomavirus humain de type 16 et, pour 3 autres, suggère la présence de mutations du gène p53

Human papillomavirus 16 is an aetiological factor of scrotal cancer

Guimerà, Núria ; Alemany, Laia ; Halec, Gordana ; Pawlita, Michael ; Wain, Gerard Vincent ; Vailen, Jose Santos Salas ; Azike, Jerome E. ; Jenkins, David ; de Sanjose, Silvia ; Quint, Wim ; Bosch, F. Xavier

Background: Squamous cell scrotal carcinoma (SCSC) is an infrequent skin cancer associated historically with occupational carcinogens. Human papillomavirus (HPV) DNA has been associated with SCSC but there is no definitive proof of its oncogenic role. Methods:Human papillomavirus-DNA and –E6*I mRNA were analysed in six invasive histologically typed SCSC. LCM-PCR was used to localise HPV DNA to tumour cells. P16INK4aand p53 expression were studied by immunohistochemistry. Results:In three warty [...]

A partir des données de la cohorte européenne EPIC portant sur 26 331 participants grecs, cette étude évalue l'association entre une polyarthrite rhumatoïde et le risque de cancer

Rheumatoid arthritis and cancer risk: results from the Greek European prospective investigation into cancer and nutrition cohort

Klinaki, Eleni ; Katsoulis, Michail ; La Vecchia, Carlo ; Trichopoulou, Antonia

To investigate the relative risk of cancer development in rheumatoid arthritis (RA) patients in Greece after taking into consideration treatment modalities. The present analysis used data on the medical history of 26 331 participants in the Greek arm of the European Prospective Investigation into Cancer and Nutrition that were collected at enrollment and thereafter during active follow-up. A history of RA and of drug treatment for the disease, as reported at baseline examination, was linked to [...]

A partir d'une revue systématique de la littérature (32 études, plus de 50 000 enfants), cette méta-analyse évalue l'association entre des antécédents de fausses couches ou de naissances d'enfants sans vie et le risque de leucémie pédiatrique (avant 14 ans), par sous-type histologique

Maternal fetal loss history and increased acute leukemia subtype risk in subsequent offspring: a systematic review and meta-analysis

Karalexi, M. A. ; Dessypris, N. ; Skalkidou, A. ; Biniaris-Georgallis, S. -I ; Kalogirou, Ε. Ι. ; Thomopoulos, T. P. ; Herlenius, E. ; Spector, L. G. ; Loutradis, D. ; Chrousos, G. P. ; Petridou, E. Th.

Purpose : History of fetal loss including miscarriage and stillbirth has been inconsistently associated with childhood (0–14 years) leukemia in subsequent offspring. A quantitative synthesis of the inconclusive literature by leukemia subtype was therefore conducted. Methods : Eligible studies (N = 32) were identified through the screening of over 3500 publications. Random-effects meta-analyses were conducted on the association of miscarriage/stillbirth history with overall (AL; 18,868 [...]

Menée en Suède auprès de 325 599 participants âgés de plus de 20 ans, cette étude de cohorte évalue l'association entre divers marqueurs d'une inflammation systémique mesurés avant le diagnostic, le risque de développer un cancer colorectal, et la mortalité spécifique (4 764 cas)

Serum inflammatory markers and colorectal cancer risk and survival

Ghuman, Sundeep ; Van Hemelrijck, Mieke ; Garmo, Hans ; Holmberg, Lars ; Malmstrom, Hakan ; Lambe, Mats ; Hammar, Niklas ; Walldius, Goran ; Jungner, Ingmar ; Wulaningsih, Wahyu

Background: Inflammation has been linked with development of some cancers. We investigated systemic inflammation in relation to colorectal cancer incidence and subsequent survival using common serum inflammatory markers Design: A cohort of men and women aged 20 years and older in greater Stockholm area with serum C-reactive protein (CRP) and albumin measured between 1986 and 1999 were included (n=325 599). A subset of these had baseline measurements of haptoglobin and leukocytes. Multivariable [...]

Menée par une méthode de randomisation mendélienne à partir de données portant sur 9 254 atteints d'un cancer colorectal et sur 18 386 témoins, cette étude évalue l'association entre une hyperlipidémie, caractérisée par les niveaux sanguins de cholestérol, de triglycérides et de lipoprotéines, et le risque de développer la maladie

Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer

Rodriguez-Broadbent, Henry ; Law, Philip J. ; Sud, Amit ; Palin, Kimmo ; Tuupanen, Sari ; Gylfe, Alexandra ; Hanninen, Ulrika A. ; Cajuso, Tatiana ; Tanskanen, Tomas ; Kondelin, Johanna ; Kaasinen, Eevi ; Sarin, Antti-Pekka ; Ripatti, Samuli ; Eriksson, Johan G. ; Rissanen, Harri ; Knekt, Paul ; Pukkala, Eero ; Jousilahti, Pekka ; Salomaa, Veikko ; Palotie, Aarno ; Renkonen-Sinisalo, Laura ; Lepisto, Anna ; Bohm, Jan ; Mecklin, Jukka-Pekka ; Al-Tassan, Nada A. ; Palles, Claire ; Martin, Lynn ; Barclay, Ella ; Farrington, Susan M. ; Timofeeva, Maria N. ; Meyer, Brian F. ; Wakil, Salma M. ; Campbell, Harry ; Smith, Christopher G. ; Idziaszczyk, Shelley ; Maughan, Timothy S. ; Kaplan, Richard ; Kerr, Rachel ; Kerr, David ; Passarelli, Michael N. ; Figueiredo, Jane C. ; Buchanan, Daniel D. ; Win, Aung K. ; Hopper, John L. ; Jenkins, Mark A. ; Lindor, Noralane M. ; Newcomb, Polly A. ; Gallinger, steven ; Conti, David ; Schumacher, Fred ; Casey, Graham ; Aaltonen, Lauri A. ; Cheadle, Jeremy P. ; Tomlinson, Ian P. ; Dunlop, Malcolm G. ; Houlston, Richard S.

While elevated blood cholesterol has been associated with an increased risk of colorectal cancer (CRC) in observational studies, causality is uncertain. Here we apply a Mendelian randomisation (MR) analysis to examine the potential causal relationship between lipid traits and CRC risk. We used single nucleotide polymorphisms (SNPs) associated with blood levels of total cholesterol (TC), triglyceride (TG), low-density c (LDL), and high-density lipoprotein (HDL) as instrumental variables (IV). We [...]

Menée aux Etats-Unis à partir d'échantillons sériques prélevés avant le diagnostic sur 741 patients atteints d'un cancer papillaire de la thyroïde et sur 741 témoins, cette étude évalue l'association entre le niveau d'hormones thyroïdiennes et le risque de développer la maladie

Thyroid-Stimulating Hormone, Thyroid Hormones and Risk of Papillary Thyroid Cancer: A Nested Case-Control Study

Huang, Huang ; Rusiecki, Jennifer ; Zhao, Nan ; Chen, Yingtai ; Ma, Shuangge ; Yu, Herbert ; Ward, Mary H. ; Udelsman, Robert ; Zhang, Yawei

Background:The effects of thyroid-stimulating hormone (TSH) and thyroid hormones on the development of human papillary thyroid cancer (PTC) remain poorly understood. Methods:The study population consisted of 741 (341 women, 300 men) histologically confirmed PTC cases and 741 matched controls with pre-diagnostic serum samples stored in the Department of Defense Serum Repository. Concentrations of TSH, total T3 (TT3), total T4 (TT4), and free T4 (FT4) were measured in serum samples. Conditional [...]

Menée sur un modèle murin, cette étude identifie des mécanismes faisant le lien entre des variants du gène NEIL1, une exposition alimentaire à l'aflatoxine et le risque de développer un carcinome hépatocellulaire

NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice

Vartanian, Vladimir ; Minko, Irina G. ; Chawanthayatham, Supawadee ; Egner, Patricia A. ; Lin, Ying-Chih ; Earley, Lauriel F. ; Makar, Rosemary ; Eng, Jennifer R. ; Camp, Matthew T. ; Li, Liang ; Stone, Michael P. ; Lasarev, Michael R. ; Groopman, John D. ; Croy, Robert G. ; Essigmann, John M. ; McCullough, Amanda K. ; Lloyd, R. Stephen

Global distribution of hepatocellular carcinomas (HCCs) is dominated by its incidence in developing countries, accounting for >700,000 estimated deaths per year, with dietary exposures to aflatoxin (AFB1) and subsequent DNA adduct formation being a significant driver. Genetic variants that increase individual susceptibility to AFB1-induced HCCs are poorly understood. Herein, it is shown that the DNA base excision repair (BER) enzyme, DNA glycosylase NEIL1, efficiently recognizes and excises the [...]

Menée aux Pays-Bas à partir de données portant sur 2 586 femmes âgées de 55 à 69 ans, cette étude de cohorte prospective évalue l'association entre des polymorphismes de gènes impliqués dans le métabolisme de l'acrylamide, une consommation d'acrylamide d'origine alimentaire et le risque de cancer de l'ovaire (durée de suivi : 20,3 ans ; 252 cas)

Interactions between dietary acrylamide intake and genes for ovarian cancer risk

Hogervorst, Janneke G. F. ; van den Brandt, Piet A. ; Godschalk, Roger W. L. ; van Schooten, Frederik-Jan ; Schouten, Leo J.

Some epidemiological studies observed a positive association between dietary acrylamide intake and ovarian cancer risk but the causality needs to be substantiated. By analyzing gene-acrylamide interactions for ovarian cancer risk for the first time, we aimed to contribute to this. The prospective Netherlands Cohort Study on diet and cancer includes 62,573 women, aged 55–69 years. At baseline in 1986, a random subcohort of 2589 women was sampled from the total cohort for a case cohort analysis [...]

A partir d'une revue systématique de la littérature publiée depuis 2012 (12 études), cette étude met à jour les données portant sur l'association entre des indicateurs de troubles du rythme circadien (travail de nuit posté, troubles du sommeil, gènes liés aux rythmes circadiens) et le risque de cancer de la prostate

Circadian Disruption and Prostate Cancer Risk: An Updated Review of Epidemiological Evidences

Wendeu-Foyet, Méyomo G. ; Menegaux, Florence

Since the publication of the IARC Monograph in 2007 classifying night shift work leading to a disruption of circadian rhythm as probably carcinogenic to humans, there is an increasingly growing interest in understanding how circadian disruption may play a role in cancer development. This systematic review provides a comprehensive update on epidemiological evidences on circadian disruption and prostate cancer since the last review published in 2012. We identified 12 new studies evaluating the [...]