A partir d'une revue systématique de la littérature (26 études, 1 074 patients, 23 aidants, 169 professionnels de santé), cette étude analyse les divers facteurs facilitant ou entravant la pratique d'une activité physique chez des patients atteints d'un cancer du poumon

Understanding factors influencing physical activity and exercise in lung cancer: a systematic review

Granger, Catherine L. ; Connolly, Bronwen ; Denehy, Linda ; Hart, Nicholas ; Antippa, Phillip ; Lin, Kuan-Yin ; Parry, Selina M.

Purpose : Despite evidence and clinical practice guidelines supporting physical activity (PA) for people with lung cancer, this evidence has not translated into clinical practice. This review aims to identify, evaluate and synthesise studies examining the barriers and enablers for patients with lung cancer to participate in PA from the perspective of patients, carers and health care providers (HCPs). Methods : Systematic review of articles using electronic databases: MEDLINE (1950–2016), CINAHL [...]

Menée au Royaume-Uni par enquête auprès de 292 patientes ayant survécu à un cancer du sein 2 à 4 ans après le diagnostic, cette étude analyse les facteurs associés à l'abandon, intentionnel ou non, d'une hormonothérapie adjuvante

Factors associated with intentional and unintentional non-adherence to adjuvant endocrine therapy following breast cancer

Brett, J. ; Fenlon, D. ; Boulton, M. ; Hulbert-Williams, N. J. ; Walter, F. M. ; Donnelly, P. ; Lavery, B. ; Morgan, A. ; Morris, C. ; Watson, E.

Adherence to adjuvant endocrine therapy (AET) following breast cancer is known to be suboptimal despite its known efficacy in reducing recurrence and mortality. This study aims to investigate factors associated with non-adherence and inform the development of interventions to support women and promote adherence. A questionnaire survey to measure level of adherence, side effects experienced, beliefs about medicine, support received and socio-demographic details was sent to 292 women 2–4 years [...]

A partir des données des registres des cancers de 195 pays portant sur la période 1990-2015, cette étude internationale analyse l'évolution géographique de l'incidence de 32 types de cancers, et évalue les années de vie perdues, les années de vie passées en situation de handicap, les années de vie perdues ajustées sur l'incapacité et la mortalité

Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: A systematic analysis for the global burden of disease study

Global Burden of Disease Cancer, Collaboration ; Christina Fitzmaurice

Importance  : Cancer is the second leading cause of death worldwide. Current estimates on the burden of cancer are needed for cancer control planning. Objective : To estimate mortality, incidence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs) for 32 cancers in 195 countries and territories from 1990 to 2015. Evidence Review : Cancer mortality was estimated using vital registration system data, cancer registry incidence data [...]

A partir des données des registres américains des cancers portant sur la période 1992-2013, cette étude analyse l'évolution de l'incidence d'une leucémie diagnostiquée chez des patients de moins de 19 ans, en fonction de l'origine ethnique

Trends in childhood leukemia incidence over two decades from 1992 to 2013

Barrington-Trimis, Jessica L. ; Cockburn, Myles ; Metayer, Catherine ; Gauderman, W. James ; Wiemels, Joseph ; McKean-Cowdin, Roberta

Incidence rates of childhood leukemia in the United States have steadily increased over the last several decades, but only recently have disparities in the increase in incidence been recognized. In the current analysis, Surveillance, Epidemiology and End Results (SEER) data were used to evaluate recent trends in the incidence of childhood leukemia diagnosed at age 0–19 years from 1992 to 2013, overall and by age, race/ethnicity, gender and histologic subtype. Hispanic White children were more [...]

A partir des données des registres américains des cancers portant sur 3 318 patients atteints d'un cancer du poumon non à petites cellules diagnostiqué en 1996, 2005 ou 2010, cette étude analyse l'évolution de la survie en lien avec les traitements utilisés

Temporal Patterns of Care and Outcomes of Non-Small Cell Lung Cancer Patients in the United States Diagnosed in 1996, 2005, and 2010

Kaniski, Filip ; Enewold, Lindsey ; Thomas, Anish ; Malik, Shakuntala ; Stevens, Jennifer L. ; Harlan, Linda C.

Introduction : Lung cancer remains a common and deadly cancer in the United States. This study evaluated factors associated with stage-specific cancer therapy and survival focusing on temporal trends and sociodemographic disparities. Methods : A random sample (n = 3,318) of non-small cell lung cancer (NSCLC) patients diagnosed in 1996, 2005 and 2010, and reported to the National Cancer Institute’s Surveillance Epidemiology and End Results (SEER) program was analyzed. Logistic regression was [...]

Menée sur 1 958 patients atteints d'un cancer du côlon de stade III ayant subi une résection curative et inclus dans un essai randomisé pour recevoir une chimiothérapie adjuvante de type FOLFOX avec ou sans cétuximab, cette étude évalue les effets de la metformine sur la survie sans progression, la survie globale et le temps écoulé avant récidive

Relationship Between Metformin Use and Recurrence and Survival in Patients With Resected Stage III Colon Cancer Receiving Adjuvant Chemotherapy: Results From North Central Cancer Treatment Group N0147 (Alliance)

Singh, Preet Paul ; Shi, Qian ; Foster, Nathan R. ; Grothey, Axel ; Nair, Suresh G. ; Chan, Emily ; Shields, Anthony F. ; Goldberg, Richard M. ; Gill, Sharlene ; Kahlenberg, Morton S. ; Sinicrope, Frank A. ; Sargent, Daniel J. ; Alberts, Steven R.

Preclinical and epidemiological data suggest that metformin might have antineoplastic properties against colon cancer (CC). However, the effect of metformin use on patient survival in stage III CC after curative resection is unknown. The survival outcomes were comparable regardless of the duration of metformin use.Before randomization to FOLFOX (folinic acid, 5-fluorouracil, oxaliplatin) with or without cetuximab, 1,958 patients with stage III CC enrolled in the N0147 study completed a [...]

A partir d'une revue systématique de la littérature (12 études, 18 105 patients), cette méta-analyse évalue l'association entre une utilisation de statines et la survie chez des patients atteints d'un cancer du rein

Statin use and kidney cancer survival outcomes: A systematic review and meta-analysis

Nayan, Madhur ; Punjani, Nahid ; Juurlink, David N. ; Finelli, Antonio ; Austin, Peter C. ; Kulkarni, Girish S. ; Uleryk, Elizabeth ; Hamilton, Robert J.

Background : Statin use has been associated with improved survival outcomes in various malignancies. Randomized controlled trials are currently underway evaluating their utility as adjunctive cancer therapies. However, studies evaluating the association between statin use and outcomes in kidney cancer yield conflicting results. Methods : We searched Medline and EMBASE to identify studies evaluating the association between statin use and kidney cancer survival outcomes. We evaluated risk of bias [...]

Menée à partir de données portant sur 209 patientes ayant survécu à un cancer du sein et sur 106 témoins, cette étude longitudinale analyse les effets indésirables des traitements sur l'évolution du niveau des cytokines pro-inflammatoires, sur les comorbidités et sur la mortalité prématurée

Inflammatory Cytokines and Comorbidity Development in Breast Cancer Survivors Versus Noncancer Controls: Evidence for Accelerated Aging?

Catherine M. Alfano ; Juan Peng ; Rebecca R. Andridge ; Monica E. Lindgren ; Stephen P. Povoski ; Adele M. Lipari ; Doreen M. Agnese ; William B. Farrar ; Lisa D. Yee ; William E. Carson III ; Janice K. Kiecolt-Glaser

Purpose : The sequelae of cancer treatment may increase systemic inflammation and create a phenotype at increased risk of functional decline and comorbidities, leading to premature mortality. Little is known about how this trajectory compares with natural aging among peers of the same age without cancer. This longitudinal study investigated proinflammatory cytokines and comorbidity development over time among breast cancer survivors and a noncancer control group. Methods : Women (N = 315; 209 [...]

A partir de données internationales (31 centres, 20 pays) portant sur 185 patients atteints d'un séminome de stade I, ayant subi une orchitectomie par voie inguinale et reçu un traitement adjuvant à base de carboplatine, cette étude rétrospective analyse la survie sans progression, la survie globale, la durée avant récidive et les traitements de la récidive (durée médiane de suivi : 53 mois)

Outcome of Men With Relapse After Adjuvant Carboplatin for Clinical Stage I Seminoma

Stefanie Fischer ; Torgrim Tandstad ; Matthew Wheater ; Emilio Porfiri ; Aude Fléchon ; Jorge Aparicio ; Dirk Klingbiel ; Breda Skrbinc ; Umberto Basso ; Jonathan Shamash ; Anja Lorch ; Klaus-Peter Dieckmann ; Gabriella Cohn-Cedermark ; Olof Ståhl ; Caroline Chau ; Edurne Arriola ; Kalena Marti ; Paul Hutton ; Brigitte Laguerre ; Pablo Maroto ; Jörg Beyer ; Silke Gillessen

Purpose : Adjuvant carboplatin is one of three management strategies that may follow inguinal orchiectomy in clinical stage I seminoma. However, little is known about the outcome of patients who experience a relapse after such treatment. Patients and Methods : Data from 185 patients who relapsed after adjuvant carboplatin between January 1987 and August 2013 at 31 centers/groups from 20 countries were collected and retrospectively analyzed. Primary outcomes were disease-free survival and [...]

Menée au Japon auprès de 119 parents d'enfants atteints de cancer (âge moyen des parents : 41,4 ans), cette étude analyse les facteurs associés à un processus de croissance post-traumatique

Factors associated with posttraumatic growth among parents of children with cancer

Nakayama, Nao ; Mori, Naoko ; Ishimaru, Sae ; Ohyama, Wataru ; Yuza, Yuki ; Kaneko, Takashi ; Kanda, Eiichiro ; Matsushima, Eisuke

Background: Parents of children with cancer are susceptible to psychological distress; however, many parents also report posttraumatic growth (PTG). The objective of this study was to explore the variables associated with PTG in parents of children with cancer who were either on treatment or off treatment. Methods: One hundred and nineteen parents (71 mothers and 48 fathers) of children with cancer completed self-report questionnaires, including the PTG Inventory, Center for Epidemiologic [...]

Mené aux Etats-Unis sur 29 patients atteints de cancer, cet essai randomisé évalue l'efficacité de la psilocybine, un principe actif de certains champignons hallucinogènes, pour prendre en charge leurs symptômes d'anxiété et de dépression liés à la maladie

Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial

Ross, Stephen ; Bossis, Anthony ; Guss, Jeffrey ; Agin-Liebes, Gabrielle ; Malone, Tara ; Cohen, Barry ; Mennenga, Sarah E ; Belser, Alexander ; Kalliontzi, Krystallia ; Babb, James ; Su, Zhe ; Corby, Patricia ; Schmidt, Brian L

Background: Clinically significant anxiety and depression are common in patients with cancer, and are associated with poor psychiatric and medical outcomes. Historical and recent research suggests a role for psilocybin to treat cancer-related anxiety and depression. Methods: In this double-blind, placebo-controlled, crossover trial, 29 patients with cancer-related anxiety and depression were randomly assigned and received treatment with single-dose psilocybin (0.3 mg/kg) or niacin, both in [...]

Menée aux Etats-Unis auprès de 701 patients atteints de cancer, ayant reçu une greffe de cellules souches hématopoïétiques et inclus dans un essai clinique multicentrique, cette étude analyse l'efficacité de l'outil "Cancer and Treatment Distress" pour mesurer l'évolution de leur détresse psychologique, 100 et 180 jours après la greffe

Cancer and treatment distress psychometric evaluation over time: A BMT CTN 0902 secondary analysis

Syrjala, Karen L. ; Sutton, Steven K. ; Jim, Heather S. L. ; Knight, Jennifer M. ; Wood, William A. ; Lee, Stephanie J. ; Jacobsen, Paul B. ; Abidi, Muneer H. ; Yi, Jean C.

BACKGROUND: Routine monitoring of cancer-related distress is recognized as essential to quality care and mandated by a major accrediting organization. However, to the authors' knowledge, few cancer-specific measures have been developed to date to assess the multiple cancer-related factors contributing to this distress. In the current study, the authors examined the psychometric properties of the Cancer and Treatment Distress (CTXD) measure over time in hematopoietic cell transplantation (HCT) [...]

A partir d'une revue systématique de la littérature (15 articles), cette étude analyse les discussions entre le médecin et son patient atteint de cancer relatives aux coûts des traitements restant à la charge du patient

A review of cost communication in oncology: Patient attitude, provider acceptance, and outcome assessment

Shih, Ya-Chen Tina ; Chien, Chun-Ru

The American Society of Clinical Oncology released its first guidance statement on the cost of cancer care in August 2009, affirming that patient-physician cost communication is a critical component of high-quality care. This forward-thinking recommendation has grown increasingly important in oncology practice today as the high costs of cancer care impose tremendous financial burden to patients, their families, and the health care system. For the current review, a literature search was [...]

Menée au Royaume-Uni à partir de données portant sur 2 416 patients atteints d'un cancer de stade avancé et pris en charge dans des services de soins palliatifs, cette étude analyse les facteurs de risque et la prévalence d'une anémie liée à un déficit martial fonctionnel

Estimating prevalence of functional iron deficiency anaemia in advanced cancer

Neoh, Karen ; Stanworth, Simon ; Pasricha, Sant-Rayn ; Bennett, Michael I.

Purpose : Anaemia is a common complication of cancer causing symptoms including fatigue. It is also associated with shorter survival. Cancer causes systemic inflammation which interrupts iron metabolism leading to a functional iron deficiency (FID). There are few data on prevalence or aetiology of anaemia in those with advanced cancer. We aimed to establish the prevalence of anaemia and estimate extent of FID anaemia in patients with advanced cancer. Methods : All patients with advanced cancer [...]

Menée en Italie à partir de données portant sur 2 211 patients décédés d'un cancer, cette étude analyse l'efficacité d'un programme de soins palliatifs à domicile, en fonction du moment de sa mise en place et de son intensité, pour améliorer la qualité des soins de fin de vie

Impact of intensity and timing of integrated home palliative cancer care on end-of-life hospitalization in Northern Italy

Pellizzari, M. ; Hui, D. ; Pinato, E. ; Lisiero, M. ; Serpentini, S. ; Gubian, L. ; Figoli, F. ; Cancian, M. ; De Chirico, C. ; Ferroni, E. ; Avossa, F. ; Saugo, M.

Purpose : The Veneto Region implemented a novel integrated home-based palliative cancer care (HPCC) program embedded in primary care. We examined the impact of timing and intensity of this program on the quality of end-of-life (EOL) care. Methods : We selected adult cancer patients died in the Veneto Region between March and December 2013, excluding those died from haematological malignancies as well as the very elderly (85+ years). We retrieved the claim-based data on hospitalization and [...]