Menée en Australie auprès de 441 patients atteints d'un cancer, cette étude évalue l'impact, sur leur qualité de vie, d'une greffe de cellules souches hématopoïétiques

Haematopoietic stem cell transplantation survivorship and quality of life: is it a small world after all?

Brice, Lisa ; Gilroy, Nicole ; Dyer, Gemma ; Kabir, Masura ; Greenwood, Matt ; Larsen, Stephen ; Moore, John ; Kwan, John ; Hertzberg, Mark ; Brown, Louisa ; Hogg, Megan ; Huang, Gillian ; Tan, Jeff ; Ward, Christopher ; Gottlieb, David ; Kerridge, Ian

Purpose : The aim of this qualitative study was to gain a rich understanding of the impact that haematopoietic stem cell transplantation (HSCT) has on long-term survivor’s quality of life (QoL). Method : Participants included 441 survivors who had undergone HSCT for a malignant or non-malignant disease. Data were obtained by a questionnaire positing a single open-ended question asking respondents to list the three issues of greatest importance to their QoL in survivorship. Responses were [...]

Menée au Canada par entretiens auprès de patients adolescents et jeunes adultes atteints d'un cancer de stade avancé, cette étude qualitative analyse leurs expériences et leurs besoins en soins de support

Lost and stranded: the experience of younger adults with advanced cancer

Knox, Matthew K. ; Hales, Sarah ; Nissim, Rinat ; Jung, Judy ; Lo, Christopher ; Zimmermann, Camilla ; Rodin, Gary

Purpose : There has been increased awareness recently of the unique medical and psychosocial needs of adolescents and young adults (AYAs) with cancer. However, the existing AYA literature is mainly focused on curative disease or survivorship rather than on advanced disease. Using qualitative methodology, we sought to understand the experience of younger adults with advanced cancer. Methods : Participants were interviewed using open-ended, discovery-oriented interviews. Data was analyzed using [...]

Menée au Canada auprès de 830 patients ayant survécu à un cancer de la prostate, cette étude prospective évalue l'association entre l'évolution de leur activité physique de loisirs, avant et après le diagnostic, et leur qualité de vie

Associations of post-diagnosis physical activity and change from pre-diagnosis physical activity with quality of life in prostate cancer survivors

Farris, Megan S. ; Kopciuk, Karen A. ; Courneya, Kerry S. ; McGregor, Elizabeth ; Wang, Qinggang ; Friedenreich, Christine M

Background: This prospective study examined the associations between post-diagnosis physical activity and change from pre-diagnosis physical activity with quality of life (QoL) in prostate cancer survivors. Methods: Prostate cancer survivors (n=830) who participated in a case-control study with invasive stage {greater than or equal to}II disease were followed up to 2007 to capture QoL outcomes. At baseline and three time points post-diagnosis (2000-2007), interviews/questionnaires were used to [...]

Mené auprès de 142 patients atteints d'un cancer localisé de la prostate (âge moyen : 61 ans), cet essai randomisé évalue l'efficacité d'une intervention psychologique en ligne pour améliorer leur satisfaction relative à leur sexualité après les traitements

An online psychological intervention can improve the sexual satisfaction of men following treatment for localized prostate cancer: outcomes of a Randomised Controlled Trial evaluating My Road Ahead

Wootten, Addie C. ; Meyer, Denny ; Abbott, Jo-Anne M. ; Chisholm, Katherine ; Austin, David W. ; Klein, Britt ; McCabe, Marita ; Murphy, Declan G. ; Costello, Anthony J.

Background: Prostate cancer treatment often results in significant psycho-sexual challenges for men following treatment; however, many men report difficulty in accessing appropriate care. Methods: A randomized controlled trial was undertaken to assess the efficacy of a 10-week self-guided online psychological intervention called My Road Ahead (MRA) for men with localized prostate cancer in improving sexual satisfaction. Participants were randomized to 1 of 3 conditions MRA alone or MRA plus [...]

A partir d'une revue de la littérature publiée entre 1988 et 2014 (111 essais, 61 531 patients atteints d'un cancer colorectal de stade avancé), cette étude fait le point sur l'utilisation et la pertinence de la qualité de vie comme critère d'évaluation de l'efficacité des traitements dans les essais de phase III

Health-related quality of life assessment in contemporary phase III trials in advanced colorectal cancer

Adamowicz, Krzysztof ; Saad, Everardo D. ; Jassem, Jacek

Highlights : •Health-related quality of life (HRQOL) has been formally assessed in 36% of recent phase III trials in advanced colorectal cancer. •A significant gain in HRQOL was found in 39% of trials. •There is a significant decrease in the use of HRQOL as an endpoint in phase III trials in advanced colorectal cancer. •It is questionable whether HRQOL results may largely help select between competing treatments in this disease. Background : Health-related quality of life (HRQOL) is often used [...]

Menée au Canada par questionnaire auprès de 1 513 patientes atteintes d'un cancer du sein, cette étude analyse leurs symptômes et leur qualité de vie en fonction des types de traitements reçus

Quality of life (QOL) and symptom burden (SB) in patients with breast cancer

Hamer, Julia ; McDonald, Rachel ; Zhang, Liying ; Verma, Sunil ; Leahey, Angela ; Ecclestone, Christine ; Bedard, Gillian ; Pulenzas, Natalie ; Bhatia, Anchal ; Chow, Ronald ; DeAngelis, Carlo ; Ellis, Janet ; Rakovitch, Eileen ; Lee, Justin ; Chow, Edward

Purpose : The purpose of this study was to determine the quality of life (QOL) and symptom burden (SB) among breast cancer patients. Methods : Patients with DCIS, early stage, locally advanced, or metastatic breast cancer completed the Edmonton Symptom Assessment System (ESAS) and the Functional Assessment of Cancer Therapy for Breast Cancer (FACT-B). Patients were divided into subsequent cohorts based on their last day of treatment, age at enrollment, radiation, chemotherapy, and hormone [...]

Menée auprès de 172 patients atteints d'un cholangiocarcinome et de 91 patients atteints d'un cancer de la vésicule biliaire, cette étude internationale multicentrique analyse l'efficacité d'un outil, le module QLQ-BIL21 du questionnaire européen EORTC, pour évaluer leur qualité de vie

Validation of the EORTC QLQ-BIL21 questionnaire for measuring quality of life in patients with cholangiocarcinoma and cancer of the gallbladder

Kaupp-Roberts, S. D. ; Yadegarfar, G. ; Friend, E. ; O'Donnell, C. M. ; Valle, J. W. ; Byrne, C. ; Bahar, I. ; Finch-Jones, M. ; Gillmore, R. ; Johnson, C. D. ; Pereira, S. P. ; Wiggers, J. K. ; Pinto, M. ; Al-Sarireh, B. ; Ramage, J. K.

Background: There is no specific quality of life (QoL) measurement tool to quantify QoL in patients with biliary tract cancer. Quality of life measurement is an increasingly crucial trial end point and is now being incorporated into clinical practice. Methods: This International Multicentre Phase IV Validation Study assessed the QLQ-BIL21 module in 172 patients with cholangiocarcinoma and 91 patients with cancer of the gallbladder. Patients completed the questionnaire at baseline pretherapy and [...]

Menée au Danemark auprès de 54 patients atteints d'un cancer de la tête et du cou, cette étude observationnelle analyse les facteurs associés à un syndrome de renutrition inappropriée

Incidence and Risk Factors of Refeeding Syndrome in Head and Neck Cancer Patients—An Observational Study

Rasmussen, Stine Ostenfeldt ; Kristensen, Marianne Boll ; Wessel, Irene ; Andersen, Jens Rikardt

This study aimed to determine the incidence rates of refeeding phenomena (defined as a decline in p-phosphate) and refeeding syndrome (RFS; defined as development of clinical symptoms in addition to a decline in p-phosphate) in head and neck cancer patients, and to identify risk factors. Fifty-four head and neck cancer patients referred for surgery were included. Forty-six potential risk factors were registered at the baseline, and p-phosphate was measured at Days 2, 4, and 7. Eleven patients [...]

A partir des données du registre suisse des cancers pédiatriques incluant 5 776 patients âgés de moins de 14 ans, cette étude analyse les facteurs associés à l'évolution de la survie à 5 ans sur la période 1976-2013

Childhood cancer survival in Switzerland (1976–2013): Time-trends and predictors

Schindler, Matthias ; Belle, Fabiën N. ; Grotzer, Michael A. ; von der Weid, Nicolas X. ; Kuehni, Claudia E. ; for the Swiss Paediatric Oncology, Group

Population-based studies on childhood cancer survival are key to monitor progress against cancer and to detect potential differences between regions and other subgroups in the population. We investigated time trends and factors associated with childhood cancer survival on a national level in Switzerland, from 1976 to 2013. We extracted data from the population-based Swiss Childhood Cancer Registry of 5,776 children (age 0–14 years) diagnosed with cancer from 1985 to 2014 in Switzerland. We [...]

Menée en Allemagne à partir de données portant sur 5 306 patients atteints d'un lymphome hodgkinien, cette étude analyse la sévérité de leur fatigue liée à la maladie, avant et jusqu'à 9 ans après les traitements, puis évalue les effets de cette fatigue sur la survie et sur leur réadaptation à la vie sociale

Cancer-Related Fatigue in Patients With and Survivors of Hodgkin Lymphoma: The Impact on Treatment Outcome and Social Reintegration

Behringer, Karolin ; Goergen, Helen ; Müller, Horst ; Thielen, Indra ; Brillant, Corinne ; Kreissl, Stefanie ; Halbsguth, Teresa Veronika ; Meissner, Julia ; Greil, Richard ; Moosmann, Peter ; Shonukan, Oluwatoyin ; Rueffer, Jens Ulrich ; Flechtner, Hans-Henning ; Fuchs, Michael ; Diehl, Volker ; Engert, Andreas ; Borchmann, Peter

Purpose : Cancer-related fatigue occurs frequently in patients with Hodgkin lymphoma (HL) and has a major impact on their quality of life. We hypothesized that severe fatigue (sFA) might have an impact on patients’ treatment outcome and social reintegration. Methods Of 5,306 patients enrolled in the German Hodgkin Study Group’s fifth generation of clinical trials in HL (HD13, HD14, and HD15; nonqualified and older [> 60 years] patients excluded), 4,529 provided data on health-related quality of [...]

Menée au Japon à partir de données portant sur 358 patients atteints d'un lymphome T ou NK extraganglionnaire de type nasal diagnostiqué entre 2000 et 2013 (âge médian : 58 ans ; durée médiane de suivi : 5,8 ans), cette étude identifie les traitements de première ligne reçus, analyse les taux de survie et la toxicité de ces traitements, puis identifie les facteurs associés à la survie

Treatments and Outcomes of Patients With Extranodal Natural Killer/T-Cell Lymphoma Diagnosed Between 2000 and 2013: A Cooperative Study in Japan

Yamaguchi, Motoko ; Suzuki, Ritsuro ; Oguchi, Masahiko ; Asano, Naoko ; Amaki, Jun ; Akiba, Takeshi ; Maeda, Takeshi ; Itasaka, Satoshi ; Kubota, Nobuko ; Saito, Yoshihiro ; Kobayashi, Yukio ; Itami, Jun ; Ueda, Kyoko ; Miyazaki, Kana ; Ii, Noriko ; Tomita, Naoto ; Sekiguchi, Nodoka ; Takizawa, Jun ; Saito, Bungo ; Murayama, Tohru ; Ando, Toshihiko ; Wada, Hideho ; Hyo, Rie ; Ejima, Yasuo ; Hasegawa, Masatoshi ; Katayama, Naoyuki

Purpose : To elucidate the management and outcomes of patients with extranodal natural killer/T-cell lymphoma, nasal type (ENKL), who were diagnosed between 2000 and 2013 in Japan. Patients and Methods : Data from 358 patients with ENKL diagnosed between 2000 and 2013 from 31 institutes were retrospectively analyzed. Results : Patients’ median age was 58 years, and 257 (72%) had localized disease. The most common first-line treatment was radiotherapy with dexamethasone, etoposide, ifosfamide, [...]

Menée aux Etats-Unis auprès de 548 patientes atteintes d'un cancer du sein, cette étude évalue l'association entre une hormonothérapie (tamoxifène ou inhibiteurs de l'aromatase) et des symptômes d'incontinence urinaire

Endocrine therapy and urogenital outcomes among women with a breast cancer diagnosis

Landi, Suzanne N. ; Doll, Kemi M. ; Bensen, Jeannette T. ; Hendrix, Laura ; Anders, Carey K. ; Wu, Jennifer M. ; Nichols, Hazel B.

Purpose : Endocrine therapy for breast cancer can exacerbate menopausal symptoms. The association between endocrine therapy and common pelvic floor disorders including urinary incontinence has rarely been evaluated. We examined urogenital and sexual side effects among women with a breast cancer diagnosis, comparing endocrine therapy users to nonusers. Methods : Urogenital and sexual symptoms were self-reported during the enrollment interview within the University of North Carolina Cancer [...]

Menée en Israël à partir de données portant sur 3 731 patientes atteintes d'un cancer du sein après la ménopause et sur 15 915 témoins, cette étude évalue l'association entre une utilisation de bisphosphonates oraux après le diagnostic et l'amélioration de la survie (durée moyenne de suivi : 70 mois, 799 décès)

Oral bisphosphonates and improved survival of breast cancer

Rennert, Gad ; Pinchev, Mila ; Gronich, Naomi ; Saliba, Walid ; Flugelman, Anath ; Lavi, Idit ; Goldberg, Hadassah ; Fried, Georgeta ; Steiner, Mariana ; Bitterman, Arie ; Landsman, Keren ; Rennert, Hedy

Purpose:Bisphosphonates are used for treatment or prevention of osteoporosis and of bone metastases. The use of oral bisphosphonates was suggested to be associated with reduced risk of developing breast cancer and their positive influence on breast cancer survival was only demonstrated with third generation bisphosphonates. We studied the association of use of oral bisphosphonates after breast cancer diagnosis on overall and breast cancer survival. Experimental Design:A nested case-control [...]

Menée au Danemark à partir de données portant sur 5 190 patients atteints de tumeurs germinales du testicule, cette étude de cohorte évalue l'association entre les traitements, le risque de second cancer (durée médiane de suivi : 14,4 ans) et le risque de décès

Second malignant neoplasms and cause of death in patients with germ cell cancer: A danish nationwide cohort study

Kier, M. G. ; Hansen, M. K. ; Lauritsen, J. ; et al.,

Importance : Patients given systemic treatment for testicular germ cell cancer (GCC) are at increased risk for a second malignant neoplasm (SMN). Previous studies on SMN and causes of death lacked information on the exact treatment applied or were based on patients receiving former treatment options. Objective : To evaluate the treatment-specific risks for SMN and death in a nationwide population-based cohort of patients with GCC treated with current standard regimens. Design, Setting, and [...]

Menée au Portugal par questionnaire auprès de 106 patients atteints de tumeurs cutanées, cette étude analyse l'association entre leurs représentations de la maladie, les morbidités psychologiques, leur image corporelle, le soutien social et leur qualité de vie

Quality of life in patients with skin tumors: the mediator role of body image and social support

Pereira, M. Graça ; Ponte, Mafalda ; Ferreira, Gabriela ; Machado, José C.

Objective: This study analyzed the relationships between illness representations, psychological morbidity, family stress, and quality of life and whether these variables were mediated by body image and social support. Methods: The sample consisted of 106 patients with skin tumors, who answered the following measures: Dermatology Life Quality Index, Illness Perception Questionnaire–Brief, Medical Outcomes Study Social Support Survey, Index of Family Relations, Hospital Anxiety and Depression [...]

Menée aux Etats-Unis auprès de 1 790 patients atteints d'un cancer du poumon, cette étude prospective analyse l'évolution de leurs symptômes de dépression et leurs effets sur la survie

Longitudinal Changes in Depression Symptoms and Survival Among Patients With Lung Cancer: A National Cohort Assessment

Sullivan, Donald R. ; Forsberg, Christopher W. ; Ganzini, Linda ; Au, David H. ; Gould, Michael K. ; Provenzale, Dawn ; Slatore, Christopher G.

Purpose : Depression symptoms are common among patients with lung cancer patients; however, longitudinal changes and their impact on survival are understudied. Methods : This was a prospective, observational study from the Cancer Care Outcomes Research and Surveillance Consortium from five US geographically defined regions from September 2003 through December 2005. Patients enrolled within 3 months of their lung cancer diagnosis were eligible. The eight-item Center for Epidemiologic Studies [...]

A partir des données des registres américains des cancers portant sur 393 patients atteints d'une leucémie myéloïde chronique diagnostiquée entre 2007 et 2011, cette étude évalue l'impact du système de protection sociale Medicare sur l'initiation et l'adhésion aux traitements par inhibiteurs de tyrosine kinase, en lien avec les coûts restant à charge du patient

Factors Associated With Tyrosine Kinase Inhibitor Initiation and Adherence Among Medicare Beneficiaries With Chronic Myeloid Leukemia

Winn, Aaron N. ; Keating, Nancy L. ; Dusetzina, Stacie B.

Purpose : There is substantial concern surrounding affordability of orally administered anticancer therapies, particularly for Medicare beneficiaries. We examined rates of initiation and adherence to tyrosine kinase inhibitors (TKIs) among Medicare beneficiaries with chronic myeloid leukemia (CML) with and without cost-sharing subsidies. We selected TKIs given their effectiveness and strong indication for use among patients diagnosed with CML. Patients and Methods : Using SEER-Medicare data, we [...]

Menée aux Etats-Unis par enquête auprès de 2 279 patientes atteintes d'un cancer du sein récemment diagnostiqué, cette étude analyse leurs perceptions relatives à l'implication de leur médecin généraliste dans la prise de décision thérapeutique et dans le suivi des soins

Involvement of Primary Care Physicians in the Decision Making and Care of Patients With Breast Cancer

Wallner, Lauren P. ; Abrahamse, Paul ; Uppal, Jaspreet K. ; Friese, Christopher R. ; Hamilton, Ann S. ; Ward, Kevin C. ; Katz, Steven J. ; Hawley, Sarah T.

Purpose : Collaborative care between cancer specialists and primary care providers (PCPs) may improve the delivery of high-quality cancer care. Yet, patient perspectives about how involved the PCPs were in their breast cancer care and treatment decisions remain unknown. Patients and Methods : A weighted random sample of women newly diagnosed with breast cancer in 2013 to 2014, as reported to the SEER registries in Los Angeles, California, and Georgia, were sent a survey approximately 6 months [...]

Mené au Canada auprès de 182 soignants de patients atteints d'un cancer de stade avancé, cet essai randomisé évalue l'association entre des soins palliatifs, dispensés précocément à leurs patients, et leur satisfaction et leur qualité de vie

Impact of early Palliative Care on Caregivers of Patients with Advanced Cancer: Cluster Randomised Trial

McDonald, J. ; Swami, N. ; Hannon, B. ; Lo, C. ; Pope, A. ; Oza, A. ; Leighl, N. ; Krzyzanowska, M. ; Rodin, G. ; Le, L.W. ; Zimmermann, C.

Background: Early palliative care improves the quality of life (QOL) and satisfaction with care of patients with advanced cancer, but little is known about its effect on caregivers. Here we report outcomes of caregiver satisfaction with care and QOL from a trial of early palliative care. Patient and Methods: Twenty-four medical oncology clinics were cluster-randomised, stratified by tumour site (lung, gastrointestinal, genitourinary, breast, gynaecological), to early palliative care team [...]

Menée à Taïwan auprès de 1 495 patients atteints d'un cancer de stade avancé, cette étude évalue l'association entre un consentement éclairé signé par le patient pour ne pas être réanimé et l'amélioration de la qualité des soins de fin de vie

Do-not-resuscitate consent signed by patients indicates a more favorable quality of end-of-life care for patients with advanced cancer

Liang, Yi-Hsin ; Wei, Chih-Hsin ; Hsu, Wen-Hui ; Shao, Yu-Yun ; Lin, Ya-Chin ; Chou, Pei-Chun ; Cheng, Ann-Lii ; Yeh, Kun-Huei

Purpose : Do-not-resuscitate (DNR) consent is crucial in end-of-life (EOL) care for patients with advanced cancer. However, DNR consents signed by patients (DNR-P) and surrogates (DNR-S) reflect differently on patient autonomy and awareness. Methods : This retrospective study enrolled advanced cancer patients treated at National Taiwan University Hospital, Hsin-Chu Branch between 2012 and 2014. Patients who signed DNR consent at other hospitals were excluded; the remaining patients were [...]