Mené aux Etats-Unis auprès de 90 patients atteints d'un cancer de la prostate, cet essai randomisé évalue l'efficacité de techniques de Qigong et de Tai chi pour soulager leurs troubles du sommeil et leur fatigue pendant la radiothérapie

Qigong/tai chi for sleep and fatigue in prostate cancer patients undergoing radiotherapy: a randomized controlled trial

McQuade, Jennifer L. ; Prinsloo, Sarah ; Chang, David Z. ; Spelman, Amy ; Wei, Qi ; Basen-Engquist, Karen ; Harrison, Carol ; Zhang, Zonghao ; Kuban, Debra ; Lee, Andrew ; Cohen, Lorenzo

Objectives: Sleep disturbances and fatigue are common in prostate cancer patients undergoing radiotherapy. Prior research suggests mind-body techniques may improve these outcomes. We conducted a randomized controlled trial of qigong/tai chi (QGTC) in men with prostate cancer undergoing radiotherapy. Methods: Men with prostate cancer starting definitive radiation were randomized to 1 of 3 groups: (1) QGTC; (2) light exercise (LE); or (3) waiting list control. Sleep disturbances (Pittsburgh Sleep [...]

Mené en Australie auprès de 55 patients atteints d'un cancer de la prostate et présentant des métastases osseuses (âge moyen : 69,7 ans), cet essai évalue l'association entre la pratique et l'intensité d'exercices physiques, et leur santé physique et psychique

Associations between aerobic exercise levels and physical and mental health outcomes in men with bone metastatic prostate cancer: a cross-sectional investigation

Zopf, E. M. ; Newton, R. U. ; Taaffe, D. R. ; Spry, N. ; Cormie, P. ; Joseph, D. ; Chambers, S. K. ; Baumann, F. T. ; Bloch, W. ; Galvão, D. A.

Cancer patients with bone metastases have previously been excluded from participation in physical activity programmes due to concerns of skeletal fractures. Our aim was to provide initial information on the association between physical activity levels and physical and mental health outcomes in prostate cancer patients with bone metastases. Between 2012 and 2015, 55 prostate cancer patients (mean age 69.7 ± 8.3; BMI 28.6 ± 4.0) with bone metastases (58.2% >2 regions affected) undertook [...]

Menée en Espagne auprès de 1 057 patientes atteintes d'un cancer du sein diagnostiqué dans le cadre d'un programme de dépistage, cette étude analyse les facteurs associés à la prévalence et à la persistance de douleurs après les traitements

Prevalence of persistent pain after breast cancer treatment by detection mode among participants in population-based screening programs

Romero, Anabel ; Torà-Rocamora, Isabel ; Baré, Marisa ; Barata, Teresa ; Domingo, Laia ; Ferrer, Joana ; Torà, Núria ; Comas, Mercè ; Merenciano, Carmen ; Macià, Francesc ; Castells, Xavier ; Sala, Maria

Background : To date, the study of the risks and benefits of breast cancer screening has not included the onset of persistent pain after breast cancer treatment within the context of population-based screening programs. Our purpose was to investigate the prevalence of persistent pain and associated factors in women diagnosed with breast cancer (screening or interval) in the context of a population-based breast cancer screening program in Spain. Methods : A total of 1,057 women participating in [...]

Menée en Angleterre sur la période 1993-2014, cette étude analyse l'évolution des préférences relatives au lieu du décès chez des jeunes patients atteints d'un cancer (âgés de moins de 24 ans) et à l'organisation des soins de fin de vie

Place of death in children and young people with cancer and implications for end of life care: a population-based study in England, 1993–2014

Gao, Wei ; Verne, Julia ; Peacock, Janet ; Stiller, Charles ; Wells, Claudia ; Greenough, Anne ; Higginson, Irene J.

Background : Efforts to improve end of life care (EoLC) have made tangible impacts on care in adults, including enabling more people to die at their preferred place of death (PoD), usually home or hospices. Little is known how the PoD in children and young people (CYP, ≤24 years) has changed over time, especially in the context of a series of national initiatives for EoLC improvement since the late 1990s. To inform evidence-based policy-making and service development, we evaluated the national [...]

Menée en Italie à partir de données portant sur 60 patientes atteintes d'un cancer pendant la grossesse, cette étude analyse les morbidités et la mortalité néonatales liées aux chimiothérapies

Perinatal outcome in pregnant women with cancer: are there any effects of chemotherapy?

Garofalo, S. ; Degennaro, V. A. ; Salvi, S. ; De Carolis, M. P. ; Capelli, G. ; Ferrazzani, S. ; De Carolis, S. ; Lanzone, A.

Cancer is the leading cause of death in women of reproductive age. During the last decades and especially in developed countries, the incidence of cancer is increasing dramatically, with an incidence of 1 in 1,000 pregnancies. This is mostly related to delay of pregnancy into the late reproductive years. The aim of this study was to investigate the outcome of pregnancy in women with diagnosis of cancer; in particular, neonatal morbidity and mortality, after in utero exposure to chemotherapy, [...]

Menée aux Etats-Unis à partir de données des certificats de naissance et d'un registre des cancers portant sur des individus nés entre 1945 et 1959, cette étude évalue l'association entre leur statut socio-économique au début de la vie, déterminé par l'emploi des parents et le revenu moyen du foyer, et le risque de cancer à l'âge adulte

Baby Boomers and Birth Certificates: Early Life Socioeconomic Status and Cancer Risk in Adulthood

Stroup, Antoinette M ; Herget, Kimberly A ; Hanson, Heidi A ; Reed, Diana Lane ; Butler, Jared T ; Henry, Kevin A ; Harrell, C Janna ; Sweeney, Carol ; Smith, Ken R.

Background: Early life socioeconomic status (SES) may play a role in cancer risk in adulthood. However, measuring SES retrospectively presents challenges. Parental occupation on the birth certificate is a novel method of ascertaining early-life SES that has not been applied in cancer epidemiology. Methods: For a Baby-Boom cohort born in 1945-1959 in two Utah counties, individual-level Nam-Powers SES (Np-SES) was derived from parental industry/occupation reported on birth certificates. [...]

Menée à partir des données du registre suédois des cancers portant sur 3 554 patients atteints d'un mélanome malin cutané diagnostiqué entre 2005 et 2012, cette étude rétrospective analyse les facteurs associés à la survie spécifique (stade de la maladie, comorbidités, traitements, etc), et le risque de récidive ou de progression de la maladie

Epidemiology of cutaneous melanoma in Sweden—Stage-specific survival and rate of recurrence

Rockberg, Julia ; Amelio, Justyna M. ; Taylor, Aliki ; Jörgensen, Leif ; Ragnhammar, Peter ; Hansson, Johan

Cutaneous malignant melanoma (CMM) incidence is increasing globally, making a thorough understanding of the disease and its outcomes essential for optimizing care even more urgent. In this population-based, retrospective study, we investigated stage-specific survival and recurrence/progression rates of CMM among patients diagnosed in Stockholm County Council during 2005–2012, before the wide introduction of targeted therapy. A total of 3,554 CMM patients from the Stockholm Melanoma Register [...]

Menée aux Etats-Unis à partir de données portant sur 4 957 patients atteints d'un myélome multiple, cette étude de cohorte évalue l'association entre l'utilisation de statines, la mortalité toutes causes confondues et la mortalité spécifique

Statins Are Associated With Reduced Mortality in Multiple Myeloma

Sanfilippo, Kristen Marie ; Keller, Jesse ; Gage, Brian F. ; Luo, Suhong ; Wang, Tzu-Fei ; Moskowitz, Gerald ; Gumbel, Jason ; Blue, Brandon ; O’Brian, Katiuscia ; Carson, Kenneth R.

Purpose : The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) have activity in one of the pathways influenced by nitrogen-containing bisphosphonates, which are associated with improved survival in multiple myeloma (MM). To understand the benefit of statins in MM, we evaluated the association between statin use and mortality in a large cohort of patients with MM. Patients and Methods : From the Veterans Administration Central Cancer Registry, we identified patients diagnosed [...]

Menée aux Etats-Unis à partir de données portant sur 8 745 patientes atteintes d'un cancer du sein traité par divers régimes de chimiothérapies entre 2008 et 2013, cette étude analyse le risque d'hospitalisation liée à la survenue d'une neutropénie induite par les traitements ainsi que l'efficacité d'un traitement prophylactique par facteur de stimulation des colonies de granulocytes

Risk of Neutropenia-Related Hospitalization in Patients Who Received Colony-Stimulating Factors With Chemotherapy for Breast Cancer

Agiro, Abiy ; Ma, Qinli ; Acheson, Anupama Kurup ; Wu, Sze-jung ; Patt, Debra A. ; Barron, John J. ; Malin, Jennifer L. ; Rosenberg, Alan ; Schilsky, Richard L. ; Lyman, Gary H.

Purpose : To describe outcomes after granulocyte colony-stimulating factor (G-CSF) prophylaxis in patients with breast cancer who received chemotherapy regimens with low-to-intermediate risk of induction of neutropenia-related hospitalization. Patients and Methods : We identified 8,745 patients age ≥ 18 years from a medical and pharmacy claims database for 14 commercial US health plans. This retrospective analysis included patients with breast cancer who began first-cycle chemotherapy from 2008 [...]

Menée en Suède à partir de données portant sur 12 243 patientes atteintes d'un cancer du sein in situ, cette étude de cohorte analyse l'évolution de la mortalité spécifique de 1980 à 2013

Cause-specific mortality in women with breast cancer in situ

He, Wei ; Sofie Lindström, Linda ; Hall, Per ; Czene, Kamila

The long-term mortality remains unknown in women diagnosed with breast cancer in situ (BCIS). Here, we assessed the cause-specific mortality in BCIS patients. This population-based cohort study included 12,243 women diagnosed with BCIS in Sweden between 1980 and 2011. Patients were followed until death, emigration, or 31 December 2013, whichever came first. The 30-year cumulative incidence of breast cancer-specific mortality was 6.3%, which is considerably lower than 49.7% observed for [...]

Menée aux Etats-Unis à partir de données portant sur 4 452 patientes ayant survécu à un cancer du sein, cette étude de cohorte évalue l'association entre le respect de recommandations nutritionnelles et la mortalité spécifique (398 décès)

Pre- and postdiagnostic diet in relation to mortality among breast cancer survivors in the CPS-II Nutrition Cohort

McCullough, Marjorie L. ; Gapstur, Susan M. ; Shah, Roma ; Campbell, Peter T. ; Wang, Ying ; Doyle, Colleen ; Gaudet, Mia M.

Purpose : Due to the limited evidence on the role of diet and cause-specific mortality among breast cancer survivors, current nutrition guidelines for this population are consistent with those for cancer prevention. We evaluated whether diets consistent with the American Cancer Society recommendations for cancer prevention were associated with risk of death in breast cancer survivors. Methods : Participants reported information on diet and other factors at baseline in 1992–1993 and twice during [...]

Menée aux Etats-Unis à partir des données du registre national des cancers portant sur 4 637 patients pédiatriques atteints d'une tumeur primitive du système nerveux central diagnostiquée entre 2004 et 2012, cette étude identifie les facteurs prédictifs associés à l'utilisation de la protonthérapie

Patterns-of-care in Proton Radiotherapy for Pediatric Central Nervous System Malignancies

Odei, B. ; Frandsen, J. E. ; Boothe, D. ; Ermoian, R. P. ; Poppe, M. M.

Purpose : Proton beam therapy (PBT) potentially allows for improved sparing of normal tissues, hopefully leading to decreased late side effects in children. Using a national registry, we sought to perform a patterns-of-care analysis for children receiving PBT for primary CNS malignancies. Methods and Materials : Using the National Cancer Data Base (NCDB), we identified pediatric patients with primary CNS malignancies who were diagnosed between 2004 and 2012. We utilized a standard t-test for [...]

Menée aux Pays-Bas à partir des données de consultations menées par 32 oncologues avec 100 patients atteints de cancer, cette étude analyse les échanges d'informations et questions des patients et de leurs conjoints sur les bénéfices et inconvénients d'un traitement adjuvant pour aider la prise de décision

Oncologist, patient, and companion questions during pretreatment consultations about adjuvant cancer treatment: a shared decision-making perspective

Pieterse, A. H. ; Kunneman, M. ; Engelhardt, E. G. ; Brouwer, N. J. ; Kroep, J. R. ; Marijnen, C. A. M. ; Stiggelbout, A. M. ; Smets, E. M. A.

Objectives: To assess the occurrence of questions that foster shared decision making, in particular cancer patients' understanding of treatment decisions and oncologists' understanding of patients' priorities, during consultations in which preference-sensitive decisions are discussed. Specifically, (a) regarding patient understanding, do oncologists ask about patients' preexisting knowledge, information preferences, and understanding and do patients and companions ask about the disease and [...]