A partir d'une revue systématique de la littérature (16 études), cette étude analyse l'association entre une consommation d'alcool, le risque de récidive d'un cancer du sein et le risque de développer un second cancer primitif du sein

To what extent is alcohol consumption associated with breast cancer recurrence and second primary breast cancer?: A systematic review

Simapivapan, Phanthira ; Boltong, Anna ; Hodge, Allison

Highlights : •Breast cancer recurrence is a major cause of mortality in breast cancer survivors. •There is some evidence that alcohol intake increases risk of breast cancer recurrence. •This association may be stronger in postmenopausal women. •Methodological differences between studies render interpretation of results problematic. Background : The association between alcohol intake and breast cancer recurrence or development of second primary breast cancer in the survivor population is [...]

A partir d'une revue systématique de la littérature (20 études), cette méta-analyse évalue l'association entre une consommation d'alcool, la densité mammaire et le risque de cancer du sein

The association between alcohol consumption and breast density: a systematic review and meta-analysis

Ziembicki,, Stephanie ; Zhu, Jie ; Tse, Elizabeth ; Martin, Lisa J. ; Minkin, Salomon ; Boyd, Norman F.

Background:Percent breast density (PBD) is a strong risk factor for breast cancer that is influenced by several other risk factors for the disease. Alcohol consumption is associated with an increased risk of breast cancer with an uncertain association with PBD. We have carried out a systematic review and meta-analysis to examine the association of alcohol consumption with PBD. Methods:We searched nine databases to identify all relevant studies on the association between alcohol intake and [...]

A partir d'une revue systématique de la littérature publiée jusqu'en avril 2015 (51 articles, 154 939 cas), cette méta-analyse évalue l'association, chez les hommes et chez les femmes, entre l'indice de masse corporelle et le risque de cancer

Body mass index and the risk of cancer in women compared with men: a meta-analysis of prospective cohort studies

Xue, Kai ; Li, Feng-Feng ; Chen, Yi-Wei ; Zhou, Yu-Hao ; He, Jia

Studies investigating the association between BMI and the risk of the common cancers in men or women have reported inconsistent results. We searched the PubMed, Embase, and Cochrane Library electronic databases for relevant articles published until April 2015. Overall, we analyzed 128 datasets (51 articles), including 154 939 incident cancer cases. The pooled relative risk ratio (RRR) (female to male) showed that the relative risk of overweight associated with colorectal [RRR: 0.91; 95% [...]

Menée au Canada à partir de données portant sur 28 546 individus travaillant dans une mine d'uranium, cette étude évalue l'association entre une exposition professionnelle au radon et le risque de cancer, notamment du poumon, ou la mortalité spécifique sur la période 1954-2007

Cancer incidence and mortality from exposure to radon progeny among Ontario uranium miners

Navaranjan, Garthika ; Berriault, Colin ; Do, Minh ; Villeneuve, Paul J ; Demers, Paul A

Objectives : The study objectives were to extend the follow-up of the Ontario uranium miners cohort, one of the largest cohorts of uranium miners with low cumulative exposures, to examine the relationship between radon exposure and lung cancer mortality and, for the first time incidence, and address gaps in the literature, including dose–response relationship between radon exposure and other cancer sites, and non-cancer mortality. Methods : The cohort of mine and mill workers was created using [...]

Menée aux Etats-Unis à partir des données de la cohorte "Nurses’ Health Study II" incluant 74 323 participantes, cette étude évalue l'association entre le travail de nuit en rotation, la durée du sommeil et le risque de cancer de la peau (durée de suivi : 10 ans ; 4 308 cas de carcinome basocellulaire, 334 cas de carcinome épidermoïde, 212 cas de mélanome)

Associations among rotating night shift work, sleep and skin cancer in Nurses' Health Study II participants

Heckman, Carolyn J ; Kloss, Jacqueline D ; Feskanich, Diane ; Culnan, Elizabeth ; Schernhammer, Eva S

Background : Night shift work and sleep duration have been associated with breast and other cancers. Results from the few prior studies of night shift work and skin cancer risk have been mixed and not fully accounted for other potentially important health-related variables (eg, sleep characteristics). This study evaluated the relationship between rotating night shift work and skin cancer risk and included additional skin cancer risk factors and sleep-related variables. Methods : The current [...]

Menée aux Etats-Unis à partir de données portant sur 265 patients atteints de syndromes myélodysplasiques, sur 420 patients atteints d'une leucémie myéloïde aiguë et sur 1 388 témoins, cette étude évalue l'association entre des expositions au travail ou près du lieu de résidence à divers produits chimiques (benzène, chlorures de vinyle, suie, encres, pesticides, etc) et le risque de la maladie

Chemical exposures and risk of acute myeloid leukemia and myelodysplastic syndromes in a population-based study

Poynter, Jenny N. ; Richardson, Michaela ; Roesler, Michelle ; Blair, Cindy K. ; Hirsch, Betsy ; Nguyen, Phuong ; Cioc, Adina ; Cerhan, James R. ; Warlick, Erica

Benzene exposure is one of the few well-established risk factors for myeloid malignancy. Exposure to other chemicals has been inconsistently associated with hematologic malignancies. We evaluated occupational and residential chemical exposures as risk factors for acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) using population-based data. AML and MDS cases were identified by the Minnesota Cancer Surveillance System. Controls were identified through the Minnesota driver's [...]

Menée au Danemark à partir de données portant sur 1 318 929 participantes entre 1978 et 2012, cette étude de cohorte évalue l'association entre une maladie inflammatoire pelvienne (81 281 cas) et le risque de cancer de l'ovaire (5 356 cas)

Is pelvic inflammatory disease a risk factor for ovarian cancer?

Rasmussen, Christina B. ; Jensen, Allan ; Albieri, Vanna ; Andersen, Klaus K ; Kjaer, Susanne K.

Background: Pelvic inflammatory disease (PID) has been proposed as a risk factor for ovarian cancer. However, the existing literature on the association between PID and ovarian cancer risk is inconclusive and only few cohort studies have been conducted. Methods: Using nationwide Danish registries, we conducted a population-based cohort study including all women from the birth cohorts 1940-1970 in Denmark during 1978-2012 (n=1,318,929) to investigate the association between PID and subsequent [...]

Menée aux Etats-Unis à partir de données portant sur un total de 430 268 participants inclus dans deux grandes cohortes prospectives, cette étude évalue l'association entre une vasectomie, le risque de cancer de la prostate et la mortalité spécifique (9 133 cas diagnostiqués entre 1992 et 2011, 7 451 décès par cancer de la prostate diagnostiqué entre 1982 et 2012)

Vasectomy and Prostate Cancer Incidence and Mortality in a Large US Cohort

Jacobs, Eric J. ; Anderson, Rebecca L. ; Stevens, Victoria L. ; Newton, Christina C. ; Gansler, Ted ; Gapstur, Susan M.

Purpose : In a recent large prospective study, vasectomy was associated with modestly higher risk of prostate cancer, especially high-grade and lethal prostate cancer. However, evidence from prospective studies remains limited. Therefore, we assessed the associations of vasectomy with prostate cancer incidence and mortality in a large cohort in the United States. Patients and Methods: We examined the association between vasectomy and prostate cancer mortality among 363,726 men in the Cancer [...]

A partir d'une revue systématique de la littérature publiée jusqu'en novembre 2014 (24 études de cohorte, plus de 20 000 cas), cette méta-analyse évalue l'association entre un diabète de type 2 et le risque de cancer du foie, en prenant en compte divers facteurs (sexe, tabagisme, consommation d'alcool, indice de masse corporelle, origine ethnique), ou la mortalité spécifique

Type 2 diabetes and gender differences in liver cancer by considering different confounding factors: a meta-analysis of cohort studies

Wang, Yuqin ; Wang, Baochan ; Yan, Shiyan ; Shen, Feng ; Cao, Haixia ; Fan, Jiangao ; Zhang, Rongrong ; Gu, Jun

Background : Questions remain uncertainty regarding the gender differences in the relationship between type 2 diabetes (T2DM) and liver cancer risk. By considering several confounding factors we aimed to identify this issue according to a meta-analysis of cohort studies. Methods : We searched EMBASE and MEDLINE for studies on the association between T2DM and risk of liver cancer up to November 30, 2014. A random-effects model was performed to calculate summary relative risks (SRRs) with [...]

Menée in vitro, cette étude met en évidence des mécanismes par lesquels deux variants constitutionnels de la région génomique APOBEC3 induisent le développement d'un cancer de la vessie ou du sein

Association of germline variants in the APOBEC3 region with cancer risk and enrichment with APOBEC-signature mutations in tumors

Middlebrooks, Candace D. ; Banday, A. Rouf ; Matsuda, Konichi ; Udquim, Krizia-Ivana ; Onabajo, Olusegun O. ; Paquin, Ashley ; Figueroa, Jonine D. ; Zhu, Bin ; Koutros, Stella ; Kubo, Michiaki ; Shuin, Taro ; Freedman, Neal D. ; Kogevinas, Manolis ; Malats, Nuria ; Chanock, Stephen J. ; Garcia-Closas, Montserrat ; Silverman, Debra T. ; Rothman, Nathaniel ; Prokunina-Olsson, Ludmila

High rates of APOBEC-signature mutations are found in many tumors, but factors affecting this mutation pattern are not well understood. Here we explored the contribution of two common germline variants in the APOBEC3 region. SNP rs1014971 was associated with bladder cancer risk, increased APOBEC3B expression, and enrichment with APOBEC-signature mutations in bladder tumors. In contrast, a 30-kb deletion that eliminates APOBEC3B and creates an APOBEC3A-APOBEC3B chimera was not important in [...]

Menée sur 610 individus issus de familles allemandes présentant des antécédents de cancer du sein ou de cancer de l'ovaire sans mutation BRCA1/2, puis sur 1 410 individus complémentaires, cette étude identifie une association entre des mutations constitutionnelles du gène RAD51C et le développement d'un cancer

The RAD51C exonic splice-site mutations c.404G>C and c.404G>T are associated with familial breast and ovarian cancer

Neidhardt, Guido ; Becker, Alexandra ; Hauke, Jan ; Horvath, Judit ; Bogdanova Markov, Nadja ; Heilmann-Heimbach, Stefanie ; Hellebrand, Heide ; Thiele, Holger ; Altmuller, Janine ; Nurnberg, Peter ; Meindl, Alfons ; Rhiem, Kerstin ; Blümcke, Britta ; Wappenschmidt, Barbara ; Schmutzler, Rita K ; Hahnen, Eric

Whereas RAD51C mutations increase the relative risk for ovarian cancer (OC) to 5.88 (95% confidence interval=2.91-11.88, P=7.65x10-7), the associated risks for breast cancer (BC) remain largely unknown, as deleterious RAD51C alterations are extremely rare in BC-only families. Here, we report the results of a RAD51C mutational screening in a large series of German familial index patients negative for pathogenic BRCA1/2 mutations and the in-vitro characterization of two novel exonic RAD51C [...]

A partir de données de 10 études incluant 1 751 patientes atteintes d'un cancer de l'ovaire et 4 051 témoins, cette étude identifie trois variants génomiques dont l'association avec le risque de cancer de l'ovaire est modifiée par un traitement hormonal substitutif de la ménopause à base d'œstrogène seulement

A splicing variant of TERT identified by GWAS interacts with menopausal estrogen therapy in risk of ovarian cancer

Lee, Alice W. ; Bomkamp, Ashley ; Bandera, Elisa V. ; Jensen, Allan ; Ramus, Susan J. ; Goodman, Marc T. ; Rossing, Mary Anne ; Modugno, Francesmary ; Moysich, Kirsten B. ; Chang-Claude, Jenny ; Rudolph, Anja ; Gentry-Maharaj, Aleksandra ; Terry, Kathryn L. ; Gayther, Simon A. ; Cramer, Daniel W. ; Doherty, Jennifer A. ; Schildkraut, Joellen M. ; Kjaer, Susanne K. ; Ness, Roberta B. ; Menon, Usha ; Berchuck, Andrew ; Mukherjee, Bhramar ; Roman, Lynda ; Pharoah, Paul D. ; Chenevix-Trench, Georgia ; Olson, Sara ; Hogdall, Estrid ; Wu, Anna H. ; Pike, Malcolm C. ; Stram, Daniel O. ; Pearce, Celeste Leigh ; for the Ovarian Cancer Association, Consortium

Menopausal estrogen-alone therapy (ET) is a well-established risk factor for serous and endometrioid ovarian cancer. Genetics also plays a role in ovarian cancer, which is partly attributable to 18 confirmed ovarian cancer susceptibility loci identified by genome-wide association studies. The interplay among these loci, ET use and ovarian cancer risk has yet to be evaluated. We analyzed data from 1,414 serous cases, 337 endometrioid cases and 4,051 controls across 10 case–control studies [...]