Menée en France par questionnaire auprès de 2 276 cas et 2 780 témoins, cette étude évalue l'association entre une activité professionnelle de soudage et le risque de cancer du poumon chez les hommes

Welding, a risk factor of lung cancer: the ICARE study

Matrat, Mireille ; Guida, Florence ; Mattei, Francesca ; Cenée, Sylvie ; Cyr, Diane ; Févotte, Joëlle ; Sanchez, Marie ; Menvielle, Gwenn ; Radoi, Loredana ; Schmaus, Annie ; Woronoff, Anne-Sophie ; Luce, Danièle ; Stücker, Isabelle ; ICARE study group

Objectives : We investigated the relationship between lung cancer and occupational exposure to welding activity in ICARE, a population-based case–control study. Methods : Analyses were restricted to men (2276 cases, 2780 controls). Welding exposure was assessed through detailed questionnaires, including lifelong occupational history. ORs were computed using unconditional logistic regression, adjusted for lifelong cigarette smoking and occupational exposure to asbestos. Results : Among the [...]

A partir des données de 15 registres américains des cancers sur la période 2001-2010, cette étude évalue l'association entre les niveaux d'exposition à des rayonnements ultraviolets et le risque de lymphome hodgkinien par sous-type (20 021 cas)

Relationship between ambient ultraviolet radiation and Hodgkin lymphoma subtypes in the United States

Bowen, Emily M. ; Pfeiffer, Ruth M. ; Linet, Martha S. ; Liu, Wayne T. ; Weisenburger, Dennis D. ; Freedman, D. Michal ; Cahoon, Elizabeth K.

Background: There are few modifiable risk factors for Hodgkin lymphoma (HL), the most common cancer among young adults in Western populations. Some studies have found a reduced risk with exposure to ultraviolet radiation (UVR), but findings have been inconsistent and limited to HL as a group or the most common subtypes. Methods: We evaluated UVR and incidence of HL subtypes using data from 15 population-based cancer registries in the United States from 2001 to 2010 (n=20 021). Ground-based [...]

Menée au Danemark auprès de 4 183 cas et 8 018 témoins, cette étude évalue l'association entre une exposition à la pollution atmosphérique liée au trafic routier et le risque de tumeurs cérébrales

Air pollution from traffic and risk for brain tumors: a nationwide study in Denmark

Poulsen, Aslak Harbo ; Sørensen, Mette ; Andersen, Zorana J. ; Ketzel, Matthias ; Raaschou-Nielsen, Ole

Purpose : Air pollution is an established lung carcinogen, and there is increasing evidence that air pollution also negatively affects the brain. We have previously reported an association between air pollution and risk of brain tumors in a cohort study based on only 95 cases. We set out to replicate that finding in a large nationwide case–control study. Methods : We identified all 4,183 adult brain tumor cases in Denmark in the years 2000–2009 and 8,018 risk set sampled population controls [...]

A partir d'échantillons sériques prélevés sur 2 623 patients, cette étude cas-témoins évalue l'association entre une infection cutanée par divers types de papillomavirus humains et le risque de carcinome épidermoïde de la peau

Cutaneous Human Papillomaviruses and squamous cell carcinoma of the skin: Nested case-control study

Faust, Helena ; Andersson, Kristin ; Luostarinen, Tapio ; Gislefoss, Randi E ; Dillner, Joakim

Background:Cutaneous Human Papillomavirus (HPV) types have been associated with non-melanoma skin cancer (NMSC), including a previous nested case-control study using HPV serology with bacterially derived fusion proteins with the major HPV capsid protein L1 (GST-L1). However, HPV serology using conformationally intact pseudovirions has been shown to correlate better with natural infection. Prospective studies using a more valid marker of infection are therefore warranted. Methods:Cancer registry [...]

Menée aux Etats-Unis auprès de 113 cas et 229 témoins, cette étude prospective évalue l'association entre une infection par le polyomavirus de Merkel et le risque de carcinome épidermoïde humain

Prospective study of human polyomaviruses and risk of cutaneous squamous cell carcinoma in the United States

Gossai, Anala ; Waterboer, Tim ; Nelson, Heather H. ; Doherty, Jennifer A. ; Michel, Angelika ; Willhauck-Fleckenstein, Martina ; Farzan, Shohreh F. ; Christensen, Brock C. ; Hoen, Anne G. ; Perry, Ann E. ; Pawlita, Michael ; Karagas, Margaret R.

Background: Merkel cell polyomavirus (PyV) is causally related to Merkel cell carcinoma, a rare skin malignancy. Little is known about the serostability of other PyVs over time, or associations with cutaneous squamous cell carcinoma (SCC). Methods: As part of a US nested case-control study, antibody response against the PyV VP1 capsid proteins of BK and JC was measured using multiplex serology on 113 SCC cases and 229 gender, age, and study center-matched controls who had a prior keratinocyte [...]

A partir de données de plusieurs cohortes européennes incluant un total de 116 462 participants (durée médiane de suivi : 10,8 ans), cette étude évalue l'association entre une durée de travail importante (55 h de travail ou plus par semaine) et le risque de cancer (4 371 cas)

Long working hours and cancer risk: a multi-cohort study

Heikkila, Katriina ; Nyberg, Solja T. ; Madsen, Ida E. H. ; de Vroome, Ernest ; Alfredsson, Lars ; Bjorner, Jacob J. ; Borritz, Marianne ; Burr, Hermann ; Erbel, Raimund ; Ferrie, Jane E. ; Fransson, Eleonor I. ; Geuskens, Goedele A. ; Hooftman, Wendela E. ; Houtman, Irene L. ; Jöckel, Karl-Heinz ; Knutsson, Anders ; Koskenvuo, Markku ; Lunau, Thorsten ; Nielsen, Martin L. ; Nordin, Maria ; Oksanen, Tuula ; Pejtersen, Jan H. ; Pentti, Jaana ; Shipley, Martin J. ; Steptoe, Andrew ; Suominen, Sakari B. ; Theorell, Tores ; Vahtera, Jussi ; Westerholm, Peter J. M. ; Westerlund, Hugo ; Dragano, Nico ; Rugulies, Reiner ; Kawachi, Ichiro ; Batty, G. David ; Singh-Manoux, Archana ; Virtanen, Marianna ; Kivimäki, Mika

Background:Working longer than the maximum recommended hours is associated with an increased risk of cardiovascular disease, but the relationship of excess working hours with incident cancer is unclear. Methods:This multi-cohort study examined the association between working hours and cancer risk in 116 462 men and women who were free of cancer at baseline. Incident cancers were ascertained from national cancer, hospitalisation and death registers; weekly working hours were self-reported. [...]

A partir des données du registre danois des cancers incluant 36 248 patients, cette étude cas-témoins évalue l'association entre une utilisation à long terme de lithium (durée d'exposition supérieure à 5 ans) et le risque de cancer colorectal, sur la période 2000-2012

Long-term use of lithium and risk of colorectal adenocarcinoma: a nationwide case-control study

Pottegård, Anton ; Ennis, Zandra Nymand ; Hallas, Jesper ; Jensen, Boye L. ; Madsen, Kirsten ; Friis, Soren

Background: Lithium accumulates in the colon and inhibits the enzyme GSK-3

Menée auprès de 745 cas et 12 805 témoins, puis répliquée auprès de 531 cas et 551 témoins, cette étude d'association sur le génome entier identifie des nouveaux loci de susceptibilité au carcinome épidermoïde cutané chez des individus de type européen

A genome-wide association study of cutaneous squamous cell carcinoma among European descendants

Siiskonen, Satu J ; Zhang, Mingfeng ; Li, Wen-Qing ; Liang, Liming ; Kraft, Peter ; Nijsten, Tamar ; Han, Jiali ; Qureshi, Abrar A

Background: No GWAS on the risk of cutaneous squamous cell carcinoma (SCC) has been published. We conducted a multi-stage genome-wide association study (GWAS) to identify novel genetic loci for SCC. Methods: The study included 745 SCC cases and 12,805 controls of European descent in the discovery stage and 531 SCC cases and 551 controls of European Ancestry in the replication stage. We selected 64 independent loci that showed the most significant associations with SCC in the discovery stage [...]

Menée au Danemark par questionnaire auprès de 86 975 participants inclus dans la cohorte "Copenhagen General Population Study" entre 2003 et 2010, cette étude évalue l'association entre la mutation 1100delC du gène CHEK2, le risque de cancer du sein (2 442 cas), et le risque d'autres cancers (6 635 cas)

Increased Risk for Other Cancers in Addition to Breast Cancer for CHEK2*1100delC Heterozygotes Estimated From the Copenhagen General Population Study

Näslund-Koch, Charlotte ; Nordestgaard, Børge G. ; Bojesen, Stig E.

Purpose : CHEK2 is a cell cycle checkpoint regulator, and the CHEK2*1100delC germline mutation leads to loss of function and increased breast cancer risk. It seems plausible that this mutation could also predispose to other cancers. Therefore, we tested the hypothesis that CHEK2*1100delC heterozygosity is associated with increased risk for other cancers in addition to breast cancer in the general population. Patients and Methods: We examined 86,975 individuals from the Copenhagen General [...]

Cette étude analyse les mécanismes moléculaires impliqués dans l'association entre l'obésité et le risque de cancer du sein (aromatisation des androgènes dans les tissus adipeux, niveau de cytokines inflammatoires, résistance à l'insuline, stress oxydant, etc)

Obesity and Breast Cancer: Molecular Interconnections and Potential Clinical Applications

Simone, Valeria ; D’Avenia, Morena ; Argentiero, Antonella ; Felici, Claudia ; Rizzo, Francesca Maria ; De Pergola, Giovanni ; Silvestris, Franco

Obesity is an important risk factor for breast cancer (BC) in postmenopausal women; interlinked molecular mechanisms might be involved in the pathogenesis. Increased levels of estrogens due to aromatization of the adipose tissue, inflammatory cytokines such as tumor necrosis factor-α, interleukin-6, and prostaglandin E2, insulin resistance and hyperactivation of insulin-like growth factors pathways, adipokines, and oxidative stress are all abnormally regulated in obese women and contribute to [...]