Menée aux Etats-Unis à partir des données de deux cohortes incluant 697 participantes, cette étude évalue l'association entre une consommation d'alcool au début de l'âge adulte (entre 20 et 29 ans) et la densité mammaire, facteur de risque d'un cancer du sein

Alcohol intake from early adulthood to midlife and mammographic density

McDonald, Jasmine A. ; Michels, Karin B. ; Cohn, Barbara A. ; Flom, Julie D. ; Tehranifar, Parisa ; Terry, Mary Beth

Purpose : Moderate alcohol consumption (15 g/day) has been consistently associated with increased breast cancer risk; however, the association between alcohol and mammographic density, a strong marker of breast cancer risk, has been less consistent. Less is known about the effect of patterns of alcohol intake across the lifecourse. Methods : Using the Early Determinants of Mammographic Density study, an adult follow-up of women born in two US birth cohorts (n = 697; Collaborative Perinatal [...]

A partir des données de la cohorte "Nurses' Health Study" incluant 73 581 femmes et celles de la cohorte "Health Professionals Follow-up Study" incluant 32 632 hommes, cette étude évalue l'association entre l'évolution des indicateurs d'adiposité et d'obésité et le risque de cancer (durée médiane de suivi : 10 ans)

Trajectory of body shape across the lifespan and cancer risk

Song, Mingyang ; Willett, Walter C. ; Hu, Frank B. ; Spiegelman, Donna ; Must, Aviva ; Wu, Kana ; Chan, Andrew T. ; Giovannucci, Edward L.

The influence of adiposity over life course on cancer risk remains poorly understood. We assessed trajectories of body shape from age 5 up to 60 using a group-based modeling approach among 73,581 women from the Nurses' Health Study and 32,632 men from the Health Professionals Follow-up Study. After a median of approximately 10 years of follow-up, we compared incidence of total and obesity-related cancers (cancers of the esophagus [adenocarcinoma only], colorectum, pancreas, breast [after [...]

A partir des données des registres finlandais des cancers portant sur 1 093 cas et 3 279 témoins entre1990 et 2011, cette étude évalue l'association entre un indicateur du brassage de populations (reflet potentiel de multiples contacts avec des agents infectieux) et le risque de leucémie chez l'enfant avant l'âge de 15 ans

Residential mobility and the risk of childhood leukemia

Järvelä, Laura ; Raitanen, Jani ; Erme, Sini ; Lohi, Olli ; Auvinen, Anssi

Purpose : An infective origin of childhood leukemia has been postulated, with leukemia developing as a rare response to an infection. Population mixing can result in increased contacts between infected and susceptible individuals and may increase the risk of leukemia. The objective of this study was to investigate the association between residential mobility as an indicator of population mixing at individual level and the risk of leukemia in children (<15 years). Methods : We conducted a [...]

A partir des données de plusieurs registres suédois portant sur la période 1973-2009, cette étude de cohorte évalue l'association entre une hystérectomie, pratiquée avec ou sans salpingo-ovariectomie bilatérale concomitante pour traiter des affections bénignes, et le risque à long terme de cancer

Long-term cancer risk after hysterectomy on benign indications: Population-based cohort study

Altman, Daniel ; Yin, Li ; Falconer, Henrik

Hysterectomy on benign indications is associated with an increased risk for adverse health effects. However, little is known about the association between hysterectomy and subsequent cancer occurrence later in life. The purpose of this study was to assess the effect of hysterectomy on the incidence of cancer. In this population-based cohort study, we used data on 111,595 hysterectomized and 537,9843 nonhysterectomized women from nationwide Swedish Health Care registers including the Inpatient [...]

A partir d'une revue systématique de la littérature (46 études), cette étude évalue l'association entre des facteurs démographiques, cliniques ou liés au mode de vie, et le risque d'endobrachyœsophage

Risk factors for Barrett’s esophagus: a scoping review

Ireland, Colin J. ; Thompson, Sarah K. ; Laws, Thomas A. ; Esterman, Adrian

Introduction : Cancer of the esophagus is a highly lethal disease with many patients presenting with metastatic spread of their tumor at diagnosis; a consequence of this late presentation is the 5-year survival rate of <20 %. Barrett’s esophagus (BE), a premalignant condition of the distal esophagus, is the main risk factor for adenocarcinoma of the esophagus. The development of a risk prediction tool that could assist healthcare professionals in identifying people at increased risk of [...]

A partir des données de la cohorte française E3N incluant 67 634 participantes âgées de 42 à 72 ans lors de l'inclusion, cette étude prospective évalue la proportion de cancers du sein (497 cas avant la ménopause, 3 138 cas après la ménopause) attribuables à des facteurs de risque connus, de nature comportementale ou autre

Proportion of premenopausal and postmenopausal breast cancers attributable to known risk factors: Estimates from the E3N-EPIC cohort

Dartois, Laureen ; Fagherazzi, Guy ; Baglietto, Laura ; Boutron-Ruault, Marie-Christine ; Delaloge, Suzette ; Mesrine, Sylvie ; Clavel-Chapelon, Françoise

Breast cancer is the most frequently diagnosed cancer among women worldwide. Breast cancer risk factors have been widely explored individually; however, little is known about their combined impact. We included 67,634 women from the French E3N prospective cohort, aged 42–72 at baseline. During a 15-year follow-up period, 497 premenopausal and 3,138 postmenopausal invasive breast cancer cases were diagnosed. Population-attributable fractions (PAFs) were used to estimate cases proportions [...]

Couplée aux données de la cohorte "Women's Health Initiative Observational Study" et portant sur 169 cas et 412 témoins, cette étude évalue l'association entre les niveaux d'œstrogènes circulants et le risque de cancer de l'ovaire après la ménopause

Circulating estrogens and postmenopausal ovarian cancer risk in the Women's Health Initiative Observational Study

Trabert, Britton ; Brinton, Louise A. ; Anderson, Garnet L. ; Pfeiffer, Ruth M. ; Falk, Roni T. ; Strickler, Howard D. ; Sliesoraitis, Sarunas ; Kuller, Lewis H. ; Gass, Margery L. ; Fuhrman, Barbara J. ; Xu, Xia ; Wentzensen, Nicolas

Background: Hormonal and reproductive factors contribute to the development of ovarian cancer, but few studies have examined associations between circulating estrogens and estrogen metabolites and ovarian cancer risk. We evaluated whether serum estrogens and estrogen metabolite levels are associated with ovarian cancer risk among postmenopausal women in a nested case-control study in the Women's Health Initiative (WHI) Observational Study (OS). Methods: We selected all 169 eligible epithelial [...]

A partir des données des cohortes "Nurses' Health", cette étude évalue l'association entre des facteurs reproductifs (âge aux premières règles, âge à la ménopause, âge à la naissance du premier enfant, durée de l'allaitement, etc) et le risque de cancer du sein, en fonction du sous-type moléculaire

Reproductive risk factors in relation to molecular subtypes of breast cancer: Results from the Nurses' Health Studies

Sisti, Julia S. ; Collins, Laura C. ; Beck, Andrew H. ; Tamimi, Rulla M. ; Rosner, Bernard A. ; Eliassen, A. Heather

Several intrinsic breast cancer subtypes, possibly representing unique etiologic processes, have been identified by gene expression profiles. Evidence suggests that associations with reproductive risk factors may vary by breast cancer subtype. In the Nurses' Health Studies, we prospectively examined associations of reproductive factors with breast cancer subtypes defined using immunohistochemical staining of tissue microarrays. Multivariate-adjusted Cox proportional hazard models were used to [...]

A partir d'une revue de la littérature et de données d'études d'associations sur le génome entier, cette méta-analyse évalue l'association entre des polymorphismes de plusieurs gènes et le risque de carcinome différencié de la thyroïde

A comprehensive meta-analysis of case-control association studies to evaluate polymorphisms associated with the risk of differentiated thyroid carcinoma

Figlioli, Gisella ; Elisei, Rossella ; Romei, Cristina ; Melaiu, Ombretta ; Cipollini, Monica ; Bambi, Franco ; Chen, Bowang ; Köhler, Aleksandra ; Cristaudo, Alfonso ; Hemminki, Kari ; GEMIGNANI, Federica ; Försti, Asta ; Landi, Stefano

Background: Linkage analyses and association studies suggested that inherited genetic variations play a role in the development of Differentiated Thyroid Carcinoma (DTC). Methods: We combined the results from a Genome-Wide Association Study (GWAS) performed by our group and from published studies on DTC. With a first approach, we evaluated whether a SNP published as associated with the risk of DTC could replicate in our GWAS (using FDR as adjustment for multiple comparisons). With the second [...]