A partir d'une revue systématique de la littérature (27 articles), cette méta-analyse évalue l'association entre l'intensité et la durée du tabagisme et le risque de leucémie myéloïde aiguë

Do the smoking intensity and duration, the years since quitting, the methodological quality and the year of publication of the studies affect the results of the meta-analysis on cigarette smoking and Acute Myeloid Leukemia (AML) in adults?

Colamesta, Vittoria ; D'Aguanno, Silvia ; Breccia, Massimo ; Bruffa, Sara ; Cartoni, Claudio ; La Torre, Giuseppe

Background : The aim was to perform a systematic review and meta-analysis on the relationship between tobacco smoking and the onset of acute myeloid leukemia (AML) in adults. Methods : PubMed and Scopus databases were systematically searched. In the meta-analysis, random or fixed effects models were used according to the presence of heterogeneity. Study quality was assessed using the Newcastle-Ottawa Scale. Results : Twenty-seven articles were included. Case-control and cohort meta-analyses [...]

A partir des données de la cohorte "NIH-AARP diet and health cohort" incluant 322 846 participants, cette étude évalue l'association entre une consommation de viande rouge, blanche ou transformée, les méthodes de préparation et de cuisson et le risque de cancer du pancréas (durée moyenne de suivi : 9,2 ans ; 1 417 cas de cancer)

Are meat and heme iron intake associated with pancreatic cancer? Results from the NIH-AARP diet and health cohort

Taunk, Pulkit ; Hecht, Eric ; Stolzenberg-Solomon, Rachael

Several studies on pancreatic cancer have reported significant positive associations for intake of red meat but null associations for heme iron. We assessed total, red, white and processed meat intake, meat cooking methods and doneness and heme iron and mutagen intake in relation to pancreatic cancer in the NIH-AARP Diet and Health Study cohort. A total of 322,846 participants (187,265 men and 135,581 women) successfully completed and returned the food frequency questionnaire between 1995 and [...]

A partir d'échantillons tumoraux fixés au formol et inclus en paraffine après prélèvement sur 133 patients vivant en Afrique du sud, en Chine et en Iran, puis à partir de données de 14 études menées précédemment, cette méta-analyse évalue l'association entre une infection par les papillomavirus de type alpha et le risque de carcinome épidermoïde de l'œsophage

Mucosal alpha-papillomaviruses are not associated with esophageal squamous cell carcinomas: Lack of mechanistic evidence from South Africa, China and Iran and from a world-wide meta-analysis

Halec, Gordana ; Schmitt, Markus ; Egger, Sam ; Abnet, Christian C. ; Babb, Chantal ; Dawsey, Sanford M. ; Flechtenmacher, Christa ; Gheit, Tarik ; Hale, Martin ; Holzinger, Dana ; Malekzadeh, Reza ; Taylor, Philip R. ; Tommasino, Massimo ; Urban, Margaret I. ; Waterboer, Tim ; Pawlita, Michael ; Sitas, Freddy ; on behalf of the Inter, Scope Collaboration

Epidemiological and mechanistic evidence on the causative role of human papillomaviruses (HPV) in esophageal squamous cell carcinoma (ESCC) is unclear. We retrieved alcohol- and formalin-fixed paraffin-embedded ESCC tissues from 133 patients seropositive for antibodies against HPV early proteins, from high-incidence ESCC regions: South Africa, China and Iran. With rigorous care to prevent nucleic acid contamination, we analyzed these tissues for the presence of 51 mucosotropic human [...]

Menée aux Etats-Unis à partir de données portant sur 224 cas et 396 témoins, cette étude évalue l'association entre divers facteurs (surpoids, âge à la première grossesse, allaitement, tabagisme, etc) et le risque de cancer inflammatoire du sein, en fonction du sous-type de la tumeur

Epidemiological risk factors associated with inflammatory breast cancer subtypes

Atkinson, Rachel L. ; El-Zein, Randa ; Valero, Vicente ; Lucci, Anthony ; Bevers, Therese B. ; Fouad, Tamer ; Liao, Weiqin ; Ueno, Naoto T. ; Woodward, Wendy A. ; Brewster, Abenaa M.

Background : In this single-institution case–control study, we identified risk factors associated with inflammatory breast cancer (IBC) subtypes based on staining of estrogen receptor (ER), progesterone receptor (PR) and expression of human epidermal growth factor 2 (HER2neu) to determine distinct etiologic pathways. Methods : We identified 224 women with IBC and 396 cancer-free women seen at the MD Anderson Cancer Center. Multinomial logistic regression was used to estimate odds ratios (ORs) [...]

Menée auprès de 1 508 cas et de 1 556 témoins en population, cette étude évalue l'association entre une polykystose ovarienne, les symptômes et séquelles associés à ce syndrome, et le risque de cancer du sein avant la ménopause

Polycystic ovarian syndrome (PCOS), related symptoms/sequelae, and breast cancer risk in a population-based case–control study

Kim, Jayeon ; Mersereau, Jennifer E. ; Khankari, Nikhil ; Bradshaw, Patrick T. ; McCullough, Lauren E. ; Cleveland, Rebecca ; Shantakumar, Sumitra ; Teitelbuam, Susan L. ; Neugut, Alfred I. ; Senie, Ruby T. ; Gammon, Marilie D.

Purpose : Despite the overlap between the clinical symptoms/sequelae of polycystic ovarian syndrome (PCOS) and many known reproductive risk factors for breast cancer, the relationship between PCOS and breast cancer remains unclear, possibly because of the complex heterogeneity and challenges in diagnosing PCOS over time. We hypothesized that PCOS, specific PCOS-related symptoms/sequelae, or clusters of PCOS-related symptoms/sequelae may be differentially associated with pre- versus [...]

Couplée aux données d'une cohorte prospective chinoise incluant 18 244 hommes et portant sur 325 cas et 356 témoins, cette étude évalue l'association entre des variants du gène CYP2A6, des indicateurs permettant de mesurer une exposition tabagique et le risque de cancer du poumon

Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai cohort study

Yuan, Jian-Min ; Nelson, Heather H. ; Butler, Lesley M. ; Carmella, Steven G. ; Wang, Renwei ; Kuriger-Laber, Jacquelyn K. ; Adams-Haduch, Jennifer ; Hecht, Stephen S. ; Gao, Yu-Tang ; Murphy, Sharon E.

Cytochrome P450 2A6 (CYP2A6) catalyzes nicotine metabolism and contributes to the metabolism of the tobacco-specific lung carcinogen, NNK. Genetic variation in CYP2A6 may affect smoking behavior and contribute to lung cancer risk. A nested case–control study of 325 lung cancer cases and 356 controls was conducted within a prospective cohort of 18,244 Chinese men in Shanghai, China. Quantified were 4 allelic variants of CYP2A6 [*1(+51A), *4, *7, and *9] and urinary total nicotine, total [...]