A partir d'une revue de la littérature (18 articles), cette étude analyse le respect des recommandations relatives à la qualité des soins de support chez des patients inclus dans des essais cliniques

Best supportive care in clinical trials: review of the inconsistency in control arm design

Nipp, R. D. ; Currow, D. C. ; Cherny, N. I. ; Strasser, F. ; Abernethy, A. P. ; Zafar, S. Y.

Background: Best supportive care (BSC) as a control arm in clinical trials is poorly defined. We conducted a review to evaluate clinical trials’ concordance with published, consensus-based framework for BSC delivery in trials. Methods: A consensus-based Delphi panel previously identified four key domains of BSC delivery in trials: multidisciplinary care; supportive care documentation; symptom assessment; and symptom management. We reviewed trials including BSC control arms from 2002 to 2014 to [...]

A partir de données portant sur 5 677 patients atteints d'un cancer avec métastases osseuses et inclus dans 3 essais, cette étude compare l'association entre le dénosumab ou l'acide zolédronique et le risque d'hypocalcémie

Hypocalcaemia in patients with metastatic bone disease treated with denosumab

Body, Jean-Jacques ; Bone, Henry G. ; de Boer, Richard H. ; Stopeck, Alison ; Van Poznak, Catherine ; Damião, Ronaldo ; Fizazi, Karim ; Henry, David H. ; Ibrahim, Toni ; Lipton, Allan ; Saad, Fred ; Shore, Neal ; Takano, Toshimi ; Shaywitz, Adam J. ; Wang, Huei ; Bracco, Oswaldo L. ; Braun, Ada ; Kostenuik, Paul J.

Background : This analysis was performed to further characterise treatment-emergent hypocalcaemia in patients with bone metastases receiving denosumab. Methods : Laboratory abnormalities and adverse events of hypocalcaemia in patients with metastatic bone disease were analysed using data from three identically designed phase 3 trials of subcutaneous denosumab 120 mg (n = 2841) versus intravenous zoledronic acid 4 mg (n = 2836). Results : The overall incidence of laboratory events of [...]

Menée en Australie auprès de 66 patients atteints d'un cancer colorectal de stade I à III, cette étude analyse l'efficacité d'un outil permettant d'évaluer leurs problèmes physiques et psychologiques lors de leur visite chez le médecin généraliste

A trial of a self-assessment tool of problems following treatment of colorectal cancer: a prospective study in Australia primary care

Ngune, I. ; Jiwa, M. ; McManus, A. ; Parsons, R. ; Hodder, R.

Patients treated for colorectal cancer (CRC) experience considerable physical, social and psychological morbidity. In this study, 66 participants with stages I–III CRC were enrolled in this study. Participants completed the self-assessment tool for patients (SATp) over a 5-month period and visited a general practitioner with a copy of their SATp to assist in the management of any problems associated with CRC treatment. General practitioners' notes were reviewed for management actions. Of the 66 [...]

Menée au Canada par enquête auprès de 1 985 patients ayant survécu à un cancer du rein, cette étude analyse les facteurs démographiques, médicaux, sociaux, cognitifs et environnementaux associés à la pratique d'une activité physique

Social-ecological correlates of physical activity in kidney cancer survivors

Trinh, Linda ; Larsen, Kristian ; Faulkner, GuyE ; Plotnikoff, RonaldC ; Rhodes, RyanE ; North, Scott ; Courneya, KerryS

Purpose : Previous studies in cancer survivors have examined behavioral correlates of physical activity (PA), but no study to date has adopted a broader social-ecological framework in understanding PA. This study examined the associations among demographic, medical, social-cognitive, and environmental correlates of meeting PA guidelines among kidney cancer survivors (KCS). Methods : All 1985 KCS diagnosed between 1996 and 2010 identified through a Canadian provincial registry were mailed a [...]

Menée aux Etats-Unis à partir des données des registres des cancers et des registres "HIV/AIDS" (1 816 461 patients atteints de cancer, dont 6 459 infectés par le VIH), cette étude analyse la mortalité par cancer chez les patients infectés par le VIH

Elevated Cancer-Specific Mortality Among HIV-Infected Patients in the United States

Coghill, Anna E. ; Shiels, Meredith S. ; Suneja, Gita ; Engels, Eric A.

Purpose : Despite advances in the treatment of HIV, HIV-infected people remain at increased risk for many cancers, and the number of non–AIDS-defining cancers is increasing with the aging of the HIV-infected population. No prior study has comprehensively evaluated the effect of HIV on cancer-specific mortality. Patients and Methods : We identified cases of 14 common cancers occurring from 1996 to 2010 in six US states participating in a linkage of cancer and HIV/AIDS registries. We used Cox [...]

Menée aux Etats-Unis auprès de 847 patientes ayant survécu à un cancer pédiatrique, cette étude de cohorte rétrospective analyse la prévalence d'une cardiomyopathie durant la grossesse

Pregnancy-associated cardiomyopathy in survivors of childhood cancer

Hines, MelissaR ; Mulrooney, DanielA ; Hudson, MelissaM ; Ness, KirstenK ; Green, DanielM ; Howard, ScottC ; Krasin, Matthew ; Metzger, MonikaL

Purpose : Current information regarding pregnancy-associated cardiomyopathy among women treated for childhood cancer is insufficient to appropriately guide counseling and patient management. This study aims to characterize its prevalence within a large cohort of females exposed to cardiotoxic therapy. Methods : This is a retrospective cohort study of female cancer survivors treated at St. Jude Children’s Research Hospital between 1963 and 2006, at least 5 years from diagnosis, ≥13 years old at [...]

Menée en Angleterre sur la période 1986-2004, cette étude analyse l'évolution des disparités ethniques dans la survie, chez des patients atteints de cancer et originaires de pays d'Asie du Sud, en fonction de l'âge du patient et de son statut socioéconomique

Cancer survival differences between South Asians and non-South Asians of England in 1986-2004, accounting for age at diagnosis and deprivation

Maringe, C. ; Li, R. ; Mangtani, P. ; Coleman, M. P. ; Rachet, B.

Background: South Asian migrants show lower cancer incidence than their host population in England for most major cancers. We seek to study the ethnic differences in survival from cancer. Methods: We described and modelled the effect of ethnicity, time, age and deprivation on survival for the five most incident cancers in each sex in South Asians in England between 1986 and 2004 using national cancer registry data. South Asian ethnicity was flagged using the validated name-recognition algorithm [...]

A partir des données des registres américains des cancers, cette étude analyse l'évolution des disparités dans la survie à 5 ans chez des adolescents et jeunes adultes (âges de 15 à 39 ans) atteints d'un lymphome non hodgkinien diagnostiqué entre 1992 et 2011 (16 694 cas)

US trends in survival disparities among adolescents and young adults with non-Hodgkin lymphoma

Kent, ErinE ; Breen, Nancy ; Lewis, DeniseR ; de Moor, JanetS ; Smith, AshleyWilder ; Seibel, NitaL

Purpose : Improvement in US survival rates among adolescents and young adults (AYAs, ages 15 through 39 years inclusive) diagnosed with non-Hodgkin lymphoma (NHL) has been documented over the last two decades. We examined national trends in survival disparities for AYAs with NHL by race/ethnicity and socioeconomic status (SES, county-level poverty) to further understand NHL and to begin monitoring health outcome disparities for this disease. Methods : Surveillance Epidemiology and End Results [...]

Menée aux Etats-Unis à partir de données portant sur 45 777 patients atteints d'un lymphome hodgkinien de stade I à IV, cette étude analyse les disparités dans la survie des patients en fonction de leur couverture médicale

Disparities in survival by insurance status in patients with Hodgkin lymphoma

Parikh, Rahul R. ; Grossbard, Michael L. ; Green, B. Lee ; Harrison, Louis B. ; Yahalom, Joachim

BACKGROUND The association between insurance status and outcomes has not been well established for patients with Hodgkin lymphoma (HL). The purpose of this study was to examine the disparities in overall survival (OS) by insurance status in a large cohort of patients with HL. METHODS The National Cancer Data Base (NCDB) was used to evaluate patients with stage I to IV HL from 1998 to 2011. The association between insurance status, covariables, and outcomes was assessed in a multivariate Cox [...]

Menée en Italie à partir de données portant sur 78 patientes ayant survécu à un cancer pédiatrique ou à un lymphome hodgkinien et atteintes d'un cancer du sein radio-induit, cette étude analyse leurs caractéristiques cliniques et leur survie

Management of breast cancer after Hodgkin’s lymphoma and paediatric cancer

Terenziani, M. ; Massimino, M. ; Magazzù, D. ; Gandola, L. ; Capri, G. ; Carcangiu, M. L. ; Catania, S. ; Di Russo, A. ; Gennaro, M. ; Meazza, C. ; Podda, M. ; Schiavello, E. ; Valagussa, P.

Rationale : The risk of women developing a breast cancer (BC) after receiving chest radiotherapy for paediatric cancers and Hodgkin lymphomas is well established. The aim of this study was to assess these patients’ clinical characteristics and clinical outcomes. Methods : The study concerns women with a history of primary neoplasms treated with chest irradiation ± chemotherapy and subsequently diagnosed with BC. Results : We identified 78 women who developed BC (invasive in 68 cases, 87%). They [...]

A partir des données du registre italien du mésothéliome, cette étude analyse l'évolution de l'incidence du mésothéliome malin lié à une exposition non professionnelle à l'amiante, sur la période 1993-2008 (15 845 cas)

Malignant mesothelioma due to non-occupational asbestos exposure from the Italian national surveillance system (ReNaM): epidemiology and public health issues

Marinaccio, Alessandro ; Binazzi, Alessandra ; Bonafede, Michela ; Corfiati, Marisa ; Di Marzio, Davide ; Scarselli, Alberto ; Verardo, Marina ; Mirabelli, Dario ; Gennaro, Valerio ; Mensi, Carolina ; Schallemberg, Gert ; Merler, Enzo ; Negro, Corrado ; Romanelli, Antonio ; Chellini, Elisabetta ; Silvestri, Stefano ; Cocchioni, Mario ; Pascucci, Cristiana ; Stracci, Fabrizio ; Ascoli, Valeria ; Trafficante, Luana ; Angelillo, Italo ; Musti, Marina ; Cavone, Domenica ; Cauzillo, Gabriella ; Tallarigo, Federico ; Tumino, Rosario ; Melis, Massimo

Introduction : Italy produced and imported a large amount of raw asbestos, up to the ban in 1992, with a peak in the period between 1976 and 1980 at about 160 000 tons/year. The National Register of Mesotheliomas (ReNaM, “Registro Nazionale dei Mesoteliomi” in Italian), a surveillance system of mesothelioma incidence, has been active since 2002, operating through a regional structure. Methods : The Operating Regional Center (COR) actively researches cases and defines asbestos exposure on the [...]

Cette étude analyse l'évolution de l'incidence du cancer des os, par sous-type morphologique (ostéosarcome, sarcome d'Ewing, chondrosarcome), pour les cinq continents, sur la période 1988-2007

Bone cancer incidence by morphological subtype: a global assessment

Valery, PatriciaC ; Laversanne, Mathieu ; Bray, Freddie

Purpose : To better understand the relevance of environmental factors to the changing patterns of bone cancer subtypes, we examine the incidence of osteosarcoma (OS), Ewing sarcoma (ES), and chondrosarcoma (CS) using data from cancer incidence in five continents. Methods : Age-specific and age-standardized incidence rates (ASRs) per 100,000 person-years were computed and stratified by country (n = 43), subtype, and sex during 2003–2007. Temporal patterns of ASRs were examined during 1988–2007 [...]

Menée sur 699 patientes atteintes d'un carcinome épithélial de l'ovaire, cette étude met en évidence l'absence d'association entre l'utilisation d'analgésiques (ibuprofène, paracétamol, aspirine) avant le diagnostic de la maladie et la survie des patientes

Use of common analgesics is not associated with ovarian cancer survival

Minlikeeva, Albina N ; Freudenheim, Jo L. ; Lo-Ciganic, Wei-Hsuan ; Eng, Kevin H. ; Friel, Grace ; Diergaarde, Brenda ; Modugno, Francesmary ; Cannioto, Rikki ; Gower, Emily ; Szender, J. Brian ; Grzankowski, Kassondra ; Odunsi, Kunle ; Ness, Roberta B. ; Moysich, Kirsten B.

Background : Use of analgesics has been associated with lower risk of ovarian cancer, but to date, very few studies have explored the association between analgesics and ovarian cancer survival. Methods : We examined the relationship between self-reported pre-diagnostic use of aspirin, ibuprofen, and acetaminophen and overall survival (OS), progression-free survival (PFS), ascites at the time of primary treatment, and persistence of disease after primary treatment among 699 women diagnosed with [...]

Menée aux Etats-Unis à partir de données portant sur 5 683 patients atteints d'un cancer du poumon diagnostiqué entre 2005 et 2009, cette étude analyse les effets de diverses comorbidités sur la survie globale des patients

Comorbidity and Survival in Lung Cancer Patients

Islam, K.M. Monirul ; Jiang, Xiaqing ; Anggondowati, Trisari ; Lin, Ge ; Ganti, Apar Kishor

Background: As the population of the United States ages, there will be increasing numbers of lung cancer patients with comorbidities at diagnosis. Comorbid conditions are important factors in both the choice of the lung cancer treatment and outcomes. However, the impact of individual comorbid conditions on patient survival remains unclear. Methods: A population-based cohort study of 5,683 first-time diagnosed lung cancer patients was captured using the Nebraska Cancer Registry (NCR) linked with [...]

A partir des données d'un registre australien du cancer portant sur la période 1983-2007, cette étude analyse l'évolution de la prévalence du cancer du poumon sur cette période et présente des projections jusqu'en 2017

Lung cancer prevalence in New South Wales (Australia): Analysis of past trends and projection of future estimates

Yu, Xue Qin ; Kahn, Clare ; Luo, Qingwei ; Sitas, Freddy ; O’Connell, Dianne L.

Background : To provide a temporal analysis of lung cancer prevalence over two decades in New South Wales (NSW), Australia and projections of future lung cancer prevalence up to 2017. Methods : Data for lung cancer cases diagnosed in 1983–2007 with survival follow-up to the end of 2007 were extracted from the population-based NSW Central Cancer Registry. Five-year prevalence was calculated by the counting method at five time points (1987, 1992, 1997, 2002, and 2007) for which data were [...]

Menée aux Etats-Unis auprès de 926 patients atteints d'un cancer de la prostate non métastatique, cette étude de cohorte prospective évalue l'association entre une alimentation riche en graisses saturées après le diagnostic et le risque de décès

Fat intake after prostate cancer diagnosis and mortality in the Physicians’ Health Study

Van Blarigan, ErinL ; Kenfield, StaceyA ; Yang, Meng ; Sesso, HowardD ; Ma, Jing ; Stampfer, MeirJ ; Chan, JuneM ; Chavarro, JorgeE

Purpose : Diet after prostate cancer diagnosis may impact disease progression. We hypothesized that consuming saturated fat after prostate cancer diagnosis would increase risk of mortality, and consuming vegetable fat after diagnosis would lower the risk of mortality. Methods : This was a prospective study among 926 men with non-metastatic prostate cancer in the Physicians’ Health Study who completed a food frequency questionnaire a median of 5 years after diagnosis and were followed for a [...]

Menée en France à partir des données du registre des cancers de Côte- d'Or portant sur des patients atteints d'un cancer colorectal diagnostiqué entre 1995 et 2002, cette étude analyse, à une échelle géographique fine, les disparités socioéconomiques dans le taux de détection de ces cancers et leur incidence

Small-area geographic and socioeconomic inequalities in colorectal tumour detection in France

Fournel, Isabelle ; Bourredjem, Abderrahmane ; Sauleau, Erik-André ; Cottet, Vanessa ; Dejardin, Olivier ; Bouvier, Anne-Marie ; Launoy, Guy ; Bonithon-Kopp, Claire

The aim of this study was to assess the impact of area deprivation and primary care facilities on colorectal adenoma detection and on colorectal cancer (CRC) incidence in a French well-defined population before mass screening implementation. The study population included all patients aged 20 years or more living in Cote d'Or (France) with either colorectal adenoma or invasive CRC first diagnosed between 1995 and 2002 and who were identified from the Burgundy Digestive Cancer Registry and the [...]

A partir des données des registres américains des cancers, cette étude analyse l'évolution des pratiques de suivi des patients après la résection d'un cancer colorectal, sur la période 2001-2009

Trends in surveillance for resected colorectal cancer, 2001-2009

Paulson, E. Carter ; Veenstra, Christine M. ; Vachani, Anil ; Ciunci, Christine A. ; Epstein, Andrew J.

BACKGROUND Little is known about recent trends in surveillance among the more than 1 million US colorectal cancer (CRC) survivors. Moreover, for stage I disease, which accounts for more than 30% of survivors, the guidelines are limited, and the use of surveillance has not been well studied. Guidelines were changed in 2005 to include recommendations for computed tomography (CT) surveillance in select patients, but the impact of these changes has not been explored. METHODS A retrospective [...]

Menée sur 198 patientes atteintes d'un cancer du sein diagnostiqué entre 2000 et 2009, cette étude rétrospective multicentrique européenne analyse les effets à long terme, du point de vue de l'évolution de la maladie, du recours à une procréation médicalement assistée

Pregnancy following breast cancer using assisted reproduction and its effect on long-term outcome

Goldrat, Oranite ; Kroman, Niels ; Peccatori, Fedro A. ; Cordoba, Octavi ; Pistilli, Barbara ; Lidegaard, Oejvind ; Demeestere, Isabelle ; Azim, Hatem A., Jr.

Introduction and aims : We have previously shown that pregnancy is safe following breast cancer, even in endocrine sensitive disease. Yet infertility remains common following systemic treatment. To date, no study has evaluated the safety of assisted reproductive technology (ART) after breast cancer treatment. In this study, we evaluated the impact of ART on pregnancy and long-term outcomes of young breast cancer survivors. Methods : This is a multi-centre retrospective study in which women who [...]

A partir des données d'un registre britannique des cancers, cette étude analyse l'évolution des disparités socioéconomiques et ethniques dans la survie des patientes atteintes d'un cancer du sein diagnostiqué entre 1980 et 2011, et invitées à participer à un dépistage (âge : 50-70 ans)

Ethnicity, deprivation and screening: survival from breast cancer among screening-eligible women in the West Midlands diagnosed from 1989 to 2011

Morris, M. ; Woods, L. M. ; Rogers, N. ; O'Sullivan, E. ; Kearins, O. ; Rachet, B.

Background: Social inequalities in breast cancer survival are smaller when the cancer is screen-detected. We examined survival from screen-detected and non screen-detected breast cancer by ethnicity and deprivation. Methods: Cancer registry data for 20 283 women aged 50–70 years, diagnosed between 1989–2011 and invited for screening, were linked with screening and ethnicity data. We examined Asian, Black and White groups, less deprived and middle/more deprived women. Net survival was estimated [...]

Menée aux Etats-Unis par enquête auprès de 298 patientes ayant survécu à un cancer du sein (6 ans après le diagnostic), cette étude analyse la conformité des pratiques de surveillance et de soins de suivi, chez les médecins généralistes et les oncologues, par rapport aux recommandations de l'ASCO

Surveillance and beliefs about follow-up care among long-term breast cancer survivors: a comparison of primary care and oncology providers

Risendal, BetsyC ; Sedjo, RebeccaL ; Giuliano, AnnaR ; Vadaparampil, Susan ; Jacobsen, PaulB ; Kilbourn, Kristin ; Barón, Anna ; Byers, Tim

Purpose : Delivery of follow-up care to breast cancer survivors is an important public health issue due to their increasing number and the anticipated shortage of oncology providers. This study evaluated adherence to American Society of Clinical Oncology (ASCO)-recommended surveillance tests in a bi-ethnic cohort of long-term breast cancer survivors. Methods : Women (n = 298) in Arizona and Colorado who had previously participated in a population-based study of breast cancer were enrolled into [...]

A partir des données des registres américains des cancers, cette étude analyse l'évolution de l'incidence du cancer de la vésicule biliaire et la mortalité spécifique, sur la période 1999-2011

Gallbladder cancer incidence and mortality, United States 1999-2011

Henley, S. Jane ; Weir, Hannah K ; Jim, Melissa A. ; Watson, Meg ; Richardson, Lisa C.

Background: Gallbladder cancer is a rare cancer with unusual distribution, and few population-based estimates for the United States have been published. Methods: Using population-based cancer incidence and mortality data, we examined U.S. gallbladder cancer incidence and death rates for 2007-2011 and trends for 1999-2011. Results: During 2007-2011, approximately 3,700 persons were diagnosed with primary gallbladder cancer (rate = 1.13 cases per 100,000) and 2,000 died from the disease (rate = [...]

Mené aux Etats-Unis auprès de 138 dyades constituées du patient et de son aidant, cet essai randomisé analyse l'efficacité d'un programme de formation dédié à l'aidant pour améliorer son sentiment d'auto-efficacité à prendre en charge les symptômes du patient et améliorer son bien-être psychologique

Effects of enhanced caregiver training program on cancer caregiver’s self-efficacy, preparedness, and psychological well-being

Hendrix, CristinaC ; Bailey, DonaldE, Jr. ; Steinhauser, KarenE ; Olsen, MarenK ; Stechuchak, KarenM ; Lowman, SarahG ; Schwartz, AbbyJ ; Riedel, RichardF ; Keefe, FrancisJ ; Porter, LauraS ; Tulsky, JamesA

Purpose : We examined the effects of an enhanced informal caregiver training (Enhanced-CT) protocol in cancer symptom and caregiver stress management to caregivers of hospitalized cancer patients. Methods : We recruited adult patients in oncology units and their informal caregivers. We utilized a two-armed, randomized controlled trial design with data collected at baseline, post-training, and at 2 and 4 weeks after hospital discharge. Primary outcomes were self-efficacy for managing patients’ [...]

A partir d'une revue de la littérature publiée entre 1990 et 2013 (23 études), cette étude fait le point sur les cadres théoriques permettant d'analyser et de rendre compte du vécu de couples faisant face au cancer

Couples coping with cancer: exploration of theoretical frameworks from dyadic studies

Regan, Tim W. ; Lambert, Sylvie D. ; Kelly, Brian ; Falconier, Mariana ; Kissane, David ; Levesque, Janelle V.

Objective : A diagnosis of cancer and subsequent treatment are distressing not only for the person directly affected, but also for their intimate partner. The aim of this review is to (a) identify the main theoretical frameworks underpinning research addressing dyadic coping among couples affected by cancer, (b) summarise the evidence supporting the concepts described in these theoretical frameworks, and (c) examine the similarities and differences between these theoretical perspectives. [...]

Menée aux Etats-Unis auprès de 365 patientes atteintes d'un cancer de l'ovaire, cette étude évalue l'association entre le bien-être psychologique avant le diagnostic et le niveau de noradrénaline dans les tumeurs

Eudaimonic well-being and tumor norepinephrine in patients with epithelial ovarian cancer

Davis, Lauren Z. ; Slavich, George M. ; Thaker, Premal H. ; Goodheart, Michael J. ; Bender, David P. ; Dahmoush, Laila ; Farley, Donna M. ; Markon, Kristian E. ; Penedo, Frank J. ; Lubaroff, David M. ; Cole, Steve W. ; Sood, Anil K. ; Lutgendorf, Susan K.

BACKGROUND The impact of psychological well-being on the physiologic processes involved in cancer progression remains unclear. Prior research has implicated adrenergic signaling in tumor growth and metastasis. Given that adrenergic signaling is influenced by both positive and negative factors, the authors examined how 2 different aspects of well-being (eudaimonic and positive affect) and psychological distress were associated with tumor norepinephrine (NE) in patients with ovarian cancer. [...]

Menée en Belgique par entretiens auprès de 31 patientes atteintes d'un cancer du sein, cette étude qualitative analyse les facteurs psychosociaux associés à l'adhésion et au suivi d'une hormonothérapie adjuvante

Factors influencing the process of medication (non-)adherence and (non-)persistence in breast cancer patients with adjuvant antihormonal therapy: a qualitative study

Verbrugghe, M. ; Verhaeghe, S. ; Decoene, E. ; De Baere, S. ; Vandendorpe, B. ; Van Hecke, A.

Non-adherence and non-persistence in breast cancer patients taking antihormonal therapy (AHT) is common. However, the complex patterns and dynamics of adherence and persistence are still not fully understood. This study aims to give insight into the process of (non-)adherence and (non-)persistence by researching influencing factors and their interrelatedness in breast cancer patients taking AHT by means of a qualitative study with semi-structured interviews. The sample consisted of 31 breast [...]

Menée aux Etats-Unis à partir des données 2012 d'une enquête nationale de santé et de données hospitalières, cette étude estime, en fonction de catégories d'âge, du sexe et du statut tabagique, les coûts médicaux associés au tabagisme

Smoking-attributable medical expenditures by age, sex, and smoking status estimated using a relative risk approach

Maciosek, Michael V. ; Xu, Xin ; Butani, Amy L. ; Pechacek, Terry F.

Objective : To accurately assess the benefits of tobacco control interventions and to better inform decision makers, knowledge of medical expenditures by age, gender, and smoking status is essential. Method : We propose an approach to distribute smoking-attributable expenditures by age, gender, and cigarette smoking status to reflect the known risks of smoking. We distribute hospitalization days for smoking-attributable diseases according to relative risks of smoking-attributable mortality, and [...]

Menée aux Etats-Unis à partir d'une enquête en ligne auprès de 776 médecins, cette étude analyse leurs perceptions vis-à-vis de la vaccination contre le papillomavirus humain chez les adolescentes ainsi que leurs pratiques de communication auprès de ces dernières

Physician communication about adolescent vaccination: How is human papillomavirus vaccine different?

Gilkey, Melissa B. ; Moss, Jennifer L. ; Coyne-Beasley, Tamera ; Hall, Megan E. ; Shah, Parth D. ; Brewer, Noel T.

Background : Low human papillomavirus (HPV) vaccination coverage stands in stark contrast to our success in delivering other adolescent vaccines. To identify opportunities for improving physicians' recommendations for HPV vaccination, we sought to understand how the communication context surrounding adolescent vaccination varies by vaccine type. Methods : A national sample of 776 U.S. physicians (53% pediatricians, 47% family medicine physicians) completed our online survey in 2014. We assessed [...]

Menée au Japon à partir de données portant sur 2 361 patients atteints d'un cancer de stade avancé et traités dans des unités de soins palliatifs, cette étude analyse la faisabilité et la pertinence de 4 indicateurs permettant d'estimer le pronostic

Survival prediction for advanced cancer patients in the real world: A comparison of the Palliative Prognostic Score, Delirium-Palliative Prognostic Score, Palliative Prognostic Index and modified Prognosis in Palliative Care Study predictor model

Baba, Mika ; Maeda, Isseki ; Morita, Tatsuya ; Inoue, Satoshi ; Ikenaga, Masayuki ; Matsumoto, Yoshihisa ; Sekine, Ryuichi ; Yamaguchi, Takashi ; Hirohashi, Takeshi ; Tajima, Tsukasa ; Tatara, Ryohei ; Watanabe, Hiroaki ; Otani, Hiroyuki ; Takigawa, Chizuko ; Matsuda, Yoshinobu ; Nagaoka, Hiroka ; Mori, Masanori ; Tei, Yo ; Hiramoto, Shuji ; Suga, Akihiko ; Kinoshita, Hiroya

Purpose : The aim of this study was to investigate the feasibility and accuracy of the Palliative Prognostic Score (PaP score), Delirium-Palliative Prognostic Score (D-PaP score), Palliative Prognostic Index (PPI) and modified Prognosis in Palliative Care Study predictor model (PiPS model). Patients and methods : This multicentre prospective cohort study involved 58 palliative care services, including 19 hospital palliative care teams, 16 palliative care units and 23 home palliative care [...]

Menée aux Etats-Unis par enquête auprès de 240 médecins, dont 120 hématologues et 120 oncologues spécialistes des tumeurs solides, cette étude analyse les différences dans leurs comportements relatifs aux soins de fin de vie dispensés aux patients

Differences in attitudes and beliefs toward end-of-life care between hematologic and solid tumor oncology specialists

Hui, D. ; Bansal, S. ; Park, M. ; Reddy, A. ; Cortés, J. ; Fossella, F. ; Bruera, E.

Background : Patients with hematologic malignancies often receive aggressive care at the end-of-life. To better understand the end-of-life decision-making process among oncology specialists, we compared the cancer treatment recommendations, and attitudes and beliefs toward palliative care between hematologic and solid tumor specialists. Patients and methods : We randomly surveyed 120 hematologic and 120 solid tumor oncology specialists at our institution. Respondents completed a survey [...]

Cet article analyse les enjeux médicaux, éthiques et économiques associés au traitement des patients âgés atteints de cancers hématologiques

Therapy for hematologic cancers in older patients, quality of life, and health economics: Difficult decisions

Deeg, H. ; Steuten, L. M.

Modern medicine provides unprecedented treatment options, including therapy for cancer, a frequent problem in an aging population. Comorbidities in older patients render decisions on intensive, potentially curative therapy difficult because such therapy affects quality of life (QOL), and success rates are lower than in younger patients. When considering intensive chemotherapy and hematopoietic cell transplantation for patients with myelodysplastic syndromes (MDS) or acute myeloid leukemia [...]

Cette étude analyse les éventuels besoins en formation complémentaire chez les professionnels de santé pour prendre en charge la prévention du cancer en fonction du risque génétique du patient, en Europe et aux Etats-Unis

Do Health Professionals Need Additional Competencies for Stratified Cancer Prevention Based on Genetic Risk Profiling?

Chowdhury, Susmita ; Henneman, Lidewij ; Dent, Tom ; Hall, Alison ; Burton, Alice ; Pharoah, Paul ; Pashayan, Nora ; Burton, Hilary

There is growing evidence that inclusion of genetic information about known common susceptibility variants may enable population risk-stratification and personalized prevention for common diseases including cancer. This would require the inclusion of genetic testing as an integral part of individual risk assessment of an asymptomatic individual. Front line health professionals would be expected to interact with and assist asymptomatic individuals through the risk stratification process. In that [...]