Menée en Australie par enquête auprès de 129 professionnels de santé, cette étude analyse leurs connaissances et leurs pratiques relatives à la prise en charge de la fatigue liée au cancer

Cancer-related fatigue: a survey of health practitioner knowledge and practice

Pearson, ElizabethJ M. ; Morris, MegE ; McKinstry, CarolE

Purpose : This study aims to identify the current practices of health professionals in the assessment and treatment of cancer-related fatigue (CRF). Methods : Health professionals working with oncology clients participated in an electronic survey distributed via professional associations and oncology societies. Results : One hundred twenty-nine professionals from nursing, medical, and allied health disciplines participated in an electronic survey. Overall, there was a perception that CRF was [...]

Menée en Allemagne auprès de 309 patients ayant survécu à un cancer (178 femmes), cette étude analyse l'efficacité d'un programme d'exercices physiques destinés à améliorer leur capacité d'endurance et leur fréquence cardiaque de récupération

Heart rate recovery and aerobic endurance capacity in cancer survivors: interdependence and exercise-induced improvements

Niederer, Daniel ; Vogt, Lutz ; Gonzalez-Rivera, Javier ; Schmidt, Katharina ; Banzer, Winfried

Purpose : Whilst evidence supports beneficial effects of exercise on heart rate variability in cancer patients, its impact on heart rate recovery (HRR) and possible associations of exercise capacity and HRR have not yet been investigated. We aimed to evaluate the effects of an exercise intervention on HRR in relation to the baseline aerobic capacity. Methods : Cancer patients (n = 309, 178 females) performed a cardiopulmonary exercise test at baseline and at a 4-month interval follow-up with [...]

Menée en Italie auprès de 669 patients atteints d'un cancer de stade avancé (âge moyen : 72, 1 ans), cette étude multicentrique analyse la prévalence et les caractéristiques des symptômes buccaux, tels qu'une mucite orale, une sécheresse buccale ou une dysphagie

Prevalence of oral mucositis, dry mouth, and dysphagia in advanced cancer patients

Mercadante, Sebastiano ; Aielli, Federica ; Adile, Claudio ; Ferrera, Patrizia ; Valle, Alessandro ; Fusco, Flavio ; Caruselli, Amanda ; Cartoni, Claudio ; Massimo, Pizzuto ; Masedu, Francesco ; Valenti, Marco ; Porzio, Giampiero

Background : Oral symptoms can be a sign of an underlying systemic condition and have a significant impact on quality of life, nutrition, and cost of care, while these lesions are often studied in the context of cancer treatment. However, information regarding oral symptoms in advanced cancer patients is poor. The aim of this multicenter study was to determine the prevalence and the characteristics of oral symptoms in a large population of advanced cancer patients. Methods : A consecutive [...]

Menée en Allemagne auprès de 99 patients atteints d'un cancer diagnostiqué entre 15 et 39 ans (33 hommes), cette étude transversale analyse leur vie amoureuse et sexuelle et leurs besoins en soins de support

Sexuality and romantic relationships in young adult cancer survivors: satisfaction and supportive care needs

Geue, Kristina ; Schmidt, Ricarda ; Sender, Annekathrin ; Sauter, Siegfried ; Friedrich, Michael

Objective : In recent years, psycho-oncology has focused more and more on adolescents and young adults with cancer (AYA). Many studies have concentrated on fertility issues in AYAs, but romantic relationships and sexuality have only been researched to a limited extent. This cross-sectional study examined AYAs' quality of relationships and sexuality satisfaction thereby identifying sex differences. Methods : Ninety-nine cancer patients (N = 33 males) diagnosed between 15 and 39 years who were in [...]

Menée en Allemagne auprès de 4 020 patients atteints de cancer (âge moyen : 58 ans) à l'aide d'un questionnaire européen EORTC et d'un modèle statistique, cette étude analyse l'association entre des indicateurs de performance physique et de dépression et leur qualité de vie

Performance status and depressive symptoms as predictors of quality of life in cancer patients. A structural equation modeling analysis

Faller, Hermann ; Brähler, Elmar ; Härter, Martin ; Keller, Monika ; Schulz, Holger ; Wegscheider, Karl ; Weis, Joachim ; Boehncke, Anna ; Richard, Matthias ; Sehner, Susanne ; Koch, Uwe ; Mehnert, Anja

Objective : This study aimed to examine whether depressive symptoms and performance status are independent predictors of both the physical and psychological domains of health-related quality of life (HRQoL) in cancer patients. Methods : A sample of 4020 cancer patients (mean age 58 years, 51% women) was evaluated. Depressive symptoms were measured with the patient health questionnaire and HRQoL with the European Organisation for Research and Treatment of Cancer quality of life questionnaire [...]

Mené en Inde auprès de 93 patients pédiatriques atteints de cancer (âge : 5-18 ans), cet essai randomisé évalue l'efficacité de l'aprépitant pour diminuer les symptômes de nausées et vomissements induits par une chimiothérapie hautement émétisante

Aprepitant as an add-on therapy in children receiving highly emetogenic chemotherapy: a randomized, double-blind, placebo-controlled trial

Bakhshi, Sameer ; Batra, Atul ; Biswas, Bivas ; Dhawan, Deepa ; Paul, Reeja ; Sreenivas, Vishnubhatla

Background : Aprepitant, a neurokinin-1 receptor antagonist, in combination with 5 HT-3 antagonist and dexamethasone is recommended in adults receiving moderately and highly emetogenic chemotherapy to reduce chemotherapy-induced vomiting (CIV). Data for use of aprepitant in children is limited and hence aprepitant is not recommended by Pediatric Oncology Group of Ontario guidelines for prevention of CIV in children <12 years. Methods : A randomized, double-blind, placebo-controlled trial was [...]

Menée au Canada auprès de 66 patients ayant survécu à un cancer du poumon, cette étude transversale rétrospective analyse leurs préférences en termes d'exercices physiques avant, pendant et après les traitements et évalue l'impact de l'activité physique sur leur qualité de vie

Exercise preferences, levels and quality of life in lung cancer survivors

Leach, H. J. ; Devonish, J. A. ; Bebb, D. G. ; Krenz, K. A. ; Culos-Reed, S. N.

Purpose : Lung cancer poses multiple challenges to adopting an exercise (EX) program, and the ideal timing of an EX program to improve quality of life (QoL) is unknown. This study explored the EX counselling and programming preferences of lung cancer survivors and examined the association of EX before diagnosis, during treatment and after treatment on QoL. Methods : Cross-sectional, retrospective survey design in a sample of lung cancer survivors. EX preferences were compared between patients [...]

Menée au Canada auprès de 305 patients âgés de moins de 75 ans et atteints d'un cancer de la prostate à faible risque, cette étude prospective compare les effets d'une surveillance active ou d'une prostatectomie radicale en termes de qualité de vie et de morbidités

Prospective quality-of-life outcomes for low-risk prostate cancer: Active surveillance versus radical prostatectomy

Jeldres, Claudio ; Cullen, Jennifer ; Hurwitz, Lauren M. ; Wolff, Erika M. ; Levie, Katherine E. ; Odem-Davis, Katherine ; Johnston, Richard B. ; Pham, Khanh N. ; Rosner, Inger L. ; Brand, Timothy C. ; L'Esperance, James O. ; Sterbis, Joseph R. ; Etzioni, Ruth ; Porter, Christopher R.

BACKGROUND For patients with low-risk prostate cancer (PCa), active surveillance (AS) may produce oncologic outcomes comparable to those achieved with radical prostatectomy (RP). Health-related quality-of-life (HRQoL) outcomes are important to consider, yet few studies have examined HRQoL among patients with PCa who were managed with AS. In this study, the authors compared longitudinal HRQoL in a prospective, racially diverse, and contemporary cohort of patients who underwent RP or AS for [...]

A partir d'une revue systématique de la littérature publiée depuis 2010 (34 études), cette étude fait le point sur l'impact de facteurs socio-géographiques sur l'incidence, le diagnostic, les traitements du cancer ainsi que sur la survie des patients

The impact of neighborhood social and built environment factors across the cancer continuum: Current research, methodological considerations, and future directions

Gomez, Scarlett Lin ; Shariff-Marco, Salma ; DeRouen, Mindy ; Keegan, Theresa H. M. ; Yen, Irene H. ; Mujahid, Mahasin ; Satariano, William A. ; Glaser, Sally L.

Neighborhood social and built environments have been recognized as important contexts in which health is shaped. The authors reviewed the extent to which these neighborhood factors have been addressed in population-level cancer research by scanning the literature for research focused on specific social and/or built environment characteristics and their association with outcomes across the cancer continuum, including incidence, diagnosis, treatment, survivorship, and survival. The commonalities [...]

Menée aux Etats-Unis, cette étude cas-témoins analyse les fonctions pulmonaires de survivants à long terme d'un cancer pédiatrique (âge médian au diagnostic : 16, 5 ans)

Long-Term Pulmonary Function in Survivors of Childhood Cancer

Armenian, Saro H. ; Landier, Wendy ; Francisco, Liton ; Herrera, Claudia ; Mills, George ; Siyahian, Aida ; Supab, Natt ; Wilson, Karla ; Wolfson, Julie A. ; Horak, David ; Bhatia, Smita

Purpose : This study was undertaken to determine the magnitude of pulmonary dysfunction in childhood cancer survivors when compared with healthy controls and the extent (and predictors) of decline over time. Patients and Methods : Survivors underwent baseline (t1) pulmonary function tests, followed by a second comprehensive evaluation (t2) after a median of 5 years (range, 1.0 to 10.3 years). Survivors were also compared with age- and sex-matched healthy controls at t2. Results : Median age at [...]

Menée aux Etats-Unis à partir de données portant sur 52 patients atteints d'une leucémie lymphocytaire chronique à haut risque et 20 patients atteints d'un syndrome de Richter, cette étude analyse l'évolution de la maladie et la survie des patients après l'échec d'un traitement par greffe allogénique de cellules souches

Outcomes of Patients With Chronic Lymphocytic Leukemia and Richter's Transformation After Transplantation Failure

Rozovski, Uri ; Benjamini, Ohad ; Jain, Preetesh ; Thompson, Philip A. ; Wierda, William G. ; O'Brien, Susan ; Burger, Jan A. ; Ferrajoli, Alessandra ; Faderl, Stefan ; Shpall, Elizabeth ; Hosing, Chitra ; Khouri, Issa F. ; Champlin, Richard ; Keating, Michael J. ; Estrov, Zeev

Purpose : Allogeneic stem-cell transplantation (SCT) induces long-term remission in a fraction of patients with high-risk chronic lymphocytic leukemia (CLL) or Richter's transformation (RT). Our purpose was to determine the outcomes of patients whose disease progressed after allogeneic SCT. Patients and Methods : We retrospectively analyzed the outcomes of 72 patients (52 with CLL and 20 with RT) who underwent allogeneic SCT between 1998 and 2011 and had documented progression after [...]

Menée en Australie à partir de données portant sur 1 506 961 individus, cette étude cas-témoins met en évidence un risque accru de mélanome avant 40 ans chez des personnes ayant des antécédents familiaux de mélanome

The aggregation of early-onset melanoma in young Western Australian families

Ward, S. V. ; Dowty, J. G. ; Webster, R. J. ; Cadby, G. ; Glasson, E. J. ; Heyworth, J. S. ; Emery, J. ; Cole, J. M. ; Millward, M. J. ; Wood, F. M. ; Palmer, L. J.

Background : Few studies have examined the familial aggregation of melanoma or its co-aggregation with other cancers using whole-population based designs. This study aimed to investigate aggregation patterns in young Western Australian families, using population-based linked health data to identify individuals born in Western Australia between 1974 and 2007, their known relatives, and all incident cancer diagnoses within the resulting 1,506,961 individuals. Methods : Cox proportional hazards [...]

Menée au Danemark à partir de données portant sur 2 873 patientes atteintes d'un cancer de l'ovaire diagnostiqué entre 2005 et 2010, cette étude de cohorte évalue l'association entre le stade de la maladie au diagnostic, des comorbidités, le niveau socio-économique des patientes, l'accès aux traitements et les disparités socio-économiques dans la survie

Do stage of disease, comorbidity or access to treatment explain socioeconomic differences in survival after ovarian cancer? – A cohort study among Danish women diagnosed 2005–2010

Ibfelt, Else Helene ; Dalton, Susanne Oksbjerg ; Høgdall, Claus ; Fagö-Olsen, Carsten Lindberg ; Steding-Jessen, Marianne ; Osler, Merete ; Johansen, Christoffer ; Frederiksen, Kirsten ; Kjær, Susanne K.

Aims : In order to reduce social inequality in cancer survival, knowledge is needed about where in the cancer trajectory disparities occur, and how social and health-related aspects may interact. We aimed to determine whether socioeconomic factors are related to cancer diagnosis stage, and whether socioeconomic disparities in survival after ovarian cancer can be explained by socioeconomic differences in cancer stage, comorbidity, treatment or lifestyle factors. Methods : In the Danish [...]

Mené au Royaume-Uni par questionnaire auprès de 511 participants, cet essai randomisé contrôlé analyse les changements de comportements en temes d'activité physique, de consommation d'alcool, de nutrition et de tabagisme chez des patients atteints d'un cancer de la prostate récemment diagnostiqué

Physical activity, alcohol consumption, BMI and smoking status before and after prostate cancer diagnosis in the ProtecT trial: Opportunities for lifestyle modification

Hackshaw-McGeagh, Lucy E. ; Penfold, Chris M. ; Walsh, Eleanor ; Donovan, Jenny L. ; Hamdy, Freddie C. ; Neal, David E. ; Jeffreys, Mona ; Martin, Richard M. ; Lane, J. Athene ; the Protec, T. Study Group

Associations between certain lifestyle characteristics and prostate cancer risk have been reported, and continuation post-diagnosis can adversely affect prognosis. We explored whether men make spontaneous changes to their physical activity and alcohol intake, body mass index (BMI) and smoking status, following a diagnosis of localised prostate cancer. A detailed diet, health and lifestyle questionnaire was completed by 511 participants within the Prostate Testing for Cancer and Treatment [...]

A partir des données du "Children's Oncology Group" incluant 3 250 patients pédiatriques et adolescents atteints d'un carcinome à cellules rénales, cette étude prospective analyse les caractéristiques des tumeurs, les examens de diagnostic pratiqués et les traitements chirurgicaux

Characterization of adolescent and pediatric renal cell carcinoma: A report from the Children's Oncology Group study AREN03B2

Geller, James I. ; Ehrlich, Peter F. ; Cost, Nicholas G. ; Khanna, Geetika ; Mullen, Elizabeth A. ; Gratias, Eric J. ; Naranjo, Arlene ; Dome, Jeffrey S. ; Perlman, Elizabeth J.

BACKGROUND The current study was conducted to characterize the epidemiology, histology, and radiographic features of as well as the surgical approach to pediatric and adolescent renal cell carcinoma (pRCC). METHODS pRCC cases prospectively enrolled on the Children's Oncology Group study AREN03B2 underwent central pathology, radiology, surgery, and oncology review. RESULTS As of June 2012, 120 of a total of 3250 patients enrolled on AREN03B2 (3.7%) were found to have unilateral RCC (median age, [...]

Menée aux Etats-Unis auprès de 363 participantes (317 patientes atteintes d'un cancer du sein et 46 témoins non malades), cette étude transversale analyse les facteurs associés à des difficultés et déficiences cognitives ressenties par les patientes avant, pendant et après une chimiothérapie

Potential factors associated with perceived cognitive impairment in breast cancer survivors

Myers, JamieS ; Wick, JoA ; Klemp, Jennifer

Purpose : This cross-sectional study was designed to explore potential factors associated with perceived cognitive impairment (PCI) in breast cancer survivors compared to controls and gain insight into perceived levels of severity for cognitive complaints. Methods : Women (N = 363, 317: breast cancer, 46: healthy controls) completed demographic questionnaire, MD Anderson Symptom Inventory, Attentional Function Index, and Functional Assessment for Cancer Therapy-Cognition. Group classification [...]

Menée au Danemark auprès de 66 patients atteints d'un cancer du testicule et 25 témoins, cette étude analyse les facteurs biologiques et psychologiques associés à leurs difficultés cognitives après une orchidectomie

Cognitive impairment and potential biological and psychological correlates of neuropsychological performance in recently orchiectomized testicular cancer patients

Amidi, Ali ; Wu, Lisa M. ; Agerbæk, Mads ; Larsen, Patrick Londin ; Pedersen, Anders D. ; Mehlsen, Mimi ; Larsen, Lars ; Zachariae, Robert

Objective : The aim of this study was to determine the prevalence of cognitive impairment (CI) in newly diagnosed and orchiectomized testicular cancer (TC) patients prior to systemic treatment, and to explore biological and psychological correlates. Methods : Sixty-six TC patients were compared with 25 healthy men on neuropsychological tests and a measure of cognitive complaints. CI status and a global composite score (representing overall neuropsychological performance) were calculated for [...]

Menée aux Etats-Unis auprès de 35 patients atteints d'un cancer localisé de la prostate, cette étude analyse l'évolution de leurs besoins en information tout au long de leur radiothérapie

Information Needs of Men with Localized Prostate Cancer During Radiation Therapy

Wolpin, SethE ; Parks, Jason ; Galligan, Mary ; Russell, KennethJ ; Berry, DonnaL

The purpose of this study was to describe how patient information needs change over the course of receiving radiation therapy for prostate cancer. Convenience sampling was utilized to recruit men with stage I–III prostate cancer. A longitudinal repeated measures design was implemented for this pilot study. Patients were presented with 36 paired comparisons, each asking the participant to choose the most important information topic(s) for today. Following completion of the survey instruments, [...]

Mené en France auprès de 45 participants, cet essai randomisé analyse l'efficacité d'une intervention pédagogique destinée à améliorer les capacités de communication des médecins généralistes afin d'inciter leurs patients à participer au dépistage du cancer colorectal

Efficacy of communication skills training on colorectal cancer screening by GPs: a cluster randomised controlled trial

Aubin-Auger, I. ; Laouénan, C. ; Le Bel, J. ; Mercier, A. ; Baruch, D. ; Lebeau, J. P. ; Youssefian, A. ; Le Trung, T. ; Peremans, L. ; Van Royen, P.

Colorectal cancer (CRC) mass screening has been implemented in France since 2008. Participation rates remain too low. The objective of this study was to test if the implementation of a training course focused on communication skills among general practitioners (GP) would increase the delivery of gaiac faecal occult blood test and CRC screening participation among the target population of each participating GP. A cluster randomised controlled trial was conducted with GP's practice as a cluster [...]

A partir des données des registres américains des cancers portant sur 1 536 patientes atteintes d'un cancer du sein, cette étude de cohorte analyse leurs expériences et leurs préférences en matière de consultation génétique

Concerns About Cancer Risk and Experiences With Genetic Testing in a Diverse Population of Patients With Breast Cancer

Jagsi, Reshma ; Griffith, Kent A. ; Kurian, Allison W. ; Morrow, Monica ; Hamilton, Ann S. ; Graff, John J. ; Katz, Steven J. ; Hawley, Sarah T.

Purpose : To evaluate preferences for and experiences with genetic testing in a diverse cohort of patients with breast cancer identified through population-based registries, with attention to differences by race/ethnicity. Methods : We surveyed women diagnosed with nonmetastatic breast cancer from 2005 to 2007, as reported to the SEER registries of metropolitan Los Angeles and Detroit, about experiences with hereditary risk evaluation. Multivariable models evaluated correlates of a strong [...]