A partir des données de la cohorte "Nurses' Health Study" incluant 103 577 participantes, cette étude évalue l'association entre des caractéristiques morphologiques (taille, poids, indice de masse corporelle), une activité physique et le risque de cancer du sein en fonction du statut des récepteurs des androgènes de la tumeur

Adult body size and physical activity in relation to risk of breast cancer according to tumor androgen receptor status

Zhang, Xuehong ; Eliassen, A. Heather ; Tamimi, Rulla M. ; Hazra, Aditi ; Beck, Andrew H. ; Brown, Myles ; Collins, Laura C. ; Rosner, Bernard ; Hankinson, Susan E.

Background: Obesity and physical activity have been hypothesized to affect breast cancer risk partly via the androgen signaling pathway. We conducted the first study to evaluate these associations by tumor androgen receptor (AR) status. Methods: Height, weight, and physical activity were assessed using questionnaires in the Nurses' Health Study. AR, estrogen receptor (ER) and progesterone receptor (PR) status were determined using immunohistochemistry on tumor tissue and medical/pathology [...]

A partir des données de dossiers médicaux portant sur 20 990 patients et 82 054 témoins, cette étude britannique évalue l'association entre des dysfonctionnements thyroïdiens, l'utilisation ou non d'un traitement thyroïdien substitutif et le risque de cancer colorectal

Thyroid Dysfunction, Thyroid Hormone Replacement and Colorectal Cancer Risk

Boursi, Ben ; Haynes, Kevin ; Mamtani, Ronac ; Yang, Yu-Xiao

Background: Current screening guidelines for colorectal cancer (CRC) do not consider thyroid dysfunction as a risk factor for disease development. We sought to determine the risk of developing CRC in patients with thyroid dysfunction, with and without thyroid hormone replacement (THR). Methods: We conducted a nested case-control study using a large population-based medical records database from the United Kingdom. Study case patients were defined as those with any medical code of CRC. Subjects [...]

A partir de données de 11 cohortes australiennes et néo-zélandaises incluant 79 458 participants, cette étude analyse l'association entre diverses caractéristiques anthropométriques (indice de masse corporelle, tour de taille, indice de forme corporelle, etc) et le risque de cancer

Comparison of anthropometric measures as predictors of cancer incidence: A pooled collaborative analysis of 11 Australian cohorts

Harding, Jessica L. ; Shaw, Jonathan E. ; Anstey, Kaarin J. ; Adams, Robert ; Balkau, Beverley ; Brennan-Olsen, Sharon L. ; Briffa, Tom ; Davis, Timothy M. E. ; Davis, Wendy A. ; Dobson, Annette ; Flicker, Leon ; Giles, Graham ; Grant, Janet ; Huxley, Rachel ; Knuiman, Matthew ; Luszcz, Mary ; MacInnis, Robert J. ; Mitchell, Paul ; Pasco, Julie A. ; Reid, Christopher ; Simmons, David ; Simons, Leon ; Tonkin, Andrew ; Woodward, Mark ; Peeters, Anna ; Magliano, Dianna J.

Obesity is a risk factor for cancer. However, it is not known if general adiposity, as measured by body mass index (BMI) or central adiposity [e.g., waist circumference (WC)] have stronger associations with cancer, or which anthropometric measure best predicts cancer risk. We included 79,458 men and women from the Australian and New Zealand Diabetes and Cancer Collaboration with complete data on anthropometry [BMI, WC, Hip Circumference (HC), WHR, waist to height ratio (WtHR), A Body Shape [...]

Menée aux Etats-Unis auprès de 1 206 cas et 2 469 témoins, cette étude évalue l'association entre 47 polymorphismes à simple nucléotide de 21 régions génétiques précédemment identifiés dans des études d'association sur le génome entier et le risque de mélanome primitif multiple

Inherited genetic variants associated with occurrence of multiple primary melanoma

Gibbs, David C ; Orlow, Irene ; Kanetsky, Peter A. ; Luo, Li ; Kricker, Anne ; Armstrong, Bruce K. ; Anton-Culver, Hoda ; Gruber, Stephen B. ; Marrett, Loraine D. ; Gallagher, Richard P. ; Zanetti, Roberto ; Rosso, Stefano ; Dwyer, Terence ; Sharma, Ajay ; La Pilla, Emily ; From, Lynn ; Busam, Klaus J. ; Cust, Anne E. ; Ollila, David W ; Begg, Colin B. ; Berwick, Marianne ; Thomas, Nancy E.

Recent studies including genome-wide association studies have identified several putative low-penetrance susceptibility loci for melanoma. We sought to determine their generalizability to genetic predisposition for multiple primary melanoma in the international population-based Genes, Environment, and Melanoma (GEM) Study. GEM is a case-control study of 1,206 incident cases of multiple primary melanoma and 2,469 incident first primary melanoma participants as the control group. We investigated [...]

A partir des données de la cohorte "Nurses’ Health Study" incluant 60 560 participantes, cette étude prospective évalue l'association entre une perte osseuse parodontale, une inflammation systémique et le risque de cancer épithélial de l'ovaire

Periodontal bone loss and risk of epithelial ovarian cancer

Babic, Ana ; Poole, ElizabethM ; Terry, KathrynL ; Cramer, DanielW ; Teles, RicardoP ; Tworoger, ShelleyS

Purpose : Periodontitis, a chronic inflammatory response to pathogenic bacteria in the oral microbiome, is common among adults. It is associated with several medical conditions, including cardiovascular diseases, and potentially with esophageal, lung, oral, and pancreatic cancer. One of the proposed mechanisms behind these associations is systemic inflammation, which has also been implicated in ovarian cancer etiology. The aim of this study was to evaluate association between ovarian cancer and [...]

A partir de données portant sur 40 414 individus, cette étude évalue l'association entre 25 loci de susceptibilité au cancer de la prostate précédemment identifiés dans des études d'association sur le génome entier et le risque de cancer de la prostate

Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci

Amin Al Olama, Ali ; Benlloch, Sara ; Antoniou, Antonis C. ; Giles, Graham G. ; Severi, Gianluca ; Neal, David ; Hamdy, Freddie C ; Donovan, Jenny L ; Muir, Kenneth ; Schleutker, Johanna ; Henderson, Brian E. ; Haiman, Christopher ; Schumacher, Fredrick R. ; Pashayan, Nora ; Pharoah, Paul D.P. ; Ostrander, Elaine A. ; Stanford, Janet L. ; Batra, Jyotsna ; Clements, Judith A. ; Chambers, Suzanne K ; Weischer, Maren ; Nordestgaard, Børge G ; Ingles, Sue Ann ; Sorensen, Karina D ; Orntoft, Torben F. ; Park, Jong Y. ; Cybulski, Cezary ; Maier, Christiane ; Doerk, Thilo ; Dickinson, Joanne L ; Cannon-Albright, Lisa ; Brenner, Hermann ; Rebbeck, Timothy R. ; Zeigler-Johnson, Charnita ; Habuchi, Tomonori ; Thibodeau, Stephen N. ; Cooney, Kathleen ; Chappuis, Pierre O. ; Hutter, Pierre ; Kaneva, Radka P. ; Foulkes, William D. ; Zeegers, Maurice P. ; Lu, Yong-Jie ; Zhang, Hong-Wei ; Stephenson, Robert ; Cox, Angela ; Southey, Melissa C. ; Spurdle, Amanda B. ; FitzGerald, Liesel ; Leongamornlert, Daniel ; Saunders, Edward ; Tymrakiewicz, Malgorzata ; Guy, Michelle ; Dadaev, Tokhir ; Little, Sarah J. ; Govindasami, Koveela ; Sawyer, Emma ; Wilkinson, Rosemary ; Herkommer, Kathleen ; Hopper, John L. ; Lophatonanon, Aritaya ; Rinckleb, Antje E ; Kote-Jarai, Zsofia ; Eeles, Rosalind A. ; Easton, Douglas F.

Background: Genome-wide association studies have identified multiple genetic variants associated with prostate cancer (PrCa) risk which explain a substantial proportion of familial relative risk. These variants can be used to stratify individuals by their risk of PrCa. Methods: We genotyped 25 PrCa susceptibility loci in 40,414 individuals and derived a polygenic risk score (PRS). We estimated empirical Odds Ratios for PrCa associated with different risk strata defined by PRS and derived [...]

Menée au Canada auprès de 83 cas et 1 027 témoins, cette étude analyse les divers facteurs associés au risque de cancer de l'endomètre chez des femmes porteuses de mutations BRCA1 ou BRCA2 (facteurs reproductifs, utilisation d'une contraception orale, d'un traitement hormonal substitutif de la ménopause, hystérectomie, antécédent de cancer du sein, utilisation de tamoxifène)

Risk factors for endometrial cancer among women with a BRCA1 or BRCA2 mutation: a case control study

Segev, Yakir ; Rosen, Barry ; Lubinski, Jan ; Gronwald, Jacek ; Lynch, HenryT ; Moller, Pal ; Kim-Sing, Charmaine ; Ghadirian, Parviz ; Karlan, Beth ; Eng, Charis ; Gilchrist, Dawna ; Neuhausen, SusanL ; Eisen, Andrea ; Friedman, Eitan ; Euhus, David ; Ping, Sun ; Narod, StevenA

BRCA mutation carriers may use tamoxifen for breast cancer prevention or treatment. Hormone replacement therapy is often prescribed after surgical menopause and oral contraceptives are recommended for ovarian cancer prevention. The objective of this study was to assess the impact of these medications and other risk factors on endometrial cancer risk in BRCA carriers. Women with a BRCA1 or BRCA2 mutation were identified from a registry of mutation carriers. Cases were 83 women who had a [...]