Menée au Canada auprès de 41 patients atteints de myélome multiple (âge moyen : 61 ans ; 73 % d'hommes) et recevant une chimiothérapie, cette étude rétrospective analyse leur adhésion aux recommandations de pratique d'exercices physiques

Exercise compliance among patients with multiple myeloma undergoing chemotherapy: a retrospective study

Shallwani, Shirin ; Dalzell, Mary-Ann ; Sateren, Warren ; O’Brien, Suzanne

Purpose : Multiple myeloma (MM) is often associated with osteolytic bone disease and anemia, resulting in skeletal fragility and persistent fatigue, pain, and reduced quality of life. Exercise is considered safe and beneficial for this population. Our objectives were to evaluate the extent to which MM patients undergoing chemotherapy complied with exercise recommendations and to identify factors associated with noncompliance. Methods : This retrospective study included 41 MM patients referred [...]

Menée au Canada auprès de 47 patients atteints de cancer, cette étude de cohorte observationnelle évalue l'efficacité d'un traitement oral par dexaméthasone pour prévenir et soulager la douleur chez des patients traités par radiothérapie stéréotaxique corporelle ciblant la colonne vertébrale

Prophylactic dexamethasone effectively reduces the incidence of pain flare following spine stereotactic body radiotherapy (SBRT): a prospective observational study

Khan, Luluel ; Chiang, Andrew ; Zhang, Liying ; Thibault, Isabelle ; Bedard, Gillian ; Wong, Erin ; Loblaw, Andrew ; Soliman, Hany ; Fehlings, MichaelG ; Chow, Edward ; Sahgal, Arjun

Purpose : The purpose of this study was to determine the incidence of pain flare (PF) in patients receiving spine stereotactic body radiotherapy (SBRT) treated with prophylactic oral dexamethasone (DEX) 1 h before and for 4 days following SBRT. Methods : Forty-seven patients were accrued on this prospective observational study. The first cohort of 24 patients was treated with 4 mg, while a second cohort of 23 patients treated with 8 mg of DEX. The Brief Pain Inventory (BPI) was used to score [...]

A partir d'une revue de la littérature, cette étude fait le point sur les améliorations faites dans la prévention des nausées et vomissements induits par la chimiothérapie depuis les 25 dernières années

Recent developments in the prevention of chemotherapy-induced nausea and vomiting (CINV): A comprehensive review

Jordan, Karin ; Jahn, Franziska ; Aapro, Matti

The prevention of chemotherapy-induced nausea and vomiting (CINV) has been revolutionized over the past 25 years. Guideline-based treatment means that vomiting can be prevented in the majority, but not in all patients. Therefore, antiemetic research continues with the goal of optimizing CINV control for all patients. This comprehensive review summarizes the research efforts in this field over the past few years. Emerging from this research are two new antiemetic agents, NEPA, the first [...]

Menée en Belgique auprès de 28 patients atteints de cancer, cette éude qualitative analyse leur façon de prendre en charge et de gérer leurs symptômes liés à la chimiothérapie à leur domicile

Dealing with chemotherapy-related symptoms at home: a qualitative study in adult patients with cancer

Coolbrandt, A. ; Dierckx de Casterlé, B. ; Wildiers, H. ; Aertgeerts, B. ; Van der Elst, E. ; van Achterberg, T. ; Milisen, K.

Given that chemotherapy treatments are done mostly in an outpatient setting, patients with cancer must deal with treatment-related symptoms mainly at home. Evidence suggests that they often feel left alone or unprepared to do so. This qualitative study explores how patients deal with chemotherapy-related symptoms in their home, which factors and ideas influence their self-management and what role professional caregivers play. One-off, semi-structured interviews were held with 28 adult patients [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2012 (128 études), cette étude analyse les aspects multidimensionnels de la souffrance liée au cancer

Conceptual analysis of suffering in cancer: a systematic review

Best, Megan ; Aldridge, Lynley ; Butow, Phyllis ; Olver, Ian ; Webster, Fleur

Objective : Patient suffering is a neglected area of care, partly because of poor definitions. The aim of this study was to distill what is currently known about suffering in the health literature in order to generate a conceptual basis for further research. Methods : A systematic review focusing on suffering across all cancers was undertaken. The search included peer-reviewed English articles published between 1992 and 2012 in MEDLINE, Embase, PsycINFO and the Cochrane Library databases [...]

Mené en Allemagne auprès de 2 659 patients atteints d'un cancer métastatique, cet essai prospectif multicentrique évalue l'impact des toxicités du docétaxel sur leur qualité de vie

The impact of docetaxel-related toxicities on health-related quality of life in patients with metastatic cancer (QoliTax)

Al-Batran, S.-E. ; Hozaeel, W. ; Tauchert, F. K. ; Hofheinz, R.-D. ; Hinke, A. ; Windemuth-Kieselbach, C. ; Hübner, A. ; Burmester, M. ; Koenigsmann, M. ; Wiegand, J. ; Hausen, G. zur ; Linsse, B. ; Kuhl, R. ; Pauligk, C.

Background : Docetaxel is a widely used cytotoxic agent. This study evaluates the impact of docetaxel toxicities on patient's health-related Quality of life (QoL). Patients and methods : We conducted a multicenter, prospective, non-interventional trial, in which the QoL was assessed using the EORTC QLQ-C30 questionnaires at baseline and every 4 weeks up to 40 weeks in patients receiving a docetaxel-based chemotherapy for metastatic disease. Treatment-related adverse events were correlated with [...]

Mené au Royaume-Uni auprès de 68 patients atteints d'un cancer de la prostate et recevant une hormonothérapie anti-androgénique, cet essai randomisé évalue l'efficacité d'une thérapie cognitive et comportementale pour les aider à prendre en charge les bouffées de chaleur et sueurs nocturnes liées au traitement, et améliorer les troubles de l'humeur et leur qualité de vie

A randomised controlled trial of a brief cognitive behavioural intervention for men who have hot flushes following prostate cancer treatment (MANCAN)

Stefanopoulou, Evgenia ; Yousaf, Omar ; Grunfeld, Elizabeth A. ; Hunter, Myra S.

Objective : Hot flushes and night sweats (HFNS) are experienced by up to 80% of prostate cancer patients undergoing androgen deprivation therapy (ADT). This study evaluates the effects of a guided self-help cognitive behavioural therapy (CBT) intervention on HFNS problem-rating (primary outcome), HFNS frequency, mood and health-related quality of life (secondary outcomes) in patients undergoing ADT. Methods : Patients reporting treatment-induced HFNS were randomly assigned to CBT (n = 33) or [...]

Menée aux Pays-Bas auprès de 174 survivantes d'un cancer du sein et 195 témoins, cette étude analyse les effets indésirables à long terme (en moyenne, 20 ans après la fin du traitement) d'une chimiothérapie adjuvante à base de cyclophosphamide/méthotrexate/5-fluorouracile sur leurs fonctions de préhension et de manipulation (motricité fine)

Late effects of adjuvant chemotherapy for breast cancer on fine motor function

Hoogendam, Yoo Young ; Schagen, Sanne B. ; Ikram, M. Arfan ; Boogerd, Willem ; Seynaeve, Caroline ; Seidler, Rachael D. ; Breteler, Monique M. B. ; Van der Geest, Jos N. ; Koppelmans, Vincent

Background : Adjuvant chemotherapy for breast cancer has been associated with deterioration of fine motor skill. Which aspects of motor performance are underlying this problem is unclear but important because manual motor deterioration could affect quality of life. The current study aims to investigate late effects of adjuvant chemotherapy for breast cancer on fine motor function, using both speed and accuracy measures. Method : We compared fine motor function of 174 women who had received [...]

Mené en Allemagne auprès de 40 patientes ayant survécu à un cancer du sein, cet essai randomisé évalue l'efficacité d'une intervention basée sur la pratique du yoga et de la méditation pour soulager les symptômes liés à la ménopause (fatigue, dépression, anxiété) et améliorer leur qualité de vie

Yoga and meditation for menopausal symptoms in breast cancer survivors—A randomized controlled trial

Cramer, Holger ; Rabsilber, Sybille ; Lauche, Romy ; Kümmel, Sherko ; Dobos, Gustav

BACKGROUND Breast cancer survivors have only very limited treatment options for menopausal symptoms. The objective of this trial was to evaluate the effects of a 12-week traditional Hatha yoga and meditation intervention on menopausal symptoms in breast cancer survivors. METHODS Patients were randomly assigned either to a 12-week yoga and meditation intervention or to usual care. The primary outcome measure was total menopausal symptoms (Menopause Rating Scale [MRS] total score). Secondary [...]

A partir des données des registres américains des cancers portant sur la période 1996-2010, cette étude compare le stade du cancer au diagnostic chez deux populations de patients immunodéprimés, patients infectés par le VIH et patients ayant reçu une greffe d'organe

Cancer stage at diagnosis in patients infected with the human immunodeficiency virus and transplant recipients

Shiels, Meredith S. ; Copeland, Glenn ; Goodman, Marc T. ; Harrell, Janna ; Lynch, Charles F. ; Pawlish, Karen ; Pfeiffer, Ruth M. ; Engels, Eric A.

BACKGROUND It is unknown whether immunosuppression results in more aggressive, advanced stage cancers. Because cancer stage is influenced both by tumor biology and medical surveillance, the authors assessed cancer stage in individuals infected with the human immunodeficiency virus (HIV) and solid organ transplant recipients, 2 immunosuppressed groups with differences in their health care use. METHODS The authors used data on all cases of 15 cancer types diagnosed during 1996 through 2010 in 2 [...]

A partir des données des registres américains des cancers portant sur des patients atteints d'un cancer du côlon, du sein ou du testicule diagnostiqué entre 1985 et 2011, cette étude analyse les indicateurs d'espérance de vie en fonction de l'âge au diagnostic et du type de cancer

Life expectancy of colon, breast and testicular cancer patients. An analysis of US-SEER population-based data

Capocaccia, Riccardo ; Gatta, Gemma ; Dal Maso, Luigino

Background : Cancer survivorship is an increasingly important issue in cancer control. Life expectancy of patients diagnosed with breast, colon, and testicular cancers, stratified by age at diagnosis and time since diagnosis, is provided as an indicator to evaluate future mortality risks and health care needs of cancer survivors. Patients and methods : The standard period life table methodology was applied to excess mortality risk estimates for cancer patients diagnosed in 1985-2011 from SEER [...]

A partir des données des registres suédois des cancers, cette étude en population analyse le risque de cancers durant la grossesse et la période post-partum, sur la période 1963-2007

Cancer during pregnancy and the postpartum period: A population-based study

Andersson, Therese M. L. ; Johansson, Anna L. V. ; Fredriksson, Irma ; Lambe, Mats

BACKGROUND The purpose of this study was to assess patterns of cancer occurrence during pregnancy and the postpartum period. METHODS This was a register-based study using data from the Swedish Multi-Generation Register and the National Cancer Register from 1963 to 2007. Pregnancy-associated cancer (PAC) was defined as a malignancy detected during pregnancy or within 2 years of delivery and was assessed in 7 time windows: pregnancy, trimesters 1-3, 0-6 months, 7-12 months, and second year [...]

Menée aux Etats-Unis, cette étude analyse les modalités de prise en charge d'une occlusion intestinale d'origine maligne chez des patients atteints de cancer (942 014 patients hospitalisés en 2006, 1 103 528 patients hospitalisés en 2010), puis évalue l'impact des traitements sur la mortalité

Management patterns and predictors of mortality among US patients with cancer hospitalized for malignant bowel obstruction

Alese, Olatunji B. ; Kim, Sungjin ; Chen, Zhengjia ; Owonikoko, Taofeek K. ; El-Rayes, Bassel F.

BACKGROUND Malignant bowel obstruction affects an estimated 3% to 15% of patients with cancer, with a mean survival of <4 weeks reported in patients with inoperable malignant bowel obstruction. In the current study, the authors assessed predictors of survival and the influence of treatment modality in US patients with cancer who were hospitalized for malignant bowel obstruction. METHODS All the US cancer patients hospitalized with malignant bowel obstruction in 2006 and 2010 were included. Data [...]

A partir des données des registres américains des cancers, cette étude analyse l'évolution, depuis 1973, de la mortalité à court terme chez des patients atteints d'une leucémie myéloïde aiguë et traités par chimiothérapie avant l'âge de 65 ans (9 380 cas)

Improvements in the early death rate among 9380 patients with acute myeloid leukemia after initial therapy: A SEER database analysis

Percival, Mary-Elizabeth M. ; Tao, Li ; Medeiros, Bruno C. ; Clarke, Christina A.

BACKGROUND Acute myeloid leukemia (AML) is treated with conventional induction chemotherapy shortly after diagnosis for the majority of patients aged ≤65 years. A recent report suggested a substantial decline in the early, or 1-month, mortality rate in patients treated on clinical trials over the past 2 decades. It is unknown whether a similar improvement has been observed in the general population. METHODS The authors examined the 1-month mortality rate in a large population-based series of [...]

Menée en Norvège à partir de données portant sur 140 survivants à long terme d'un cancer (lymphome, myélome multiple, carcinome de l'épipharynx), cette étude analyse la prévalence de dysfonctionnements hormonaux liés aux effets d'une radiothérapie ciblant la région de la tête et du cou (durée médiane de suivi : 16 ans après le diagnostic)

Hormonal dysfunction is frequent in cancer survivors treated with radiotherapy to the head and neck region

Seland, Mette ; Bjøro, Trine ; Furre, Torbjørn ; Schreiner, Thomas ; Bollerslev, Jens ; Fosså, SophieDorothea ; Loge, JonHåvard ; Holte, Harald ; Kiserud, CecilieEssholt

Purpose : Cancer treatment may lead to hormonal dysfunction. Therefore, we assessed the prevalence of dysfunction in four hormonal axes among long-term cancer survivors who received radiotherapy to the head and neck region and analyzed associations between hormonal status and clinical variables. Methods : We included 140 cancer survivors who received radiotherapy to the head and neck region, either locally or through total body irradiation after a diagnosis of lymphoma, plasmacytoma/multiple [...]

Menée aux Etats-Unis par questionnaire auprès de 117 patients atteints d'un cancer du poumon recevant une chimiothérapie, cette étude analyse les facteurs psychosociaux et cliniques associés à un comportement de dissimulation du diagnostic de leur maladie vis-à-vis de leur entourage

Concealment of lung cancer diagnosis: prevalence and correlates

Gonzalez, Brian D. ; Jim, Heather S. L. ; Cessna, Julie M. ; Small, Brent J. ; Sutton, Steven K. ; Jacobsen, Paul B.

Background : Lung cancer has a commonly understood behavioral etiology. Thus, lung cancer patients are often blamed for their illness and may seek to avoid this blame by concealing their diagnosis from others. This study sought to determine the prevalence of concealment and identify demographic, clinical, and psychosocial correlates of concealment among lung cancer patients. Methods : A sample of 117 lung cancer patients receiving chemotherapy for non-small cell or small cell lung cancer was [...]

A partir d'une revue systématique de la littérature (11 études), cette méta-analyse évalue l'efficacité des interventions psychosociales visant à diminuer les symptômes de dépression chez des patients atteints d'un cancer de la prostate

Interventions that may reduce depressive symptoms among prostate cancer patients: a systematic review and meta-analysis

Newby, Timothy A. ; Graff, Julie N. ; Ganzini, Linda K. ; McDonagh, Marian S.

Objective : Prostate cancer patients are at increased risk of depression yet there is no standard intervention to address this. The purpose of this meta-analysis is to examine the efficacy of interventions in reducing depressive symptoms in men with prostate cancer. Methods : Searches for studies were conducted in four databases and by hand. Randomized controlled trials of any intervention relative to control for depression in prostate cancer patients at any stage of their cancer treatment were [...]

Menée par questionnaire auprès de 180 patients ayant survécu à un cancer du côlon (91 Canadiens, 89 Australiens), cette étude évalue l'association entre l'intensité de leur activité physique mesurée objectivement, la durée d'inactivité et leur état de santé psychologique

Accelerometer-assessed physical activity and sedentary time among colon cancer survivors: associations with psychological health outcomes

Vallance, JeffK ; Boyle, Terry ; Courneya, KerryS ; Lynch, BrigidM

Purpose : The purpose of this study was to determine associations of objectively assessed moderate-to-vigorous intensity physical activity (MVPA) and sedentary time with psychological health outcomes including depression symptoms, anxiety symptoms, and overall satisfaction with life in colon cancer survivors. Methods : Colon cancer survivors (N = 180) from Alberta, Canada (n = 91), and Western Australia (n = 89) completed a mailed survey that assessed depression symptom severity, state anxiety, [...]

Menée aux Etas-Unis auprès de 41 cas et 41 témoins, cette étude identifie les troubles cognitifs susceptibles d'altérer la compréhension des décisions thérapeutiques chez des patients atteints de métastases cérébrales récemment diagnostiquées

Cognitive predictors of understanding treatment decisions in patients with newly diagnosed brain metastasis

Gerstenecker, Adam ; Meneses, Karen ; Duff, Kevin ; Fiveash, John B. ; Marson, Daniel C. ; Triebel, Kristen L.

BACKGROUND Medical decision-making capacity is a higher-order functional skill that refers to a patient's ability to make informed, sound decisions related to care and treatment. In a medical context, understanding is the most cognitively demanding consent standard and refers to a patient's ability to comprehend information to the extent that informed decisions can be made. METHODS The association between reasoning and cognition was examined using data from 41 patients with diagnosed brain [...]

Menée en Irlande par enquête auprès de 748 participants d'âge compris entre 18 et 74 ans, cette étude analyse les connaissances du grand public sur les facteurs de risque de cancer afin de développer des programmes de prévention

Poor Awareness of Risk Factors for Cancer in Irish Adults: Results of a Large Survey and Review of the Literature

Ryan, Aoife M. ; Cushen, Samantha ; Schellekens, Harriët ; Bhuachalla, Eadaoin Ni ; Burns, Lisa ; Kenny, Ursula ; Power, Derek G.

Background : Knowledge of cancer risk factors is unknown in Ireland. An understanding of risk factors could help inform cancer prevention programs. Aims and Methods : A 48-question online survey was designed to gather data to assess levels of public knowledge about cancer risk factors. Results : There were 748 participants (648 women, 100 men). Mean age was 37 years (range: 18–74 years). For the public, 81% were concerned about developing cancer; however, 20% believed that cancer is unavoidable [...]

A partir des données des registres américains des cancers, cette étude présente la méthodologie utilisée pour élaborer les estimations d'incidence de cancer pour l'année 2012 aux Etats-Unis

Early estimates of SEER cancer incidence for 2012: Approaches, opportunities, and cautions for obtaining preliminary estimates of cancer incidence

Lewis, Denise Riedel ; Chen, Huann-Sheng ; Midthune, Douglas N. ; Cronin, Kathleen A. ; Krapcho, Martin F. ; Feuer, Eric J.

BACKGROUND The National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program collects and publishes population-based cancer incidence data from registries covering approximately 28% (seer.cancer.gov/registries/data.html) of the US population. SEER incidence rates are released annually in April from data submitted the prior November. The time needed to identify, consolidate, clean, and submit data requires the latest diagnosis year included to be 3 years before release. [...]