A partir des données de cinq études de cohorte (2 552 cas de cancer du poumon, 6 386 cas de cancer de la vessie, 3 179 cas de cancer du rein, 2 967 cas de cancer de la tête et du cou), cette étude évalue l'association entre le tabagisme avant le diagnostic initial du premier cancer et le risque de second cancer primitif

Cigarette Smoking Prior to First Cancer and Risk of Second Smoking-Associated Cancers Among Survivors of Bladder, Kidney, Head and Neck, and Stage I Lung Cancers

Shiels, Meredith S. ; Gibson, Todd ; Sampson, Joshua ; Albanes, Demetrius ; Andreotti, Gabriella ; Beane Freeman, Laura ; Berrington de Gonzalez, Amy ; Caporaso, Neil ; Curtis, Rochelle E. ; Elena, Joanne ; Freedman, Neal D. ; Robien, Kim ; Black, Amanda ; Morton, Lindsay M.

Purpose : Data on smoking and second cancer risk among cancer survivors are limited. We assessed associations between smoking before first cancer diagnosis and risk of second primary smoking-associated cancers among survivors of lung (stage I), bladder, kidney, and head/neck cancers. Methods : Data were pooled from 2,552 patients with stage I lung cancer, 6,386 with bladder cancer, 3,179 with kidney cancer, and 2,967 with head/neck cancer from five cohort studies. We assessed the association [...]

Menée au Chili auprès de 92 cas et 288 témoins, cette étude évalue l'association entre une exposition à de faibles concentrations d'arsenic dans l'eau potable et le risque de cancer du poumon chez des adultes

Elevated Lung Cancer in Younger Adults and Low Concentrations of Arsenic in Water

Steinmaus, Craig ; Ferreccio, Catterina ; Yuan, Yan ; Acevedo, Johanna ; González, Francisca ; Pérez, Liliana ; Cortes, Sandra ; Balmes, John R. ; Liaw, Jane ; Smith, Allan H.

Arsenic concentrations greater than 100 µg/L in drinking water are a known cause of cancer, but the risks associated with lower concentrations are less well understood. The unusual geology and good information on past exposure found in northern Chile are key advantages for investigating the potential long-term effects of arsenic. We performed a case-control study of lung cancer from 2007 to 2010 in areas of northern Chile that had a wide range of arsenic concentrations in drinking water. [...]

Menée aux Etats-Unis à partir d'échantillons sériques de patients atteints d'un ostéosarcome, cette étude évalue l'association entre une infection par le virus simien 40 et le risque d'ostéosarcome

Significant association between human osteosarcoma and simian virus 40

Mazzoni, Elisa ; Benassi, Maria Serena ; Corallini, Alfredo ; Barbanti-Brodano, Giovanni ; Taronna, Angelo ; Picci, Piero ; Guerra, Giovanni ; D'Agostino, Antonio ; Trevisiol, Lorenzo ; Nocini, Pier Francesco ; Casali, Maria Vittoria ; Barbanti-Brodano, Giuseppe ; Martini, Fernanda ; Tognon, Mauro

BACKGROUND Simian virus 40 (SV40) has been considered to be an oncogenic viral agent in the development of osteosarcoma (OS), which to the authors' knowledge continues to be of unknown etiology. METHODS In the current study, serum samples from patients with OS were investigated with an indirect enzyme-linked immunoadsorbent assay (ELISA) to test for the presence of immunoglobulin G antibodies, which react with SV40 antigens. In ELISA, SV40 antigens were represented by 2 synthetic polypeptides [...]

Menée en Suède à partir de biopsies de 280 patients, cette étude analyse l'association entre une infection par le papillomavirus humain et le risque de carcinome épidemoïde de la base de la langue ou des amygdales

Incidence of human papillomavirus positive tonsillar and base of tongue carcinoma: A stabilisation of an epidemic of viral induced carcinoma?

Näsman, Anders ; Nordfors, Cecilia ; Holzhauser, Stefan ; Vlastos, Andrea ; Tertipis, Nikolaos ; Hammar, Ulf ; Hammarstedt-Nordenvall, Lalle ; Marklund, Linda ; Munck-Wikland, Eva ; Ramqvist, Torbjörn ; Bottai, Matteo ; Dalianis, Tina

Aim : To investigate whether the rise during the past decades in the incidence of tonsillar and base of tongue squamous cell carcinoma (TSCC and BOTSCC) and the proportion of human papillomavirus (HPV) positive cancer has continued in Stockholm. Patients and methods : Pre-treatment biopsies (n = 252) available from 280 patients diagnosed with TSCC and BOTSCC during 2008–2012 in the County of Stockholm were tested for HPV DNA by a multiplex bead-based assay. Incidence records were acquired from [...]

Menée auprès de 22 269 survivants à 5 ans d'un cancer du testicule diagnostiqué entre 1959 et 1987, cette étude de cohorte évalue l'association entre une radiothérapie abdominale et le risque de cancer de l'estomac, en fonction de la dose de rayonnements

Increased stomach cancer risk following radiotherapy for testicular cancer

Hauptmann, M. ; Fossa, S. D. ; Stovall, M. ; van Leeuwen, F. E. ; Johannesen, T. B. ; Rajaraman, P. ; Gilbert, E. S. ; Smith, S. A. ; Weathers, R. E. ; Aleman, B. M. P. ; Andersson, M. ; Curtis, R. E. ; Dores, G. M. ; Fraumeni, J. F. ; Hall, P. ; Holowaty, E. J. ; Joensuu, H. ; Kaijser, M. ; Kleinerman, R. A. ; Langmark, F. ; Lynch, C. F. ; Pukkala, E. ; Storm, H. H. ; Vaalavirta, L. ; van den Belt-Dusebout, A. W. ; Travis, L. B. ; Morton, L. M.

Background: Abdominal radiotherapy for testicular cancer (TC) increases risk for second stomach cancer, although data on the radiation dose–response relationship are sparse. Methods: In a cohort of 22 269 5-year TC survivors diagnosed during 1959–1987, doses to stomach subsites were estimated for 92 patients who developed stomach cancer and 180 matched controls. Chemotherapy details were recorded. Odds ratios (ORs) were estimated using logistic regression. Results: Cumulative incidence of [...]

Menée aux Pays-Bas, cette étude de cohorte évalue la relation entre trois marqueurs associés à une allergie et le risque d'hospitalisation lié à un cancer ou de décès par cancer

Objective allergy markers and risk of cancer mortality and hospitalization in a large population-based cohort

Taghizadeh, Niloofar ; Vonk, JudithM ; Hospers, JeannetteJ ; Postma, DirkjeS ; de Vries, ElisabethG E. ; Schouten, JanP ; Boezen, H. Marike

Purpose : There are indications that a history of allergy may offer some protection against cancer. We studied the relation of three objectively determined allergy markers with cancer mortality and hospitalization risk. Methods : Associations between three allergy markers (number of peripheral blood eosinophil counts, skin test positivity, and serum total IgE) with mortality and hospitalization from any type and four common types of cancer (lung, colorectal, prostate, and breast cancer) were [...]

Couplée aux données de la cohorte européenne EPIC, cette étude cas-témoins prospective (565 cas) évalue l'association entre la concentration sérique de IGF-I et le risque de cancer épithélial de l'ovaire, en fonction des caractéristiques de la tumeur

Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: results from the EPIC cohort

Ose, J. ; Fortner, R. T. ; Schock, H. ; Peeters, P. H. ; Onland-Moret, N. C. ; Bueno-de-Mesquita, H. B. ; Weiderpass, E. ; Gram, I. T. ; Overvad, K. ; Tjonneland, A. ; Dossus, L. ; Fournier, A. ; Baglietto, L. ; Trichopoulou, A. ; Benetou, V. ; Trichopoulos, D. ; Boeing, H. ; Masala, G. ; Krogh, V. ; Matiello, A. ; Tumino, R. ; Popovic, M. ; Obón-Santacana, M. ; Larranaga, N. ; Ardanaz, E. ; Sanchez, M. J. ; Menendez, V. ; Chirlaque, M. D. ; Travis, R. C. ; Khaw, K. T. ; Brandstedt, J. ; Idahl, A. ; Lundin, E. ; Rinaldi, S. ; Kuhn, E. ; Romieu, I. ; Gunter, M. J. ; Merritt, M. A. ; Riboli, E. ; Kaaks, R.

Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations. [...]

Menée au Canada auprès de 1 936 cas et 1 995 témoins, cette étude en population évalue l'association entre un asthme, des allergies et le risque de cancer de la prostate

Asthma, allergy and the risk of prostate cancer: Results from the Montreal PROtEuS study

Weiss, Deborah ; El-Zein, Mariam ; Rousseau, Marie-Claude ; Richard, Hugues ; Karakiewicz, Pierre I. ; Parent, Marie-Élise

Background : The few previous studies examining the association between asthma or allergy and prostate cancer (PCa) risk were inconclusive. This study aimed to evaluate these associations, and to explore in details the possible influence of current versus former allergic condition, age at onset, time since onset, and duration of each allergic condition. Methods : Detailed information on self-reported asthma and allergy was collected in the context of a large population-based case–control study [...]

A partir des données de trois études de cohorte (une islandaise et deux américaines) portant sur 169 cas, cette étude évalue l'association entre 96 polymorphismes à simple nucléotide de 12 gènes liés au rythme circadien et le risque de cancer fatal de la prostate

Circadian clock genes and risk of fatal prostate cancer

Markt, SarahC ; Valdimarsdottir, UnnurA ; Shui, IreneM ; Sigurdardottir, LaraG ; Rider, JenniferR ; Tamimi, RullaM ; Batista, JulieL ; Haneuse, Sebastien ; Flynn-Evans, Erin ; Lockley, StevenW ; Czeisler, CharlesA ; Stampfer, MeirJ ; Launer, Lenore ; Harris, Tamara ; Smith, AlbertVernon ; Gudnason, Vilmundur ; Lindström, Sara ; Kraft, Peter ; Mucci, LoreleiA

Purpose : Circadian genes may be involved in regulating cancer-related pathways, including cell proliferation, DNA damage response, and apoptosis. We aimed to assess the role of genetic variation in core circadian rhythm genes with the risk of fatal prostate cancer and first morning void urinary 6-sulfatoxymelatonin levels. Methods : We used unconditional logistic regression to evaluate the association of 96 single-nucleotide polymorphisms (SNPs) across 12 circadian-related genes with fatal [...]

Menée aux Etats-Unis auprès de 180 femmes âgées de 25 à 29 ans, cette étude de cohorte transversale évalue l'association entre le niveau d'hormones sexuelles endogènes, la densité mammaire et le risque de cancer du sein

Endogenous sex hormones and breast density in young women

Jung, Seungyoun ; Stanczyk, Frank Z. ; Egleston, Brian L. ; Snetselaar, Linda G ; Stevens, Victor J ; Shepherd, John A ; Horn, Linda Van ; LeBlanc, Erin S ; Paris, Kenneth ; Klifa, Catherine ; Dorgan, Joanne F

BACKGROUND: Breast density is a strong risk factor for breast cancer and reflects epithelial and stromal content. Breast tissue is particularly sensitive to hormonal stimuli before it fully differentiates following the first full-term pregnancy. Few studies have examined associations between sex hormones and breast density among young women. METHODS: We conducted cross-sectional study among 180 women aged 25-29 years old who participated in the Dietary Intervention Study in Children 2006 [...]