Menée aux Etats-Unis auprès de 182 patientes atteintes de tumeurs gynécologiques, cette étude analyse l'association entre l'obésité et leur qualité de vie

Obesity is associated with worse quality of life in women with gynecologic malignancies: An opportunity to improve patient-centered outcomes

Doll, Kemi M. ; Kalinowski, Alison K. ; Snavely, Anna C. ; Irwin, Debra E. ; Bensen, Jeannette T. ; Bae-Jump, Victoria L. ; Kim, Kenneth H. ; Van Le, Linda ; Clarke-Pearson, Daniel L. ; Gehrig, Paola A.

BACKGROUND The objective of the current study was to evaluate the effect of obesity on pretreatment quality of life (QoL) in gynecologic oncology patients. METHODS The authors analyzed collected data from an institution-wide cohort study of women with gynecologic cancers enrolled from August 2012 to June 2013. The Functional Assessment of Cancer Therapy-General, site-specific symptom scales, and the National Institutes of Health Patient-Reported Outcomes Measurement Information System (PROMIS) [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2013 (10 essais), cette étude analyse l'efficacité de divers médicaments du système nerveux central pour soulager une neuropathie périphérique induite par la chimiothérapie chez des patients atteints de cancer

Current use of drugs affecting the central nervous system for chemotherapy-induced peripheral neuropathy in cancer patients: a systematic review

Chu, SangHui ; Lee, YoungJoo ; Lee, EonSook ; Geng, Yimin ; Wang, XinShelley ; Cleeland, CharlesS

Purpose : Chemotherapy-induced peripheral neuropathy (CIPN) is common among cancer patients who undergo chemotherapy with platinum analogues, taxanes, vinca alkaloids, epothilone, bortezomib, and thalidomide. The purpose of this study was to investigate the evidence of using drugs affecting the central nervous system (CNS) to alleviate CIPN in cancer patients. Methods : A systematic literature search was conducted using the CINAHL, EMBASE, and Medline databases to identify randomized controlled [...]

Menée au Canada aupès de 21 participants, cette étude évalue l'efficacité d'un programme d'exercices physiques en groupe pour limiter les effets secondaires des traitements et améliorer la qualité de vie de survivants d'un cancer de la tête et du cou

A clinic-supported group exercise program for head and neck cancer survivors: managing cancer and treatment side effects to improve quality of life

Capozzi, LaurenC ; Boldt, KevinR ; Lau, Harold ; Shirt, Lisa ; Bultz, Barry ; Culos-Reed, S. Nicole

Purpose : The purpose of the evaluation of this clinic-supported 12-week progressive strength-training program was to assess the feasibility and impact of an exercise intervention for head and neck cancer (HNC) survivors. Methods : Recruitment and adherence feasibility, as well as health-related fitness measures and patient-reported symptom management were assessed on the 21 HNC survivors in the exercise program. Results : Overall, this program was feasible, as indicated by recruitment, [...]

Menée aux Etats-Unis auprès de 134 patients atteints d'un cancer de la tête et du cou et ayant reçu un traitement chirurgical, cette étude analyse l'association entre leur statut tabagique après l'opération et des indicateurs de qualité de vie (fatigue, douleur, symptômes dépressifs)

Post-operative smoking status in lung and head and neck cancer patients: association with depressive symptomatology, pain, and fatigue

Bloom, Erika Litvin ; Oliver, Jason A. ; Sutton, Steven K. ; Brandon, Thomas H. ; Jacobsen, Paul B. ; Simmons, Vani Nath

Objective : An estimated 35–50% of lung and head and neck cancer patients are smoking at diagnosis; most try to quit; however, a substantial proportion resumes smoking. As cancer treatments improve, attention to the effects of continued smoking on quality of life in the survivorship period is increasing. The current study examines if smoking abstinence following surgical treatment is associated with better quality of life. Methods : Participants were 134 patients with head and neck or lung [...]

Menée aux Etats-Unis auprès de 263 participants (âge moyen : 67 ans), cette étude rétrospective évalue le taux d'admissions hospitalières liées à la survenue d'une thrombose veineuse chez des patients atteints de cancer et venant de subir une chirurgie abdomino-pelvienne

Readmission rates due to venous thromboembolism in cancer patients after abdominopelvic surgery, a retrospective chart review

White, ChristineKlimowicz ; Langholtz, Jessica ; Burns, ZackoryT ; Kruse, Susan ; Sallee, Kimberly ; Henry, DavidH

Purpose : Venous thromboembolism (VTE) is a known cause of morbidity in the oncology patient population. As hospital readmission rates are more frequently scrutinized, we sought to determine the most common causes of 30-day readmissions in the cancer patient following abdominopelvic surgery. Furthermore, due to the high risk of VTE, there have been guidelines established for prophylaxis. As guidelines are based on asymptomatic VTE, we studied the compliance rates of these guidelines in our [...]

Menée à Taïwan auprès de 1 082 cas et 10 820 témoins, cette étude en population analyse l'association entre une leucémie myéloïde chronique et le risque de tuberculose

Risk and impact of tuberculosis in patients with chronic myeloid leukemia: A nationwide population-based study in Taiwan

Liu, Chia-Jen ; Hong, Ying-Chung ; Teng, Chung-Jen ; Hung, Man-Hsin ; Hu, Yu-Wen ; Ku, Fan-Chen ; Chen, Yung-Tai ; Chien, Sheng-Hsuan ; Yeh, Chiu-Mei ; Chen, Tzeng-Ji ; Chiou, Tzeon-Jye ; Gau, Jyh-Pyng ; Tzeng, Cheng-Hwai

The relationship between chronic myeloid leukemia (CML) and tuberculosis (TB) has not been determined. We conducted a national survey including 1,082 CML patients identified from the Taiwan National Health Insurance database covering a period between 1998 and 2011; the matched non-exposed cohort included 10,820 subjects without CML that were matched for age, sex and comorbidities. The impact of TB was measured by the overall mortality, and the risk factors were identified by a multivariate Cox [...]

A partir des données d'une cohorte américaine et d'une cohorte française (total de 680 patients atteints d'un lymphome diffus à grandes celllules B), cette étude évalue l'intérêt d'un protocle de suivi régulier, par imagerie, des patients après les traitements

Utility of Routine Post-Therapy Surveillance Imaging in Diffuse Large B-Cell Lymphoma

Thompson, Carrie A. ; Ghesquieres, Herve ; Maurer, Matthew J. ; Cerhan, James R. ; Biron, Pierre ; Ansell, Stephen M. ; Chassagne-Clément, Catherine ; Inwards, David J. ; Gargi, Thérèse ; Johnston, Patrick B. ; Nicolas-Virelizier, Emmanuelle ; Macon, William R. ; Peix, Marie ; Micallef, Ivana N. ; Sebban, Catherine ; Nowakowski, Grzegorz S. ; Porrata, Luis F. ; Weiner, George J. ; Witzig, Thomas E. ; Habermann, Thomas M. ; Link, Brian K.

Purpose : We examined the utility of post-therapy surveillance imaging in a large, prospectively enrolled cohort of patients with diffuse large B-cell lymphoma (DLBCL) from the United States and confirmed our results in an independent cohort of patients from France. Methods : Patients with newly diagnosed DLBCL and treated with anthracycline-based immunochemotherapy were identified from the Molecular Epidemiology Resource (MER) of the University of Iowa/Mayo Clinic Lymphoma Specialized Program [...]

A partir de données de deux essais prospectifs portant sur 1 033 patients atteints d'un cancer colorectal, cette étude analyse l'association entre des événements indésirables liés à une chimiothérapie adjuvante à base de 5-fluorouracile et de leucovorine, la survie sans maladie et la survie globale

Association of adverse events and survival in colorectal cancer patients treated with adjuvant 5-fluorouracil and leucovorin: Is efficacy an impact of toxicity?

Soveri, L. M. ; Hermunen, K. ; de Gramont, A. ; Poussa, T. ; Quinaux, E. ; Bono, P. ; André, T. ; Österlund, P.

Background : Adverse events associated with 5-fluorouracil (5FU) based adjuvant therapy in colorectal cancer (CRC) patients may predict survival. We studied whether haematological (leucopenia, neutropenia, thrombocytopenia) or non-haematological (mucositis, diarrhoea, nausea/vomiting, hand-foot syndrome or other toxicity) adverse events were associated with disease-free survival (DFS) or overall survival (OS) in a large patient material treated with 5-fluorouracil based adjuvant chemotherapy. [...]

Menée aux Etats-Unis auprès de 80 patients atteints d'un cancer de la prostate de stade avancé et recevant une hormonothérapie anti-androgénique, cette étude analyse les effets d'un soutien social sur l'association entre symptômes de stress et humeur des patients

Positive and negative mood in men with advanced prostate cancer undergoing androgen deprivation therapy: considering the role of social support and stress

Benedict, Catherine ; Dahn, Jason R. ; Antoni, Michael H. ; Traeger, Lara ; Kava, Bruce ; Bustillo, Natalie ; Zhou, Eric S. ; Penedo, Frank J.

Advanced prostate cancer patients often undergo androgen deprivation therapy (ADT). Advanced disease and adverse ADT side effects are often debilitating and negatively impact mood. Social support has been shown to mitigate detrimental effects of stress on mood. Objective : This study sought to characterize positive and negative mood in this select patient population and determine whether social support moderated relations between stress and mood. Methods : Participants (N = 80) completed the [...]

Menée aux Etats-Unis auprès de 173 participantes, cette étude de cohorte observationnelle analyse les fonctions cognitives et les troubles de nature neuropsychologique chez des patientes atteintes d'un cancer du sein de stade précoce après le début d'une hormonothérapie

Cognitive Function After the Initiation of Adjuvant Endocrine Therapy in Early-Stage Breast Cancer: An Observational Cohort Study

Ganz, Patricia A. ; Petersen, Laura ; Castellon, Steven A. ; Bower, Julienne E. ; Silverman, Daniel H.S. ; Cole, Steven W. ; Irwin, Michael R. ; Belin, Thomas R.

Purpose : This report examines cognitive complaints and neuropsychological (NP) testing outcomes in patients with early-stage breast cancer after the initiation of endocrine therapy (ET) to determine whether this therapy plays any role in post-treatment cognitive complaints. Patients and Methods : One hundred seventy-three participants from the Mind Body Study (MBS) observational cohort provided data from self-report questionnaires and NP testing obtained at enrollment (T1, before initiation of [...]

Cet article fait le point sur les enjeux psychologiques de la communication entre le médecin et son patient, principalement en matière de transition vers les soins palliatifs

Current State of the Art and Science of Patient-Clinician Communication in Progressive Disease: Patients' Need to Know and Need to Feel Known

van Vliet, Liesbeth M. ; Epstein, Andrew S.

Effective communication rests at the core of medicine, especially when patients are confronted with progressive disease and death. Communication can mitigate the distress of receiving bad news and influence patients’ psychological functioning and adaptation to a new situation.1-3 Whereas the benefits of good communication might seem clear, the costs of its failure are perhaps even clearer. Especially in progressive disease (which we define as entailing palliative and endof- life care in [...]

Menée en Allemagne auprès de 169 patients atteints de cancer, cette étude prospective analyse l'impact de l'entretien initial avec le médecin oncologue sur la peur de la progression et de la récidive de la maladie chez le patient

The initial clinical interview—can it reduce cancer patients’ fear?

Groß, SophieElisabeth ; Nitzsche, Anika ; Gloede, TristanD ; Ansmann, Lena ; Street, Richard ; Pfaff, Holger ; Neumann, Melanie ; Wirtz, Markus ; Baumann, Walter ; Schmitz, Stephan ; Ernstmann, Nicole

Purpose : A common phenomenon among cancer patients is a fear of cancer recurrence or cancer progression (FOP). The aim of the present study was to analyze whether the oncologist is able to reduce patients’ FOP at the initial clinical interview. Method : A prospective, longitudinal study included patients who were consulting private-practice oncologists in Germany for the first time. Recruitment was carried out by 44 members of the Professional Organization of Office-Based Hematologists and [...]

A partir d'une revue systématique de la littérature publiée entre 2006 et 2013 (42 études), cet article passe en revue les travaux récents sur l'évaluation des programmes de parcours de soins après cancer

Summing it up: An integrative review of studies of cancer survivorship care plans (2006-2013)

Mayer, Deborah K. ; Birken, Sarah A. ; Check, Devon K. ; Chen, Ronald C.

In 2006, the Institute of Medicine recommended that cancer survivors who are completing primary treatment receive a survivorship care plan (SCP) based on face validity. The state of scientific knowledge regarding the SCP is unclear. The authors conducted an integrative review of existing evidence regarding SCPs. The MEDLINE/PubMed database, the Excerpta Medica Database (EMBASE), and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) database were searched for relevant studies [...]