Cette étude passe en revue les mécanismes de développement d'une neuropathie périphérique induite par une chimiothérapie, sa prévention, sa prise en charge et les options thérapeutiques

Chemotherapy-induced peripheral neuropathy in the adult

Saad, Mehdi ; Tafani, Camille ; Psimaras, Dimitri ; Ricard, Damien

Purpose of review: This review focuses on the newest data on mechanistic aspects of chemotherapy-induced peripheral neuropathy (CIPN), its assessment and the current status of neuroprotection and treatment options. Recent findings: Several anticancer drugs are associated with CIPN. Rodent models showed that axons, dorsal root ganglia and terminal trees are affected, whereas myelin remains unaffected. Oxidative stress and mitochondrial damage, as well as the role of nerve growth factor, have [...]

Menée en Australie auprès de 25 survivants d'un cancer colorectal, cette étude évalue l'incidence d'une neuropathie périphérique induite par un traitement à base d'oxaliplatine ainsi que ses effets sur la qualité de vie au minimum deux ans après le début du traitement

Late effects of oxaliplatin-induced peripheral neuropathy (LEON)—cross-sectional cohort study of patients with colorectal cancer surviving at least 2 years

Padman, Sunita ; Lee, Jaein ; Kumar, Rajiv ; Slee, Mark ; Hakendorf, Paul ; Richards, Alison ; Koczwara, Bogda ; Kichenadasse, Ganessan ; Sukumaran, Shawgi ; Roy, Amitesh ; Vatandoust, Sina ; Karapetis, ChristosS

Objectives : Oxaliplatin accumulates in dorsal root ganglia, causing an axonal neuronopathy. Symptoms include numbness, pain and gait disturbance which may persist and impact on quality of life (QOL). Despite widespread use of this drug, its late effects and patient satisfaction outcomes have not been widely reported. Furthermore, there has been limited qualitative research published in this area. The objectives of this study were to establish the incidence and clinical impact of chronic [...]

Cette étude analyse les facteurs associés au risque de cardiotoxicité induite par les traitements anticancéreux et propose des stratégies de détection précoce ainsi que des modalités de traitement

An update on the risk prediction and prevention of anticancer therapy-induced cardiotoxicity

Bhave, Manali ; Shah, Ami N. ; Akhter, Nausheen ; Rosen, Steven T.

Purpose of review: Cardiotoxicity is a well established complication of anticancer therapy. As cancer survivorship and life expectancy for cancer patients improves, the morbidity and mortality of anticancer therapy-related cardiotoxicity has become more problematic. It is of utmost importance to identify patients at the highest risk for the development of cardiotoxicity and to determine strategies for prevention, early detection and treatment. Recent findings: Clinical risk factors, biomarkers, [...]

Mené auprès de 162 patients atteints d'une leucémie promyélocytaire aiguë, cet essai randomisé de phase III compare la qualité de vie associée à deux traitements, l'un combinant ATRA (acide tout-trans rétinoïque) et chimiothérapie, l'autre combinant ATRA et trioxyde d'arsenic

Randomized Phase III Trial of Retinoic Acid and Arsenic Trioxide Versus Retinoic Acid and Chemotherapy in Patients With Acute Promyelocytic Leukemia: Health-Related Quality-of-Life Outcomes

Efficace, Fabio ; Mandelli, Franco ; Avvisati, Giuseppe ; Cottone, Francesco ; Ferrara, Felicetto ; Di Bona, Eros ; Specchia, Giorgina ; Breccia, Massimo ; Levis, Alessandro ; Sica, Simona ; Finizio, Olimpia ; Kropp, Maria Grazia ; Fioritoni, Giuseppe ; Cerqui, Elisa ; Vignetti, Marco ; Amadori, Sergio ; Schlenk, Richard F. ; Platzbecker, Uwe ; Lo-Coco, Francesco

Purpose : A randomized clinical trial compared efficacy and toxicity of standard all-trans-retinoic acid (ATRA) plus chemotherapy versus ATRA plus arsenic trioxide in patients with newly diagnosed, low- or intermediate-risk acute promyelocytic leukemia (APL). Here, we report health-related quality-of-life (HRQOL) results. Patients and Methods : HRQOL was a secondary end point of this trial. The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire–Core 30 was [...]

Menée au Japon auprès de 96 patients atteints de tumeurs malignes thoraciques, cette étude analyse l'efficacité de l'aprépitant en prévention et en traitement des nausées et vomissements induits par la chimiothérapie

Therapeutic and preventive antiemetic effect of aprepitant in Japanese patients with thoracic malignancies who truly need it

Ito, Sumiyo ; Tsukiyama, Ikuto ; Ando, Masahiko ; Katakami, Masayo ; Hamanaka, Rie ; Kosaka, Kenshi ; Matsubara, Ayako ; Nishimura, Masaki ; Tanaka, Hiroyuki ; Asai, Nobuhiro ; Yokoe, Norihito ; Takahashi, Ayumu ; Baba, Kenji ; Matsuura, Katsuhiko ; Yamaguchi, Etsuro ; Kubo, Akihito

Purpose : Neurokinin-1 (NK-1) receptor antagonist is recommended for chemotherapy-induced nausea and vomiting (CINV) in highly emetogenic chemotherapy (HEC) and has recently been introduced to oncology practice in Japan. However, whether all patients undergoing HEC truly need NK-1 receptor antagonist remains unknown, and increasing medical costs due to uniform use of NK-1 receptor antagonist are a concern. This study was conducted to examine the prevalence of patients who needed aprepitant at [...]

A partir des données du registre néerlandais des cancers portant sur 1 643 survivants d'un cancer colorectal diagnostiqué entre 2000 et 2009, cette étude longitudinale analyse l'association entre leur dégré d'alphabétisation, leurs comportements de santé et leur qualité de vie

Low subjective health literacy is associated with adverse health behaviors and worse health-related quality of life among colorectal cancer survivors: results from the profiles registry

Husson, O. ; Mols, F. ; Fransen, M. P. ; van de Poll-Franse, L. V. ; Ezendam, N. P. M.

Background : The objectives of the study were to examine the prevalence of health literacy (HL) among colorectal cancer (CRC) survivors and the relation between HL and health behaviors and to explore whether or not HL and health behaviors are independently associated with health-related quality of life (HRQoL) and mental distress. Methods : This analysis is part of a longitudinal, population-based survey among CRC survivors diagnosed between 2000 and 2009 and registered by the Eindhoven Cancer [...]

Menée en Italie auprès de 102 patients atteints d'un cancer de la tête et du cou, cette étude transversale analyse l'efficacité d'un questionnaire permettant aux patients de signaler une xérostomie induite par la radiothérapie

Assessment of radiation-induced xerostomia: validation of the Italian version of the xerostomia questionnaire in head and neck cancer patients

Pellegrino, Federica ; Groff, Elena ; Bastiani, Luca ; Fattori, Bruno ; Sotti, Guido

Purpose : Xerostomia is the most common acute and late side effect of radiation treatment for head and neck cancer. Affecting taste perception, chewing, swallowing and speech, xerostomia is also the major cause of decreased quality of life. The aims of this study were to validate the Italian translation of the self-reported eight-item xerostomia questionnaire (XQ) and determine its psychometric properties in patients treated with radiotherapy for head and neck cancer. Methods : An observational [...]

Menée dans une région industrialisée d'Italie (Vénétie), cette étude analyse l'évolution de l'incidence du mésothéliome sur la période 1987-2010 et présente des projections pour la période 2011-2026

Past trends and future prediction of mesothelioma incidence in an industrialized area of Italy, the Veneto Region

Girardi, Paolo ; Bressan, Vittoria ; Merler, Enzo

Background : Malignant Mesothelioma (MM) is so associated with (professional, familial or environmental) asbestos exposure that trends in incidence and mortality parallel, after 30–40 years, the trend in asbestos consumption. In recent decades, the industrialized countries have witnessed a steady growth of pleural MM (MPM), following a stabilization or decline in rates in the countries that first adopted restrictive policies. The aim of this study was to evaluate the temporal variations of [...]

Menée à Taïwan auprès de 22 257 participantes , cette étude de cohorte évalue l'association entre l'utilisation de tamoxifène et le risque de diabète chez des patientes atteintes d'un cancer du sein diagnostiqué entre 2000 et 2004

Association of tamoxifen use and increased diabetes among Asian women diagnosed with breast cancer

Sun, L. M. ; Chen, H. J. ; Liang, J. A. ; Li, T. C. ; Kao, C. H.

Background: We conducted a population-based cohort study to assess whether tamoxifen treatment is associated with an increased incidence of diabetes. Methods: Data obtained from the Taiwanese National Health Insurance Research Database were used for a population-based cohort study. The study cohort included 22 257 breast cancer patients diagnosed between 1 January 2000 and 31 December 2004. Among them, 15 210 cases received tamoxifen treatment and 7047 did not. Four subjects without breast [...]

Menée au Royaume-Uni, cette étude analyse l'évolution de l'incidence du cancer du sein chez une population de femmes originaires du sud de l'Asie, sur la période 2001-2011

Temporal changes in breast cancer incidence in South Asian women

Stotter, Anne ; Jenkins, Jacquie ; Edmondson-Jones, Mark ; Blackledge, Hanna ; Kearins, Olive

Background : Breast cancer in the UK resident population of South Asian ethnicity has been lower than that in indigenous women. Leicester has a large South Asian population and a breast cancer unit with comprehensive data on diagnosed cancers. This study analysed the annual incidence of new breast cancer diagnoses in females from 1998 to 2009 to determine any changes in recent years. Methods : Ethnicity was known in over 98% of cases. Population denominators were based on published figures for [...]

A partir des données des registres américains des cancers, cette étude analyse l'évolution de l'incidence du cancer du sein chez les femmes afro-américaines, sur la période 2008-2010

Changing in the pattern of breast cancer burden among African-American Evidence based on 29 states and District of Columbia during 1998−2010

Sighoko, Dominique ; Fackenthal, James D. ; Hainaut, Pierre

Purpose : Assessment of breast cancer (BC) pattern in individual states with respect to ethnicity. Methods Population-based cancer registries from the Cancer Incidence in Five Continents databases (1998−2007) supplemented with SEER data from 2008−2010 were used. Results : The age-specific burden showed a clear convergence of BC burden among African American (AA) and Caucasian American (CA) in most states. This was primarily due to a decrease in the BC rate among CA aged ≥50 years, and an [...]

A partir des données du registre californien des cancers portant sur 225 441 patientes atteintes d'un cancer du sein invasif de stade 1 à 4, cette étude analyse les disparités dans le risque de cancer du sein, par sous-type histologique, chez sept ethnies d'origine asiatique

Disparities in the risk of the ER/PR/HER2 breast cancer subtypes among Asian Americans in California

Parise, Carol ; Caggiano, Vincent

Background : Population-based studies of breast cancer often aggregate all Asians into a single category termed Asian/Pacific Islander (API). Purpose (1) Describe the demographic and clinicopathologic features of early breast cancer utilizing all eight ER/PR/HER2 subtypes among white, black, Hispanic, American Indian, seven Asian ethnicities, and the aggregate API category; (2) ascertain the risk of the ER+/PR+/HER2+, ER−/PR−/HER2−, and ER−/PR−/HER2+ subtypes when compared with the [...]

Menée au Danemark auprès de 18 251 patientes atteintes d'un cancer du sein, cette étude de cohorte prospective évalue l'association entre l'utilisation de glucocorticoïdes (anti-inflammatoires stéroïdiens) et le risque de récidive de cancer

Glucocorticoid Prescriptions and Breast Cancer Recurrence: A Danish nationwide prospective cohort study

Lietzen, L. W. ; Ahern, T. ; Christiansen, P. ; Jensen, A. B. ; Sørensen, H. T. ; Lash, T. L. ; Cronin-Fenton, D. P.

Background : Treatment with synthetic glucocorticoids (GCs) depresses the immune response and may therefore modify cancer outcomes. We investigated the association between GC use and breast cancer recurrence. Materials and methods: We conducted a population-based cohort study to examine the risk of breast cancer recurrence associated with GC use among incident stage I–III female breast cancer patients aged >18 years diagnosed 1996-2003 in Denmark. Data on patients, clinical and treatment [...]

A partir des données de 13 registres américains des cancers portant sur des patients atteints d'un cancer de la thyroïde, cette étude analyse l'association entre l'âge du médecin faisant le diagnostic et l'incidence de ce cancer

Age of diagnosing physician impacts the incidence of thyroid cancer in a population

Nagar, Sapna ; Aschebrook-Kilfoy, Briseis ; Kaplan, EdwinL ; Angelos, Peter ; Grogan, RaymonH

Background : Thyroid ultrasound and fine-needle aspiration (FNA) have been implicated in the overdiagnosis of thyroid cancer. To study how the use of diagnostic tools impacts thyroid cancer incidence, we propose using physician age as a surrogate. We aimed to determine whether thyroid cancer incidence is higher in areas with a high density of young physicians compared with areas with a high density of older physicians. Methods : SEER 13 database was used to determine thyroid cancer incidence. [...]

Menée aux Etats-Unis auprès de 883 patients atteints de cancer et traités à l'extérieur de l'hôpital (âge moyen : 65, 5 ans), cette étude rétrospective évalue l'association entre leur bien-être spirituel, des symptômes liés à la maladie (dépression, anxiété, fatigue, douleur, etc) et l'efficacité du traitement anti-cancer et des soins palliatifs concomitants

Spiritual well-being among outpatients with cancer receiving concurrent oncologic and palliative care

Rabow, MichaelW ; Knish, SarahJ

Purpose : Spiritual well-being is threatened by cancer, but its correlation with other illness symptoms and the efficacy of palliative care (PC) to ameliorate spiritual suffering are not well understood. Methods : We conducted a retrospective study using a convenience sample of oncology patients at a comprehensive cancer center who received concurrent oncologic and palliative care between 2008 and 2011 and completed ESAS, QUAL-E, and Steinhauser Spiritual well-being survey questions was [...]

Cette étude américaine passe en revue les travaux récents sur les effets psychologiques, à court et long terme, associés à la réalisation d'un test génétique pour identifier un risque héréditaire de cancer

Psychiatric implications of cancer genetic testing

Hirschberg, April Malia ; Chan-Smutko, Gayun ; Pirl, William F.

As genetic testing for hereditary cancer syndromes has transitioned from research to clinical settings, research regarding its accompanying psychosocial effects has grown. Men and women being tested for hereditary cancer syndromes may experience some psychological distress while going through the process of testing or after carrier status is identified. Psychological distress appears to decrease over the course of the first year and it is typically not clinically significant. Longer term [...]

Menée dans 27 pays européens sur la période 1990-2009, cette étude analyse les effets de la crise économique (accroissement du taux de chômage, réduction des dépenses de santé) sur la mortalité par cancer du sein

Unemployment, public-sector health-care spending and breast cancer mortality in the European Union: 1990–2009

Maruthappu, Mahiben ; Watkins, Johnathan A. ; Waqar, Mueez ; Williams, Callum ; Ali, Raghib ; Atun, Rifat ; Faiz, Omar ; Zeltner, Thomas

Background: The global economic crisis has been associated with increased unemployment, reduced health-care spending and adverse health outcomes. Insights into the impact of economic variations on cancer mortality, however, remain limited. Methods: We used multivariate regression analysis to assess how changes in unemployment and public-sector expenditure on health care (PSEH) varied with female breast cancer mortality in the 27 European Union member states from 1990 to 2009. We then determined [...]

Menée à Mexico auprès de 169 professionnels de santé (âge moyen : 36 ans), cette étude analyse l'efficacité d'un programme de formation destiné à améliorer leurs connaissances relatives au cancer du sein

Evaluation of Breast Cancer Knowledge Among Health Promoters in Mexico Before and After Focused Training

Keating, Nancy L. ; Kouri, Elena M. ; Ornelas, Héctor Arreola ; Méndez, Oscar ; Valladares, Laura Magaña ; Knaul, Felicia Marie

Objective. Breast cancer is a leading cause of morbidity and mortality in Mexico. We assessed the effectiveness of a train-the-trainer program in two Mexican states in improving knowledge among professional and nonprofessional community health workers. Materials and Methods. We worked with local organizations to develop and implement a train-the-trainer program to improve breast cancer knowledge among community health workers, including professional health promoters (PHPs) who were trained and [...]

Menée au Canada auprès de 368 patients atteints d'un cancer de stade avancé et traités à l'extérieur de l'hôpital, cette étude analyse l'intérêt d'un outil d'évaluation de l'état des patients, appelé "Palliative Performance Scale", pour les orienter vers un service de soins palliatifs

Palliative performance scale and survival among outpatients with advanced cancer

Myers, Jeff ; Kim, Audrey ; Flanagan, Jamie ; Selby, Debbie

Purpose : Previous studies have examined the association between the Palliative Performance Scale (PPS) and survival duration; however, few have examined patients with incurable cancer in the outpatient setting. In addition to exploring this association further, the purpose of this study was to identify key PPS markers that could serve as triggers to signify the need for key care discussions. Methods : Study subjects were followed prospectively from the time of referral for a specialist [...]

Cet article américain analyse la controverse sur l'intérêt des approches intégrant médecines complémentaires et alternatives en oncologie

Integrative oncology: really the best of both worlds?

Gorski, David H.

Over the past two decades there has been a growing acceptance of 'integrative oncology', also known as complementary and alternative medicine (CAM), in cancer care and research at academic medical centres and medical schools. Proponents of integrative oncology argue that it is based in science and provides the 'best of both worlds' by combining science-based treatments and 'holistic' medicine. However, a close examination of the methodologies indicates that, from a standpoint of basic science, [...]

Menée au Canada par enquête auprès de 111 oncologues radiothérapeutes, cette étude analyse leurs pratiques dans les soins de suivi dédiés aux survivants d'un cancer

Follow-up patterns of cancer survivors: a survey of Canadian radiation oncologists

Ye, AllisonY ; Cheung, WinsonY ; Goddard, KarenJ ; Horvat, Daniel ; Olson, RobertA

Purpose : With continual advancements in cancer care, improved outcomes, and increasing survivors, survivorship has become an important area of research. This project seeks to determine the current status of follow-up care in oncology. Methods : An electronic survey was sent to the Canadian Association of Radiation Oncology members. Based on brief clinical scenarios pertaining to various survivor populations, questions were posed to determine routine follow-up practices. Results : One hundred [...]

Menée aux Etats-Unis à partir de données portant sur 22 666 participants atteints d'un cancer de la prostate diagnostiqué entre 2000 et 2010, cette étude analyse la variabilité des dates du diagnostic selon les diverses sources d'information

Variability in Date of Prostate Cancer Diagnosis: A Comparison of Cancer Registry, Pathology Report, and Electronic Health Data Sources

Porter, Kimberly R. ; Chao, Chun ; Quinn, Virginia P. ; Hsu, Jin-Wen Y. ; Jacobsen, Steven J.

Purpose : The date of cancer diagnosis is a critical data element for clinical care and research. Because this date can be abstracted from various data sources, its comparability from source to source is unclear. This study compared the date of diagnosis from multiple sources within the same population of prostate cancer patients. Methods : We linked cancer registry, pathology report, and electronic health data sources from the Kaiser Permanente Southern California health data systems for a [...]