A partir d'une revue de la littérature (56 études), cette méta-analyse évalue l'association entre une exposition professionnelle à du chrome hexavalent inhalé et le risque de cancer de l'estomac

Chromium VI and stomach cancer: a meta-analysis of the current epidemiological evidence

Welling, Roberta ; Beaumont, James J ; Petersen, Scott J ; Alexeeff, George V ; Steinmaus, Craig

Objectives : Chromium VI (hexavalent chromium, Cr(VI)) is an established cause of lung cancer, but its association with gastrointestinal cancer is less clear. The goal of this study was to examine whether the current human epidemiological research on occupationally inhaled Cr(VI) supports the hypothesis that Cr(VI) is associated with human stomach cancer. Methods : Following a thorough literature search and review of individual studies, we used meta-analysis to summarise the current [...]

A partir des données des certificats de décès et menée en milieu rural au centre du Mexique, cette étude rétrospective évalue l'association entre une exposition environnementale à des fibres d'érionite et le risque de cancer du poumon ou de mésothéliome malin

High incidence of lung cancer and malignant mesothelioma linked to erionite fibre exposure in a rural community in Central Mexico

Ortega-Guerrero, M Adrián ; Carrasco-Núñez, Gerardo ; Barragán-Campos, Héctor ; Ortega, Martín R

Objective : To report the high incidence of lung cancer (LC) and malignant mesothelioma (MM) linked to environmental exposure to erionite fibres in a rural village of central Mexico. Methods : This is a retrospective survey of clinical and mortality records from the years 2000–2012, accompanied by an environmental survey for nine Group-1 lung and pleura carcinogenic agents listed by the International Agency for Research on Cancer (IARC). Results : Out of a total of 45 deaths between 2000 and [...]

A partir d'une revue systématique de la littérature publiée jusqu'en 2014 (41 études), cette étude fait le point sur l'association entre des infections par différents virus et le risque de cancer colorectal

Viral infections and colorectal cancer: A systematic review of epidemiological studies

Chen, Hongda ; Chen, Xin-Zu ; Waterboer, Tim ; Castro, Felipe Andres ; Brenner, Hermann

Numerous studies have found the presence of viral DNA in colorectal tumor tissues. However, whether viral infections contribute to the risk of colorectal cancer (CRC) is still under debate. We aimed to provide an overview of published epidemiological studies on the association between viral infections and CRC. A systematic literature search was performed in PubMed to find relevant studies published until 8 May 2014. Information collected included study population, sample type, laboratory method [...]

Menée aux Etats-Unis auprès de 1 072 femmes porteuses de gènes mutés BRCA1 ou BRCA2, cette étude évalue l'association entre la présence de mutations et le risque de cancer autre que le cancer du sein ou le cancer de l'ovaire

Cancers associated with BRCA1 and BRCA2 mutations other than breast and ovarian

Mersch, Jacqueline ; Jackson, Michelle A. ; Park, Minjeong ; Nebgen, Denise ; Peterson, Susan K. ; Singletary, Claire ; Arun, Banu K. ; Litton, Jennifer K.

BACKGROUND Previous studies have reported additional cancers associated with BRCA mutations; however, the type, magnitude of risk, and sex differences remain to be clarified. The purpose of this study was to evaluate the incidence of cancers other than breast and ovarian cancer in known mutation carriers. METHODS An institutional review board–approved study identified 1072 patients who had genetic counseling at the authors' institution and tested positive for a deleterious BRCA mutation. The [...]

Menée auprès de 289 patients britaniques puis auprès de 748 patients italiens, cette étude évalue l'association entre 86 polymorphismes à simple nucléotide de la lignée germinale et la survie des patients atteints d'un adénocarcinome pulmonaire

Germline polymorphisms and survival of lung adenocarcinoma patients: A genome-wide study in two European patient series

Galvan, Antonella ; Colombo, Francesca ; Frullanti, Elisa ; Dassano, Alice ; Noci, Sara ; Wang, Yufei ; Eisen, Timothy ; Matakidou, Athena ; Tomasello, Luisa ; Vezzalini, Marzia ; Sorio, Claudio ; Dugo, Matteo ; Ambrogi, Federico ; Iacobucci, Ilaria ; Martinelli, Giovanni ; Incarbone, Matteo ; Alloisio, Marco ; Nosotti, Mario ; Tosi, Davide ; Santambrogio, Luigi ; Pelosi, Giuseppe ; Pastorino, Ugo ; Houlston, Richard S. ; Dragani, Tommaso A.

In lung cancer, the survival of patients with the same clinical stage varies widely for unknown reasons. In this two-phase study, we examined the hypothesis that germline variations influence the survival of patients with lung adenocarcinoma. First, we analyzed existing genotype and clinical data from 289 UK-resident patients with lung adenocarcinoma, identifying 86 single nucleotide polymorphisms (SNPs) that associated with survival (p < 0.01). We then genotyped these candidate SNPs in a [...]

Menée aux Etats-Unis auprès de 1 946 cas et 1 747 témoins, cette étude évalue l'association entre 18 polymorphismes des gènes CYB5A et CYB5R3 et le risque de cancer du sein en fonction de l'origine ethnique

Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women

Blanke, KristinaL ; Sacco, JamesC ; Millikan, RobertC ; Olshan, AndrewF ; Luo, Jingchun ; Trepanier, LaurenA

Purpose : Cytochrome b 5 (encoded by CYB5A) and NADH cytochrome b 5 reductase (encoded by CYB5R3) detoxify aromatic and heterocyclic amine mammary carcinogens found in cigarette smoke. We hypothesized that CYB5A and CYB5R3 polymorphisms would be associated with breast cancer risk in women. Methods : We characterized the prevalence of 18 CYB5A and CYB5R3 variants in genomic DNA from African American (AfrAm) and Caucasian (Cauc) women from the Carolina Breast Cancer Study population (1,946 cases [...]

Menée en Chine auprès de 3 976 cas et 1 342 témoins, cette étude évalue l'association entre des polymorphismes du gène NF-κB, la persistence d'une infection par le virus de l'hépatite B et le risque de carcinome hépatocellulaire

Effect of functional nuclear factor kappaB genetic polymorphisms on hepatitis B virus persistence and their interactions with viral mutations on the risk of hepatocellular carcinoma

Zhang, Q. ; Ji, X. W. ; Hou, X. M. ; Lu, F. M. ; Du, Y. ; Yin, J. H. ; Sun, X. Y. ; Deng, Y. ; Zhao, J. ; Han, X. ; Yang, G. S. ; Zhang, H. W. ; Chen, X. M. ; Shen, H. B. ; Wang, H. Y. ; Cao, G. W.

Background: Non-resolving inflammation and viral mutations are important in hepatitis B virus (HBV)-induced hepatocarcinogenesis. However, the effects of genetic polymorphisms affecting nuclear factor kappaB (NF-κB) on HBV persistence and generation of hepatocellular carcinoma (HCC)-related HBV mutations remain unknown. Patients and methods : rs28362491 (NFKB1 -94Ins>Del), rs2233406 (NFKBIA -826C>T), rs3138053 (NFKBIA -881A>G), and rs696 (NFKBIA +2758G>A) were genotyped in 1,342 healthy [...]