Menée en Pologne auprès de 575 cas et 575 témoins, cette étude évalue l'association entre le taux d'un métabolite du bisphénol A mesuré dans les urines et le risque de cancer du sein après la ménopause

Urinary bisphenol A-glucuronide and postmenopausal breast cancer in Poland

Trabert, Britton ; Falk, RoniT ; Figueroa, JonineD ; Graubard, BarryI ; Garcia-Closas, Montserrat ; Lissowska, Jolanta ; Peplonska, Beata ; Fox, StephenD ; Brinton, LouiseA

Purpose : Concerns regarding a possible link between bisphenol A (BPA) and breast cancer have been mounting, but studies in human populations are lacking. We evaluated the association between the major urinary BPA metabolite [BPA-glucuronide (BPA-G)] and postmenopausal breast cancer risk in a large population-based case–control study conducted in two cities in Poland (2000–2003); we further explored the association of BPA-G levels with known postmenopausal breast cancer risk factors in our [...]

Menée aux Etats-Unis auprès de 1 044 cas et 469 témoins (âge : de 55 à 74 ans), cette étude évalue l'association entre le fait de porter un soutien-gorge et le risque de cancer du sein chez des femmes ménopausées

Bra Wearing Not Associated with Breast Cancer Risk: A Population-Based Case–Control Study

Chen, Lu ; Malone, Kathleen E. ; Li, Christopher I.

Despite the widespread use of bras among U.S. women and concerns in the lay media that bra wearing may increase breast cancer risk, there is a scarcity of credible scientific studies addressing this issue. The goal of the study was to evaluate the relationship between various bra-wearing habits and breast cancer risk among postmenopausal women. We conducted a population-based case–control study of breast cancer in the Seattle–Puget Sound metropolitan area that compared 454 invasive ductal [...]

Cet article passe en revue les travaux récents suggérant que, dans le cadre d'une reconstruction mammaire, une greffe de tissus adipeux blancs serait associée à un risque de néoplasie intraépithéliale

Obesity, proinflammatory mediators, adipose tissue progenitors, and breast cancer

Bertolini, Francesco ; Orecchioni, Stefania ; Petit, Jean-Yves ; Kolonin, Mikhail G.

Purpose of review: There is emerging evidence that obesity is associated with an increase in the incidence, severity, and mortality from different types of cancer, including postmenopausal breast cancer. Here, we discuss the role of white adipose tissue (WAT) cells and of related soluble factors in the local and metastatic growth of this neoplastic disease. Moreover, we discuss the recent increase in the use of WAT-derived progenitor cells in breast cancer patients to enhance the quality of [...]

A partir d'une revue de la littérature publiée depuis 2004, cette étude analyse les différents facteurs associés au risque de tumeurs cérébrales chez l'enfant

Childhood Brain Tumor Epidemiology: A Brain Tumor Epidemiology Consortium Review

Johnson, Kimberly J. ; Cullen, Jennifer ; Barnholtz-Sloan, Jill S. ; Ostrom, Quinn T. ; Langer, Chelsea E. ; Turner, Michelle C. ; McKean-Cowdin, Roberta ; Fisher, James L. ; Lupo, Philip J. ; Partap, Sonia ; Schwartzbaum, Judith A. ; Scheurer, Michael E.

Childhood brain tumors are the most common pediatric solid tumor and include several histological subtypes. Although progress has been made in improving survival rates for some subtypes, understanding of risk factors for childhood brain tumors remains limited to a few genetic syndromes and ionizing radiation to the head and neck. In this report, we review descriptive and analytical epidemiology childhood brain tumor studies from the past decade and highlight priority areas for future [...]

Couplée aux données de la cohorte "Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial" et portant sur 195 cas et 195 témoins, cette étude américaine évalue l'association entre le niveau sérique d'hormones sexuelles stéroïdiennes et le risque de cancer aggressif de la prostate

Sex steroid hormone metabolism in relation to risk of aggressive prostate cancer

Black, Amanda ; Pinsky, Paul F. ; Grubb, Robert L. ; Falk, Roni T. ; Hsing, Ann W. ; Chu, Lisa ; Meyer, Tamra ; Veenstra, Timothy D. ; Xu, Xia ; Yu, Kai ; Ziegler, Regina G. ; Brinton, Louise A. ; Hoover, Robert N. ; Cook, Michael B.

Background: The combined action of androgens and estrogens-specifically their balance-may play a role in prostate carcinogenesis but existing evidence is sparse and inconsistent. We investigated associations between serum sex steroid hormones, including estrogen metabolites, and risk of aggressive prostate cancer. Methods: In a case-control study nested within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial cohort we measured serum estrone, estradiol and 13 estrogen [...]

Couplée aux données de la base britannique "General Practice Research Database" et portant sur 849 cas et 3 417 témoins, cette étude analyse l'association entre des maladies auto-immunes et le risque de syndromes myélodysplasiques

Relative risk of myelodysplastic syndromes in patients with autoimmune disorders in the General Practice Research Database

Wilson, Amanda B. ; Neogi, Tuhina ; Prout, Marianne ; Jick, Susan

Background: Certain immunosuppressant drugs are known to increase the risk of myeloid neoplasms although it is unclear if underlying autoimmune disorder itself increases the risk of myeloid neoplasms. Methods: Using a nested case-control study in the General Practice Research Database (GPRD), we estimated the relative risk of myeloid neoplasms, specifically myelodysplastic syndromes (MDS) in patients with autoimmune disorders compared with patients without autoimmune disorders. Results: We [...]

Menée en population chinoise initialement sur 993 cas de carcinome épidermoïde du larynx et 1 995 témoins, puis validée sur 2 398 cas et 2 804 témoins, cette étude d'association sur le génome entier identifie trois nouveaux loci de susceptibilité à la maladie sur les régions chromosomiques 11q12, 6p21 et 12q24

Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population

Wei, Qingyi ; Yu, Dianke ; Liu, Mingbo ; Wang, Mengyun ; Zhao, Miaoqing ; Liu, Ming ; Jia, Weihua ; Ma, Hongxia ; Fang, Jugao ; Xu, Wei ; Chen, Kexing ; Xu, Zhengang ; Wang, Jialing ; Tian, Linli ; Yuan, Hua ; Chang, Jiang ; Hu, Zhibin ; Wei, Lixun ; Huang, Ying ; Han, Yaling ; Liu, Jie ; Han, Demin ; Shen, Hongbing ; Yang, Shiming ; Zheng, Hong ; Ji, Qinghai ; Li, Duanshu ; Tan, Wen ; Wu, Chen ; Lin, Dongxin

To identify genetic markers for laryngeal squamous cell carcinoma (LSCC), we conducted a genome-wide association study (GWAS) on 993 individuals with LSCC (cases) and 1,995 cancer-free controls from Chinese populations. The most promising variants (association P < 1 × 10−5) were then replicated in 3 independent sets including 2,398 cases and 2,804 controls, among which we identified 3 new susceptibility loci at 11q12 (rs174549), 6p21 (rs2857595) and 12q24 (rs10492336). The minor alleles of each [...]

Menée aux Etats-Unis auprès de 518 cas et 597 témoins, cette étude évalue l'effet de 24 polymorphismes à simple nucléotide de 16 gènes impliqués dans la réparation de l'ADN sur l'association entre l'utilisation de produits colorants pour cheveux et le risque de lymphome non hodgkinien

Polymorphisms in DNA repair genes, hair dye use, and the risk of non-Hodgkin lymphoma

Guo, Huan ; Bassig, BryanA ; Lan, Qing ; Zhu, Yong ; Zhang, Yawei ; Holford, TheodoreR ; Leaderer, Brian ; Boyle, Peter ; Qin, Qin ; Zhu, Cairong ; Li, Ni ; Rothman, Nathaniel ; Zheng, Tongzhang

Purpose : Genetic polymorphisms in DNA repair genes and hair dye use may both have a role in the development of non-Hodgkin lymphoma (NHL). We aimed to examine the interaction between variants in DNA repair genes and hair dye use with risk of NHL in a population-based case–control study of Connecticut women. Methods : We examined 24 single nucleotide polymorphisms in 16 DNA repair genes among 518 NHL cases and 597 controls and evaluated the associations between hair dye use and risk of overall [...]

Menée en Europe auprès de 9 006 cas et 9 503 témoins, cette étude évalue l'effet de polymorphismes à simple nucléotide de gènes impliqués dans des voies de signalisation liées au calcium, et précédemment identifiés dans des études d'association sur le génome entier, sur l'association entre consommation de calcium et risque de cancer colorectal

No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk

Du, Mengmeng ; Zhang, Xuehong ; Hoffmeister, Michael ; Schoen, Robert E ; Baron, John ; Berndt, Sonja I. ; Brenner, Hermann ; Carlson, Christopher S. ; Casey, Graham ; Chan, Andrew T. ; Curtis, Keith R ; Duggan, David ; Gauderman, W. James ; Giovannucci, Edward L. ; Gong, Jian ; Harrison, Tabitha A. ; Hayes, Richard B. ; Henderson, Brian E ; Hopper, John L. ; Hsu, Li ; Hudson, Thomas J ; Hutter, Carolyn M. ; Jenkins, Mark A. ; Jiao, Shuo ; Kocarnik, Jonathan M. ; Kolonel, Laurence N ; Le Marchand, Loic ; Lin, Yi ; Newcomb, Polly A. ; Rudolph, Anja ; Seminara, Daniela ; Thornquist, Mark ; Ulrich, Cornelia M. ; White, Emily ; Wu, Kana ; Zanke, Brent W. ; Campbell, Peter T. ; Slattery, Martha L. ; Peters, Ulrike ; Chang-Claude, Jenny ; Potter, John D.

Background: Calcium intake may reduce risk of colorectal cancer (CRC), but the mechanisms remain unclear. Studies of interaction between calcium intake and single nucleotide polymorphisms (SNPs) in calcium-related pathways have yielded inconsistent results. Methods: To identify gene-calcium interactions, we tested interactions between ~2.7 million SNPs across the genome with self-reported calcium intake (from dietary or supplemental sources) in 9,006 CRC cases and 9,503 controls of European [...]