Mené sur 147 patients présentant des métastases osseuses douloureuses, cet essai multicentrique de phase III évalue l'efficacité, pour réduire la douleur des patients, et la sécurité d'une technique à base d'ultrasons focalisés guidés par résonance magnétique

Magnetic Resonance–Guided Focused Ultrasound for Patients With Painful Bone Metastases: Phase III Trial Results

Hurwitz, Mark D. ; Ghanouni, Pejman ; Kanaev, Sergey V. ; Iozeffi, Dmitri ; Gianfelice, David ; Fennessy, Fiona Mary ; Kuten, Abraham ; Meyer, Joshua E. ; LeBlang, Suzanne D. ; Roberts, Ann ; Choi, Junsung ; Larner, James M. ; Napoli, Alessandro ; Turkevich, Vladimir G. ; Inbar, Yael ; Tempany, Clare Mary C. ; Pfeffer, Raphael M.

Background : Pain due to bone metastases is a common cause of cancer-related morbidity, with few options available for patients refractory to medical therapies and who do not respond to radiation therapy. This study assessed the safety and efficacy of magnetic resonance-guided focused ultrasound surgery (MRgFUS), a noninvasive method of thermal tissue ablation for palliation of pain due to bone metastases. Methods : Patients with painful bone metastases were randomly assigned 3:1 to receive [...]

A partir d'une revue systématique de la littérature publiée jusqu'en janvier 2011 et à partir de données issues de rapports d'études cliniques, cette méta-analyse (37 essais, 10 581 patients) évalue les effets des médicaments stimulant l'érythropoïèse sur les symptômes de fatigue et d'anémie chez les patients atteints d'un cancer traité par chimiothérapie

Effects of erythropoiesis-stimulating agents on fatigue- and anaemia-related symptoms in cancer patients: systematic review and meta-analyses of published and unpublished data

Bohlius, J. ; Tonia, T. ; Nuesch, E. ; Juni, P. ; Fey, M. F. ; Egger, M. ; Bernhard, J.

Background : Erythropoiesis-stimulating agents (ESAs) reduce the need for red blood cell transfusions; however, they increase the risk of thromboembolic events and mortality. The impact of ESAs on quality of life (QoL) is controversial and led to different recommendations of medical societies and authorities in the USA and Europe. We aimed to critically evaluate and quantify the effects of ESAs on QoL in cancer patients. Methods : We included data from randomised controlled trials (RCTs) on the [...]

Menée à partir de questionnaires auprès de 4 560 patientes ménopausées incluses dans un essai évaluant l'intérêt de l'exémestane, un inhibiteur stéroïdien de l'aromatase, pour réduire le risque de cancer du sein, cette étude évalue l'effet du traitement sur la qualité de vie des patientes

Quality of Life in MAP.3 (Mammary Prevention 3): A Randomized, Placebo-Controlled Trial Evaluating Exemestane for Prevention of Breast Cancer

Maunsell, Elizabeth ; Goss, Paul E. ; Chlebowski, Rowan T. ; Ingle, James N. ; Alés-Martínez, José E. ; Sarto, Gloria E. ; Fabian, Carol J. ; Pujol, Pascal ; Ruiz, Amparao ; Cooke, Andrew L. ; Hendrix, Susan ; Thayer, Debra W. ; Rowland, Kendrith M. ; Dubé, Pierre ; Spadafora, Silvana ; Pruthi, Sandhya ; Lickley, Lavina ; Ellard, Susan L. ; Cheung, Angela M. ; Wactawski-Wende, Jean ; Gelmon, Karen A. ; Johnston, Dianne ; Hiltz, Andrea ; Brundage, Michael ; Pater, Joseph L. ; Tu, Dongsheng ; Richardson, Harriet

Purpose : Exemestane, a steroidal aromatase inhibitor, reduced invasive breast cancer incidence by 65% among 4,560 postmenopausal women randomly assigned to exemestane (25 mg per day) compared with placebo in the National Cancer Institute of Canada (NCIC) Clinical Trials Group MAP.3 (Mammary Prevention 3) trial, but effects on quality of life (QOL) were not fully described. Patients and Methods : Menopause-specific and health-related QOL were assessed by using the four Menopause-Specific [...]

Menée à partir de données portant sur 21 cohortes asiatiques incluant au total 1 049 929 participants, cette étude évalue la mortalité, toutes causes confondues ou par causes spécifiques, associée au tabagisme chez les adultes âgés de 45 ans ou plus

Burden of Total and Cause-Specific Mortality Related to Tobacco Smoking among Adults Aged ≥45 Years in Asia: A Pooled Analysis of 21 Cohorts

Zheng, Wei ; McLerran, Dale F. ; Rolland, Betsy A. ; Fu, Zhenming ; Boffetta, Paolo ; He, Jiang ; Gupta, Prakash Chandra ; Ramadas, Kunnambath ; Tsugane, Shoichiro ; Irie, Fujiko ; Tamakoshi, Akiko ; Gao, Yu-Tang ; Koh, Woon-Puay ; Shu, Xiao-Ou ; Ozasa, Kotaro ; Nishino, Yoshikazu ; Tsuji, Ichiro ; Tanaka, Hideo ; Chen, Chien-Jen ; Yuan, Jian-Min ; Ahn, Yoon-Ok ; Yoo, Keun-Young ; Ahsan, Habibul ; Pan, Wen-Harn ; Qiao, You-Lin ; Gu, Dongfeng ; Pednekar, Mangesh Suryakant ; Sauvaget, Catherine ; Sawada, Norie ; Sairenchi, Toshimi ; Yang, Gong ; Wang, Renwei ; Xiang, Yong-Bing ; Ohishi, Waka ; Kakizaki, Masako ; Watanabe, Takashi ; Oze, Isao ; You, San-Lin ; Sugawara, Yumi ; Butler, Lesley M. ; Kim, Dong-Hyun ; Park, Sue K. ; Parvez, Faruque ; Chuang, Shao-Yuan ; Fan, Jin-Hu ; Shen, Chen-Yang ; Chen, Yu ; Grant, Eric J. ; Lee, Jung Eun ; Sinha, Rashmi ; Matsuo, Keitaro ; Thornquist, Mark ; Inoue, Manami ; Feng, Ziding ; Kang, Daehee ; Potter, John D.

Background : Tobacco smoking is a major risk factor for many diseases. We sought to quantify the burden of tobacco-smoking-related deaths in Asia, in parts of which men's smoking prevalence is among the world's highest. Methods and Findings : We performed pooled analyses of data from 1,049,929 participants in 21 cohorts in Asia to quantify the risks of total and cause-specific mortality associated with tobacco smoking using adjusted hazard ratios and their 95% confidence intervals. We then [...]

Menée à partir de données portant sur 7 399 patients atteints d'un cancer en phase terminale et décédés entre décembre 2010 et mai 2012, cette étude rétrospective évalue la proportion de patients ayant reçu une chimiothérapie dans les 14 derniers jours de vie

Use of chemotherapy within the last 14 days of life in patients treated at a comprehensive cancer center

Rodriguez, M. ; DeJesus, A. ; Cheng, L.

Evidence suggests that minimizing aggressive treatment for patients with terminal cancer may provide a better quality of life during the patients’ final days.1,2 One of the proposed metrics for determining quality of cancer care is whether chemotherapy is administered in the last 14 days of life.3 We assessed the proportion of patients who received chemotherapy in the last 14 days of life at our institution by diagnostic categories of solid tumor or hematologic malignant neoplasm and by factors [...]

Menée à partir des données des bases de l'Organisation Mondiale de la Santé et d'Eurostat, cette étude estime pour l'année 2014 la mortalité par cancer dans 6 pays européens (France, Allemagne, Italie, Pologne, Espagne et Royaume-Uni)

European cancer mortality predictions for the year 2014

Malvezzi, M. ; Bertuccio, P. ; Levi, F. ; La Vecchia, C. ; Negri, E.

Background : From most recent available data, we projected cancer mortality statistics for 2014, for the European Union (EU) and its six more populous countries. Specific attention was given to pancreatic cancer, the only major neoplasm showing unfavorable trends in both sexes. Patients and methods : Population and death certification data from stomach, colorectum, pancreas, lung, breast, uterus, prostate, leukemias and total cancers were obtained from the World Health Organisation database and [...]

Menée à partir des données du registre norvégien des cancers portant sur la période 1980-2000, cette étude analyse l'association entre le niveau d'éducation des patients atteints d'un cancer, leur accès aux traitements et leur survie

Access to Treatment and Educational Inequalities in Cancer Survival

Fiva, Jon H. ; Hægeland, Torbjørn ; Rønning, Marte ; Syse, Astri

The public health care systems in the Nordic countries provide high quality care almost free of charge to all citizens. However, social inequalities in health persist. Previous research has, for example, documented substantial educational inequalities in cancer survival. We investigate to what extent this may be driven by differential access to and utilization of high quality treatment options. Quasi-experimental evidence based on the establishment of regional cancer wards indicates that i) [...]

Menée à partir de données de registres portant sur l'année 2000 et couvrant trois régions américaines (Détroit, Californie et New Jersey), cette étude évalue, par rapport au reste de la population et aux minorités ethniques, l'incidence de cancers chez les Américains d'origine arabe

Cancer Incidence Among Arab Americans in California, Detroit, and New Jersey SEER Registries

Bergmans, Rachel ; Soliman, Amr S. ; Ruterbusch, Julie ; Meza, Rafael ; Hirko, Kelly ; Graff, John ; Schwartz, Kendra

Objectives : We calculated cancer incidence for Arab Americans in California; Detroit, Michigan; and New Jersey, and compared rates with non-Hispanic, non-Arab Whites (NHNAWs); Blacks; and Hispanics. Methods : We conducted a study using population-based data. We linked new cancers diagnosed in 2000 from the Surveillance, Epidemiology, and End Results Program (SEER) to an Arab surname database. We used standard SEER definitions and methodology for calculating rates. Population estimates were [...]

Menée à l'aide des données d'une étude canadienne portant sur 5 892 patientes atteintes d'un cancer invasif du sein traité entre 1987 et 2008 et à l'aide d'une revue systématique de la littérature (9 études), cette méta-analyse évalue l'association entre le statut tabagique des patientes au diagnostic et leur survie

Smoking at time of diagnosis and breast cancer-specific survival: new findings and systematic review with meta-analysis

Berube, Sylvie ; Lemieux, Julie ; Moore, Lynne ; Maunsell, Elizabeth ; Brisson, Jacques

Introduction : In women with breast cancer who smoke, it is unclear whether smoking could impair their survival from the disease. Methods : We examined the relation of smoking at diagnosis to breast cancer-specific and overall survival among 5,892 women with invasive breast cancer treated in one Canadian center (1987 to 2008). Women were classified as never, former or current smokers. Current smokers were further classified according to total, intensity and duration of smoking. Deaths were [...]

A partir d'une revue systématique de la littérature publiée entre 1946 et 2013 (11 études), cet article identifie les études sur les interventions psychosociales visant à soutenir les partenaires de vie des patients atteints d'un cancer de la prostate et analyse les critères utilisés pour évaluer l'efficacité de ces interventions

Psychosocial interventions to support partners of men with prostate cancer: a systematic and critical review of the literature

Wootten, A. C. ; Abbott, J. M. ; Farrell, A. ; Austin, D. W. ; Klein, B.

Purpose : Prostate cancer poses many challenges for both the man and his partner. Partners have reported a range of issues that impact their own mental health following their partner’s diagnosis of prostate cancer. The aim of this review is to summarise and critically evaluate the current literature reporting psychosocial intervention studies for partners of prostate cancer patients. Methods : An extensive literature search of electronic databases was conducted (OvidMEDLINE 1946, 26th September [...]

Menée à partir d'une enquête auprès de 1 130 oncologues et 1 020 médecins généralistes, cette étude évalue la proportion de médecins délivrant aux patients ayant survécu à un cancer des recommandations relatives au suivi médical et aux soins, puis identifie les facteurs associés à la délivrance de ces recommandations

Provision and Discussion of Survivorship Care Plans Among Cancer Survivors: Results of a Nationally Representative Survey of Oncologists and Primary Care Physicians

Blanch-Hartigan, Danielle ; Forsythe, Laura P. ; Alfano, Catherine M. ; Smith, Tenbroeck ; Nekhlyudov, Larissa ; Ganz, Patricia A. ; Rowland, Julia H.

Purpose : Survivorship care planning should involve discussions between providers and cancer survivors to address survivors’ needs and optimize adherence. We examined the frequency and factors associated with oncologists’ and primary care physicians’ (PCPs) reports of provision of written survivorship care plans (SCPs) and discussion of survivorship care recommendations with survivors. Methods : A nationally representative sample of 1,130 oncologists and 1,020 PCPs was surveyed about [...]

Menée à partir d'une enquête en ligne réalisée en 2013 auprès d'un échantillon national de 17 522 adultes âgés de 18 ans ou plus, cette étude américaine évalue leur niveau de connaissance de la cigarette électronique, identifie leurs sources d'informations sur ce produit et en déduit des recommandations pour la conception de campagnes de santé publique

How U.S. Adults Find Out About Electronic Cigarettes: Implications for Public Health Messages

Pepper, Jessica K. ; Emery, Sherry L. ; Ribisl, Kurt M. ; Brewer, Noel T.

Introduction: Electronic cigarettes (e-cigarettes) are battery-powered nicotine delivery systems that have become increasingly popular in the United States. We sought to understand how U.S. adults hear about e-cigarettes. Methods: A U.S. national sample of 17,522 adults (≥18 years old) completed an online survey in March 2013 assessing their awareness of and sources of information about e-cigarettes. Results: Most respondents (86%) had heard of e-cigarettes. Current and former smokers were more [...]