A partir d'une revue systématique de la littérature (570 études), cette étude internationale met à jour les recommandations de pratique clinique pour la prise en charge et le traitement d'une mucite orale ou gastrointestinale liée aux traitements du cancer

MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy

Lalla, Rajesh V. ; Bowen, Joanne ; Barasch, Andrei ; Elting, Linda ; Epstein, Joel ; Keefe, Dorothy M. ; McGuire, Deborah B. ; Migliorati, Cesar ; Nicolatou-Galitis, Ourania ; Peterson, Douglas E. ; Raber-Durlacher, Judith E. ; Sonis, Stephen T. ; Elad, Sharon ; The Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in, Cancer ; International Society of Oral, Oncology

BACKGROUND Mucositis is a highly significant, and sometimes dose-limiting, toxicity of cancer therapy. The goal of this systematic review was to update the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO) Clinical Practice Guidelines for mucositis. METHODS A literature search was conducted to identify eligible published articles, based on predefined inclusion/exclusion criteria. Each article was independently reviewed by 2 reviewers. [...]

Menée aux Etats-Unis auprès de 131 patients masculins atteints d'un cancer de stade avancé (âge médian : 64 ans), cette étude évalue l'association entre de faibles niveaux de testostérone, un hypogonadisme, la nature et la sévérité de divers symptômes, et la survie des patients

Association between hypogonadism, symptom burden, and survival in male patients with advanced cancer

Dev, Rony ; Hui, David ; Del Fabbro, Egidio ; Delgado-Guay, Marvin O. ; Sobti, Nikhil ; Dalal, Shalini ; Bruera, Eduardo

BACKGROUND A high frequency of hypogonadism has been reported in male patients with advanced cancer. The current study was performed to evaluate the association between low testosterone levels, symptom burden, and survival in male patients with cancer. METHODS Of 131 consecutive male patients with cancer, 119 (91%) had an endocrine evaluation of total (TT), free (FT), and bioavailable testosterone (BT); high-sensitivity C-reactive protein (CRP); vitamin B12; thyroid-stimulating hormone; [...]

A partir d'une revue systématique de la littérature, cette étude européenne propose des recommandations pour la prise en charge de la malnutrition et de la cachexie chez les patients atteints de cancer

Early recognition of malnutrition and cachexia in the cancer patient: a position paper of a European School of Oncology Task Force

Aapro, M. ; Arends, J. ; Bozzetti, F. ; Fearon, K. ; Grunberg, S. M. ; Herrstedt, J. ; Hopkinson, J. ; Jaquelin-Ravel, N. ; Jatoi, A. ; Kaasa, S. ; Strasser, F.

Background : Weight loss and cachexia are common, reduce tolerance of cancer treatment and the likelihood of response, and independently predict poor outcome. Methods : A group of experts met under the auspices of the European School of Oncology to review the literature and - on the basis of the limited evidence at present - make recommendations for malnutrition and cachexia management and future research. Conclusions : Our focus should move from end-stage wasting to supporting patients' [...]

Mené aux Etats-Unis auprès de 52 patients atteints d'un cancer de l'œsophage, cet essai de phase II évalue l'efficacité d'une endoprothèse œsophagienne auto-expansible pour améliorer leur qualité de vie et faciiliter la nutrition durant une thérapie néo-adjuvante

Evaluation of Quality of Life Following Placement of Self-Expanding Plastic Stents as a Bridge to Surgery in Patients Receiving Neoadjuvant Therapy for Esophageal Cancer

Martin, Robert C.G. ; Cannon, Robert M. ; Brown, Russell E. ; Ellis, Susan F. ; Williams, Sharon ; Scoggins, C.R. ; Abbas, Abbas E.

Purpose : To determine whether self-expanding plastic stent (SEPS) placement significantly improves quality of life and maintains optimal nutrition while allowing full-dose neoadjuvant therapy (NAT) in patients with esophageal cancer. Patients and Methods : A prospective, dual-institution, single-arm, phase II (http://ClinicalTrials.gov: NCT00727376) evaluation of esophageal cancer patients undergoing NAT prior to resection. All patients had a self-expanding polymer stent placed prior to NAT. [...]

Menée auprès de 109 patientes atteintes d'un cancer du sein de stade 0 à III, cet essai randomisé évalue l'efficacité du yoga pour améliorer leur qualité de vie durant la radiothérapie

Randomized, Controlled Trial of Yoga in Women With Breast Cancer Undergoing Radiotherapy

Chandwani, Kavita D. ; Perkins, George ; Nagendra, Hongasandra Ramarao ; Raghuram, Nelamangala V. ; Spelman, Amy ; Nagarathna, Raghuram ; Johnson, Kayla ; Fortier, Adoneca ; Arun, Banu ; Wei, Qi ; Kirschbaum, Clemens ; Haddad, Robin ; Morris, G. Stephen ; Scheetz, Janet ; Chaoul, Alejandro ; Cohen, Lorenzo

Purpose : Previous research incorporating yoga (YG) into radiotherapy (XRT) for women with breast cancer finds improved quality of life (QOL). However, shortcomings in this research limit the findings. Patients and Methods : Patients with stages 0 to III breast cancer were recruited before starting XRT and were randomly assigned to YG (n = 53) or stretching (ST; n = 56) three times a week for 6 weeks during XRT or waitlist (WL; n = 54) control. Self-report measures of QOL (Medical Outcomes [...]

Menée en Australie auprès de 385 patients atteints de cancer et âgés de plus de 70 ans, cette étude analyse la prévalence et les facteurs associés à l'utilisation de multiples médicaments dont l'interaction est susceptible d'induire des événements indésirables

Prevalence and factors associated with polypharmacy in older people with cancer

Turner, JustinP ; Shakib, Sepehr ; Singhal, Nimit ; Hogan-Doran, Jonathon ; Prowse, Robert ; Johns, Sally ; Bell, J. Simon

Purpose : Polypharmacy has been associated with drug–drug interactions, adverse drug events, hospitalisation and increased mortality. The purpose of this study was to investigate the prevalence and factors associated with polypharmacy in older people with cancer. Patients and methods : Patients aged ≥70 years (n=385) presenting to the medical oncology outpatient clinic at Royal Adelaide Hospital between January 2009 and July 2010 completed a structured data collection instrument. The instrument [...]

Menée à Montréal auprès de 537 étudiantes à l'université, cette étude canadienne analyse les facteurs comportementaux et biologiques associés à des co-infection par le papillomavirus humain

Determinants of human papillomavirus coinfections among Montreal university students: the influence of behavioural and biological factors

Smith, Michaela A ; Tellier, Pierre-Paul ; Roger, Michel ; Coutlée, François ; Franco, Eduardo L. ; Richardson, Harriet

Background: HPV coinfections are common among HPV-infected individuals, but the significance and etiology of these infections remain unclear. Though current evidence suggests that women with coinfections have increased HPV exposure (i.e. more sexual partners), it is also hypothesized that these women may represent a subgroup with increased biological susceptibility. This study sought to examine determinants of coinfections in a cohort of young women, examining both behavioural and biological [...]

A partir d'une revue systématique de la littérature (5 études incluant 2 330 cas de cancer colorectal, 5 études incluant 4 413 cas de cancer du sein), cette méta-analyse évalue l'association entre les niveaux sériques de la vitamine D et la survie des patients atteints d'un cancer du côlon-rectum ou du sein

Serum 25-hydroxyvitamin D levels and survival in colorectal and breast cancer patients: Systematic review and meta-analysis of prospective cohort studies

Maalmi, Haifa ; Ordóñez-Mena, José Manuel ; Schottker, Ben ; Brenner, Hermann

To estimate the association between serum 25-hydroxyvitamin D (25(OH)D) levels and survival among colorectal and breast cancer patients. We performed a comprehensive literature search of prospective cohort studies assessing the association of serum 25(OH)D levels with survival in colorectal and breast cancer patients. Study characteristics and results were extracted and dose–response relationships were graphically displayed in a standardised manner. Meta-analyses using random effects models [...]

Menée en Angleterre auprès de 10 297 patients atteints d'un cancer (18 types différents, période 2009-2010), cette étude analyse les disparités dans le délai entre l'apparition des premiers symptômes et la consultation d'un médecin généraliste

Variation in promptness of presentation among 10,297 patients subsequently diagnosed with one of 18 cancers: Evidence from a National Audit of Cancer Diagnosis in Primary Care

Keeble, Stuart ; Abel, Gary A. ; Saunders, Catherine L. ; McPhail, Sean ; Walter, Fiona M. ; Neal, Richard D. ; Rubin, Gregory P. ; Lyratzopoulos, Georgios

Cancer awareness public campaigns aim to shorten the interval between symptom onset and presentation to a doctor (the ‘patient interval’). Appreciating variation in promptness of presentation can help to better target awareness campaigns. We explored variation in patient intervals recorded in consultations with general practitioners among 10,297 English patients subsequently diagnosed with one of 18 cancers (bladder, brain, breast, colorectal, endometrial, leukaemia, lung, lymphoma, melanoma, [...]

A partir des données des registres américains des cancers et de la base Medicare portant sur la période 1992-2005, cette étude analyse l'incidence d'une sclérose latérale amyotrophique après la survenue d'un cancer

The risk of amyotrophic lateral sclerosis after cancer in U.S. elderly adults: A population-based prospective study

Freedman, D. Michal ; Wu, Jincao ; Daugherty, Sarah E. ; Kuncl, Ralph W. ; Enewold, Lindsey R. ; Pfeiffer, Ruth M.

Although epidemiologic studies have examined the risk of amyotrophic lateral sclerosis (ALS) in relation to cancer, none have been large population-based studies using incident ALS and adjusting for medical surveillance. Addressing those limitations, all first primary cancer cases from the Surveillance, Epidemiology and End Results (SEER) Program (1992–2005), linked to Medicare claims data were used. Cases were followed from cancer diagnosis until the earliest date of ALS diagnosis, a break in [...]

A partir des données du registre allemand des cancers pédiatriques portant sur des cas diagnostiqués entre 1992 et 1994, cette étude évalue l'association entre des facteurs socioéconomiques et la survie de patients atteints d'une leucémie lymphoblastique aiguë durant l'enfance

Survival from childhood acute lymphoblastic leukaemia in West Germany: Does socio-demographic background matter?

Erdmann, Friederike ; Kaatsch, Peter ; Zeeb, Hajo ; Roman, Eve ; Lightfoot, Tracy ; Schüz, Joachim

Sex, age, immunophenotype and white blood cell count at diagnosis are well accepted predictors of survival from acute lymphoblastic leukaemia (ALL) in children. Less is known about the relationship between socio-economic determinants and survival from paediatric ALL, studied here for the first time in German children. ALL cases were diagnosed between 1992 and 1994 and their parents interviewed during a previous nationwide case-control study. Children were followed-up for 10years after diagnosis [...]

A partir des données d'un registre canadien des cancers portant sur 1 357 patients âgés de 18 à 80 ans (âge médian : 64 ans), cette étude analyse les disparités géographiques dans les traitements reçus et la survie des patients atteints d'un lymphome diffus à grandes cellules B

Effect of Place of Residence and Treatment on Survival Outcomes in Patients With Diffuse Large B-Cell Lymphoma in British Columbia

Lee, Benny ; Goktepe, Ozge ; Hay, Kevin ; Connors, Joseph M. ; Sehn, Laurie H. ; Savage, Kerry J. ; Shenkier, Tamara ; Klasa, Richard ; Gerrie, Alina ; Villa, Diego

Background. We examined the relationship between location of residence at the time of diagnosis of diffuse large B-cell lymphoma (DLBCL) and health outcomes in a geographically large Canadian province with publicly funded, universally available medical care. Patients and Methods. The British Columbia Cancer Registry was used to identify all patients 18–80 years of age diagnosed with DLBCL between January 2003 and December 2008. Home and treatment center postal codes were used to determine urban [...]

A partir des données des registres américains des cancers portant sur 61 213 patients atteints d'un cancer colorectal et âgés de plus de 67 ans, cette étude évalue l'effet d'un diabète pré-existant sur le pronostic de la maladie

Diabetes and prognosis in older persons with colorectal cancer

Luo, J. ; Lin, H. C. ; He, K. ; Hendryx, M.

Background: Epidemiological studies have reported that diabetes significantly increases overall mortality in patients with colorectal cancer. However, it is unclear whether diabetes increases colorectal cancer-specific mortality. We used the US Surveillance Epidemiology and End Results (SEER) database linked with Medicare claims data to assess the influence of pre-existing diabetes on prognosis of patients with colorectal cancer. Methods: Data from 61 213 patients aged 67 or older with [...]

Menée aux Etats-Unis par enquêtes auprès de 477 patients atteints de syndromes myélodysplasiques et de 102 professionnels de santé, cette étude analyse les disparités dans les perceptions des caractéristiques de la maladie, dans l'efficacité des thérapies et dans l'adhésion aux traitements

Disparity in perceptions of disease characteristics, treatment effectiveness, and factors influencing treatment adherence between physicians and patients with myelodysplastic syndromes

Steensma, David P. ; Komrokji, Rami S. ; Stone, Richard M. ; List, Alan F. ; Garcia-Manero, Guillermo ; Huber, John M. ; Dennison, Betsy ; Sekeres, Mikkael A.

BACKGROUND Previous studies have suggested that many patients with myelodysplastic syndromes (MDS) have an incomplete understanding of their disease, which may influence adherence to prescribed regimens and outcomes. METHODS To better understand physician and patient perceptions about MDS and MDS therapy, the authors conducted 2 surveys in February 2012: 1 for patients with MDS and 1 for health care professionals (HCPs) who cared for patients with MDS. Patient and HCP surveys consisted of 57 [...]

A partir des données de la cohorte "National Runners' and Walkers' Health Studies" portant sur 986 participantes atteintes d'un cancer du sein, cette étude américaine montre que la pratique de la course à pied, après le diagnostic, est associée à une plus forte réduction de la mortalité par cancer du sein que la marche

Significantly greater reduction in breast cancer mortality from post-diagnosis running than walking

Williams, Paul T.

The purpose of these analyses is to test prospectively whether post-diagnosis running and walking differ significantly in their association with breast cancer mortality. Cox proportional hazard analyses were used to compare breast cancer mortality to baseline exercise energy expenditure (METs, 1 MET-hour ≅1 km run) in 272 runners and 714 walkers previously diagnosed with breast cancer from the National Runners' and Walkers' Health Studies when adjusted for age, race, menopause, family history, [...]

Menée en Allemagne auprès de 2 542 survivantes d'un cancer du sein âgées de 50 à 74 ans lors du diagnostic, cette étude analyse la prévalence et la nature des comorbidités associés à divers traitements (inhibiteurs d'aromatase, trastuzumab...)

Determinants of newly diagnosed comorbidities among breast cancer survivors

Obi, Nadia ; Gornyk, Daniela ; Heinz, Judith ; Vrieling, Alina ; Seibold, Petra ; Chang-Claude, Jenny ; Flesch-Janys, Dieter

Purpose : Comorbid conditions have become increasingly relevant for breast cancer care given the large numbers of long-term survivors. Our aim was to identify potential determinants associated with the development of comorbidities after breast cancer. Methods : Self-reported comorbidities and lifestyle were assessed at recruitment and after a median follow up of 69.4 months from diagnosis in a population-based cohort of breast cancer cases aged 50 to 74 years at diagnosis (MARIEplus study). [...]

Menée aux Pays-Bas auprès de 561 survivantes d'un cancer du sein, cette étude cas-témoins évalue le risque de maladies cardiovasculaires chez une population ayant été traitée par chimiothérapie et/ou radiothérapie

Long-term follow-up for cardiovascular disease after chemotherapy and/or radiotherapy for breast cancer in an unselected population

Boerman, L. M. ; Berendsen, A. J. ; Meer, P. ; Maduro, J. H. ; Berger, M. Y. ; Bock, G. H.

Purpose : Whereas earlier research focused on specific patient groups, this study assessed the risk of cardiovascular disease (CVD) in an unselected population curatively treated for breast cancer (BC), compared with an age-matched random sample of controls. Methods : Risks were determined in BC survivors and controls. CVD was divided into three categories: congestive heart failure, vascular cardiac diseases, and “other” cardiac diseases. Hazard ratios (HRs) and 95 % confidence intervals (95 % [...]

Menée aux Etats-Unis auprès de 41 062 participants, cette étude compare, chez des adolescents et jeunes adultes (âge : de 15 à 39 ans), les caractéristiques et les traitements associés à un cancer primitif ou secondaire de la thyroïde, ainsi que la survie

Comparison of secondary and primary thyroid cancer in adolescents and young adults

Goldfarb, Melanie ; Freyer, David R.

BACKGROUND Thyroid cancer is one of the 5 most common malignancies in adolescent and young adult (AYA) patients (ages 15-39 years) and may develop de novo or in patients previously treated for cancer. This study compared the tumor characteristics, treatment, and overall survival (OS) of secondary malignant neoplasm (SMN) versus primary thyroid cancer in AYA patients. METHODS All cases of AYA thyroid cancer contained in the 1998 to 2010 American College of Surgeons National Cancer Database were [...]

Menée aux Etast-Unis auprès de 111 survivants d'un cancer et 111 témoins sans histoire de cancer, cette étude analyse la prévalence du phénomène dit d'amplification somatique et son association avec la sévérité des symptômes physiques signalés par les patients

Daily well-being of cancer survivors: the role of somatic amplification

Barrineau, Mary Jon ; Zarit, Steven H. ; King, Heather A. ; Costanzo, Erin S. ; Almeida, David M.

Objective : The current study examined the role that somatic amplification plays in placing cancer survivors at an increased risk of impairments in daily well-being, specifically severity of physical symptoms, positive affect and negative affect. Methods : Participants were drawn from Midlife Development in the United States National Study of daily health and well-being (MIDUS) and the National Study of Daily Experiences (NSDE, Project 2). One hundred eleven individuals with a cancer history [...]

A partir des données de 252 patients atteints d'un cancer colorectal, cette étude américaine évalue les facteurs financiers et psychologiques associés à une consultation médicale tardive après l'apparition des premiers symptômes de la maladie

Factors associated with delayed patient appraisal of colorectal cancer symptoms

Siminoff, Laura ; Thomson, Maria ; Dumenci, Levent

Objective : To evaluate the relationship between symptoms, financial and cognitive barriers with patient delays in seeking evaluation of symptoms. Methods : Data were collected from 252 colorectal cancer patients from academic and community oncology practices in Virginia and Ohio. We used a cross-sectional, mixed methods design collected data through patient interviews and medical record reviews. Structural equation modeling (SEM) tested the hypothesized relationships between symptoms, [...]

Mené aux Etats-Unis auprès de 18 couples dont un des partenaires est atteint d'un cancer colorectal, cet essai randomisé évalue la faisabilité et l'efficacité d'une intervention menée par téléphone destinée à aider les couples dans leurs relations intimes et sexuelles

A randomized pilot trial of a telephone-based couples intervention for physical intimacy and sexual concerns in colorectal cancer

Reese, Jennifer Barsky ; Porter, Laura S. ; Regan, Katelyn R. ; Keefe, Francis J. ; Azad, Nilofer S. ; Diaz, Luis A. ; Herman, Joseph M. ; Haythornthwaite, Jennifer A.

Background : We previously developed and piloted a telephone-based intimacy enhancement (IE) intervention addressing sexual concerns of colorectal cancer patients and their partners in an uncontrolled study. The current study tested the feasibility, acceptability, and preliminary efficacy of the IE intervention in a randomized, controlled trial. Methods : Twenty-three couples were randomized to either the four-session IE condition or to a wait list control condition and completed sexual and [...]

A partir des données de la cohorte "Women's Healthy Eating and Living Study" incluant 2 431 survivantes d'un cancer du sein, cette étude américaine analyse les effets de la détresse associée à un lymphœdème sur divers indicateurs de leur santé mentale et physique

The psychosocial impact of lymphedema-related distress among breast cancer survivors in the WHEL Study

Dominick, Sally A. ; Natarajan, Loki ; Pierce, John P. ; Madanat, Hala ; Madlensky, Lisa

Objective : Lymphedema is a distressing and chronic condition affecting up to 30% of breast cancer survivors. Using a cross-sectional study design, we examined the impact of self-reported lymphedema-related distress on psychosocial functioning among breast cancer survivors in the Women's Healthy Eating and Living Study. The Women's Healthy Eating and Living Study has a dataset that includes self-report data on lymphedema status, symptoms, and distress. Methods : Chi-square tests and binary [...]

Menée en Chine auprès de 287 patients atteints de tumeurs buccales et maxillo-faciales, cette étude transversale analyse leurs morbidités psychologiques (anxiété, dépression, détresse) et leur qualité de vie en fonction de leur degré de conscience du diagnostic de cancer

Psychological morbidity and health-related quality of life in patients with differing awareness of cancer diagnosis: a cross-sectional study

Wang, Dian Can ; Guo, Chuan Bin ; Peng, Xin ; Su, Yan Jie

Objective : Concealment of cancer diagnosis from patients is not rare worldwide and physicians in mainland China are in fact discouraged from disclosing a cancer diagnosis to cancer patients. Preventing worsened psychological morbidity is at the core of the argument for nondisclosure. The purpose of this study was to quantify anxiety, depression, and distress among patients with various degrees of awareness of their cancer diagnosis. Quality of life was also measured. Methods : Using a [...]

A partir de données de prescriptions de médicaments portant sur la période 2007-2012 en Angleterre et au Pays-de-Galles, cette étude évalue l'intérêt du Fonds des Médicaments Anticancéreux mis en place en Angleterre pour faciliter l'accès des patients à des traitements ayant fait l'objet d'une appréciation défavorable de leur rapport coût-efficacité par le "National Institute for Health and Care Excellence"

Does the cancer drugs fund lead to faster uptake of cost-effective drugs ? A time-trend analysis comparing England and Wales

Chamberlain, C. ; Collin, S. M. ; Stephens, P. ; Donovan, J. ; Bahl, A. ; Hollingworth, W.

Background: The Cancer Drugs Fund (CDF) provides £200 million annually in England for ‘anti-cancer’ drugs. Methods: We used a controlled pre-/post-intervention design to compare IMS Health dispensing data for 15 cancer drugs (2007–2012) in England vs Wales, stratified by pre-CDF NICE drug approval status (rejected, mixed recommendations, recommended, not appraised). Results: The CDF was associated with increased prescribing in England for three of five drugs rejected or with mixed NICE [...]

Menée aux Etats-Unis par enquête adressée à 1 366 spécialistes médicaux, radio-oncologues ou urologues, cette étude américaine analyse les biais induits par leur spécialité médicale dans leurs recommandations thérapeutiques pour un cancer localisé de la prostate ainsi que dans leurs perceptions de l'efficacité du traitement en termes d'amélioration de la qualité de vie et de la survie du patient

Specialty bias in treatment recommendations and quality of life among radiation oncologists and urologists for localized prostate cancer

Kim, S. P. ; Gross, C. P. ; Nguyen, P. Y. ; Smaldone, M. C. ; Thompson, R. H. ; Shah, N. D. ; Kutikov, A. ; Han, L. C. ; Karnes, R. J. ; Ziegenfuss, J. Y. ; Tilburt, J. C.

Background: Given the importance of physician attitudes about different treatments and the quality of life (QOL) in prostate cancer, we performed a national survey of specialists to assess treatment recommendations and perceptions of treatment-related survival and QOL. Methods: We mailed a self-administered survey instrument to a random sample of 1366 specialists in the US. Respondents were asked for treatment recommendations and survival that varied by PSA levels and Gleason scores and [...]